These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
VGF-Derived Peptide Therapy for Alzheimer’s Disease: Studies of Mouse and Human TLQP-21 and its Receptor, C3aR1 |
2020, 2024 $345,000 |
|
VGF, a Novel Therapeutic Effector of Alzheimer’s Disease Pathogenesis and Progression |
2017, 2019 $300,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Pan, A. L., Audrain, M., Sakakibara, E., Joshi, R., Zhu, X., Wang, Q., Wang, M., Beckmann, N. D., Schadt, E. E., Gandy, S., Zhang, B., Ehrlich, M. E., & Salton, S. R. Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice, Frontiers in Aging Neuroscience, June 28, 2024, Read More
Sahu, B. S., Nguyen, M. E., Rodriguez, P., Pallais, J. P., Ghosh, V., Razzoli, M., Sham, Y. Y., Salton, S. R., & Bartolomucci, A. The molecular identity of the TLQP-21 peptide receptor, Cellular and Molecular Life Sciences, October 9, 2021, Read More
Jiang, C., Lin, W. J., & Salton, S. R. Role of VGF/BDNF/TrkB Autoregulatory Feedback Loop in Rapid-Acting Antidepressant Efficacy, Journal of Molecular Neuroscience, July 18, 2019, Read More
Lin, W. J., Zhao, Y., Li, Z., Zheng, S., Zou, J. L., Warren, N. A., Bali, P., Wu, J., Xing, M., Jiang, C., Tang, Y., Salton, S. R., & Ye, X. An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function, Translational Psychiatry, July 8, 2021, Read More
Pan, A. L., Audrain, M., Sakakibara, E., Joshi, R., Zhu, X., Wang, Q., Wang, M., Beckmann, N. D., Schadt, E. E., Gandy, S., Zhang, B., Ehrlich, M. E., & Salton, S. R. Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces β-Amyloid Load in Males and Females, Cells, December 1, 2022, Read More
Beckmann, N. D., Lin, W. J., Wang, M., … Gandy, S., Tu, Z., Ehrlich, M. E., Zhang, B., Schadt, E. E. Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease, Nature Communications, August 7, 2020, Read More
El Gaamouch, F., Audrain, M., Lin, W. J., Beckmann, N., Jiang, C., Hariharan, S., Heeger, P. S., Schadt, E. E., Gandy, S., Ehrlich, M. E., & Salton, S. R. VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice, Molecular Neurodegenration, January 10, 2020, Read More
Bose, M., Farias Quipildor, G., Ehrlich, M. E., & Salton, S. R. Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development, Cells, November 16, 2022, Read More
Wang, E., Pan, A. L., Bagchi, P., Rangaraju, S., Seyfried, N. T., Ehrlich, M. E., Salton, S. R., & Zhang, B. Proteomic signaling of dual specificity phosphatase 4 (DUSP4) in Alzheimer’s disease, Biomolecules, January 3, 2024, Read More