These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Optimization of Pharmacalogic Properties of Molecular Tweezers |
2015 $100,000 |
|
Molecular Tweezers—Novel Inhibitors of Amyloidogenic Proteins and Promising Drug Candidates for Alzheimer’s Disease |
2011 $100,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Attar, A., & Bitan, G. Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by “molecular tweezers” — from the test tube to animal models, Current Pharmaceutical Design, May 1, 2014, Read More
Ferreira, N., Pereira-Henriques, A., Attar, A., Klärner, F. G., Schrader, T., Bitan, G., Gales, L., Saraiva, M. J., & Almeida, M. R. Molecular tweezers targeting transthyretin amyloidosis, Neurotherapeutics, April 1, 2014, Read More
Attar, A., Liu, T., Chan, W. T., Hayes, J., Nejad, M., Lei, K., & Bitan, G. A shortened Barnes Maze Protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer’s disease, PLoS One, November 13, 2013, Read More
Attar, A., Rahimi, F., & Bitan, G. Modulators of amyloid protein aggregation and toxicity: EGCG and CLR01, Translational Neuroscience, December 20, 2013, Read More
Despres, C., Di, J., Cantrelle, F. X., Li, Z., Huvent, I., Chambraud, B., Zhao, J., Chen, J., Chen, S., Lippens, G., Zhang, F., Linhardt, R., Wang, C., Klärner, F. G., Schrader, T., Landrieu, I., Bitan, G., & Smet-Nocca, C. Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in vitro Phosphorylated Tau and their Modulation by Potential Inhibitors, ACS Chemical Biology, May 2, 2019, Read More
Li, H., Rahimi, F., & Bitan, G. Modulation of amyloid beta-protein (A beta) assembly by homologous C-terminal fragments strategy for inhibiting Amyloid beta toxicity, ACS Chemical Neuroscience, July 5, 2016, Read More
Di, J., Siddique, I., Li, Z., Malki, G., Hornung, S., Dutta, S., Hurst, I., Ishaaya, E., Wang, A., Tu, S., Boghos, A., Ericsson, I., Klärner, F. G., Schrader, T., & Bitan, G. The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice, Alzheimer's Research & Therapy, January 4, 2021, Read More
Connors, C. R., Rosenman, D. J., Lopes, D. H., Mittal, S., Bitan, G., Sorci, M., Belfort, G., Garcia, A., & Wang, C. Tranilast binds to A beta monomers and promotes A beta fibrillation, Biochemistry, May 31, 2013, Read More
Attar, A., Chan, W. T., Klärner, F. G., Schrader, T., & Bitan, G. Safety and pharmacological characterization of the molecular tweezer CLR01- a broad spectrum inhibitor of amyloid protein’s toxicity, BMC Pharmacology and Toxicology, April 16, 2014, Read More
Attar, A., Ripoli, C., Riccardi, E., Maiti, P., Li Puma, D. D., Liu, T., Hayes, J., Jones, M. R., Lichti-Kaiser, K., Yang, F., Gale, G. D., Tseng, C. H., Tan, M., Xie, C. W., Straudinger, J. L., Klärner, F. G., Schrader, T., Frautschy, S. A., Grassi, C., & Bitan, G. Protection of primary neurons and mouse brain from Alzheimer’s pathology by molecular tweezers, Brain, November 24, 2012, Read More
Schrader, T., Bitan, G., & Klärner, F. G. Molecular tweezers for lysine and arginine — powerful inhibitors of pathologic protein aggregation, Chemical Communications, August 22, 2016, Read More
Liu, T., & Bitan, G. Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: strategies and mechanisms, ChemMedChem, February 9, 2012, Read More
Linares, G. R., Ivanova, M. I., Ichida, J., Weil, T., Münch, J., Sanchez-Garcia, E., Klärner, F. G., Schrader, T., & Bitan, G. Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications, Pharmacological Reviews, December 22, 2022, Read More