Cure Alzheimer's Fund Cure Alzheimer's Fund

Howard L. Weiner, M.D.

Robert L. Kroc Professor of Neurology, Harvard Medical School; Chief, Division of Multiple Sclerosis and Neuro-Immunology, Department of Neurology; Co-Director, Ann Romney Center for Neurologic Diseases, Brigham & Women’s Hospital

Howard L. Weiner, M.D.,  is the Robert L. Kroc Professor of Neurology at the Harvard Medical School, Director and Founder of the Partners Multiple Sclerosis Center and Co-Director of the Ann Romney Center for Neurologic Diseases at Brigham & Women’s Hospital in Boston which has over 200 scientists and investigates five major brain diseases: Multiple Sclerosis, Alzheimer’s disease, Amyotrophic Lateral Sclerosis (ALS), Parkinson’s disease and brain tumors. He is the recipient of the NIH Director’s Transformative R01 for the study of the innate immune system in Alzheimer’s disease. He has pioneered the investigation of the mucosal immune system and the gut microbiome in neurologic diseases including MS, Alzheimer’s disease and ALS.

Related Research:

T-Cell Modulation of Microglia to Treat Alzheimer’s Disease Howard L. Weiner 2024-02-28 Targeting the Microbiome and Innate Immunity in Alzheimer’s Disease Howard L. Weiner Laura Cox 2022-06-23 Targeting the Microbiome and Microglia in Alzheimer’s Disease Howard L. Weiner Laura Cox 2020-01-09

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
T-Cell Modulation of Microglia to Treat Alzheimer’s Disease 2024, 2025

$402,468
Targeting the Microbiome and Innate Immunity in Alzheimer’s Disease 2022, 2023

$402,500
Targeting the Microbiome and Microglia in Alzheimer’s Disease 2019, 2021

$345,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Kimura, K., Subramanian, A., Yin, Z., Khalilnezhad, A., Wu, Y., He, D., Dixon, K. O., Chitta, U. K., Ding, X., Adhikari, N., Guzchenko, I., Zhang, X., ... Selkoe, D., Weiner, H. L., Blurton-Jones, M., Cruchaga, C., … Butovsky, O., Kuchroo, V. K. Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease, Nature, April 9, 2025, Read More

Hu, D., Chen, M., Li, X., Daley, S., Morin, P., Han, Y., Hemberg, M., Weiner, H. L., & Xia, W. ApoE ε4-dependent Alteration of CXCR3 + CD127+ CD4+ T cells associates with elevated plasma neurofilament light chain in Alzheimer’s disease, Journal of Alzheimer's Disease, March 20, 2025, Read More

Brandao, W., Jain, N., Yin, Z., Kleemann, K. L., … Ulrich, J. D., Blurton-Jones, M., Ilin, I., Weiner., H. L., Holtzman, D. M., Butovsky, O. Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy, Science Translational Medicine, January 15, 2025, Read More

Rosenzweig, N., Kleemann, K. L., Rust, T., Carpenter, M., Grucci, M., Aronchik, M., Brouwer, N., Valenbreder, I., Cooper-Hohn, J., Iyer, M., Krishnan, R. K., Sivanathan, K. N., Brandão, W., Yahya, T., Durao, A., Yin, Z., Chadarevian, J. P., Properzi, M. J., Nowarski, R., Davtyan, H., Weiner, L. H., Blurton Jones, M., … Butovsky, O. Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease, Nature Medicine, July 3, 2024, Read More

Wasén, C., Beauchamp, L. C., Vincentini, J., Li, S., LeServe, D. S., Gauthier, C., Lopes, J. R., Moreira, T. G., Ekwudo, M. N., Yin, Z., da Silva, P., Krishnan, R. K., Butovsky, O., Cox, L. M., & Weiner, H. L. Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer’s disease mouse models, Nature Communications, May 8, 2024, Read More

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