Joseph Park, Ph.D.

Instructor in Neurology, Massachusetts General Hospital

Dr. Park is a neuroscientist with bioengineering backgrounds in Massachusetts General Hospital/Harvard Medical School. Dr. Park started working on modeling human neurodegenerative disease by utilizing microfabrication technology (brain-on-a-chip). For the Alzheimer’s Disease (AD), Dr. Park successfully established a 3D human neuron-astrocyte-microglia triculture model that recapitulated neuroinflammation and neurodegeneration (Park et al., Nature Neuroscience, 2018) based on a three-dimensional (3D) human neural cell culture model of AD (Choi et al., Nature, 2014). Currently, his research is focusing on 1) developing a 3D human neuron-astrocyte-microglia triculture model with human induced pluripotent stem cells (iPSCs)-derived microglia with functional AD variants and 2) analyzing transcriptomic and proteomic changes of neuronal and glial cells in triculture system.


Funded Research

These projects were made possible from Cure Alzheimer's Fund support.