Hui Zheng, Ph.D.

Huffington Foundation Endowed Chair in Aging; Director, Huffington Center on Aging; Professor, Departments of Molecular & Human Genetics, Baylor College of Medicine


Dr. Zheng obtained her Ph.D. degree from Baylor College of Medicine in 1990. After brief postdoctoral training at Baylor, she joined Merck & Co. where she began her research on Alzheimer’s disease, which continued after her return to Baylor in 1999. Dr. Zheng’s expertise is in mouse genetics and she is a pioneer in utilizing sophisticated mouse models to probe the biology and pathophysiology of the amyloid precursor protein and presenilins. Dr. Zheng’s current research is focused on the investigation of the autophagy-lysosomal pathway and neuron-immune interaction in AD and related disorders.

Dr. Zheng has published over 100 papers. She is a recipient of the New Scholar Award from the Ellison Medical Foundation and the Zenith Award from the Alzheimer’s Association. She served on the Alzheimer’s Association Medical & Scientific Advisory Council from 2011 to 2018. Currently, she is a member of the Tau Consortium Scientific Advisory Board and a co-Chair of the Scientific Review Committee of the BrightFocus Foundation.



Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Roy ER, Chiu G, Li S, Propson NE, Kanchi R, Wang B, Coarfa C, Zheng H, Cao W. Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques, Immunity, May 10, 2022, Read More

Gedam, M., Comerota, M. M., Propson, N. E., Chen, T., Jin, F., Wang, M. C., & Zheng, H. Complement C3aR depletion reverses HIF-1α–induced metabolic impairment and enhances microglial response to Aβ pathology, Journal of Clinical Investigation, June 15, 2023, Read More

Comerota, M. M., Gedam, M., Xiong, W., Jin, F., Deng, L., Wang, M. C., Wang, J., & Zheng, H. Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease, Molecular Neurodegeneration, August 15, 2023, Read More

Wang, B., Martini-Stoica, H., Qi, C., Lu, T. C., Wang, S., Xiong, W., Qi, Y., Xu, Y., Sardiello, M., Li, H., & Zheng, H. TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy, Nature Neuroscience, November 20, 2023, Read More