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Casey Cook, Ph.D.

Associate Professor, Department of Neuroscience, Mayo Clinic, Jacksonville

Dr. Casey Cook, Ph.D. is an Associate Professor in the Department of Neuroscience at Mayo Clinic in Florida. The main research focus of Dr. Cook and her team is identifying and uncovering common pathological mechanisms across a spectrum of neurodegenerative disorders. By combining expertise in molecular biology, animal model generation/characterization, and assay development, her lab also seeks to provide insight into mechanisms by which genetic modifiers modulate toxicity in order to discover new approaches to prevent or reverse neurotoxic processes that contribute to disease pathogenesis in Alzheimer’s disease (AD) and related disorders. To achieve these goals, the lab frequently utilizes in vitro biochemical assays in addition to cell and animal models, followed by validation in human biofluids and postmortem tissue samples.

Dr. Cook’s faculty bio at Mayo Clinic

Related Research:

Evaluating TMEM106B Accumulation in Alzheimer’s Disease Leonard Petrucelli Casey Cook 2022-08-15

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Evaluating TMEM106B Accumulation in Alzheimer’s Disease 2022, 2023

$402,500

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Todd, T. W., Islam, N. N., Cook, C. N., Caulfield, T. R., & Petrucelli, L. Cryo-EM structures of pathogenic fibrils and their impact on neurodegenerative disease research, Neuron, June 3, 2024, Read More

Yan, Y., & Cook, C. N. Using mass spectrometry to validate mouse models of tauopathy, Molecular Neurodegenration, April 5, 2023, Read More

Marks, J. D., Ayuso, V. E., Carlomagno, Y., Yue, M., Todd, T. W., Hao, Y., Li, Z., McEachin, Z. T., Shantaraman, A., Duong, D. M., Daughrity, L. M., Jansen-West, K., Shao, W., Calliari, A., Bejarano, J. G., DeTure, M., … Petrucelli, L., Cook, C. N. TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia, Science Translational Medicine, January 17, 2024, Read More

Carlomagno, Y., Manne, S., DeTure, M., Prudencio, M., Zhang, Y. J., Hanna Al-Shaikh, R., Dunmore, J. A., Daughrity, L. M., Song, Y., Castanedes-Casey, M., Lewis-Tuffin, L. J., Nicholson, K. A., Wszolek, Z. K., Dickson, D. W., Fitzpatrick, A. W. P., Petrucelli, L., & Cook, C. N. The AD tau core spontaneously self-assembles and recruits full-length tau to filaments, Cell Reports, March 16, 2021, Read More

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