Elizabeth R. Sharlow, Ph.D.

Professor of Research in Pharmacology, University of Virginia


Elizabeth Sharlow, Ph.D., is Professor of Research in Pharmacology, at the University of Virginia School of Medicine and Co-Director of the Fiske Drug Discovery Laboratory.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Lazo, J. S., Isbell, K. N., Vasa, S. A., Llaneza, D. C., Rastelli, E. J., Wipf, P., & Sharlow, E. R. Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase, Journal of Pharmacology and Experimental Therapeutics, February 23, 2023, Read More

Czub, M. P., Boulton, A. M., Rastelli, E. J., Tasker, N. R., Maskrey, T. S., Blanco, I. K., McQueeney, K. E., Bushweller, J. H., Minor, W., Wipf, P., Sharlow, E. R., & Lazo, J. S. Structure of the complex of an iminopyridinedione PTP4A3 phosphatase inhibitor with human serum albumin, Molecular Pharmacology, September 25, 2020, Read More

Lazo, J. S., McQueeney, K. E., & Sharlow, E. R. New Approaches to Difficult Drug Discovery, SLAS Discovery, July 26, 2017, Read More

Lazo, J. S., McQueeney, K. E., Burnett, J. C., Wipf, P., & Sharlow, E. R. Small molecule targeting of PTPs in Cancer, International Journal of Biochemistry & Cell Biology, September 21, 2017, Read More

Porterfield, V., Khan, S. S., Foff, E. P., Koseoglu, M. M., Blanco, I. K., Jayaraman, S., Lien, E., McConnell, M. J., Bloom, G. S., Lazo, J. S., & Sharlow, E. R. A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype, Neurobiology of Aging, February 19, 2020, Read More

Sharlow, E. R. Emerging drug discovery ecosystems, SLAS Discovery, May 30, 2023, Read More

Sharlow, E. R. Benefits of Strategic Small-Scale Targeted Screening, Assay and Drug Development Technologies, August 1, 2016, Read More

Sharlow, E. R. Revisiting repurposing, Assay and Drug Development Technologies, December 1, 2016, Read More

Sharlow, E. R., Leimgruber, S., Lira, A., McConnell, M. J., Norambuena, A., Bloom, G. S., Epperly, M. W., Greenberger, J. S., & Lazo, J. S. A Small molecule screen exposes mTOR signaling pathway involvement in radiation-induced apoptosis, ACS Chemical Biology, May 14, 2016, Read More

Sharlow, E. R., Koseoglu, M. M., Bloom, G. S., & Lazo, J. S. The Promise and Perils of Compound Discovery Screening with Inducible Pluripotent Cell-Derived Neurons, Assay and Drug Development Technologies, February 14, 2020, Read More

Sharlow, E. R., Llaneza, D. C., Tewari, B. P., Mingledorff, G. A., Mendelson, A. J., Sontheimer, H., Bloom, G. S., & Lazo, J. S. Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations, FEBS Journal, July 10, 2023, Read More

Koseoglu, M. M., Norambuena, A., Sharlow, E. R., Lazo, J. S., & Bloom, G. S. Aberrant neuronal cell-cycle re-entry: the pathological confluence fo Alzheimer’s disease and brain insulin resistance, and its relation to cancer., Journal of Alzheimer's Disease, January 8, 2019, Read More

Koseoglu, M. M., Norambuena, A., Sharlow, E. R., Lazo, J. S., & Bloom, G. S. Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer’s Disease and Brain Insulin Resistance, and Its Relation to Cancer, Journal of Alzheimer's Disease, January 8, 2019, Read More

Sharlow, E. R., Llaneza, D. C., Grever, W. E., Mingledorff, G. A., Mendelson, A. J., Bloom, G. S., & Lazo, J. S. High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons, SLAS Discovery, October 20, 2022, Read More

Eastman, G., Sharlow, E. R., Lazo, J. S., Bloom, G. S., & Sotelo-Silveira, J. R. Transcriptome and Translatome Regulation of Pathogenesis in Alzheimer’s Disease Model Mice, Journal of Alzheimer's Disease, March 8, 2022, Read More