Cure Alzheimer's Fund Cure Alzheimer's Fund

Josh Morganti, Ph.D.

Assistant Professor, Department of Neuroscience, University of Kentucky

Dr. Morganti is an Assistant Professor in the Department of Neuroscience and Sanders Brown Center of Aging at the University of Kentucky. Research in Dr.

Morganti’s lab focuses on understanding the heterogeneity and susceptibility of astrocyte and microglial cell populations in order to provide exciting clues as to the mechanisms underlying brain dysfunction. Approaches in the Morganti lab are geared toward applying multidisciplinary approaches to study the complex heterogeneous inflammatory response of astrocytes and microglia across a  variety of neurodegenerative disease models. Cutting-edge technologies used in the lab include single-cell RNA sequencing (scRNAseq), spatial transcriptomics, fluorescently activated cell sorting (FACS), cell-specific conditional knockout (cKO) models, and bioinformatics.

@Morganti_Lab

https://www.morgantilab.com/

 

Related Research:

Apolipoprotein E and Immunometabolism in Alzheimer’s Disease Lance Johnson Josh Morganti Ramon Sun 2022-02-14

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Apolipoprotein E and Immunometabolism in Alzheimer’s Disease 2021

$172,500

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Goulding, D. S., Williams, H. C., Gorman, A. A., Devanney, N. A., Harrison, D. A., Walsh, A. E., Tuck, T., Zajac, D. J., Macauley, S. L., Estus, S., Tcw, J., A Johnson, L., & Morganti, J. M. APOE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes, Journal of Neuroinflammation, February 11, 2026, Read More

Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., … Gate, D., … , Iadecola, C., Johnson, L. A., Kanekiyo, T., … Lamb, B.T., … Marcora, E., … Morganti, J. M., … Ramachandran, K. V., … Tsai, L. H., … Ulrich, J. D., van der Kant, R., … Wellington, C. L., … Zhao, N., Bu, G., Goate, A. M., Holtzman, D. M. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference, Alzheimer's & Dementia, July 19, 2024, Read More

Lee, S., Devanney, N. A., Golden, L. R., Smith, C. T., Schwartz, J. L., Walsh, A. E., Clarke, H. A., Goulding, D. S., Allenger, E. J., Morillo-Segovia, G., Friday, C. M., Gorman, A. A., Hawkinson, T. R., MacLean, S. M., Williams, H. C., Sun, R. C., Morganti, J. M., & Johnson, L. A. APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge, Cell Reports, March 3, 2023, Read More

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