Teresa Gomez-Isla, M.D.

Associate Professor of Neurology, Harvard Medical School; Assistant Neurologist, Massachusetts General Hospital

Dr. Gomez-Isla is a neurologist with Massachusetts General Hospital and an Associate Professor of Neurology at Harvard Medical School, specializing in the investigation of the neurobiology of normal aging, Alzheimer’s disease, and other dementias.

Dr. Gomez-Isla received her M.D. from Universidad Complutense de Madrid, completed her residence at Hospital Doce de October and her fellowship at Massachusetts General Hospital.

Dr. Gomez-Isla’s lab focuses on the development and characterization of transgenic mouse models of Alzheimer’s disease and on testing novel therapeutic strategies. Research is also conducted with human brain tissue from individuals who suffered Alzheimer’s disease while alive.

Related Research:

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Understanding Human Brain Resilience to Alzheimer’s Pathology 2018, 2019, 2021, 2023


Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Taddei, R. N., Sanchez-Mico, M. V., Bonnar, O., Connors, T., Gaona, A., Denbow, D., Frosch, M. P., & Gómez-Isla, T. Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages, Acta Neuropathologica Communications, May 9, 2022, Read More

Taddei, R. N., Perbet, R., Mate de Gerando, A., Wiedmer, A. E., Sanchez-Mico, M., Connors Stewart, T., Gaona, A., Melloni, A., Amaral, A. C., Duff, K., Frosch, M. P., & Gómez-Isla, T. Tau Oligomer-Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease, JAMA Neurology, October 9, 2023, Read More

Barroeta-Espar, I., Weinstock, L. D., Perez-Nievas, B. G., Meltzer, A. C., Siao Tick Chong, M., Amaral, A. C., Murray, M. E., Moulder, K. L., Morris, J. C., Cairns, N. J., Parisi, J. E., Lowe, V. J., Petersen, R. C., Kofler, J., Ikonomovic, M. D., López, O., Klunk, W. E., … Gomez-Isla, T. Distinct Cytokine Profiles in human brains resilient to Alzheimer’s pathology, Neuroiology of Disease, October 15, 2018, Read More

Hyman, B. T., Growdon, J. H., Albers, M. W., Buckner, R. L., Chhatwal, J., Gomez-Isla, M. T., Haass, C., Hudry, E., Jack, C. R., Jr, Johnson, K. A., Khachaturian, Z. S., Kim, D. Y., Martin, J. B., Nitsch, R. M., Rosen, B. R., Selkoe, D. J., Sperling, R. A., St George-Hyslop, P., Tanzi, R. E., Yap, L., Young, A. B., Phelps, C. H., & McCaffrey, P.M. Massachusetts Alzheimer’s Disease Research Center: Progress and Challenges, Alzheimer's & Dementia, October 1, 2015, Read More