These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Generation of iPS Cells and Neurons from Skin Fibroblasts from Subjects with Familial and Sporadic AD |
2014 $200,000 |
|
Stem Cell Consortium |
2013 $600,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Maitane Ortiz-Virumbrales, Cesar L. Moreno, Ilya Kruglikov, Paula Marazuela, Andrew Sproul, Samson Jacob, Matthew Zimmer, Daniel Paull, Bin Zhang, Eric E. Schadt, Michelle E. Ehrlich, Rudolph E. Tanzi, Ottavio Arancio, Scott Noggle, Sam Gandy CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2(N141I) neurons, Acta Neuropathologica Communications, 5, 27 Oct 2017, 77, Read More
Dominik Paquet, Dylan Kwart, Antonia Chen, Andrew Sproul, Samson Jacob, Shaun Teo, Kimberly Moore Olsen, Andrew Gregg, Scott Noggle and Marc Tessier-Lavigne Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9, Nature, 533(7601), May 2016, 125-9, Read More, Download Paper
Michael W. Nestor, Samson Jacob, Bruce Sun, Deborah Prè, Andrew A. Sproul, Seong Im Hong, Chris Woodard, Matthew Zimmer, Vorapin Chinchalongporn, Ottavio Arancio, Scott A. Noggle Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies, American Journal of Physiology - Cell Physiology, 308(3), Feb 2015, C209-C219, Read More
Andrew A. Sproul, Samson Jacob, Deborah Pre, Soong Ho Kim, Michael W. Nestor, Miriam Navarro-Sobrino, Ismael Santa-Maria, Matthew Zimmer, Soline Aubry, John W. Steele, David J. Kahler, Alex Dranovsky, Ottavio Arancio, John F. Crary, Sam Gandy, and Scott A. Noggle Characterization and Molecular Profiling of PSEN1 Familial Alzheimer’s Disease iPSC-Derived Neural Progenitors, PLoS ONE, 9(1), Jan 8 2014, Read More