Casey A. Maguire, Ph.D.

Casey A. Maguire obtained his B.S. from the University of Maine in 2000, and his Ph.D. from the Department of Microbiology and Immunology at the University of Rochester School of Medicine and Dentistry in 2006. He was a postdoctoral fellow at Massachusetts General Hospital from 2006-2010. He was next an Instructor from 2010-2013. Currently, he is an Assistant Professor of Neurology at Harvard Medical School with laboratory space at the MGH. His labatory is focused on the development of effective gene delivery vehicles for in vivo gene therapy of various genetic diseases including Alzheimer’s disease. The current focus of the Maguire lab is the development of a unique hybrid gene delivery system called vexosomes. Vexosomes are endogenously enveloped adeno-associated virus (AAV) vectors. The envelope is derived from extracellular vesicles (EVs) which are natural lipid based nanoparticles released by cells. We have showns that EVs have several properties which enhance AAV-mediated gene delivery.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Meliani, A., Boisgerault, F., Fitzpatrick, Z., Marmier, S., Leborgne, C., Collaud, F., Simon Sola, M., Charles, S., Ronzitti, G., Vignaud, A., van Wittenberghe, L., Marolleau, B., Jouen, F., Tan, S., Boyer, O., Christophe, O., Brisson, A. R., Maguire, C. A., & Mingozzi, F. Enhanced liver gene transfer and evasion of pre-existing humoral immunity with exosome-envelope AAV vectors, Blood Advances, October 16, 2017, Read More

György, B., Sage, C., Indzhykulian, A. A., Scheffer, D. I., Brisson, A. R., Tan, S., Wu, X., Volak, A., Mu, D., Tamvakologos, P. I., Li, Y., Fitzpatrick, Z., Ericsson, M., Breakefield, X. O., Corey, D. P., & Maguire, C. A. Rescue of Hearing by Gene Delivery to inner-ear hair cells using exome associated AAV, Molecular Therapy, February 1, 2017, Read More

Berezovskii, V. K., Born, R. T., O'Brien, M., Lafond, J. F., Arsenijevic, Y., Kenna, M. A., Maguire, C. A., & Corey, D. P. Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate, Molecular Therapy - Methods & Clinical Development, November 18, 2018, Read More

Prabhakar, S., Beauchamp, R. L., Cheah, P. S., Yoshinaga, A., Haidar, E. A., Lule, S., Mani, G., Maalouf, K., Stemmer-Rachamimov, A., Jung, D. H., Welling, D. B., Giovannini, M., Plotkin, S. R., Maguire, C. A., Ramesh, V., & Breakefield, X. O. Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2, Molecular Therapy - Methods & Clinical Development, June 22, 2022, Read More

Wassmer, S. J., Carvalho, L. S., György, B., Vandenberghe, L. H., & Maguire, C. A. Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection, Scientific Reports, March 31, 2017, Read More

Griciuc, A., Federico, A. N., Natasan, J., Forte, A. M., McGinty, D., Nguyen, H., Volak, A., LeRoy, S., Gandhi, S., Lerner, E. P., Hudry, E., Tanzi, R. E., & Maguire, C. A. Gene therapy for Alzheimer’s Disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation., Human Molecular Genetics, August 17, 2020, Read More

Volak, A., LeRoy, S. G., Natasan, J. S., Park, D. J., Cheah, P. S., Maus, A., Fitzpatrick, Z., Hudry, E., Pinkham, K., Gandhi, S., Hyman, B. T., Mu, D., GuhaSarkar, D., Stemmer-Rachamimov, A. O., Sena-Esteves, M., Badr, C. E., & Maguire, C. A. Virus vector mediated genetic modification of brain tumor stromal cells after intravenous delivery, Journal of Neuro-Oncology, September 1, 2018, Read More

Hudry, E., Andres-Mateos, E., Lerner, E. P., Volak, A., Cohen, O., Hyman, B. T., Maguire, C. A., & Vandenberghe, L. H. Efficient Gene Transfer to the Central Nervous System by single-stranded Anc80L65, Molecular Therapy - Methods & Clinical Development, September 21, 2018, Read More