Joseph Park, Ph.D.

Instructor in Neurology, Massachusetts General Hospital

Dr. Park is a neuroscientist with bioengineering backgrounds in Massachusetts General Hospital/Harvard Medical School. Dr. Park started working on modeling human neurodegenerative disease by utilizing microfabrication technology (brain-on-a-chip). For the Alzheimer’s Disease (AD), Dr. Park successfully established a 3D human neuron-astrocyte-microglia triculture model that recapitulated neuroinflammation and neurodegeneration (Park et al., Nature Neuroscience, 2018) based on a three-dimensional (3D) human neural cell culture model of AD (Choi et al., Nature, 2014). Currently, his research is focusing on 1) developing a 3D human neuron-astrocyte-microglia triculture model with human induced pluripotent stem cells (iPSCs)-derived microglia with functional AD variants and 2) analyzing transcriptomic and proteomic changes of neuronal and glial cells in triculture system.


Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Park, J., Wetzel, I., Marriott, I., Dréau, D., D'Avanzo, C., Kim, D. Y., Tanzi, R. E., & Cho, H. A 3D Human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease, Nature Neuroscience, June 27, 2018, Read More

Jorfi, M., Park, J., Hall, C. K., Lin, C. J., Chen, M., von Maydell, D., Kruskop, J. M., Kang, B., Choi, Y., Prokopenko, D., Irimia, D., Kim, D. Y., & Tanzi, R. E. Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model, Nature Neuroscience, August 24, 2023, Read More

Kim, E., Kim, H., Jedrychowski, M. P., Bakiasi, G., Park, J., Kruskop, J., Choi, Y., Kwak, S. S., Quinti, L., Kim, D. Y., Wrann, C. D., Spiegelman, B. M., Tanzi, R. E., & Choi, S. H. Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling, Neuron, September 8, 2023, Read More

Park, J., Wetzel, I., Dréau, D., & Cho, H. 3D Miniaturization of Human Organs for Drug Discovery, Advanced Healthcare Materials, September 8, 2017, Read More

McAlpine, C. S., Park, J., Griciuc, A., Kim, E., Choi, S. H., Iwamoto, Y., Kiss, M. G., Christie, K. A., Vinegoni, C., Poller, W. C., Mindur, J. E., Chan, C. T., He, S., Janssen, H., Wong, L. P., Downey, J., Singh, S., Anzai, A., Kahles, F., Jorfi, M., Feruglio, P.F., Sadreyev, R. I., Weissleder, R., Kleinstiver, B. P., Nahrendorf, M., Tanzi, R. E., & Swirski, F. K. Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease, Nature, July 14, 2021, Read More