Cure Alzheimer's Fund Cure Alzheimer's Fund

Bradley T. Hyman, M.D., Ph.D.

John B. Penney, Jr., Professor of Neurology, Harvard Medical School; Director, MassGeneral Institute for Neurodegenerative Disease (MIND), Massachusetts General Hospital

Dr. Hyman directs the Alzheimer’s unit at MIND (Massachusetts Institute for Neurodegenerative Disease), with the goal of understanding the neuropathophysiologic and genetic factors that underlie dementia. The take-off point for Dr. Hyman’s research program involves understanding the neural system failure that underlies cognitive loss in Alzheimer’s, and an appreciation of how genetics impacts pathophysiology. His laboratory also uses transgenic mouse models of Alzheimer’s disease and in vitro systems to examine the roles of presenilin mutations and receptors in neuronal function and on Alzheimer’s related processes.

A recent initiative in Dr. Hyman’s laboratory has been the development of in vivo imaging with 2-photon confocal microscopy. This provides the ability to view neurons in the intact, functioning brain in mice and track the pathological changes that occur during disease processes. His lab has shown that plaques can be reversed by therapeutic application of antibodies.

Dr. Hyman is statewide chair of the Massachusetts Alzheimer’s Association Memory Walk.

Related Research:

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Alzheimer’s Disease Tau Consortium: How Do Soluble Tau Species Replicate 2022

$286,595.15
Regional Variability of Pathology-Associated Properties of Tau in Posterior Cortical Atrophy 2022, 2023

$345,000
Creation of a Fibroblast/iPS Cell Bank to Facilitate Peripheral/Brain Comparisons, and Allow Molecular Investigations into Molecular Mechanisms Underlying Differences in Disease Aggressiveness 2020, 2022

$500,000
CIRCUITS: IPS Cells and the Human Brain 2016, 2018

$293,736
Relating AD Brain Morphology to AD Genotype 2006

$100,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Viswanathan J, Haapasalo A, Bottcher C, Miettinen R, Kurkinen KMA, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Nertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M Alzheimer’s Disease-Associated Ubiquilin-1 Regulates Presenilin-1 Accumulation and Aggresome Formation, Traffic, 12(3), Mar 12, 2011, 330-48, Read More

Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE Decreased catalytic activity of the insulin degrading enzyme in chromosome 10-linked Alzheimer’s disease families., Journal of Biological Chemistry, 282(11), 03/16/2017, 7825-32, Read More

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