Victor Bustos, Ph.D.

Senior Research Associate, The Rockefeller University

Victor Bustos holds a PhD in Biomedicine from the University of Chile. Trained as a biochemist with a strong background in signal transduction pathways, Victor focuses on the role of APP metabolism in the neurodegenerative process in AD. As a senior research associate in the laboratory of the late Paul Greengard at the Rockefeller University, Victor developed a method to detect low-abundance proteolytic fragments in the human brain. Using this method, his team found that C99, the direct precursor of beta-amyloid, accumulates in dying neurons in the brain of AD patients. His efforts are directed at studying the molecular mechanism by which C99 begins the neurodegenerative process and to the preclinical development of drugs that lower C99 and beta-amyloid levels.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Discovery of Chemical Compounds That Induce Degradation of APP Beta-CTF 2018-2019


Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Ledo, J. H., Liebmann, T., Zhang, R., Chang, J. C., Azevedo, E. P., Wong, E., Silva, H. M., Troyanskaya, O. G., Bustos, V., & Greengard, P. Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia, Molecular Psychiatry, August 13, 2020, Read More

Bustos, V. H., Sunkari, Y. K., Sinha, A., Pulina, M., Bispo, A., Hopkins, M., Lam, A., Kriegsman, S. F., Mui, E., Chang, E., Jedlicki, A., Rosenthal, H., Flajolet, M., & Sinha, S. C. Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels, ASC Chemical Biology, December 11, 2023, Read More

Ledo, J. H., Zhang, R., Mesin, L., Mourão-Sá, D., Azevedo, E. P., Troyanskaya, O. G., Bustos, V., & Greengard, P. Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development, PLoS One, August 21, 2020, Read More

Pulina, M. V., Hopkins, M., Haroutunian, V., Greengard, P., & Bustos, V. C99 selectively accumulates in vulnerable neurons in Alzheimer’s disease, Alzheimer's & Dementia, January 6, 2020, Read More