Cure Alzheimer's Fund Cure Alzheimer's Fund

Samuel Harris, Ph.D.

Senior Research Fellow, University College London, England

Dr. Harris is a Senior Research Fellow at the UK Dementia Research Institute (UK DRI) at University College London (UCL), and his preclinical and clinical research centers on developing and applying novel in vivo methods and analytical techniques to understand and model the impact of peptides and proteins related to Alzheimer’s disease on neuronal (and vascular) function at the cellular, circuit and whole brain scale.

Dr. Harris studied physics (University of Southampton) and medical physics (University of Surrey) at undergraduate and master’s level, and trained as a Clinical Autonomic Scientist at the National Hospital for Neurology and Neurosurgery (Queens Square) prior to undertaking his Ph.D. in Neuroscience (University of Sheffield). He subsequently held postdoctoral positions at the University of Sheffield and the Weill Cornell Medical College, with a research focus on neurovascular function in epilepsy. After a brief period as a scientific editor at SpringerNature, he joined the UK DRI at UCL in 2019, and has since been awarded a number of dementia research grants as co-investigator, and most recently been the recipient of an Alzheimer’s Association Research Fellowship (2023).

To learn more, visit the social media pages for UK DRI, UCL and UCL Queen Square Institute of Neurology.

Related Research:

Scaling the Divide in Alzheimer’s Disease: An Integrated Molecular, Cellular and Network-Level Study Marc Aurel Busche Samuel Harris 2023-12-08

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Scaling the Divide in Alzheimer’s Disease: An Integrated Molecular, Cellular and Network-Level Study 2023, 2025

$392,822.48

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Harris, S. S., Rajani, R. M., Zünkler, J., Ellingford, R., Yang, M., Rowland, J. M., Schmidt, A., Lee, B. I., Kehring, M., Hellmuth, M., Lam, F. K. W., Fässler, D., Erdinger, S., Wolfer, D. P., Sala Frigerio, C., Wolf, F., Hyman, B. T., Müller, U. C., & Busche, M. A. The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo, Cell Reports, June 24, 2025, Read More

Papanikolaou, A., Graykowski, D., Lee, B. I., Yang, M., Ellingford, R., Zünkler, J., Bond, S. A., Rowland, J. M., Rajani, R. M., Harris, S. S., Sharp, D. J., & Busche, M. A. Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo, Neuron, May 7, 2025, Read More

Harris, S. S., Ellingford, R., Hartmann, J., Dasgupta, D., Kehring, M., Rajani, R. M., Graykowski, D., Quittot, N., Sivasankaran, D., Commins, C., Fan, Z., Bond, S. A., Wolf, F., Dupret, D., Dolan, R. J., Konnerth, A., Neef, A., Hyman, B. T., & Busche, M. A. Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons, Cell, April 28, 2025, Read More

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