These published papers resulted from Cure Alzheimer’s Fund support.
| Title | Researchers | Date |
|---|---|---|
| Identification of late-stage tau accumulation using plasma phospho-tau217, eBioMedicine | Woo, M. S., Therriault, J., Jonaitis, E. M., Wilson, R., Langhough, R. E., Rahmouni, N., Benedet, A. L., Ashton, N. J., Tissot, C., Lantero-Rodriguez, J., Macedo, A. C., Servaes, S., Wang, Y. T., Arias, J. F., Hosseini, S. A., Betthauser, T. J., Lussier, F. Z., Hopewell, R., Triana-Baltzer, G., Kolb, H. C., … Rosa-Neto, P. | 2024-11-04 |
| Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease, Neurology | Safransky, M., Groh, J. R., Blennow, K., Zetterberg, H., Tripodis, Y., Martin, B., Weller, J., Asken, B. M., Rabinovici, G. D., Qiu, W. W. Q., McKee, A. C., Stein, T. D., Mez, J., Henson, R. L., Long, J., Morris, J. C., Perrin, R. J., Schindler, S. E., & Alosco, M. L. | 2024-11-04 |
| A luminescent-based protocol for NAD+/NADH detection in C. elegans, mice, and human whole blood, STAR Protocols | Wang, H. L., Zhang, J., Cao, S. Q., Lagartos-Donate, M. J., Zhang, S. Q., Lautrup, S., Hu, Z., Lyssiotis, C. A., Houtkooper, R. H., & Fang, E. F. | 2024-11-01 |
| Costs of Care in Relation to Alzheimer’s Disease Severity in Sweden: A National Registry-Based Cohort Study, PharmacoEconomics | Aye, S., Frisell, O., Zetterberg, H., Skillbäck, T. B., Kern, S., Eriksdotter, M., Aho, E., Xia, X., Winblad, B., Wimo, A., & Jönsson, L. | 2024-11-01 |
| Brain-targeting liposome-based APOE2 gene delivery exacerbates soluble amyloid-β accumulation in App NL-G-F mice, Heliyon | Wang, N., Parsons, T. M., Ren, Y., Pan, Y., Kurti, A., Starling, S. C., Muolokwu, C., Singh, J., & Kanekiyo, T. | 2024-10-30 |
| Myocardial infarction augments sleep to limit cardiac inflammation and damage, Nature | Huynh, P., Hoffmann, J. D., Gerhardt, T., Kiss, M. G., Zuraikat, F. M., Cohen, O., Wolfram, C., Yates, A. G., Leunig, A., Heiser, M., Gaebel, L., Gianeselli, M., Goswami, S., Khamhoung, A., Downey, J., Yoon, S., Chen, Z., Roudko, V., Dawson, T., Ferreira da Silva, J., … McAlpine, C. S. | 2024-10-30 |
| Anti-seizure effects of norepinephrine-induced free fatty acid release, Cell Metabolism | Li, B., Sun, Q., Ding, F., Xu, Q., Kang, N., Xue, Y., Ladron-de-Guevara, A., Hirase, H., Weikop, P., Gong, S., Nathan, S., & Nedergaard, M. | 2024-10-29 |
| A Comprehensive Head-to-Head Comparison of Key Plasma Phosphorylated Tau 217 Biomarker Tests, Brain | Warmenhoven, N., Salvadó, G., Janelidze, S., Mattsson-Carlgren, N., Bali, D., Orduña Dolado, A., Kolb, H., Triana-Baltzer, G., Barthélemy, N. R., Schindler, S. E., Aschenbrenner, A. J., Raji, C. A., Benzinger, T. L. S., Morris, J. C., Ibanez, L., Timsina, J., Cruchaga, C., Bateman, R. J., Ashton, N., Arslan, B., … Hansson, O. | 2024-10-28 |
| Gut microbiome-derived metabolites in Alzheimer’s disease: Regulation of immunity and potential for therapeutics, Immunological Reviews | Chandra, S., & Vassar, R. J. | 2024-10-24 |
| Current insights into apolipoprotein E and the immune response in Alzheimer’s disease, Immunological Reviews | Lin, P. B., & Holtzman, D. M. | 2024-10-24 |
| Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes, Brain | Al-Diwani, A., Provine, N. M., Murchison, A., Laban, R., Swann, O. J., Koychev, I., Sheerin, F., Da Mesquita, S., Heslegrave, A., Zetterberg, H., Klenerman, P., & Irani, S. R. | 2024-10-21 |
| Dietary salt, vascular dysfunction, and cognitive impairment, Cardiovascular Research | Faraco G. | 2024-10-21 |
| Plasma neurofilament light chain as prognostic marker of cognitive decline in neurodegenerative diseases, a clinical setting study, Alzheimer's Research & Therapy | Götze, K., Vrillon, A., Dumurgier, J., Indart, S., Sanchez-Ortiz, M., Slimi, H., Raynaud-Simon, A., Cognat, E., Martinet, M., Zetterberg, H., Blennow, K., Hourrègue, C., Bouaziz-Amar, E., Paquet, C., & Lilamand, M. | 2024-10-19 |
| Individualized, cross-validated prediction of future dementia using cognitive assessments in people with mild cognitive symptoms, Alzheimer's & Dementia | Borland, E., Mattson-Carlgren, N., Tideman, P., Alzheimer's Disease Neuroimaging Initiative, Stomrud, E., Hansson, O., & Palmqvist, S. | 2024-10-17 |
| Comparison of nanoimaging and nanoflow based detection of extracellular vesicles at a single particle resolution, Journal of Extracellular biology | Xu, S., Zhang, Z., Melvin, B. C., Basu Ray, N., Ikezu, S., & Ikezu, T. | 2024-10-16 |
| Biological mechanisms of resilience to tau pathology in Alzheimer’s disease, Alzheimer's Research & Therapy | Svenningsson, A. L., Bocancea, D. I., Stomrud, E., van Loenhoud, A., Barkhof, F., Mattsson-Carlgren, N., Palmqvist, S., Hansson, O., & Ossenkoppele, R. | 2024-10-12 |
