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Sriram Balusu, Ph.D.

Senior Postdoctoral Scientist, VIB-KU Leuven Center for Neuroscience, Belgium

Sriram Balusu, Ph.D., is a senior postdoctoral scientist in Prof. Bart De Strooper’s laboratory at VIB-KU Leuven Center for Brain & Disease Research in Leuven, Belgium. Dr. Balusu’s research focuses on understanding the fundamental processes that govern neurodegeneration and neuronal cell death in Alzheimer’s disease (AD). Specifically, he aims to understand the modality of neuronal cell death in AD and the role of the microtubule-associated protein TAU and its modulators in this process. He seeks to integrate complementary approaches using both in vitro and in vivo model systems, as well as post-mortem human brain tissue, to comprehend neurodegeneration mechanisms. His goal is to develop novel bench-to-bedside therapeutic strategies to prevent neuronal cell loss and subsequent cognitive decline, with a special focus on AD.

Related Research:

Identifying Mediators of Tau-Mediated Neuronal Necroptosis Using an Innovative In Vivo CRISPR Screen Bart De Strooper Sriram Balusu 2023-12-08

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Identifying Mediators of Tau-Mediated Neuronal Necroptosis Using an Innovative In Vivo CRISPR Screen 2023, 2024

$460,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

van Vierbergen, J. F. M., Calatayud, C., Balusu, S., Carrano, N., Peredo, N., Vints, K., Gallego, S. F., Horré, K., De Strooper, B., & Verstreken, P. Aβ plaques induce local pre-synaptic toxicity in human iPSC-derived neuron xenografts, Stem Cell Reports, January 2, 2026, Read More

Balusu, S., & De Strooper, B. The necroptosis cell death pathway drives neurodegeneration in Alzheimer’s disease, Acta Neuropathologica, June 9, 2024, Read More

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