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Stephan Kaeser, Ph.D.

Group Leader, University of Tübingen

Stephan Kaeser, Ph.D.,  studied Biology and Neuroscience at the University of Basel, Switzerland. For his Ph.D., he joined the lab of Prof. Mathias Jucker at the Hertie Institute for Clinical Brain Research at the University of Tübingen. He currently heads the group of ‘Molecular Biomarkers’ in the department of ‘Cellular Neurology‘ at the Hertie Institute for Clinical Brain Research and the German Center of Neurodegenerative Diseases (DZNE) in Tübingen, Germany. His major research focus is on the characterization and interpretation of molecular biomarker changes in Alzheimer’s disease and other neurological disorders using a translational approach. To this end, he developed a refined and now standardized method for collecting mouse cerebrospinal fluid and blood ensuring the highest sample quality with maximum yield. He established a mouse biobank containing a large set of ready-to-use tissue and fluid biosamples from various disease models at different ages. He also generated several highly sensitive immunoassays for the assessment and validation of novel biomarker candidates.

To learn more about Dr. Kaeser, click here.

Related Research:

Cerebrospinal Fluid Neuroinflammatory Signature in Alzheimer´s Disease and Related Proteopathies Mathias Jucker Stefan Lichtenthaler Stephan Kaeser 2022-11-22 Understanding Molecular Biomarker Changes in Alzheimer’s Disease Using Genetically Defined Mouse Models Mathias Jucker Stephan Kaeser 2019-06-11

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Cerebrospinal Fluid Neuroinflammatory Signature in Alzheimer´s Disease and Related Proteopathies 2022, 2023

$361,100
Understanding Molecular Biomarker Changes in Alzheimer’s Disease Using Genetically Defined Mouse Models 2019-2020

$345,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Kaeser, S. A., Häsler, L. M., Lambert, M., Bergmann, C., Bottelbergs, A., Theunis, C., Mercken, M., & Jucker, M. CSF p-tau increase in response to A beta-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles, Acta Neuropathologica, December 28, 2021, Read More

Rother, C., Uhlmann, R. E., Müller, S. A., Schelle, J., … Kaeser, S. A., … Jucker, M. Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae, Nature Communications, November 28, 2022, Read More

Kaeser, S. A., Lehallier, B., Thinggaard, M., Häsler, L. M., Apel, A., Bergmann, C., Berdnik, D., Jeune, B., Christensen, K., Grönke, S., Partridge, L., Wyss-Coray, T., Mengel-From, J., & Jucker, M. A neuronal blood marker is associated with mortality in old age, Nature Aging, February 11, 2021, Read More

Eninger, T., Müller, S. A., Bacioglu, M., Schweighauser, M., Lambert, M., Maia, L. F., Neher, J. J., Hornfeck, S. M., Obermüller, U., Kleinberger, G., Haass, C., Kahle, P. J., Staufenbiel, M., Ping, L., Duong, D. M., Levey, A. I., Seyfried, N. T., Lichtenthaler, S. F., Jucker, M., & Kaeser, S. A. Signatures of glial activity can be detected in the CSF proteome, Proceedings of the National Academy of Sciences of the United States of America, June 6, 2022, Read More

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