| Waste clearance shapes aging brain health, Neuron | Jiang-Xie, L. F., Drieu, A., & Kipnis, J. | 2024-10-11 |
| Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?, The Journal of Neuroscience | Capocchi, J. K., Figueroa-Romero, C., Dunham, S. J. B., Faraci, G., Rothman, J. A., Whiteson, K. L., Seo, D. O., Holtzman, D. M., Grabrucker, S., Nolan, Y. M., Kaddurah-Daouk, R., & Jett, D. A. | 2024-10-09 |
| Cerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments, Neuroscience Insights | Schrader, J. M., Majchrzak, M., Xu, F., Lee, H., Agostinucci, K., Davis, J., Benveniste, H., & Van Nostrand, W. E. | 2024-10-08 |
| Ex vivo propagation of synaptically-evoked cortical depolarizations in a mouse model of Alzheimer’s disease at 20 Hz, 40 Hz, or 83 Hz, Scientific Reports | Patel, A. A., Zhu, M. H., Yan, R., & Antic, S. D. | 2024-10-08 |
| Plateau depolarizations in spontaneously active neurons detected by calcium or voltage imaging, Scientific Reports | Milicevic, K. D., Ivanova, V. O., Lovic, D. D., Platisa, J., Andjus, P. R., & Antic, S. D. | 2024-10-04 |
| Letter to the editor: critical evaluation of the reliability of DNA methylation probes on the illumina MethylationEPIC v1.0 BeadChip microarrays, Epigenetics | Hecker, J., Weiss, S. T., Lasky-Su, J. A., DeMeo, D. L., & Lange, C. | 2024-10-04 |
| Salience network segregation mediates the effect of tau pathology on mild behavioral impairment, Alzheimer's & Dementia | Iordan, A. D., Ploutz-Snyder, R., Ghosh, B., Rahman-Filipiak, A., Koeppe, R., Peltier, S., Giordani, B., Albin, R. L., & Hampstead, B. M. | 2024-10-04 |
| Altered Protein Palmitoylation as Disease Mechanism in Neurodegenerative Disorders, The Journal of Neuroscience | Wlodarczyk, J., Bhattacharyya, R., Dore, K., Ho, G. P. H., Martin, D. D. O., Mejias, R., & Hochrainer, K. | 2024-10-02 |
| Intracranial arteriosclerosis is not associated with cerebral amyloid deposition, Alzheimer's & Dementia | Streiber, A. M., Neitzel, J., Nguyen Ho, P. T., Vernooij, M. W., & Bos, D. | 2024-10-01 |
| Examination of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in former elite American football players, Alzheimer's & Dementia | Miner, A. E., Groh, J. R., Tripodis, Y., Adler, C. H., Balcer, L. J., Bernick, C., Zetterberg, H., Blennow, K., Peskind, E., Ashton, N. J., Gaudet, C. E., Martin, B., Palmisano, J. N., Banks, S. J., Barr, W. B., Wethe, J. V., Cantu, R. C., Dodick, D. W., Katz, D. I., Mez, J., … DIAGNOSE CTE Research Project | 2024-10-01 |
| Therapeutic targeting of senescent cells in the CNS, Nature Reviews Drug Discovery | Riessland, M., Ximerakis, M., Jarjour, A. A., Zhang, B., & Orr, M. E. | 2024-09-30 |
| Engineered 3D human neurovascular model of Alzheimer’s disease to study vascular dysfunction, Biomaterials | Pavlou, G., Spitz, S., Pramotton, F. M., Tsai, A., Li, B. M., Wang, X., Barr, O. M., Ko, E. C., Zhang, S., Ashley, S. J., Maaser-Hecker, A., Choi, S. H., Jorfi, M., Tanzi, R. E., & Kamm, R. D. | 2024-09-28 |
| Gene-variant specific effects of plasma amyloid-β levels in Swedish autosomal dominant Alzheimer disease, Alzheimer's Research & Therapy | Johansson, C., Thordardottir, S., Laffita-Mesa, J., Pannee, J., Rodriguez-Vieitez, E., Zetterberg, H., Blennow, K., & Graff, C. | 2024-09-25 |
| Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model, Neuron | Carling, G. K., Fan, L., Foxe, N. R., Norman, K., Wong, M. Y., Zhu, D., Corona, C., Razzoli, A., Yu, F., Yarahmady, A., Ye, P., Chen, H., Huang, Y., Amin, S., Sereda, R., Lopez-Lee, C., Zacharioudakis, E., Chen, X., Xu, J., Cheng, F., … Gan, L. | 2024-09-24 |
| REAL AD—Validation of a realistic screening approach for early Alzheimer’s disease, Alzheimer's & Dementia | Leuzy, A., Heeman, F., Bosch, I., Lenér, F., Dottori, M., Quitz, K., Moscoso, A., Kern, S., Zetterberg, H., Blennow, K., & Schöll, M. | 2024-09-23 |
| Association of in vivo retention of [18f] flortaucipir pet with tau neuropathology in corresponding brain regions, Acta Neuropathologica | Freiburghaus, T., Pawlik, D., Oliveira Hauer, K., Ossenkoppele, R., Strandberg, O., Leuzy, A., Rittmo, J., Tremblay, C., Serrano, G. E., Pontecorvo, M. J., Beach, T. G., Smith, R., & Hansson, O. | 2024-09-19 |
| The prion principle and Alzheimer’s disease, Science | Walker, L. C., & Jucker, M. | 2024-09-19 |
| Functional Characterization of an Arylsulfonamide-Based Small-Molecule Inhibitor of the NLRP3 Inflammasome, ACS Chemical Neuroscience | Biby, S., Mondal, P., Xu, Y., Gomm, A., Kaur, B., Namme, J. N., Wang, C., Tanzi, R. E., Zhang, S., & Zhang, C. | 2024-09-19 |
| Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer’s disease, Alzheimer's Research & Therapy | Wuestefeld, A., Pichet Binette, A., van Westen, D., Strandberg, O., Stomrud, E., Mattsson-Carlgren, N., Janelidze, S., Smith, R., Palmqvist, S., Baumeister, H., Berron, D., Yushkevich, P. A., Hansson, O., Spotorno, N., & Wisse, L. E. M. | 2024-09-16 |
| Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer’s disease, Nature Communications | Collij, L. E., Mastenbroek, S. E., Mattsson-Carlgren, N., Strandberg, O., Smith, R., Janelidze, S., Palmqvist, S., Ossenkoppele, R., & Hansson, O. | 2024-09-14 |
| New insights into innate immunity in Alzheimer’s disease: from APOE protective variants to therapies, Trends in Immunology | Chen, Y., & Holtzman, D. M. | 2024-09-14 |
| The effect of alemtuzumab on neurodegeneration in relapsing-remitting multiple sclerosis: A five-year prospective mono-center study, Multiple Sclerosis and Related Disorders | Sandgren, S., Novakova, L., Nordin, A., Sabir, H., Axelsson, M., Malmeström, C., Zetterberg, H., & Lycke, J. | 2024-09-13 |
| Endoplasmic reticulum-mitochondria lockdown in Wolfram syndrome, Cell Calcium | Filadi, R., & Pizzo, P. | 2024-09-12 |
| Associations between misfolded alpha-synuclein aggregates and Alzheimer’s disease pathology in vivo, Allheimer's & Dementia | Pichet Binette, A., Mammana, A., Wisse, L., Rossi, M., Strandberg, O., Smith, R., Mattsson-Carlgren, N., Janelidze, S., Palmqvist, S., ADNI, Ticca, A., Stomrud, E., Parchi, P., & Hansson, O. | 2024-09-11 |
| A randomized, placebo-controlled trial of purified anthocyanins on cognitive function in individuals at elevated risk for dementia: Analysis of inflammatory biomarkers toward personalized interventions, Experimental Gerontology | Borda, M. G., Barreto, G. E., Baldera, J. P., de Lucia, C., Khalifa, K., Bergland, A. K., Pola, I., Botero-Rodríguez, F., Siow, R. C., Kivipelto, M., Zetterberg, H., Ashton, N. J., Ballard, C., Aarsland, D., & NJ FINGER | 2024-09-09 |
| A γδ T cell–IL-3 axis controls allergic responses through sensory neurons, Nature | Flayer, C. H., Kernin, I. J., Matatia, P. R., Zeng, X., Yarmolinsky, D. A., Han, C., Naik, P. R., Buttaci, D. R., Aderhold, P. A., Camire, R. B., Zhu, X., Tirard, A. J., McGuire, J. T., Smith, N. P., McKimmie, C. S., McAlpine, C. S., Swirski, F. K., Woolf, C. J., Villani, A. C., & Sokol, C. L. | 2024-09-04 |
| An Ultrasensitive Molecularly Imprinted Point-Of-Care Electrochemical Sensor for Detection of Glial Fibrillary Acidic Protein, Advanced Healthcare Materials | Li, Y., Luo, L., Senicar, L., Asrosa, R., Kizilates, B., Xing, K., Torres, E., Xu, L., Li, D., Graham, N., Heslegrave, A., Zetterberg, H., Sharp, D. J., & Li, B. | 2024-09-02 |
| Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination, Immunity | das Neves, S. P., Delivanoglou, N., Ren, Y., Cucuzza, C. S., Makuch, M., Almeida, F., Sanchez, G., Barber, M. J., Rego, S., Schrader, R., Faroqi, A. H., Thomas, J. L., McLean, P. J., Oliveira, T. G., Irani, S. R., Piehl, F., & Da Mesquita, S. | 2024-08-31 |
| Blood-based multivariate methylation risk score for cognitive impairment and dementia, Alzheimer's & Dementia | Koetsier, J., Cavill, R., Reijnders, R., Harvey, J., Homann, J., … Dobricic, V., … Scheltens, P., … Zetterberg, H., … Lill, C. L., Bertram, L., … Pishva, E. | 2024-08-28 |
| Proteomic changes in Alzheimer’s disease associated with progressive Aβ plaque and tau tangle pathologies, Nature Neuroscience | Pichet Binette, A., Gaiteri, C., Wennström, M., Kumar, A., Hristovska, I., Spotorno, N., Salvadó, G., Strandberg, O., Mathys, H., Tsai, L. H., Palmqvist, S., Mattsson-Carlgren, N., Janelidze, S., Stomrud, E., Vogel, J. W., & Hansson, O. | 2024-08-26 |
| Regression convolutional neural network models implicate peripheral immune regulatory variants in the predisposition to Alzheimer’s disease, PLoS Computational Biology | Ramamurthy, E., Agarwal, S., Toong, N., Sestili, H., Kaplow, I. M., Chen, Z., Phan, B., & Pfenning, A. R. | 2024-08-26 |
| Overview of the role of purinergic signaling and insights into its role in cancer therapy, Pharmacology & Therapeutics | Di Virgilio, F., Vultaggio-Poma, V., Tarantini, M., & Giuliani, A. L. | 2024-08-22 |
| Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APPSAA knock-in mouse model of Alzheimer’s disease, Alzheimer's & Dementia | Norambuena, A., Sagar, V. K., Wang, Z., Raut, P., Feng, Z., Wallrabe, H., Pardo, E., Kim, T., Alam, S. R., Hu, S., Periasamy, A., & Bloom, G. S. | 2024-08-22 |
| Plasma p-tau181 and amyloid markers in Alzheimer’s disease: A comparison between Lumipulse and SIMOA, Neurobiology of Aging | Quaresima, V., Pilotto, A., Trasciatti, C., Tolassi, C., Parigi, M., Bertoli, D., Mordenti, C., Galli, A., Rizzardi, A., Caratozzolo, S., Benussi, A., Ashton, N. J., Blennow, K., Zetterberg, H., Giliani, S., Brugnoni, D., & Padovani, A. | 2024-08-22 |
