Cure Alzheimer's Fund Cure Alzheimer's Fund

Jaime Grutzendler, M.D.

Dr. Harry M. Zimmerman and Dr. Nicholas and Viola Spinelli Professor of Neurology and Neuroscience; Vice-Chair for Research, Neurology; Director, Center for Experimental Neuroimaging, Yale School of Medicine

Dr. Grutzendler’s laboratory is focused on understanding brain function and the cellular basis of neurological diseases. His lab develops and implements methodologies for high resolution optical imaging, cell labeling and cell manipulations in vivo, with the goal of improving the understanding of interactions between neuronal and non-neuronal cell types in their native microenvironment. A major goal of the lab is to elucidate how these cell-cell interactions are disrupted in disease states such as in Alzheimer’s disease, ischemia and demyelination with the ultimate goal of designing new therapies for these conditions.

To learn more, visit the Grutzendler Lab website.

 

 

 

Related Research:

The Role of Calcium Homeostasis in Axonal Spheroid Formation in Alzheimer’s Disease Jaime Grutzendler 2024-06-13 The Neuroprotective Glial Barrier: A Multicellular Reaction with Therapeutic Potential in Alzheimer’s Disease Jaime Grutzendler 2019-01-10

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
The Role of Calcium Homeostasis in Axonal Spheroid Formation in Alzheimer’s Disease 2024

$199,995.35
The Neuroprotective Glial Barrier: A Multicellular Reaction with Therapeutic Potential in Alzheimer’s Disease 2018, 2021

$345,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Cai, Y., Kanyo, J., Wilson, R., Bathla, S., Cardozo, P. L., Tong, L., Qin, S., Fuentes, L. A., Pinheiro-de-Sousa, I., Huynh, T., Sun, L., Mansuri, M. S., Tian, Z., Gan, H. R., Braker, A., Trinh, H. K., Huttner, A., Lam, T. T., Petsalaki, E., Brennand, K. J., … Grutzendler, J. Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease, Nature Aging, March 10, 2025, Read More

Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., ... Cruchaga, C., ... Glass C. K., ... Butovsky, O., ... Grutzendler, J., … Baker, D. J., Liddelow, S. A., ... Kipnis, J., ... Colonna, M., ... Riechers, S. P. Neuroinflammation in Alzheimer disease, Nature Reviews Immunology, December 9, 2024, Read More

Grutzendler, J., & Nedergaard, M. Cellular Control of Brain Capillary Blood Flow: In vivo imaging veritas, Trends in Neurosciences, June 26, 2019, Read More

Yuan, P., Zhang, M., Tong, L., Morse, T. M., McDougal, R. A., Ding, H., Chan, D., Cai, Y., & Grutzendler, J. PLD3 affects axonal spheroids and network defects in Alzheimer’s disease, Nature, November 30, 2022, Read More

Damisah, E. C., Hill, R. A., Rai, A., Chen, F., Rothlin, C. V., Ghosh, S., & Grutzendler, J. Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo, Science Advances, June 26, 2020, Read More

Wang, Y., Ulland, T. K., Ulrich, J. D., Song, W., Tzaferis, J. A., Hole, J. T., Yuan, P., Mahan, T. E., Shi, Y., Gilfillan, S., Cella, M., Grutzendler, J., DeMattos, R. B., Cirrito, J. R., Holtzman, D. M., & Colonna, M. TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques, Journal of Experimental Medicine, April 18, 2016, Read More

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