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Stephen R. Salton, M.D., Ph.D.

Professor of Neuroscience, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai

Stephen R. Salton, M.D., Ph.D., attended the University of Pennsylvania, graduating with magna cum laude honors in Biochemistry, completed the M.D./Ph.D. program at New York University School of Medicine, and following an internship and residency in internal medicine at Bellevue Hospital in New York, conducted postdoctoral research in molecular neuroendocrinology at Columbia University College of Physicians and Surgeons and Mount Sinai School of Medicine. Dr. Salton has received a number of academic/scientific honors including a Medical Scientist Training Program Award, Pfizer Post-Doctoral and Scholar Awards, Pew Scholars Award in the Biomedical Sciences, Irma T. Hirschl-Monique Weill-Caulier Career Scientist Award, and NARSAD van Ameringen Investigator Award. He has held faculty positions at the Icahn School of Medicine at Mount Sinai since 1989 and is currently a tenured Professor in the Departments of Neuroscience and Geriatrics. Dr. Salton’s molecular neurobiology lab investigates the mechanisms and gene products that mediate neurotrophic growth factor regulation of nervous system function during development and with aging, impacting the understanding of depression, memory, body weight control, neuropathic pain, and neurodegeneration. He additionally plays an active role in the broader educational mission of the institution and contributes to a number of committees at Mount Sinai that oversee its academic and teaching missions. Dr. Salton has been Co-Director responsible for overseeing the administration and operation of the Neuroscience Graduate Training Area since 2000, authoring the application securing Mount Sinai’s Neuroscience Ph.D. granting program that was approved in 2007 by NYU and the NY State Education Dept and is currently PI of Mount Sinai’s NIH-supported Neuroscience T32 training program.

Related Research:

VGF-Derived Peptide Therapy for Alzheimer’s Disease: Studies of Mouse and Human TLQP-21 and its Receptor, C3aR1 Michelle E. Ehrlich Stephen R. Salton 2020-11-06 VGF, a Novel Therapeutic Effector of Alzheimer’s Disease Pathogenesis and Progression Stephen R. Salton Michelle E. Ehrlich 2018-08-27

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
VGF-Derived Peptide Therapy for Alzheimer’s Disease: Studies of Mouse and Human TLQP-21 and its Receptor, C3aR1 2020

$172,500
VGF, a Novel Therapeutic Effector of Alzheimer’s Disease Pathogenesis and Progression 2017, 2019

$300,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Sahu, B. S., Nguyen, M. E., Rodriguez, P., Pallais, J. P., Ghosh, V., Razzoli, M., Sham, Y. Y., Salton, S. R., & Bartolomucci, A. The molecular identity of the TLQP-21 peptide receptor, Cellular and Molecular Life Sciences, October 9, 2021, Read More

Jiang, C., Lin, W. J., & Salton, S. R. Role of VGF/BDNF/TrkB Autoregulatory Feedback Loop in Rapid-Acting Antidepressant Efficacy, Journal of Molecular Neuroscience, July 18, 2019, Read More

Lin, W. J., Zhao, Y., Li, Z., Zheng, S., Zou, J. L., Warren, N. A., Bali, P., Wu, J., Xing, M., Jiang, C., Tang, Y., Salton, S. R., & Ye, X. An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function, Translational Psychiatry, July 8, 2021, Read More

Pan, A. L., Audrain, M., Sakakibara, E., Joshi, R., Zhu, X., Wang, Q., Wang, M., Beckmann, N. D., Schadt, E. E., Gandy, S., Zhang, B., Ehrlich, M. E., & Salton, S. R. Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces β-Amyloid Load in Males and Females, Cells, December 1, 2022, Read More

Beckmann, N. D., Lin, W. J., Wang, M., … Gandy, S., Tu, Z., Ehrlich, M. E., Zhang, B., Schadt, E. E. Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease, Nature Communications, August 7, 2020, Read More

El Gaamouch, F., Audrain, M., Lin, W. J., Beckmann, N., Jiang, C., Hariharan, S., Heeger, P. S., Schadt, E. E., Gandy, S., Ehrlich, M. E., & Salton, S. R. VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice, Molecular Neurodegenration, January 10, 2020, Read More

Bose, M., Farias Quipildor, G., Ehrlich, M. E., & Salton, S. R. Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development, Cells, November 16, 2022, Read More

Wang, E., Pan, A. L., Bagchi, P., Rangaraju, S., Seyfried, N. T., Ehrlich, M. E., Salton, S. R., & Zhang, B. Proteomic signaling of dual specificity phosphatase 4 (DUSP4) in Alzheimer’s disease, Biomolecules, January 3, 2024, Read More

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