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Sidney Strickland, Ph.D.

Dr. Strickland received his bachelor’s degree in chemistry from Rhodes College in Memphis and his PhD in biochemistry from the University of Michigan. He joined The Rockefeller University as a research associate and rose to the rank of associate professor. He moved to Stony Brook University as an associate professor and was promoted to professor and then Leading Professor. He returned to Rockefeller as head of the Laboratory of Neurobiology & Genetics and dean of graduate and postgraduate studies. Dr. Strickland has received a National Science Foundation Graduate Fellowship, a Jane Coffin Childs Postdoctoral Fellowship, an American Heart Association established investigator award, and a distinguished graduate award from the University of Michigan. He also received a distinguished alumni award and an honorary doctor of science degree from Rhodes College. He was named a John Simon Guggenheim Fellow, and awarded the International Society for Fibrinolysis and Proteolysis Prize, the Innovation Research Award from the Alzheimer’s Drug Discovery Foundation, and a Zenith Award from the Alzheimer’s Association.

 

Related Research:

The Role of the Contact System in Alzheimer’s Disease Erin H. Norris Sidney Strickland 2019-01-10 FXII System’s Effect on Alzheimer’s Disease Sidney Strickland 2014-11-19

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
The Role of the Contact System in Alzheimer’s Disease 2017-2018

$300,000
FXII System’s Effect on Alzheimer’s Disease 2014

$100,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Cajamarca, S. A., Norris, E. H., van der Weerd, L., Strickland, S., & Ahn, H. J. Cerebral amyloid angiopathy-linked beta-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen, Proceedings of the National Academy of Sciences of the United States of America, June 9, 2020, Read More

Chen, Z. L., Singh, P., Wong, J., Horn, K., Strickland, S., & Norris, E. H. An antibody against HK blocks Alzheimer’s disease peptide beta-amyloid-induced bradykinin release in human plasma, Proceedings of the National Academy of Sciences of the United States of America, November 12, 2019, Read More

Baker, S. K., Chen, Z. L., Norris, E. H., Revenko, A. S., MacLeod, A. R., & Strickland, S. Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease, Proceedings of the National Academy of Sciences of the United States of America, September 25, 2018, Read More

Chen, Z. L., Singh, P. K., Horn, K., Strickland, S., & Norris, E. H. Anti-HK antibody reveals critical roles of a 20-residue HK region for Aβ-induced plasma contact system activation, Blood Advances, May 24, 2022, Read More

Singh, P. K., Chen, Z. L., Ghosh, D., Strickland, S., & Norris, E. H. Increased plasma bradykinin level is associated with cognitive impairment in Alzheimer’s patients, Neurobiology of Disease, March 12, 2020, Read More

Baker, S. K., Chen, Z. L., Norris, E. H., & Strickland, S. Plasminogen mediates communication between the peripheral and central immune system during systemic immune challenge with lipopolysaccharide, Journal of Neuroinflammation, August 28, 2019, Read More

Singh, P. K., Chen, Z. L., Strickland, S., & Norris, E. H. Increased Contact System Activation in Mild Cognitive Impairment Patients with Impaired Short-Term Memory, Journal of Alzheimer's Disease, September 1, 2020, Read More

Farfara, D., Feierman, E., Richards, A., Revenko, A. S., MacLeod, R. A., Norris, E. H., & Strickland, S. Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits, Glia, March 18, 2019, Read More

Ahn, H. J., Chen, Z. L., Zamolodchikov, D., Norris, E. H., & Strickland, S. Interactions of beta-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer’s disease, Current Opinion in Hematology, September 1, 2017, Read More

Suidan, G. L., Singh, P. K., Patel-Hett, S., Chen, Z. L., Volfson, D., Yamamoto-Imoto, H., Norris, E. H., Bell, R. D., & Strickland, S. Abnormal clotting of the intrinsic contact pathway in Alzhiemer’s disease patients is related to cognitive ability, Blood Advances, April 26, 2018, Read More

Chen, Z. L., Revenko, A. S., Singh, P., MacLeod, A. R., Norris, E. H., & Strickland, S. Depletion of coagulation factor XII ameliorates brain pathology and cogntive impairment in Alzheimer disease mice, Blood, May 4, 2017, Read More

Zamolodchikov, D., Chen, Z. L., Conti, B. A., Renné, T., & Strickland, S. Activation of the factor XII-driven contact system in Alzheimer’s disease patient and mouse model plasma, Proceedings of the National Academy of Sciences of the United States of America, March 16, 2015, Read More

Zamolodchikov, D., Renné, T., & Strickland, S. The Alzheimer’s disease peptide beta-amyloid promotes thrombin generation through activation of coagulation factor XII, Journal of Thrombosis and Haemostasis, February 29, 2016, Read More

Baker, S. K., & Strickland, S. A critical role for plasminogen in inflammation, Journal of Experimental Medicine, March 11, 2020, Read More

Strickland S. Blood will out: vascular contributions to Alzheimer’s disease, Journal of Clinical Investigation, February 1, 2018, Read More

Berk-Rauch, H. E., Choudhury, A., Richards, A. T., Singh, P. K., Chen, Z. L., Norris, E. H., Strickland, S., & Ahn, H. J. Striatal fibrinogen extravasation and vascular degeneration correlate with motor dysfunction in an aging mouse model of Alzheimer’s disease, Frontiers in Aging Neuroscience, March 9, 2023, Read More

Tataryn, N. M., Singh, V., Dyke, J. P., Berk-Rauch, H. E., Clausen, D. M., Aronowitz, E., Norris, E. H., Strickland, S., & Ahn, H. J. Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer’s Disease, Neurobiology of Aging, July 28, 2021, Read More

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