Victor Bustos holds a PhD in Biomedicine from the University of Chile. Trained as a biochemist with a strong background in signal transduction pathways, Victor focuses on the role of APP metabolism in the neurodegenerative process in AD. As a senior research associate in the laboratory of the late Paul Greengard at the Rockefeller University, Victor developed a method to detect low-abundance proteolytic fragments in the human brain. Using this method, his team found that C99, the direct precursor of beta-amyloid, accumulates in dying neurons in the brain of AD patients. His efforts are directed at studying the molecular mechanism by which C99 begins the neurodegenerative process and to the preclinical development of drugs that lower C99 and beta-amyloid levels.