The Biological Impact of TREM Locus Mutations in Alzheimer’s Disease


Whole Genome Sequencing has identified certain polymorphisms affecting genes encoding triggering receptors expressed on myeloid cells (TREMs) with increased risk of non-familial (sporadic) Alzheimer’s disease. TREM signaling is known to be important in the innate immune response, particularly in the inflammatory response. However, the relationship between the function of TREM receptors and Alzheimer’s disease pathology is largely unresolved. This project will investigate the relevant polymorphisms to determine how they facilitate Alzheimer’s disease and how they might be targeted to improve brain immune function.

Funding to Date



Foundational, Genetic Risk Factors


Marco Colonna, M.D.

David Holtzman, M.D.

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