Effects of Cerebrovascular Insufficiency and Exercise on the Alzheimer’s Brain

2018, 2021

Vascular problems are present in almost all patients with Alzheimer’s disease (AD). However, the underlying mechanisms remain unclear. Importantly, none of the currently used animal models for testing AD therapies include vascular factors. Our project will, for the first time (a) map for the “vasculome” in AD mouse models; (b) develop and characterize AD mouse models that include vascular insufficiency; and (c) test the effects of exercise as an intervention that can rescue the diseased Alzheimer’s brain “vasculome.”

Funding to Date



Studies of Alternative Neurodegenerative Pathways, Translational


Eng H. Lo, Ph.D.