| Fluid biomarkers in multiple sclerosis: from current to future applications, The Lancet Regional Health Europe | Di Filippo, M., Gaetani, L., Centonze, D., Hegen, H., Kuhle, J., Teunissen, C. E., Tintoré, M., Villar, L. M., Willemse, E. A. J., Zetterberg, H., & Parnetti, L. | 2024-08-22 |
| Blood inflammation relates to neuroinflammation and survival in frontotemporal lobar degeneration, Brain | Malpetti, M., Swann, P., Tsvetanov, K. A., Chouliaras, L., Strauss, A., Chikaura, T., Murley, A. G., Ashton, N. J., Barker, P., Jones, P. S., Fryer, T. D., Hong, Y. T., Cope, T. E., Savulich, G., Street, D., Bevan-Jones, W. R., Rittman, T., Blennow, K., Zetterberg, H., Aigbirhio, F. I., … Rowe, J. B. | 2024-08-19 |
| Air pollution amyloidogenesis is attenuated by the gamma-secretase modulator GSM-15606, Alzheimer's & Dementia | Godoy-Lugo, J. A., Thorwald, M. A., Cacciottolo, M., D'Agostino, C., Chakhoyan, A., Sioutas, C., Tanzi, R. E., Rynearson, K. D., & Finch, C. E. | 2024-08-12 |
| Melatonin: A potential nighttime guardian against Alzheimer’s, Molecular Psychiatry | Zhang, Z., Xue, P., Bendlin, B. B., Zetterberg, H., De Felice, F., Tan, X., & Benedict, C. | 2024-08-11 |
| Biological effects of sodium phenylbutyrate and taurursodiol in Alzheimer’s disease, Alzheimer's & Dementia | Arnold, S. E., Hendrix, S., Nicodemus-Johnson, J., Knowlton, N., Williams, V. J., Burns, J. M., Crane, M., McManus, A. J., Vaishnavi, S. N., Arvanitakis, Z., Neugroschl, J., Bell, K., Trombetta, B. A., Carlyle, B. C., Kivisäkk, P., Dodge, H. H., Tanzi, R. E., Yeramian, P. D., & Leslie, K. | 2024-08-09 |
| Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism, Neuron | Profaci, C. P., Harvey, S. S., Bajc, K., Zhang, T. Z., Jeffrey, D. A., Zhang, A. Z., Nemec, K. M., Davtyan, H., O'Brien, C. A., McKinsey, G. L., Longworth, A., McMullen, T. P., Capocchi, J. K., Gonzalez, J. G., Lawson, D. A., Arnold, T. D., Davalos, D., Blurton-Jones, M., Dabertrand, F., Bennett, F. C., Daneman, R. | 2024-08-08 |
| Biomarkers of tau phosphorylation state are associated with the clinical course of multiple sclerosis, Multiple sclerosis and related disorders | Emeršič, A., Karikari, T. K., Kac, P. R., Gonzalez-Ortiz, F., Dulewicz, M., Ashton, N. J., Brecl Jakob, G., Horvat Ledinek, A., Hanrieder, J., Zetterberg, H., Rot, U., Čučnik, S., & Blennow, K. | 2024-08-05 |
| Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer’s pathology, Cell Reports | Zwang, T. J., Sastre, E. D., Wolf, N., Ruiz-Uribe, N., Woost, B., Hoglund, Z., Fan, Z., Bailey, J., Nfor, L., Buée, L., Nilsson, K. P. R., Hyman, B. T., & Bennett, R. E. | 2024-08-02 |
| Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming, Science | Sun, Z., Kwon, J. S., Ren, Y., Chen, S., Walker, C. K., Lu, X., Cates, K., Karahan, H., Sviben, S., Fitzpatrick, J. A. J., Valdez, C., Houlden, H., Karch, C. M., Bateman, R. J., Sato, C., Mennerick, S. J., Diamond, M. I., Kim, J., Tanzi, R. E., Holtzman, D. M., Yoo, A. S. | 2024-08-08 |
| Polyneuropathy in systemic sclerosis: exploring the causes and biomarkers, Frontiers in Medicine | Ivanova, K., Zolovs, M., Blennow, K., Zetterberg, H., Kurjāne, N., & Ķēniņa, V. | 2024-08-01 |
| Neuroimmune circuits in the plaque and bone marrow regulate atherosclerosis, Cardiovascular Research | Gerhardt, T., Huynh, P., & McAlpine, C. S. | 2024-08-01 |
| The choroid plexus synergizes with immune cells during neuroinflammation, Cell | Xu, H., Lotfy, P., Gelb, S., Pragana, A., Hehnly, C., Byer, L. I. J., Shipley, F. B., Zawadzki, M. E., Cui, J., Deng, L., Taylor, M., Webb, M., Lidov, H. G. W., Andermann, M. L., Chiu, I. M., Ordovas-Montanes, J., & Lehtinen, M. K. | 2024-07-31 |
| Intravesical Bacille Calmette-Guerin (BCG) Vaccine Affects Cognition, Journal of Alzheimer's Disease | Greenblatt, C. L., Bercovier, H., Klein, B. Y., & Gofrit, O. N. | 2024-07-30 |
| Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care, JAMA | Palmqvist, S., Tideman, P., Mattsson-Carlgren, N., Schindler, S. E., Smith, R., Ossenkoppele, R., Calling, S., West, T., Monane, M., Verghese, P. B., Braunstein, J. B., Blennow, K., Janelidze, S., Stomrud, E., Salvadó, G., & Hansson, O. | 2024-07-28 |
| MRI Signature of α-Synuclein Pathology in Asymptomatic Stages and a Memory Clinic Population, JAMA Neurology | Wisse, L. E. M., Spotorno, N., Rossi, M., Grothe, M. J., Mammana, A., Tideman, P., Baiardi, S., Strandberg, O., Ticca, A., van Westen, D., Mattsson-Carlgren, N., Palmqvist, S., Stomrud, E., Parchi, P., Hansson, O., & Alzheimer’s Disease Neuroimaging Initiative | 2024-07-28 |
