Cure Alzheimer's Fund Cure Alzheimer's Fund

Edoardo Marcora, Ph.D.

Associate Professor of Neuroscience and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai

Dr. Marcora received his degree in Biological Sciences from the University of Pavia in Italy, his Ph.D. in Molecular, Cellular and Developmental Biology from the University of Colorado at Boulder, and conducted postdoctoral training at the California Institute of Technology. As a wetlab biologist, he investigated the role of transcription factors, like NeuroD, in neuronal development, homeostasis and degeneration, with a focus on Huntington’s disease (HD) and the regulation of neuronal transcription by synaptic activity. In 2008, he joined the European Bioinformatics Institute in Cambridge, UK and, in 2011, the Neuroscience Discovery department at Amgen in San Francisco, CA. As a dry-lab biologist and drug discoverer and more recently, in 2016, as an Associate Professor in the Loeb Center for Alzheimer’s Disease at the Icahn School of Medicine at Mount Sinai, he has led cross-functional teams pursuing research projects aimed at translating human genetics and genomics findings into an understanding of disease etiology that is actionable from a drug discovery perspective, by integrating both computational and experimental approaches, in vitro and in vivo.

Related Research:

Investigating MEF2C Transcription Factor as a Therapeutic Target to Reprogram Pathological Microglial States in Alzheimer’s Disease Alison Goate Edoardo Marcora 2024-01-11 Systems Integration and Therapeutics Translation in Alzheimer’s Disease Alison Goate Edoardo Marcora 2022-02-14

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Investigating MEF2C Transcription Factor as a Therapeutic Target to Reprogram Pathological Microglial States in Alzheimer’s Disease 2023

$201,250
Systems Integration and Therapeutics Translation in Alzheimer’s Disease 2021, 2022

$345,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

10. Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., … Gate, D., … , Iadecola, C., Johnson, L. A., Kanekiyo, T., … Lamb, B.T., … Marcora, E., … Morganti, J. M., … Ramachandran, K. V., … Tsai, L. H., … Ulrich, J. D., van der Kant, R., … Wellington, C. L., … Zhao, N., Bu, G., Goate, A. M., Holtzman, D. M. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference, Alzheimer's & Dementia, July 19, 2024, Read More

Tcw, J., Qian, L., Pipalia, N. H., Chao, M. J., Liang, S. A., Shi, Y., Jain, B. R., Bertelsen, S. E., Kapoor, M., Marcora, E., Sikora, E., Andrews, E. J., Martini, A. C., Karch, C. M., Head, E., Holtzman, D. M., Zhang, B., Wang, M., Maxfield, F. R., Poon, W. W., & Goate, A. M. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia, Cell, June 23, 2022, Read More

Back to Our Researchers