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Helene Benveniste, M.D., Ph.D.

Professor of Anesthesiology, Yale School of Medicine

Dr. Benveniste is currently professor of Anesthesiology at Yale University School of Medicine. Over the course of her career, she has developed innovative techniques and diagnostic MRI-based platforms for brain imaging focused on neurodegenerative disease including Alzheimer’s Disease and its early detection. She also demonstrated that neuritic Ab plaques in specimens from human subjects with Alzheimer’s could be non-invasively detected by T2*-weighted MRI. Benveniste’s most recent work has been focused on studies of visualizing the ‘glymphatic system’– a novel peri-vascular based system in the central nervous system involved in brain waste removal and on understanding how the glymphatic system and cerebrospinal fluid transport is affected in Alzheimer’s disease.

Related Research:

Brain Entry and Exit Consortium: Central Nervous System Fluid Homeostasis and Waste Clearance in Alzheimer’s Disease Characterized by MRI Helene Benveniste Allen Tannenbaum David Xianfeng Gu 2022-05-09 Brain Entry and Exit Consortium: Glymphatic-Lymphatic Coupling in Alzheimer’s Disease Helene Benveniste Allen Tannenbaum 2022-02-10

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Brain Entry and Exit Consortium: Central Nervous System Fluid Homeostasis and Waste Clearance in Alzheimer’s Disease Characterized by MRI 2022, 2023

$490,485
Brain Entry and Exit Consortium: Glymphatic-Lymphatic Coupling in Alzheimer’s Disease 2021

$164,730

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Koundal, S., Chen, X., Gursky, Z., Lee, H., Xu, K., Liang, F., Xie, Z., Xu, F., Lin, H. M., Van Nostrand, W. E., Gu, X., Elkin, R., Tannenbaum, A., & Benveniste, H. Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer’s disease, iScience, December 20, 2024, Read More

Schrader, J. M., Majchrzak, M., Xu, F., Lee, H., Agostinucci, K., Davis, J., Benveniste, H., & Van Nostrand, W. E. Cerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments, Neuroscience Insights, October 8, 2024, Read More

van Veluw, S. J., Benveniste, H., Bakker, E. N. T. P., Carare, R. O., Greenberg, S. M., Iliff, J. J., Lorthois, S., Van Nostrand, W. E., Petzold, G. C., Shih, A. Y., & van Osch, M. J. P. Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies, Cellular and Molecular Life Sciences, May 27, 2024, Read More

Chen, X., Benveniste, H., & Tannenbaum, A. R. Unbalanced regularized optimal mass transport with applications to fluid flows in the brain, Scientific Reports, January 11, 2024, Read More

Chen, X., Tran, A. P., Elkin, R., Benveniste, H., & Tannenbaum, A. R. Visualizing Fluid Flows via Regularized Optimal Mass Transport with Applications to Neuroscience, Journal of Scientific Computing, September 19, 2023, Read More

Ozturk, B., Koundal, S., Al Bizri, E., Chen, X., Gursky, Z. H., Dai, F., Lim, A. S., Heerdt, P., Kipnis, J., Tannenbaum, A., Lee, H., & Benveniste, H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport, JCI Insight, May 9, 2023, Read More

Zhao, L., Tannenbaum, A., Bakker, E. N. T. P., & Benveniste, H. Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain, Physiology, September 15, 2022, Read More

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