| Plasma Phosphorylated Tau 217 and Aβ42/40 to Predict Early Brain Aβ Accumulation in People Without Cognitive Impairment, JAMA Neurology | Janelidze, S., Barthélemy, N. R., Salvadó, G., Schindler, S. E., Palmqvist, S., Mattsson-Carlgren, N., Braunstein, J. B., Ovod, V., Bollinger, J. G., He, Y., Li, Y., Raji, C. A., Morris, J. C., Holtzman, D. M., Ashton, N. J., Blennow, K., Stomrud, E., Bateman, R. J., & Hansson, O. | 2024-07-28 |
| Sex-specific associations of kynurenic acid with neopterin in Alzheimer’s disease, Alzheimer's Research & Therapy | Knapskog, A. B., Edwin, T. H., Ueland, P. M., Ulvik, A., Fang, E. F., Eldholm, R. S., Halaas, N. B., Giil, L. M., Saltvedt, I., Watne, L. O., & Aksnes, M. | 2024-07-27 |
| Single-cell multiregion dissection of Alzheimer’s disease, Nature | Mathys, H., Boix, C. A., Akay, L. A., Xia, Z., Davila-Velderrain, J., Ng, A. P., Jiang, X., Abdelhady, G., Galani, K., Mantero, J., Band, N., James, B. T., Babu, S., Galiana-Melendez, F., Louderback, K., Prokopenko, D., Tanzi, R. E., Bennett, D. A., Tsai, L. H., & Kellis, M. | 2024-07-24 |
| The role of the gut microbiome in the regulation of astrocytes in Alzheimer’s disease, Neurotherapeutics | Chandra, S., & Vassar, R. | 2024-07-24 |
| Role of the gut microbiome in mediating sex-specific differences in the pathophysiology of Alzheimer’s disease, Neurotherapeutics | Saha, P., & Sisodia, S. S. | 2024-07-24 |
| Harmonizing tau positron emission tomography in Alzheimer’s disease: The CenTauR scale and the joint propagation model, Alzheimer's & Dementia | Leuzy, A., Raket, L. L., Villemagne, V. L., Klein, G., Tonietto, M., … Petersen, R. C., ... Ossenkoppele, R., ... Hansson, O., ... Doré, V. | 2024-07-23 |
| CSF biomarkers of neurotoxicity in childhood cancer survivors after cranial radiotherapy or surgery, Annals of Clinical and Translational Neurology | Fernström, E., Jarfelt, M., Blomstrand, M., Lannering, B., Axelsson, M., Wasling, P., Björk-Eriksson, T., Zetterberg, H., & Kalm, M. | 2024-07-19 |
| Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference, Alzheimer's & Dementia | 10. Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., … Gate, D., … , Iadecola, C., Johnson, L. A., Kanekiyo, T., … Lamb, B.T., … Marcora, E., … Morganti, J. M., … Ramachandran, K. V., … Tsai, L. H., … Ulrich, J. D., van der Kant, R., … Wellington, C. L., … Zhao, N., Bu, G., Goate, A. M., Holtzman, D. M. | 2024-07-19 |
| Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling, eLife | Zoltowska, K. M., Das, U., Lismont, S., Enzlein, T., Maesako, M., Houser, M. C. Q., Franco, M. L., Özcan, B., Gomes Moreira, D., Karachentsev, D., Becker, A., Hopf, C., Vilar, M., Berezovska, O., Mobley, W., & Chávez-Gutiérrez, L. | 2024-07-19 |
| Tau protein profiling in tauopathies: a human brain study, Molecular Neurodegeneration | Lantero-Rodriguez, J., Camporesi, E., Montoliu-Gaya, L., Gobom, J., Piotrowska, D., Olsson, M., Burmann, I. M., Becker, B., Brinkmalm, A., Burmann, B. M., Perkinton, M., Ashton, N. J., Fox, N. C., Lashley, T., Zetterberg, H., Blennow, K., & Brinkmalm, G. | 2024-07-19 |
| Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer’s disease with APPdup and Down syndrome, Acta Neuropathologica | Kasri, A., Camporesi, E., Gkanatsiou, E., Boluda, S., Brinkmalm, G., Stimmer, L., Ge, J., Hanrieder, J., Villain, N., Duyckaerts, C., Vermeiren, Y., Pape, S. E., Nicolas, G., Laquerrière, A., De Deyn, P. P., Wallon, D., Blennow, K., Strydom, A., Zetterberg, H., & Potier, M. C. | 2024-07-18 |
| A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells, Frontiers in Cellular Neuroscience | Inoue, Y., Ren, Y., Zhang, S., Bamkole, M., Islam, N. N., Selvaraj, M., Lu, W., Caulfield, T. R., Li, Y., & Kanekiyo, T. | 2024-07-18 |
| Sleep as a window to understand and regulate Alzheimer’s disease: emerging roles of thalamic reticular nucleus, Neural Regeneration Research | Sun, H., Shen, S., Thomas, R. J., Westover, M. B., & Zhang, C. | 2024-07-10 |
| Therapeutic potential of exercise-hormone irisin in Alzheimer’s disease, Neural Regeneration Research | Kim, E., Tanzi, R. E., & Choi, S. H. | 2024-07-10 |
| Polygenic hazard score models for the prediction of Alzheimer’s free survival using the lasso for Cox’s proportional hazards model, Genetic Epidemiology | Hahn, G., Prokopenko, D., Hecker, J., Lutz, S. M., Mullin, K., Tanzi, R. E., DeSantis, S., & Lange, C. | 2024-07-09 |
| Associations between Microglia and Astrocytic Proteins and Tau Biomarkers across the Continuum of Alzheimer’s Disease, International Journal of Molecular Sciences | Doroszkiewicz, J., Kulczyńska-Przybik, A., Dulewicz, M., Mroczko, J., Borawska, R., Słowik, A., Zetterberg, H., Hanrieder, J., Blennow, K., & Mroczko, B. | 2024-07-09 |
