Cure Alzheimer's Fund Cure Alzheimer's Fund

Michael A. Bonaguidi, Ph.D.

Assistant Professor of Stem Cell & Regenerative Medicine and Gerontology, University of Southern California

Dr. Bonaguidi investigates how stem cells act to adapt and repair the adult brain. Using endogenous neural stem cells as a model system, the Bonaguidi Lab’s approach incorporates principles from neuroscience, stem cell biology, single cell molecular biology, cellular biology and genomics, computational biology, systems biology and engineering to unravel brain plasticity. We focus on the reciprocal interaction between neural stem cells and their surroundings during normal, aging, injured and diseased states. Our long-term goal evaluates the capacity of endogenous stem cells to serve as a cellular mediator of neural function and as a therapeutic source of cognitive rejuvenation.

Related Research:

Neural Stem Cell Rejuvenation for Symptomatic Alzheimer’s Disease Michael A. Bonaguidi Wynnie Nguyen 2025-11-05 Air Pollution and Alzheimer’s Disease Risk Interact With Premature Aging of Neural Stem Cells and Apolipoprotein E Alleles Caleb Finch Michael A. Bonaguidi 2022-02-11

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Neural Stem Cell Rejuvenation for Symptomatic Alzheimer’s Disease 2025

$57,500
Air Pollution and Alzheimer’s Disease Risk Interact With Premature Aging of Neural Stem Cells and Apolipoprotein E Alleles 2021, 2022, 2023

$778,283

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Ammothumkandy, A., Corona, L., Ravina, K., Wolseley, V., Nelson, J., Atai, N., Abedi, A., Jimenez, N., Armacost, M., D'Orazio, L. M., Zuverza-Chavarria, V., Cayce, A., McCleary, C., Nune, G., Kalayjian, L., Lee, D. J., Lee, B., Chow, R. H., Heck, C., Russin, J. J., … Bonaguidi, M. A. Human adult neurogenesis loss corresponds with cognitive decline during epilepsy progression, Cell Stem Cell, December 5, 2024, Read More

Back to Our Researchers