Novel Entry Routes for Therapeutic Biologicals to the Brain

2020, 2022

The blood-brain barrier (BBB) is a vital barrier between the bloodstream and the brain. This barrier tightly controls which molecules can enter the brain. As a consequence of this barrier, the majority of currently available drugs cannot enter the brain. Importantly, to treat Alzheimer’s disease, drugs need to reach the brain. Our laboratory has been validating an innovative methodology to discover and validate novel ways to deliver drugs over the BBB. The aim of this project is to implement this methodology in our drug discovery campaign and deliver novel tools to the community to advance treatments for neurological disorders like Alzheimer’s disease.

Funding to Date



Drug Delivery and Design, Drug Discovery


Maarten Dewilde, Ph.D.

Bart De Strooper, M.D., Ph.D.