| Effects of Aerobic Exercise on Brain Age and Health in Middle-Aged and Older Adults: A Single-Arm Pilot Clinical Trial, Life | Ouyang, A., Zhang, C., Adra, N., Tesh, R., Sun, H., Lei, D., Jing, J., Fan, P., Paixao, L., Ganglberger, W., Briggs, L., Salinas, J., Bevers, M. B., Wrann, C. D., Chemali, Z., Fricchione, G., Thomas, R. J., Rosand, J., Tanzi, R. E., & Westover, M. B. | 2024-07-08 |
| Clinical application of plasma P-tau217 to assess eligibility for amyloid-lowering immunotherapy in memory clinic patients with early Alzheimer’s disease, Alzheimer's Research & Therapy | Howe, M. D., Britton, K. J., Joyce, H. E., Menard, W., Emrani, S., Kunicki, Z. J., Faust, M. A., Dawson, B. C., Riddle, M. C., Huey, E. D., Janelidze, S., Hansson, O., & Salloway, S. P. | 2024-07-06 |
| CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer’s disease, Alzheimer's & Dementia | Delvenne, A., Gobom, J., Schindler, S. E., Kate, M. T., Reus, L. M., Dobricic, V., Tijms, B. M., Benzinger, T. L. S., Cruchaga, C., ... Bertram, L., … Zetterberg, H., ... Vos, S. J. B. | 2024-07-06 |
| Predicting progression from subjective cognitive decline to mild cognitive impairment or dementia based on brain atrophy patterns, Alzheimer's Research & Therapy | Lerch, O., Ferreira, D., Stomrud, E., van Westen, D., Tideman, P., Palmqvist, S., Mattsson-Carlgren, N., Hort, J., Hansson, O., & Westman, E. | 2024-07-05 |
| Neuroimaging and fluid biomarkers in Parkinson’s disease in an era of targeted interventions, Nature Communications | Zarkali, A., Thomas, G. E. C., Zetterberg, H., & Weil, R. S. | 2024-07-05 |
| Longitudinal plasma phosphorylated-tau217 and other related biomarkers in a non-demented Alzheimer’s risk-enhanced sample, Alzheimer's & Dementia | Du, L., Langhough, R. E., Wilson, R. E., Reyes, R. E. R., Hermann, B. P., Jonaitis, E. M., Betthauser, T. J., Chin, N. A., Christian, B., Chaby, L., Jeromin, A., Molfetta, G. D., Brum, W. S., Arslan, B., Ashton, N., Blennow, K., Zetterberg, H., & Johnson, S. C. | 2024-07-05 |
| Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases, Alzheimer's & Dementia | Andriuta, D., Ottoy, J., Ruthirakuhan, M., Feliciano, G., Dilliott, A. A., … Zetterberg, H., ... ONDRI Investigators | 2024-07-04 |
| Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease, Nature Medicine | Rosenzweig, N., Kleemann, K. L., Rust, T., Carpenter, M., Grucci, M., Aronchik, M., Brouwer, N., Valenbreder, I., Cooper-Hohn, J., Iyer, M., Krishnan, R. K., Sivanathan, K. N., Brandão, W., Yahya, T., Durao, A., Yin, Z., Chadarevian, J. P., Properzi, M. J., Nowarski, R., Davtyan, H., Weiner, L. H., Blurton Jones, M., … Butovsky, O. | 2024-07-03 |
| An emerging role for the gut microbiome in tauopathy, Neurotherapeutics | Zhu, Y., Self, W. K., & Holtzman, D. M. | 2024-07-03 |
| Free Recall Outperforms Story Recall in Associations with Plasma Biomarkers in Preclinical Alzheimer Disease, The Journal of Prevention of Alzheimer's Disease | Aschenbrenner, A., Hassenstab, J.J., Schindler, S.E., Janelidze, S., Hansson, O., Morris, J. C., Grober, E. | 2024-07-02 |
| Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals, Nature Communications | Xiong, C., Luo, J., Wolk, D. A., Shaw, L. M., Roberson, E. D., Murchison, C. F., Henson, R. L., Benzinger, T. L. S., Bui, Q., Agboola, F., Grant, E., Gremminger, E. N., Moulder, K. L., Geldmacher, D. S., Clay, O. J., Babulal, G., Cruchaga, C., Holtzman, D. M., Bateman, R. J., Morris, J. C., Schindler, S. E. | 2024-07-02 |
| Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice, Frontiers in Aging Neuroscience | Pan, A. L., Audrain, M., Sakakibara, E., Joshi, R., Zhu, X., Wang, Q., Wang, M., Beckmann, N. D., Schadt, E. E., Gandy, S., Zhang, B., Ehrlich, M. E., & Salton, S. R. | 2024-06-28 |
| Association of glial fibrillary acid protein, Alzheimer’s disease pathology and cognitive decline, Brain | Peretti, D. E., Boccalini, C., Ribaldi, F., Scheffler, M., Marizzoni, M., Ashton, N. J., Zetterberg, H., Blennow, K., Frisoni, G. B., & Garibotto, V. | 2024-06-28 |
| P2RX7 plays a critical role in extracellular vesicle‐mediated secretion of pathogenic molecules from microglia and astrocytes, Journal of Extracellular Biology | Abdullah, M., Ruan, Z., Ikezu, S., & Ikezu, T. | 2024-06-26 |
| Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load, Cell Reports | Nanaware, P. P., Khan, Z. N., Clement, C. C., Shetty, M., Mota, I., Seltzer, E. S., Dzieciatkowska, M., Gamboni, F., D'Alessandro, A., Ng, C., Nagayama, M., Lichti, C. F., Soni, R. K., Jacob B Geri, Matei, I., Lyden, D., Longman, R., Lu, T. T., Wan, X., Unanue, E. R., … Santambrogio, L. | 2024-06-25 |
