Alzheimer’s disease (AD) and related dementias caused by neurological impairment have become an increasing public health burden. Exercise has been shown in both animal models and clinical studies to exert neuroprotective effects in AD. The mechanisms by which exercise protects the brain are likely diverse and complex. The team believes that identifying the molecular mediators of exercise and developing them into therapeutics represents a promising strategy to combat AD. The goal of the proposed research is to test their hypothesis that a novel exercise-induced mediator is neuroprotective in AD. They will evaluate this hypothesis using their established cell culture and animal models of AD. This study has the potential to reveal new therapeutic targets for the treatment of AD.
