These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Mechanisms for Alzheimer’s Disease-associated SORLA Mutations in Microglia and Neurons in AD Pathogenesis |
2019 $172,500 |
These published papers resulted from Cure Alzheimer’s Fund support.
Stupack, J., Xiong, X. P., Jiang, L. L., Zhang, T., Zhou, L., Campos, A., Ranscht, B., Mobley, W., Pasquale, E. B., Xu, H., & Huang, T. Y. Soluble SORLA enhances neurite outgrowth and regeneration through activation of the EGF Receptor/ERK signaling axis, Journal of Neuroscience, June 29, 2020, Read More
Jiang, L. L., Zhu, B., Zhao, Y., Li, X., Liu, T., Pina-Crespo, J., Zhou, L., Xu, W., Rodriguez, M. J., Yu, H., Cleveland, D. W., Ravits, J., Da Cruz, S., Long, T., Zhang, D., Huang, T. Y., & Xu, H. Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment, Journal of Clinical Investigation, May 21, 2019, Read More
Zhu B, Liu Y, Hwang S, Archuleta K, Huang H, Campos A, Murad R, Piña-Crespo J, Xu H, Huang TY. Trem2 deletion enhances tau dispersion and pathology through microglia exosomes, Molecular Neurodegeneration, September 2, 2022, Read More
Liu T, Zhu B, Liu Y, Zhang X, Yin J, Li X, Jiang L, Hodges AP, Rosenthal SB, Zhou L, Yancey J, McQuade A, Blurton-Jones M, Tanzi RE, Huang TY, Xu H. Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE, Journal of Experimental Medicine, September 17, 2020, Read More