Xianlin Han, Ph.D.

Professor of Medicine, The University of Texas Health Science Center at San Antonio

Xianlin Han received his Ph.D. in Chemistry at Washington University in St. Louis and trained as a postdoctoral fellow in Dr. Richard W. Gross’ lab in Washington University School of Medicine (WUSTL). Dr. Han was promoted to Associate Professor of Medicine with tenure in WUSTL in 2008 and a Professor at Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, between 2010 and 2017. Dr. Han joined Barshop Institute for longevity and Aging Studies at the University of Texas Health Science Center at San Antonio (UT Health San Antonio) as an endowed chair professor, and the Professor of Medicine. Dr. Han is also a joint professor in Department of Biochemistry and Structural Biology and at Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases at UT Health San Antonio. Dr. Han has been a guest professor of multiple Institutes/Universities in China including Soochow University, Ocean University of China, Zhejiang Chinese Medical University, and Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. Dr. Han served as the President of Chinese American Society for Mass Spectrometry and serves as the Secretary of International Lipidomics Society. Dr. Han served as standing members of NIH study sections and many other grants review committees.

Lipidomics, which facilitates large-scale analysis of cellular lipidomes based on the principles and techniques of analytical chemistry, allows us to comprehensively and effectively determine alterations in lipid metabolism, signaling, and homeostasis under different conditions. Dr. Han is one of the pioneers in lipidomics and the inventor of shotgun lipidomics. He has published over 330 peer-reviewed papers with an H-index of 92 and citations over 30,000 (Google Scholar 2022). He holds 7 international patents. He is the author of the book “Lipidomics: Comprehensive Mass Spectrometry of Lipids” and the co-author of the book “Lipid Analysis (4th Edition)” with Dr. William W. Christie, a Fellow of the Royal Society of Edinburgh. Dr. Han is the associate editor of “Journal of Lipid Research” and serves as a member of the editorial board of numerous international journals, including Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids, Analytica Chimica Acta, Metabolites, Life Metabolism, etc.

Han has strong research interests in functional lipidomics, that is, uncovering alterations in lipid metabolism, signaling, and homeostasis that occur under patho(physio)logical conditions such as Alzheimer’s disease (AD), diabetes, and aging by lipidomics; identifying the underlying mechanisms leading to altered lipids; unraveling the consequences induced by these lipid changes in the context of diseases; and developing drug targets for the diseases based on the mechanistic and consequence studies.




Funded Research

These projects were made possible from Cure Alzheimer's Fund support.