Cure Alzheimer's Fund Cure Alzheimer's Fund

Carlos Cruchaga, Ph.D.

Professor of Psychiatry and Director of the NeuroGenomics and Informatics Center, Washington University School of Medicine in St. Louis

Carlos Cruchaga, Ph.D., is a human genomicist with expertise in multiomics, informatics, and neurodegeneration. He completed his Ph.D. in Biochemistry and Molecular Biology in 2005 at the University of Navarra in Spain. During his first post-doctoral, he conducted statistical human genetics studies focused on Alzheimer’s and Parkinson’s disease, completing his training in quantitative human genomics. Dr. Cruchaga established his laboratory at Washington University in 2011, studying the genetic architecture of neurodegenerative diseases. His interests are focused on using human genomic and other omic data (proteomics, metabolomics, lipidomics) to identify and understand the biological processes that lead to Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia, and other neurodegenerative processes. In 2019, he became the leader of the NeuroGenomics and Informatics group at Washington University.

Visit the Cruchaga Lab website.

Visit the NeuroGenomics and Informatics Center website.

Follow Dr. Cruchaga on X (formerly known as Twitter): @ccrugom

Follow the NeuroGenomics and Informatics Center on X (formerly known as Twitter): @ Neuro_Genomics

Related Research:

Multiomic and Functional Characterization of Soluble TREM2 Modifiers Carlos Cruchaga 2024-02-28

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Multiomic and Functional Characterization of Soluble TREM2 Modifiers 2024, 2025

$400,886.10

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Kimura, K., Subramanian, A., Yin, Z., Khalilnezhad, A., Wu, Y., He, D., Dixon, K. O., Chitta, U. K., Ding, X., Adhikari, N., Guzchenko, I., Zhang, X., ... Selkoe, D., Weiner, H. L., Blurton-Jones, M., Cruchaga, C., … Butovsky, O., Kuchroo, V. K. Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease, Nature, April 9, 2025, Read More

Oh, H. S., Urey, D. Y., Karlsson, L., Zhu, Z., Shen, Y., ... Stevens, B., ... Zetterberg, H., ... Hansson, O., Cruchaga C., & Wyss-Coray, T. A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease, Nature Medicine, March 31, 2025, Read More

Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., ... Cruchaga, C., ... Glass C. K., ... Butovsky, O., ... Grutzendler, J., … Baker, D. J., Liddelow, S. A., ... Kipnis, J., ... Colonna, M., ... Riechers, S. P. Neuroinflammation in Alzheimer disease, Nature Reviews Immunology, December 9, 2024, Read More

Warmenhoven, N., Salvadó, G., Janelidze, S., Mattsson-Carlgren, N., Bali, D., Orduña Dolado, A., Kolb, H., Triana-Baltzer, G., Barthélemy, N. R., Schindler, S. E., Aschenbrenner, A. J., Raji, C. A., Benzinger, T. L. S., Morris, J. C., Ibanez, L., Timsina, J., Cruchaga, C., Bateman, R. J., Ashton, N., Arslan, B., … Hansson, O. A Comprehensive Head-to-Head Comparison of Key Plasma Phosphorylated Tau 217 Biomarker Tests, Brain, October 28, 2024, Read More

Delvenne, A., Gobom, J., Schindler, S. E., Kate, M. T., Reus, L. M., Dobricic, V., Tijms, B. M., Benzinger, T. L. S., Cruchaga, C., ... Bertram, L., … Zetterberg, H., ... Vos, S. J. B. CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer’s disease, Alzheimer's & Dementia, July 6, 2024, Read More

Xiong, C., Luo, J., Wolk, D. A., Shaw, L. M., Roberson, E. D., Murchison, C. F., Henson, R. L., Benzinger, T. L. S., Bui, Q., Agboola, F., Grant, E., Gremminger, E. N., Moulder, K. L., Geldmacher, D. S., Clay, O. J., Babulal, G., Cruchaga, C., Holtzman, D. M., Bateman, R. J., Morris, J. C., Schindler, S. E. Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals, Nature Communications, July 2, 2024, Read More

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