Cure Alzheimer's Fund Cure Alzheimer's Fund

Teresa Gomez-Isla, M.D.

Professor of Neurology, Harvard Medical School; Neurologist, Massachusetts General Hospital

Dr Gomez-Isla is a Professor of Neurology at Harvard Medical School, Chief of the Memory Division in the Neurology Department at the Massachusetts General Hospital (MGH), Associate Director and Clinical Core leader of the Massachusetts Alzheimer’s Disease Research Center (MADRC), and Director of the MGH Clinical Dementia Fellowship Program. In January 2009, she rejoined Harvard after serving as Chief of the Memory Units at Clinica Universitaria of Navarre and Sant Pau Hospital, Spain. Her training includes a dementia fellowship at MGH, where she trained as a subspecialist clinician and experimental pathologist, and a research fellowship at the University of Minnesota, where she developed and characterized novel transgenic mouse models of neurodegeneration. She has designed and conducted therapeutic trials on animal models and Alzheimer’s patients. Her current research focuses on the study of brain changes associated with aging, especially those that occur very early on in Alzheimer’s disease, on understanding mechanisms of brain resilience to Alzheimer’s pathology, and on the validation of novel imaging biomarkers for early disease detection and intervention. Dr. Gomez-Isla provides clinical care for patients with dementia in the Memory Division at MGH.

Related Research:

Understanding Human Brain Resilience to Alzheimer’s Pathology Teresa Gomez-Isla 2024-08-19 Understanding Human Brain Resilience to Alzheimer’s Pathology Teresa Gomez-Isla 2018-10-15

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Understanding Human Brain Resilience to Alzheimer’s Pathology 2024, 2025

$600,000
Understanding Human Brain Resilience to Alzheimer’s Pathology 2018, 2019, 2021, 2023

$1,200,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Perbet, R., Wiedmer, A. E., Quitot, N., Bhavsar, H., Perrin, F., Gaona, A., Mate de Gerando, A., Gomez Isla, T., Frosch, M. P., Das, S., & Hyman, B. T. Seed-competent tau oligomers’ activity correlates with the rate of progression in sporadic Alzheimer’s disease patients, Journal of Alzheimer’s Disease, December 22, 2025, Read More

Taddei, R. N., Perbet, R., Mate de Gerando, A., Wiedmer, A. E., Sanchez-Mico, M., Connors Stewart, T., Gaona, A., Melloni, A., Amaral, A. C., Duff, K., Frosch, M. P., & Gómez-Isla, T. Tau Oligomer-Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease, JAMA Neurology, October 9, 2023, Read More

Taddei, R. N., Sanchez-Mico, M. V., Bonnar, O., Connors, T., Gaona, A., Denbow, D., Frosch, M. P., & Gómez-Isla, T. Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages, Acta Neuropathologica Communications, May 9, 2022, Read More

Barroeta-Espar, I., Weinstock, L. D., Perez-Nievas, B. G., Meltzer, A. C., Siao Tick Chong, M., Amaral, A. C., Murray, M. E., Moulder, K. L., Morris, J. C., Cairns, N. J., Parisi, J. E., Lowe, V. J., Petersen, R. C., Kofler, J., Ikonomovic, M. D., López, O., Klunk, W. E., … Gomez-Isla, T. Distinct Cytokine Profiles in human brains resilient to Alzheimer’s pathology, Neuroiology of Disease, October 15, 2018, Read More

Back to Our Researchers