Molecular Mechanism Underlying Hippocampal Neurogenisis by Familial AD-linked Presenilin-1 Variants

2008

The specific hypothesis behind the proposed research is that presenilin 1 regulates cell fate determination of adult neural progenitor cells by interfering with instructive intercellular signals prevailing within the neural progenitor cell niche, and that expression of the familial AD-linked presenilin 1adversely affects this process.


Funding to Date

$100,000

Focus

Foundational Genetics

Researchers

Sangram S. Sisodia, Ph.D.