Gunnar Brinkmalm, Ph.D.

Associate Professor and Senior Research Associate, University of Gothenburg, Sweden


Gunnar Brinkmalm is an Associate Professor and Senior Research Associate at the University of Gothenburg, Sweden. His main research focus and interest is development of advanced mass spectrometric methods for analysis of complex biological samples, in particular analyses related to neurodegenerative diseases. He has published more than 100 scientific articles as well as book chapters on mass spectrometry.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Meda, F. J., Dittrich, A., Skoog, I., Kern, S., Leckey, C., Wild, E. J., Paterson, R. W., Brinkmalm, G., Andreasson, U., Blennow, K., Zetterberg, H., & Kvartsberg, H. Alpha-internexin as a brain-specific neurodegeneration marker: development and validation of a novel CSF assay, Journal of Neurobiology, October 6, 2025, Read More

Acta Neuropathologica Reversible tau hyperphosphorylation in hibernation: a blood biomarker and brain tissue study, Acta Neuropathologica, September 29, 2025, Read More

Wood, J. I., Dulewicz, M., Szadziewska, A., Weiner, S., Ge, J., Stringer, K., Desai, S., Fenson, L., Piotrowska, D., Brinkmalm, G., Koutarapu, S., Hajar, H. B., Blennow, K., Zetterberg, H., Cummings, D. M., Savas, J. N., Edwards, F. A., & Hanrieder, J. Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer’s disease mouse model, Nature Communications, September 1, 2025, Read More

Montoliu-Gaya, L., Salvadó, G., Therriault, J., Nilsson, J., Janelidze, S., Weiner, S., Ashton, N. J., Benedet, A. L., Rahmouni, N., Lantero-Rodriguez, J., Mattsson-Carlgren, N., Palmqvist, S., Brinkmalm, G., Stomrud, E., Zetterberg, H., Gobom, J., Rosa-Neto, P., Blennow, K., & Hansson, O. Plasma tau biomarkers for biological staging of Alzheimer’s disease, Nature Aging, August 22, 2025, Read More

Montoliu-Gaya, L., Valeriano-Lorenzo, E., Ashton, N. J., López-González, F. J., Lantero-Rodriguez, J., Ruiz-González, A., Pastor, A. B., Frades, B., Zea-Sevilla, M. A., Valentí, M., Ruiz-Valderrey, P., Saiz, L., Burgueño-García, I., López-Martínez, M. J., Del Ser, T., Brinkmalm, G., Zetterberg, H., … Sánchez-Juan, P. Plasma tau biomarkers are distinctly associated with tau tangles and decreased with Lewy body pathology, Alzheimer's & Dementia, August 12, 2025, Read More

Becker, B., Gobom, J., Brinkmalm, G., Andreasson, U., Meda, F. J., Zetterberg, H., & Blennow, K. Novel insights into the molecular nature of neurofilament light polypeptide species in cerebrospinal fluid, Brain Communications, April 2, 2025, Read More

Watamura, N., Foiani, M. S., Bez, S., Bourdenx, M., Santambrogio, A., Frodsham, C., Camporesi, E., Brinkmalm, G., Zetterberg, H., , … Duff, K. E., Saido, T. C. In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds, Nature Neuroscience, December 24, 2024, Read More

Lantero-Rodriguez, J., Camporesi, E., Montoliu-Gaya, L., Gobom, J., Piotrowska, D., Olsson, M., Burmann, I. M., Becker, B., Brinkmalm, A., Burmann, B. M., Perkinton, M., Ashton, N. J., Fox, N. C., Lashley, T., Zetterberg, H., Blennow, K., & Brinkmalm, G. Tau protein profiling in tauopathies: a human brain study, Molecular Neurodegeneration, July 19, 2024, Read More

Kasri, A., Camporesi, E., Gkanatsiou, E., Boluda, S., Brinkmalm, G., Stimmer, L., Ge, J., Hanrieder, J., Villain, N., Duyckaerts, C., Vermeiren, Y., Pape, S. E., Nicolas, G., Laquerrière, A., De Deyn, P. P., Wallon, D., Blennow, K., Strydom, A., Zetterberg, H., & Potier, M. C. Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer’s disease with APPdup and Down syndrome, Acta Neuropathologica, July 18, 2024, Read More

Gobom, J., Brinkmalm, A., Brinkmalm, G., Blennow, K., & Zetterberg, H. Alzheimer’s disease biomarker analysis using targeted mass spectrometry, Molecular & Cellular Proteomics, January 20, 2024, Read More