| Associations of modifiable and non-modifiable risk factors with cognitive functions – a prospective, population-based, 17 years follow-up study of 3,229 individuals, Alzheimer's Research & Therapy | Glans, I., Nägga, K., Gustavsson, A. M., Stomrud, E., Nilsson, P. M., Melander, O., Hansson, O., & Palmqvist, S. | 2024-06-26 |
| Bnip3 expression is strongly associated with reelin-positive entorhinal cortex layer II neurons, Brain Structure & Function | Omholt, S. W., Lejneva, R., Donate, M. J. L., Caponio, D., Fang, E. F., & Kobro-Flatmoen, A. | 2024-06-25 |
| Development of a New Positron Emission Tomography Imaging Radioligand Targeting RIPK1 in the Brain and Characterization in Alzheimer’s Disease, Advanced Science | Bai, P., Lan, Y., Liu, Y., Mondal, P., Gomm, A., Xu, Y., Wang, Y., Wang, Y., Kang, L., Pan, L., Bagdasarian, F. A., Hallisey, M., Varela, B., Choi, S. H., Gomperts, S. N., Wey, H. Y., Shen, S., Tanzi, R. E., Wang, C., & Zhang, C. | 2024-06-25 |
| Distinct transcriptional alterations distinguish Lewy body disease from Alzheimer’s disease, Brain | Olney, K. C., Rabichow, B. E., Wojtas, A. M., DeTure, M., McLean, P. J., Dickson, D. W., Chang, R., Ross, O. A., & Fryer, J. D. | 2024-06-25 |
| Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ-on-a-Chip Technology, Advanced Science | Pramotton, F. M., Spitz, S., & Kamm, R. D. (2024). Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ-on-a-Chip Technology | 2024-06-23 |
| Effects of time of the day at sampling on CSF and plasma levels of Alzheimer’ disease biomarkers, Alzheimer's Research & Therapy | Orduña Dolado, A., Stomrud, E., Ashton, N. J., Nilsson, J., Quijano-Rubio, C., Jethwa, A., Brum, W. S., Brinkmalm Westman, A., Zetterberg, H., Blennow, K., Janelidze, S., & Hansson, O. | 2024-06-22 |
| In vivo detection of Alzheimer’s and Lewy body disease concurrence: Clinical implications and future perspectives, Alzheimer's & Dementia | Baiardi, S., Hansson, O., Levin, J., & Parchi, P. | 2024-06-21 |
| ROCK Inhibitor Fasudil Attenuates Neuroinflammation and Associated Metabolic Dysregulation in the Tau Transgenic Mouse Model of Alzheimer’s Disease, Current Alzheimer Research | Ouyang, X., Collu, R., Benavides, G., Tian, R., Darley-Usmar, V., Xia, W., & Zhang, J. | 2024-06-21 |
| Microstructural associations between locus coeruleus, cortical, and subcortical regions are modulated by astrocyte reactivity: a 7T MRI adult lifespan study, Cerebral Cortex | Beckers, E., Van Egroo, M., Ashton, N. J., Blennow, K., Vandewalle, G., Zetterberg, H., Poser, B. A., & Jacobs, H. I. L. | 2024-06-21 |
| Structural and functional connectivity associations with anterior cingulate sulcal variability, Brain Structure & Function | Harper, L., Strandberg, O., Spotorno, N., Nilsson, M., Lindberg, O., Hansson, O., & Santillo, A. F. | 2024-06-20 |
| Head-to-Head Comparison of Tau and Amyloid Positron Emission Tomography Visual Reads for Differential Diagnosis of Neurodegenerative Disorders: An International, Multicenter Study, Annals of Neurology | Soleimani-Meigooni, D. N., Smith, R., Provost, K., Lesman-Segev, O. H., Allen, I. E., Chen, M. K., Cho, H., Edwards, L., Janelidze, S., La Joie, R., Mundada, N., Ossenkoppele, R., Stomrud, E., Strandberg, O., Strom, A., Boxer, A. L., Dage, J. L., Gorno-Tempini, M. L., Kramer, J. H., Miller, B. L., …, Hansson, O., Rabinovici, G. D. | 2024-06-18 |
| Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS, Nature Medicine | Chatterjee, M., Özdemir, S., Fritz, C., Möbius, W., Kleineidam, L., Mandelkow, E., ... Bateman, R. J., … Schneider, A. | 2024-06-18 |
| The Alzheimer’s disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling, The Journal of Clinical Investigation | Schmidt, A., Hrupka, B., van Bebber, F., Sunil Kumar, S., Feng, X., Tschirner, S. K., Aßfalg, M., Müller, S. A., Hilger, L. S., Hofmann, L. I., Pigoni, M., Jocher, G., Voytyuk, I., Self, E. L., Ito, M., Hyakkoku, K., Yoshimura, A., Horiguchi, N., Feederle, R., De Strooper, B., … Lichtenthaler, S. F. | 2024-06-18 |
| Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy, Neuron | Chadarevian, J. P., Hasselmann, J., Lahian, A., Capocchi, J. K., Escobar, A., Lim, T. E., Le, L., Tu, C., Nguyen, J., Kiani Shabestari, S., Carlen-Jones, W., Gandhi, S., Bu, G., Hume, D. A., Pridans, C., Wszolek, Z. K., Spitale, R. C., Davtyan, H., & Blurton-Jones, M. | 2024-06-18 |
| Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology, Nature Communications | Mastenbroek, S. E., Vogel, J. W., Collij, L. E., Serrano, G. E., Tremblay, C., Young, A. L., Arce, R. A., Shill, H. A., Driver-Dunckley, E. D., Mehta, S. H., Belden, C. M., Atri, A., Choudhury, P., Barkhof, F., Adler, C. H., Ossenkoppele, R., Beach, T. G., & Hansson, O. | 2024-06-15 |
