Dr. Catherine Kaczorowski leads a team that pioneers techniques to identify and validate genetic and cellular mechanisms that promote resilience to cognitive aging, Alzheimer’s disease, and other age-related dementias. By combining mouse and human systems, genomic, anatomic, and behavioral approaches, and integrative analyses across multiple scales, data types, environmental factors, and species, the Kaczorowski team are accelerating the discovery of the precise genetic mechanisms of cognitive resilience that could yield the next generation of targets and therapeutic strategies for promoting brain health. They are poised to propel the field of personalized medicine forward using the team’s genetically diverse, yet reproducible models of human neurodegenerative dementias, having already contributed conceptual and technical advances that revolutionize the of study complex diseases, specifically human Alzheimer’s disease dementia.

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