Helene Benveniste, M.D., Ph.D.

Professor of Anesthesiology, Yale School of Medicine

Dr. Benveniste is currently professor of Anesthesiology at Yale University School of Medicine. Over the course of her career, she has developed innovative techniques and diagnostic MRI-based platforms for brain imaging focused on neurodegenerative disease including Alzheimer’s Disease and its early detection. She also demonstrated that neuritic Ab plaques in specimens from human subjects with Alzheimer’s could be non-invasively detected by T2*-weighted MRI. Benveniste’s most recent work has been focused on studies of visualizing the ‘glymphatic system’– a novel peri-vascular based system in the central nervous system involved in brain waste removal and on understanding how the glymphatic system and cerebrospinal fluid transport is affected in Alzheimer’s disease.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

van Veluw, S. J., Benveniste, H., Bakker, E. N. T. P., Carare, R. O., Greenberg, S. M., Iliff, J. J., Lorthois, S., Van Nostrand, W. E., Petzold, G. C., Shih, A. Y., & van Osch, M. J. P. Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies, Cellular and Molecular Life Sciences, May 27, 2024, Read More

Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., Jacobs, R. E., Doubal, F. N., Ramirez, J., Black, S. E., Nedergaard, M., Benveniste, H., Dichgans, M., Iadecola, C., Love, S., Bath, P. M., … Zlokovic, B. V. Vascular dysfunction — The disregarded partner of Alzheimer’s disease, Alzheimer's & Dementia, January 1, 2019, Read More

Ozturk, B., Koundal, S., Al Bizri, E., Chen, X., Gursky, Z. H., Dai, F., Lim, A. S., Heerdt, P., Kipnis, J., Tannenbaum, A., Lee, H., & Benveniste, H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport, JCI Insight, May 9, 2023, Read More

Chen, X., Tran, A. P., Elkin, R., Benveniste, H., & Tannenbaum, A. R. Visualizing Fluid Flows via Regularized Optimal Mass Transport with Applications to Neuroscience, Journal of Scientific Computing, September 19, 2023, Read More

Zhao, L., Tannenbaum, A., Bakker, E. N. T. P., & Benveniste, H. Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain, Physiology, September 15, 2022, Read More