These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Neuroimmune Consortium: Astrocyte Inflammatory Contributions to Alzheimer’s Disease |
2024, 2025 $575,000 |
|
Mechanisms of Astrocyte-Derived Lipid Toxicity in Alzheimer’s Disease |
2023 $208,033 |
|
The Role of Astrocyte-Derived Toxic Lipids Mediating Degeneration in Alzheimer’s Disease |
2021, 2022 $349,637 |
|
Neuroimmune Consortium: Investigation of Alzheimer’s Disease Risk Alleles in Astrocytes—Focus on Cholesterol Transport and Microglia Interactions |
2020-2022 $615,000 |
|
Neurotoxic Reactive Astrocytes in Alzheimer’s Disease |
2018-2019 $500,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Gildea, H. K., & Liddelow, S. A. Mechanisms of astrocyte aging in reactivity and disease, Molecular Neurodegeneration, February 21, 2025, Read More
Hasel, P., Cooper, M. L., Marchildon, A. E., Rufen-Blanchette, U., Kim, R. D., Ma, T. C., Groh, A. M. R., Hill, E. J., Lewis, E. M., Januszewski, M., Light, S. E. W., Smith, C. J., Stratton, J. A., Sloan, S. A., Kang, U. J., Chao, M. V., & Liddelow, S. A. Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates, Cell Reports, February 20, 2025, Read More
Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., ... Cruchaga, C., ... Glass C. K., ... Butovsky, O., ... Grutzendler, J., … Baker, D. J., Liddelow, S. A., ... Kipnis, J., ... Colonna, M., ... Riechers, S. P. Neuroinflammation in Alzheimer disease, Nature Reviews Immunology, December 9, 2024, Read More
Colonna, M., Konopka, G., Liddelow, S. A., Nowakowski, T., Awatramani, R., Bateup, H. S., Cadwell, C. R., Caglayan, E., Chen, J. L., Gillis, J., Kampmann, M., Krienen, F., Marsh, S. E., Monje, M., O'Dea, M. R., Patani, R., Pollen, A. A., Quintana, F. J., Scavuzzo, M., Schmitz, M., … Habib, N. Implementation and validation of single-cell genomics experiments in neuroscience, Nature Neuroscience, December 3, 2024, Read More
Adameyko, I., Bakken, T., Bhaduri, A., Chhatbar, C., Filbin, M. G., Gate, D., … Liddelow, S. A., Nowakowski, T. J. Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system, Nature Neuroscience, December 3, 2024, Read More
Bonev, B., Castelo-Branco, G., Chen, F., Codeluppi, S., Corces, M. R., Fan, J., Heiman, M., Harris, K., Inoue, F., Kellis, M., ... Liddelow, S. A., … Nowakowski, T. J. Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery, Nature Neuroscience, December 3, 2024, Read More
Lopez-Lee, C., Kodama, L., Fan, L., Zhu, D., Zhu, J., Wong, M. Y., Ye, P., Norman, K., Foxe, N. R., Ijaz, L., Yu, F., Chen, H., Carling, G. K., Torres, E. R., Kim, R. D., Dubal, D. B., Liddelow, S. A., Sinha, S. C., Luo, W., & Gan, L. Tlr7 drives sex differences in age- and Alzheimer’s disease-related demyelination, Science, November 29, 2024, Read More
Prescott, K., Münch, A. E., Brahms, E., Weigel, M. K., Inoue, K., Buckwalter, M. S., Liddelow, S. A., & Peterson, T. C. Blocking of microglia-astrocyte proinflammatory signaling is beneficial following stroke, Frontiers in Molecular Neuroscience, January 4, 2024, Read More
Prakash, P., Erdjument-Bromage, H., O'Dea, M. R., Munson, C. N., Labib, D., Fossati, V., Neubert, T. A., & Liddelow, S. A. Proteomic profiling of interferon-responsive reactive astrocytes in rodent and human, Glia, November 30, 2023, Read More
Frazel, P. W., Labib, D., Fisher, T., Brosh, R., Pirianian, N., Marchildon, A., Boeke, J. D., Fossati, V., & Liddelow, S. A. Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols, Nature Neuroscience, September 11, 2023, Read More
Castranio, E. L., Hasel, P., Haure-Mirande, J. V., Ramirez Jimenez, A. V., Hamilton, B. W., Kim, R. D., Glabe, C. G., Wang, M., Zhang, B., Gandy, S., Liddelow, S. A., & Ehrlich, M. E. Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer’s disease, Alzheimer's & Dementia, November 30, 2022, Read More
Titus, H. E., Xu, H., Robinson, A. P., Patel, P. A., Chen, Y., Fantini, D., Eaton, V., Karl, M., Garrison, E. D., Rose, I. V. L., Chiang, M. Y., Podojil, J. R., Balabanov, R., Liddelow, S. A., Miller, R. H., Popko, B., & Miller, S. D. Repurposing the cardiac glycoside digoxin to stimulate myelin regeneration in chemically-induced and immune-mediated mouse models of multiple sclerosis, Glia, July 9, 2022, Read More
Fernández-Castañeda, A., Lu, P., Geraghty, A. C., Song, E., Lee, M. H., Wood, J., … Liddelow, S. A., … Monje, M. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation, Cell, June 13, 2022, Read More
