Judith Steen, Ph.D.

Dr. Judith Steen is an Associate Professor of Neurobiology at Harvard Medical School, a member of the Harvard Stem Cell Institute and the Director of the Neuroproteomics Laboratory in the F. M. Kirby Neuroscience Center at Boston Children’s Hospital. Her laboratory works to understand neuro-regeneration and neurodegenerative diseases using systems biology approaches. The laboratory develops novel qualitative and quantitative methodologies at the interface of proteomics and transcriptomics with special emphasis on computational proteomics approaches. These novel quantitative methods and bioinformatics tools developed by the Steen Laboratory are being applied to understand the biology of regeneration and neurodegeneration in both mouse models, stem cells, and human tissues, to find molecular targets for therapeutics, and to identify biomarkers of the neurodegenerative process. Further functional studies using biochemical, molecular and cell biology approaches are used to verify and understand the role of the targets and biomarkers in the context of injury and disease. The goal of this research is to use molecular information provided by our quantitative proteomics measurements in order to ameliorate neurodegeneration and promote regeneration.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Temporal Analysis of Infection in Alzheimer’s Disease Models 2018


Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Fujimura, K., Guise, A. J., Nakayama, T., Schlaffner, C. N., Meziani, A., Kumar, M., Cheng, L., Vaughan, D. J., Kodani, A., Van Haren, S., Parker, K., Levy, O., Durbin, A. F., Bosch, I., Gehrke, L., Steen, H., Mochida, G. H., & Steen, J. A. Integrative systems biology characterizes immune-mediated neurodevelopmental changes in murine Zika virus microcephaly, iScience, May 19, 2023, Read More

Viode, A., van Zalm, P., Smolen, K. K., Fatou, B., Stevenson, D., Jha, M., Levy, O., Steen, J., Steen, H., & IMPACC Network A simple, time- and cost-effective, high-throughput depletion strategy for deep plasma proteomics, Science Advances, March 29, 2023, Read More