Edoardo Marcora, Ph.D.

Associate Professor of Neuroscience and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai

Dr. Marcora received his degree in Biological Sciences from the University of Pavia in Italy, his Ph.D. in Molecular, Cellular and Developmental Biology from the University of Colorado at Boulder, and conducted postdoctoral training at the California Institute of Technology. As a wetlab biologist, he investigated the role of transcription factors, like NeuroD, in neuronal development, homeostasis and degeneration, with a focus on Huntington’s disease (HD) and the regulation of neuronal transcription by synaptic activity. In 2008, he joined the European Bioinformatics Institute in Cambridge, UK and, in 2011, the Neuroscience Discovery department at Amgen in San Francisco, CA. As a dry-lab biologist and drug discoverer and more recently, in 2016, as an Associate Professor in the Loeb Center for Alzheimer’s Disease at the Icahn School of Medicine at Mount Sinai, he has led cross-functional teams pursuing research projects aimed at translating human genetics and genomics findings into an understanding of disease etiology that is actionable from a drug discovery perspective, by integrating both computational and experimental approaches, in vitro and in vivo.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Tcw, J., Qian, L., Pipalia, N. H., Chao, M. J., Liang, S. A., Shi, Y., Jain, B. R., Bertelsen, S. E., Kapoor, M., Marcora, E., Sikora, E., Andrews, E. J., Martini, A. C., Karch, C. M., Head, E., Holtzman, D. M., Zhang, B., Wang, M., Maxfield, F. R., Poon, W. W., & Goate, A. M. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia, Cell, June 23, 2022, Read More