These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Alzheimer’s Disease Tau Consortium: How Do Soluble Tau Species Replicate |
2022, 2023 $573,764.15 |
|
Regional Variability of Pathology-Associated Properties of Tau in Posterior Cortical Atrophy |
2022, 2023 $345,000 |
|
Creation of a Fibroblast/iPS Cell Bank to Facilitate Peripheral/Brain Comparisons, and Allow Molecular Investigations into Molecular Mechanisms Underlying Differences in Disease Aggressiveness |
2020, 2022 $500,000 |
|
CIRCUITS: IPS Cells and the Human Brain |
2016, 2018 $293,736 |
|
Relating AD Brain Morphology to AD Genotype |
2006 $100,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Zwang, T. J., Sastre, E. D., Wolf, N., Ruiz-Uribe, N., Woost, B., Hoglund, Z., Fan, Z., Bailey, J., Nfor, L., Buée, L., Nilsson, K. P. R., Hyman, B. T., & Bennett, R. E. Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer’s pathology, Cell Reports, August 2, 2024, Read More
Oakley, D. H., Chung, M., Abrha, S., Hyman, B. T., & Frosch, M. P. β-Amyloid species production and tau phosphorylation in iPSC-neurons with reference to neuropathologically characterized matched donor brains, Journal of Neuropathology and Experimental Neurology, June 14, 2024, Read More
Sommerer, Y., Ohlei, O., Dobricic, V., Oakley, D. H., Wesse, T., Sedghpour Sabet, S., Demuth, I., Franke, A., Hyman, B. T., Lill, C. M., & Bertram, L. A correlation map of genome-wide DNA methylation patterns between paired human brain and buccal samples, Clinical Epigenetics, November 1, 2022, Read More
Liao, F., Hori, Y., Hudry, E., Bauer, A. Q., Jiang, H., Mahan, T. E., Lefton, K. B., Zhang, T. J., Dearborn, J. T., Kim, J., Culver, J. P., Betensky, R., Wozniak, D. F., Hyman, B. T., & Holtzman, D. M. Anti-ApoE Antibody given after plaque onset decreases A beta accumulation and improves brain function in a mouse model of a beta amyloidosis, Journal of Neuroscience, May 21, 2014, Read More
Hudry, E., Andres-Mateos, E., Lerner, E. P., Volak, A., Cohen, O., Hyman, B. T., Maguire, C. A., & Vandenberghe, L. H. Efficient Gene Transfer to the Central Nervous System by single-stranded Anc80L65, Molecular Therapy - Methods & Clinical Development, September 21, 2018, Read More
Volak, A., LeRoy, S. G., Natasan, J. S., Park, D. J., Cheah, P. S., Maus, A., Fitzpatrick, Z., Hudry, E., Pinkham, K., Gandhi, S., Hyman, B. T., Mu, D., GuhaSarkar, D., Stemmer-Rachamimov, A. O., Sena-Esteves, M., Badr, C. E., & Maguire, C. A. Virus vector mediated genetic modification of brain tumor stromal cells after intravenous delivery, Journal of Neuro-Oncology, September 1, 2018, Read More
Oakley, D. H., Klickstein, N., Commins, C., Chung, M., Dujardin, S., Bennett, R. E., Hyman, B. T., & Frosch, M. P. Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons, Journal of Neuroscience, April 23, 2021, Read More
Oakley, D. H., Chung, M., Klickstein, N., Commins, C., Hyman, B. T., & Frosch, M. P. The Alzheimer Disease-Causing Presenilin-1 L435F Mutation Causes Increased Production of Soluble Aβ43 Species in Patient-Derived iPSC-Neurons, Closely Mimicking Matched Patient Brain Tissue, Journal of Neuropathology & Experimental Neurology, April 4, 2020, Read More
Jackson, R. J., Meltzer, J. C., Nguyen, H., Commins, C., Bennett, R. E., Hudry, E., & Hyman, B. T. APOE4 derived from astrocytes leads to blood-brain barrier impairment, Brain, December 27, 2021, Read More
Glynn, C., Chun, J. E., Donahue, C. C., Nadler, M. J. S., Fan, Z., & Hyman, B. T. Reconstitution of the Alzheimer’s Disease Tau Core Structure from Recombinant Tau297-391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM, Biochemistry, December 28, 2023, Read More
Hyman, B. All the Tau We Cannot See, Annual Review of Medicine, January 27, 2023, Read More
Mate De Gerando, A., Welikovitch, L. A., Khasnavis, A., Commins, C., Glynn, C., Chun, J. E., Perbet, R., & Hyman, B. T. Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau, Acta Neuropathologica, June 21, 2023, Read More
Dujardin, S., Commins, C., Lathuiliere, A., Beerepoot, P., Fernandes, A. R., Kamath, T. V., De Los Santos, M. B., Klickstein, N., Corjuc, D. L., Corjuc, B. T., Dooley, P. M., Viode, A., Oakley, D. H., Moore, B. D., Mullin, K., Jean-Gilles, D., Clark, R., Atchison, K., Moore, R., Chibnik, L. B., Tanzi, R. E., … Hyman, B. T. Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease, Nature Medicine, June 22, 2020, Read More
Cable, J., Holtzman, D. M., Hyman, B. T., Tansey, M. G., Colonna, M., Kellis, M., Brinton, R. D., Albert, M., Wellington, C. L., Sisodia, S. S., & Tanzi, R. E. Alternatives to Amyloid for Alzheimer’s Disease Therapies-A Symposium Report, Annals of the New York Academy of Sciences, May 29, 2020, Read More
Hyman, B. T., Growdon, J. H., Albers, M. W., Buckner, R. L., Chhatwal, J., Gomez-Isla, M. T., Haass, C., Hudry, E., Jack, C. R., Jr, Johnson, K. A., Khachaturian, Z. S., Kim, D. Y., Martin, J. B., Nitsch, R. M., Rosen, B. R., Selkoe, D. J., Sperling, R. A., St George-Hyslop, P., Tanzi, R. E., Yap, L., Young, A. B., Phelps, C. H., & McCaffrey, P.M. Massachusetts Alzheimer’s Disease Research Center: Progress and Challenges, Alzheimer's & Dementia, October 1, 2015, Read More
Griciuc, A., Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. H., Hyman, B. T., & Tanzi, R. E. Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta, Neuron, May 22, 2013, Read More
Viswanathan, J., Haapasalo, A., Böttcher, C., Miettinen, R., Kurkinen, K. M., Lu, A., Thomas, A., Maynard, C. J., Romano, D., Hyman, B. T., Berezovska, O., Bertram, L., Soininen, H., Dantuma, N. P., Tanzi, R. E., & Hiltunen, M. Alzheimer’s disease-associated Ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation, Traffic, January 7, 2011, Read More
Soscia, S. J., Kirby, J. E., Washicosky, K. J., Tucker, S. M., Ingelsson, M., Hyman, B., Burton, M. A., Goldstein, L. E., Duong, S., Tanzi, R. E., & Moir, R. D. The Alzheimer’s Disease-Associated Amyloid beta-Protein Is an Antimicrobial Peptide, PLoS One, March 3, 2010, Read More