G2T Research Models and Materials

2014 to 2020

Taconic Biosciences GMBH, a global provider of genetically modified mouse models and associated services, is providing customized mouse models (transgenic, conventional/conditional knock out, conventional/conditional knock in) for each specific gene and type of mutation that will be studied in the Genes to Therapies™ project.

Foundational Production of New Animal/Cellular Models of AD Taconic Biosciences

Consortium to Infer Regulatory Circuits and Uncover Innovative Therapeutic Strategies—Production Group

Christina Lill, Lars Bertram, | 2020

Personalized Disease Prediction for Alzheimer’s Disease Using Proteome Profiling: The EPIC4AD Study

Liisa Galea, | 2020

Sex Matters: Understanding the Influence of Sex and Apolipoprotein E (APOE) Genotype on Hippocampal Plasticity and Cognition

Christopher K. Glass, | 2020

Using Epigenetics to Characterize the Regulation of Cellular States in Microglia that Contribute to Alzheimer’s Disease Pathology

Bradley Hyman, | 2020

Creation of a Fibroblast/iPS Cell Bank to Facilitate Peripheral/Brain Comparisons, and Allow Molecular Investigations into Molecular Mechanisms Underlying Differences in Disease Aggressiveness

Paola Bovolenta, Pilar Esteve, | 2020

SFRP1 as a Therapeutic Target and Diagnostic/Prognostic Factor in Alzheimer’s Disease

Krista L. Moulder, | 2020

Characterization of Alzheimer’s Disease Molecular Biomarker Profiles Throughout the Pathobiological Continuum

Shirley Wray,

An Innovative Study of the Pupil Light Reflex in Alzheimer’s Disease

G2T Research Models and Materials

Funding to Date

Focus

Researchers

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