Cure Alzheimer's Fund Cure Alzheimer's Fund

Scott Noggle, Ph.D.

Scott A. Noggle, Ph.D., Principal Investigator of NYSCF’s scientific team, is conducting research at NYSCF’s state-of-the-art laboratory and also serves as a technical and scientific resource to other researchers working in the laboratory. Scott previously managed the Tri-Institutional Stem Cell Initiative’s Derivation Core facility at The Rockefeller University for two years. He was a postdoctoral fellow in the lab of Ali H. Brivanlou at The Rockefeller University studying the signaling pathways that maintain pluripotency and control neural induction in hESCs (human embryonic stem cells). He received his Ph.D. from the Medical College of Georgia and his B.S. and M.S. from the University of Arkansas at Fayetteville. He has also been appointed an Adjunct Associate Research Scientist in Pediatrics and Molecular Genetics at Columbia University.

Related Research:

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Generation of iPS Cells and Neurons from Skin Fibroblasts from Subjects with Familial and Sporadic AD 2014

$200,000
Stem Cell Consortium 2013

$600,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Maitane Ortiz-Virumbrales, Cesar L. Moreno, Ilya Kruglikov, Paula Marazuela, Andrew Sproul, Samson Jacob, Matthew Zimmer, Daniel Paull, Bin Zhang, Eric E. Schadt, Michelle E. Ehrlich, Rudolph E. Tanzi, Ottavio Arancio, Scott Noggle, Sam Gandy CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2(N141I) neurons, Acta Neuropathologica Communications, 5, 27 Oct 2017, 77, Read More

Dominik Paquet, Dylan Kwart, Antonia Chen, Andrew Sproul, Samson Jacob, Shaun Teo, Kimberly Moore Olsen, Andrew Gregg, Scott Noggle and Marc Tessier-Lavigne Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9, Nature, 533(7601), May 2016, 125-9, Read More, Download Paper

Michael W. Nestor, Samson Jacob, Bruce Sun, Deborah Prè, Andrew A. Sproul, Seong Im Hong, Chris Woodard, Matthew Zimmer, Vorapin Chinchalongporn, Ottavio Arancio, Scott A. Noggle Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies, American Journal of Physiology - Cell Physiology, 308(3), Feb 2015, C209-C219, Read More

Andrew A. Sproul, Samson Jacob, Deborah Pre, Soong Ho Kim, Michael W. Nestor, Miriam Navarro-Sobrino, Ismael Santa-Maria, Matthew Zimmer, Soline Aubry, John W. Steele, David J. Kahler, Alex Dranovsky, Ottavio Arancio, John F. Crary, Sam Gandy, and Scott A. Noggle Characterization and Molecular Profiling of PSEN1 Familial Alzheimer’s Disease iPSC-Derived Neural Progenitors, PLoS ONE, 9(1), Jan 8 2014, Read More

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