Ana Griciuc, Ph.D.

Assistant Professor of Neurology, Massachusetts General Hospital and Harvard Medical School

Dr. Griciuc received her M.Eng. in biotechnology from INSA-Lyon and M.Sc. in biochemistry from the Max Planck Institute of Neurobiology (Munich) in 2006. She then became a fellow of the European Union Research Training Network “Marie Curie-Neurotrain,” and received her Ph.D. in neuroscience from the Helmholtz Research Center Munich in 2010. Dr. Griciuc is the recipient of the 2011 Graduate Student Award in Environmental Health Research.

Dr. Griciuc performed her postdoctoral research in the laboratory of Dr. Rudolph Tanzi at Massachusetts General Hospital (MGH) and Harvard Medical School. She has been exploring how CD33, an innate immunity-related gene, serves as a pathogenetic risk factor in Alzheimer’s disease (AD). Dr. Griciuc showed that CD33 activity in microglia strongly impaired their ability to uptake and clear brain amyloid beta (Aβ). Dr. Griciuc received several awards, including a postdoctoral fellowship (German Research Foundation), Tosteson & Fund for Medical Discovery Fellowship (MGH/ECOR) and the NIH Pathway to Independence Award (K99/R00). Dr. Griciuc was appointed as Assistant Professor of Neurology at MGH and Harvard Medical School in 2017.

Furthermore, Dr. Griciuc investigated crosstalk between the microglial receptors CD33 and TREM2. Dr. Griciuc showed that TREM2 acts downstream of CD33 in modulating microglial pathology in mouse models of AD. Her research suggests that inhibiting CD33 and/or increasing TREM2 activity represent potential therapies for AD. Most recently, Dr. Griciuc showed that early intervention using an AAV vector-based system encoding an artificial microRNA targeting CD33 reduced Aβ accumulation and neuroinflammation in mouse models of AD. Her current research projects focus on investigating the function of CD33 and TREM2, and how mutations in these genes result in susceptibility to late-onset AD.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Zhang, C., Griciuc, A., Hudry, E., Wan, Y., Quinti, L., Ward, J., Forte, A. M., Shen, X., Ran, C., Elmaleh, D. R., & Tanzi, R. E. Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid Beta Protein by Promoting microglial Phagocytosis, Scientific Reports, January 18, 2018, Read More

Griciuc, A., Patel, S., Federico, A. N., Choi, S. H., Innes, B. J., Oram, M. K., Cereghetti, G., McGinty, D., Anselmo, A., Sadreyev, R. I., Hickman, S. E., El Khoury, J., Colonna, M., & Tanzi, R. E. TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease, Neuron, July 10, 2019, Read More

Liang, Y., Lee, D. Y. W., Zhen, S., Sun, H., Zhu, B., Liu, J., Lei, D., Lin, C. J., Zhang, S., Jacques, N. A., Quinti, L., Ran, C., Wang, C., Griciuc, A., Choi, S. H., Dai, R. H., Efferth, T., Tanzi, R. E., & Zhang, C. Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer’s disease, Phytomedicine, May 13, 2022, Read More

McAlpine, C. S., Park, J., Griciuc, A., Kim, E., Choi, S. H., Iwamoto, Y., Kiss, M. G., Christie, K. A., Vinegoni, C., Poller, W. C., Mindur, J. E., Chan, C. T., He, S., Janssen, H., Wong, L. P., Downey, J., Singh, S., Anzai, A., Kahles, F., Jorfi, M., Feruglio, P.F., Sadreyev, R. I., Weissleder, R., Kleinstiver, B. P., Nahrendorf, M., Tanzi, R. E., & Swirski, F. K. Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease, Nature, July 14, 2021, Read More

Griciuc, A., Federico, A. N., Natasan, J., Forte, A. M., McGinty, D., Nguyen, H., Volak, A., LeRoy, S., Gandhi, S., Lerner, E. P., Hudry, E., Tanzi, R. E., & Maguire, C. A. Gene therapy for Alzheimer’s Disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation., Human Molecular Genetics, August 17, 2020, Read More

Griciuc, A., & Tanzi, R. E. The role of innate immune genes in Alzheimer’s disease, Current Opinion in Neurology, April 1, 2021, Read More

Griciuc, A., Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. H., Hyman, B. T., & Tanzi, R. E. Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta, Neuron, May 22, 2013, Read More