These projects were made possible from Cure Alzheimer's Fund support.
| Project Description | Researchers | Funding |
|---|---|---|
| Adult Human iNeurons: A Next-Generation Drug Screening Platform for Alzheimer’s Disease |
2020, 2021 $444,498 |
|
| Targeting Cell Cycle Re-entry Using 3-D Neuron Cultures |
2017 and 2018 $420,681 |
These published papers resulted from Cure Alzheimer’s Fund support.
Lazo, J. S., Isbell, K. N., Vasa, S. A., Llaneza, D. C., Rastelli, E. J., Wipf, P., & Sharlow, E. R. Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase, Journal of Pharmacology and Experimental Therapeutics, February 23, 2023, Read More
Czub, M. P., Boulton, A. M., Rastelli, E. J., Tasker, N. R., Maskrey, T. S., Blanco, I. K., McQueeney, K. E., Bushweller, J. H., Minor, W., Wipf, P., Sharlow, E. R., & Lazo, J. S. Structure of the complex of an iminopyridinedione PTP4A3 phosphatase inhibitor with human serum albumin, Molecular Pharmacology, September 25, 2020, Read More
Lazo, J. S., McQueeney, K. E., & Sharlow, E. R. New Approaches to Difficult Drug Discovery, SLAS Discovery, July 26, 2017, Read More
Lazo, J. S., McQueeney, K. E., Burnett, J. C., Wipf, P., & Sharlow, E. R. Small molecule targeting of PTPs in Cancer, International Journal of Biochemistry & Cell Biology, September 21, 2017, Read More
Porterfield, V., Khan, S. S., Foff, E. P., Koseoglu, M. M., Blanco, I. K., Jayaraman, S., Lien, E., McConnell, M. J., Bloom, G. S., Lazo, J. S., & Sharlow, E. R. A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype, Neurobiology of Aging, February 19, 2020, Read More
Sharlow, E. R. Emerging drug discovery ecosystems, SLAS Discovery, May 30, 2023, Read More
Sharlow, E. R. Benefits of Strategic Small-Scale Targeted Screening, Assay and Drug Development Technologies, August 1, 2016, Read More
Sharlow, E. R. Revisiting repurposing, Assay and Drug Development Technologies, December 1, 2016, Read More
Sharlow, E. R., Leimgruber, S., Lira, A., McConnell, M. J., Norambuena, A., Bloom, G. S., Epperly, M. W., Greenberger, J. S., & Lazo, J. S. A Small molecule screen exposes mTOR signaling pathway involvement in radiation-induced apoptosis, ACS Chemical Biology, May 14, 2016, Read More
Sharlow, E. R., Koseoglu, M. M., Bloom, G. S., & Lazo, J. S. The Promise and Perils of Compound Discovery Screening with Inducible Pluripotent Cell-Derived Neurons, Assay and Drug Development Technologies, February 14, 2020, Read More
Sharlow, E. R., Llaneza, D. C., Tewari, B. P., Mingledorff, G. A., Mendelson, A. J., Sontheimer, H., Bloom, G. S., & Lazo, J. S. Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations, FEBS Journal, July 10, 2023, Read More
Koseoglu, M. M., Norambuena, A., Sharlow, E. R., Lazo, J. S., & Bloom, G. S. Aberrant neuronal cell-cycle re-entry: the pathological confluence fo Alzheimer’s disease and brain insulin resistance, and its relation to cancer., Journal of Alzheimer's Disease, January 8, 2019, Read More
Koseoglu, M. M., Norambuena, A., Sharlow, E. R., Lazo, J. S., & Bloom, G. S. Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer’s Disease and Brain Insulin Resistance, and Its Relation to Cancer, Journal of Alzheimer's Disease, January 8, 2019, Read More
Sharlow, E. R., Llaneza, D. C., Grever, W. E., Mingledorff, G. A., Mendelson, A. J., Bloom, G. S., & Lazo, J. S. High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons, SLAS Discovery, October 20, 2022, Read More
Eastman, G., Sharlow, E. R., Lazo, J. S., Bloom, G. S., & Sotelo-Silveira, J. R. Transcriptome and Translatome Regulation of Pathogenesis in Alzheimer’s Disease Model Mice, Journal of Alzheimer's Disease, March 8, 2022, Read More
