These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Circadian Desynchrony, Glial Dysfunction and Alzheimer’s Disease Pathogenesis |
2023 $198,994 |
|
The Circadian Clock Modulates Neurodegeneration in Alzheimer’s Disease Via REV-ERBA (Year 1) |
2018-2019 $344,634 |
These published papers resulted from Cure Alzheimer’s Fund support.
Lee, J., Dimitry, J. M., Song, J. H., Son, M., Sheehan, P. W., King, M. W., Travis Tabor, G., Goo, Y. A., Lazar, M. A., Petrucelli, L., & Musiek, E. S. Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice, Nature Communications, August 25, 2023, Read More
Griffin, P., Sheehan, P. W., Dimitry, J. M., Guo, C., Kanan, M. F., Lee, J., Zhang, J., & Musiek, E. S. REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis, eLife, December 1, 2020, Read More
Musiek, E. S., Xiong, D. D., & Holtzman, D. M. Sleep, circadian rhythms and the pathogenesis of Alzheimer Disease, Experimental and Molecular Medicine, March 1, 2015, Read More
Musiek, E. S., Lim, M. M., Yang, G., Bauer, A. Q., Qi, L., Lee, Y., Roh, J. H., Ortiz-Gonzalez, X., Dearborn, J. T., Culver, J. P., Herzog, E. D., Hogenesch, J. B., Wozniak, D. F., Dikranian, K., Giasson, B. I., Weaver, D. R., Holtzman, D. M., & Fitzgerald, G. A. Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration, Journal of Clinical Investigation, December 2, 2013, Read More
Musiek, E. S., & Holtzman, D. M. Three dimensions of the amyloid hypothesis: time, space, and ‘wingmen’, Nature Neuroscience, June 1, 2015, Read More
Wang, C., Nambiar, A., Strickland, M. R., Lee, C., Parhizkar, S., Moore, A. C., Musiek, E. S., Ulrich, J. D., & Holtzman, D. M. APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading, Journal of Clinical Investigation, July 17, 2023, Read More
Musiek, E. S., & Holtzman, D. M. Origins of Alzheiemr’s disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid beta and tau involvement, Current Opinion in Neurology, December 1, 2012, Read More