Labib, D., Wang, Z., Prakash, P., Zimmer, M., Smith, M. D., Frazel, P. W., Barbar, L., Sapar, M. L., Calabresi, P. A., Peng, J., Liddelow, S. A., & Fossati, V. Proteomic Alterations and Novel Markers of Neurotoxic Reactive Astrocytes in Human Induced Pluripotent Stem Cell Models, Frontiers in Molecular Neuroscience, May 3, 2022, Read More
Kleffman, K., Levinson, G., Rose, I., Blumenberg, L. M., … Li, Y. M., … Liddelow, S.A., … Hernando, E. Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis, Cancer Discovery, May 2, 2022, Read More
Sadick, J. S., O'Dea, M. R., Hasel, P., Dykstra, T., Faustin, A., & Liddelow, S. A. Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer’s disease., Neuron, April 4, 2022, Read More
Bandler, R. C., Vitali, I., Delgado, R. N., Ho, M. C., Dvoretskova, E., Ibarra Molinas, J. S., Frazel, P. W., Mohammadkhani, M., Machold, R., Maedler, S., Liddelow, S. A., Nowakowski, T. J., Fishell, G., & Mayer, C. Single-cell delineation of lineage and genetic identity in the mouse brain, Nature, December 15, 2021, Read More
Guttenplan, K. A., Weigel, M. K., Prakash, P., Wijewardhane, P. R., Hasel, P., Rufen-Blanchette, U., Münch, A. E., Blum, J. A., Fine, J., Neal, M. C., Bruce, K. D., Gitler, A. D., Chopra, G., Liddelow, S. A., & Barres, B. A. Neurotoxic reactive astrocytes induce cell death via saturated lipids., Nature, October 6, 2021, Read More
Hasel, P., Rose, I. V. L., Sadick, J. S., Kim, R. D., & Liddelow, S. A. Neuroinflammatory astrocyte subtypes in the mouse brain, Nature Neuroscience, August 19, 2021, Read More
Prakash, P., Jethava, K. P., Korte, N., Izquierdo, P., Favuzzi, E., Rose, I. V. L., Guttenplan, K. A., Manchanda, P., Dutta, S., Rochet, J. C., Fishell, G., Liddelow, S. A., Attwell, D., & Chopra, G. Monitoring phagocytic uptake of amyloid beta into glial cell lysosomes in real time, Chemical Science, July 21, 2021, Read More
Spanos, F., & Liddelow, S. A. An Overview of Astrocyte Responses in Genetically Induced Alzheimer’s Disease Mouse Models, Cells, November 4, 2020, Read More
Zhang, J., Velmeshev, D., Hashimoto, K., Huang, Y. H., Hofmann, J. W., Shi, X., Chen, J., Leidal, A. M., Dishart, J. G., Cahill, M. K., Kelley, K. W., Liddelow, S. A., … Huang, E. J. Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency, Nature, August 31, 2020, Read More
Liddelow, S. A., Marsh, S. E., & Stevens, B. Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?, Trends in Immunology, August 17, 2020, Read More
Guttenplan, K. A., Weigel, M. K., Adler, D. I., Couthouis, J., Liddelow, S. A., Gitler, A. D., & Barres, B. A. Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model, Nature Communications, July 27, 2020, Read More
Guttenplan, K. A., Stafford, B. K., El-Danaf, R. N., Adler, D. I., Münch, A. E., Weigel, M. K., Huberman, A. D., & Liddelow, S. A. Neurotoxic Reactive Astrocytes Drive Neuronal Death After Retinal Injury, Cell Reports, June 23, 2020, Read More
Barbar, L., Jain, T., Zimmer, M., Kruglikov, I., Sadick, J. S., Wang, M., Kalpana, K., Rose, I. V. L., Burstein, S. R., Rusielewicz, T., Nijsure, M., Guttenplan, K. A., di Domenico, A., Croft, G., Zhang, B., Nobuta, H., Hébert, J. M., Liddelow, S. A., & Fossati, V. CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes, Neuron, June 1, 2020, Read More
Sadick, J. S., Crawford, L. A., Cramer, H. C., 3rd, Franck, C., Liddelow, S. A., & Darling, E. M. Generating Cell Type-Specific Protein Signatures from Non-symptomatic and Diseased Tissues, Annals of Biomedical Engineering, April 17, 2020, Read More
Gibson, E. M., Nagaraja, S., Ocampo, A., Tam, L. T., Wood, L. S., Pallegar, P. N., Greene, J. J., Geraghty, A. C., Goldstein, A. K., Ni, L., Woo, P. J., Barres, B. A., Liddelow, S., Vogel, H., & Monje, M. Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment, Cell, December 6, 2018, Read More
Shi, Y., Yamada, K., Liddelow, S. A., Smith, S. T., Zhao, L., Luo, W., Tsai, R. M., Spina, S., Grinberg, L. T., Rojas, J. C., Gallardo, G., Wang, K., Roh, J., Robinson, G., Finn, M. B., Jiang, H., Sullivan, P. M., Baufeld, C., Wood, M. W., Sutphen, C., McCue, L., Xiong, C., Del-Aquila, J.L., Morris, J.C., Cruchage, C., Alzheimer's Disease Neuroimaging Initiative, Fagan, A.M., Miller, B.L., Boxer, A.L., Seeley, W.W., Butovsky, O., Barres, B.B., Paul, S.M., & Holtzman, D.M. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy, Nature, September 28, 2017, Read More
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W. S., Peterson, T. C., Wilton, D. K., Frouin, A., Napier, B. A., Panicker, N., Kumar, M., Buckwalter, M. S., Rowitch, D. H., Dawson, V. L., Dawson, T. M., Stevens, B., Barres, B. A. Neurotoxic reactive astrocytes are induced by activated microglia, Nature, January 18, 2017, Read More