Cure Alzheimer's Fund Cure Alzheimer's Fund

Timothy Huang, Ph.D.

Research Assistant Professor, Neuroscience Initiative, Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute

Dr. Timothy (Tim) Huang is a cell biologist, with a background in biochemistry and molecular biology. During his doctoral studies at the University of Calgary in Canada, Dr. Huang studied mechanisms that governed cell polarity in fission yeast which led him to uncover components related to the actin cytoskeleton. He then continued studying actin-related signaling mechanisms in mammalian cells at the Scripps Institute (La Jolla), which led him to characterize RhoGTPase pathways that may be dysregulated in Alzheimer’s disease (AD).

Dr. Huang joined the Sanford Burnham Prebys Medical Discovery Institute (La Jolla) to continue his studies on signaling mechanisms related to AD, where his research program is focused on how AD-related risk factors such as SORLA and TREM2 can contribute to neuronal dysfunction and AD pathogenesis.

 

Related Research:

Mechanisms for Alzheimer’s Disease-associated SORLA Mutations in Microglia and Neurons in AD Pathogenesis Huaxi Xu Timothy Huang 2019-06-11

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Mechanisms for Alzheimer’s Disease-associated SORLA Mutations in Microglia and Neurons in AD Pathogenesis 2019

$172,500

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Stupack, J., Xiong, X. P., Jiang, L. L., Zhang, T., Zhou, L., Campos, A., Ranscht, B., Mobley, W., Pasquale, E. B., Xu, H., & Huang, T. Y. Soluble SORLA enhances neurite outgrowth and regeneration through activation of the EGF Receptor/ERK signaling axis, Journal of Neuroscience, June 29, 2020, Read More

Jiang, L. L., Zhu, B., Zhao, Y., Li, X., Liu, T., Pina-Crespo, J., Zhou, L., Xu, W., Rodriguez, M. J., Yu, H., Cleveland, D. W., Ravits, J., Da Cruz, S., Long, T., Zhang, D., Huang, T. Y., & Xu, H. Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment, Journal of Clinical Investigation, May 21, 2019, Read More

Liu T, Zhu B, Liu Y, Zhang X, Yin J, Li X, Jiang L, Hodges AP, Rosenthal SB, Zhou L, Yancey J, McQuade A, Blurton-Jones M, Tanzi RE, Huang TY, Xu H. Multi-omic comparison of Alzheimer’s variants inhuman ESC–derived microglia reveals convergence at APOE, Journal of Experimental Medicine, September 17, 2020, Read More

Zhu B, Liu Y, Hwang S, Archuleta K, Huang H, Campos A, Murad R, Piña-Crespo J, Xu H, Huang TY. Trem2 deletion enhances tau dispersion and pathology through microglia exosomes, Molecular Neurodegeneration, September 2, 2022, Read More

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