| β-Amyloid species production and tau phosphorylation in iPSC-neurons with reference to neuropathologically characterized matched donor brains, Journal of Neuropathology and Experimental Neurology | Oakley, D. H., Chung, M., Abrha, S., Hyman, B. T., & Frosch, M. P. | 2024-06-14 |
| Inhaled Pollutants of the Gero-Exposome and Later-Life Health, The Journals of Gerontology | Finch, C. E., & Thorwald, M. A. | 2024-06-13 |
| Editorial overview-Artificial intelligence methodologies in structural biology: Bridging the gap to medical applications, Current Opinion in Structural Biology | Aittokallio, T., & Fang, E. F. | 2024-06-12 |
| Identification and potential clinical applications of novel autophagy/mitophagy proteins in the biofluids of Alzheimer’s disease patients, Ageing Research Reviews | Zhang, J., Wang, H. L., Veverová, K., Vyhnálek, M., & Fang, E. F. | 2024-06-12 |
| Remote and unsupervised digital memory assessments can reliably detect cognitive impairment in Alzheimer’s disease, Alzheimer's & Dementia | Berron, D., Olsson, E., Andersson, F., Janelidze, S., Tideman, P., Düzel, E., Palmqvist, S., Stomrud, E., & Hansson, O. | 2024-06-12 |
| Acceptable performance of blood biomarker tests of amyloid pathology — recommendations from the Global CEO Initiative on Alzheimer’s Disease, Nature Reviews Neurology | Schindler, S. E., Galasko, D., Pereira, A. C., Rabinovici, G. D., Salloway, S., Suárez-Calvet, M., Khachaturian, A. S., Mielke, M. M., Udeh-Momoh, C., Weiss, J., Batrla, R., Bozeat, S., Dwyer, J. R., Holzapfel, D., Jones, D. R., Murray, J. F., Partrick, K. A., Scholler, E., Vradenburg, G., Young, D., … Hansson, O. | 2024-06-12 |
| Tau Positron Emission Tomography for Predicting Dementia in Individuals With Mild Cognitive Impairment, JAMA Neurology | Groot, C., Smith, R., Collij, L. E., Mastenbroek, S. E., Stomrud, E., Binette, A. P., Leuzy, A., Palmqvist, S., Mattsson-Carlgren, N., Strandberg, O., Cho, H., Lyoo, C. H., Frisoni, G. B., Peretti, D. E., Garibotto, V., La Joie, R., Soleimani-Meigooni, D. N., Rabinovici, G., Ossenkoppele, R., & Hansson, O. | 2024-06-10 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer’s disease, Acta Neuropathologica | Balusu, S., & De Strooper, B. | 2024-06-09 |
| Prediction of disease-free survival for precision medicine using cooperative learning on multi-omic data, Briefings in Bioinformatics | Hahn, G., Prokopenko, D., Hecker, J., Lutz, S. M., Mullin, K., Sejour, L., Hide, W., Vlachos, I., DeSantis, S., Tanzi, R. E., & Lange, C. | 2024-06-05 |
| Cryo-EM structures of pathogenic fibrils and their impact on neurodegenerative disease research, Neuron | Todd, T. W., Islam, N. N., Cook, C. N., Caulfield, T. R., & Petrucelli, L. | 2024-06-03 |
| Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer’s disease, Science | Princen, K., Van Dooren, T., van Gorsel, M., Louros, N., Yang, X., … Zetterberg, H., ... Griffioen, G. | 2024-05-31 |
| Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies, Cellular and Molecular Life Sciences | van Veluw, S. J., Benveniste, H., Bakker, E. N. T. P., Carare, R. O., Greenberg, S. M., Iliff, J. J., Lorthois, S., Van Nostrand, W. E., Petzold, G. C., Shih, A. Y., & van Osch, M. J. P. | 2024-05-27 |
| Longitudinal plasma proteomic analysis of 1117 hospitalized patients with COVID-19 identifies features associated with severity and outcomes, Science Advances | Viode, A., Smolen, K. K., van Zalm, P., Stevenson, D., Jha, M., Parker, K., IMPACC Network‡, Levy, O., Steen, J. A., & Steen, H. | 2024-05-24 |
| Plasma pTau181 and pTau217 predict asymptomatic amyloid accumulation equally well as amyloid PET, Brain Communications | De Meyer, S., Schaeverbeke, J. M., Luckett, E. S., Reinartz, M., Blujdea, E. R., Cleynen, I., Dupont, P., Van Laere, K., Vanbrabant, J., Stoops, E., Vanmechelen, E., di Molfetta, G., Zetterberg, H., Ashton, N. J., Teunissen, C. E., Poesen, K., & Vandenberghe, R. | 2024-05-23 |
| Combining plasma Aβ and p-tau217 improves detection of brain amyloid in non-demented elderly, Alzheimer's Research & Therapy | Niimi, Y., Janelidze, S., Sato, K., Tomita, N., Tsukamoto, T., … Hansson, O., Iwatsubo, T. | 2024-05-23 |
| PSMC5 insufficiency and P320R mutation impair proteasome function, Human Molecular Genetics | Yu, Z. Q., Carmichael, J., Collins, G. A., D'Agostino, M. D., Lessard, M., Firth, H. V., Harijan, P., Fry, A. E., Dean, J., Zhang, J., Kini, U., Goldberg, A. L., & Rubinsztein, D. C. | 2024-05-22 |
| Supported Biomembrane Systems Incorporating Multiarm Polymers and Bioorthogonal Tethering, Langmuir | Martin, J. A., Li, Y. M., & Gilchrist, M. L. | 2024-05-20 |
| The Ocular Glymphatic System-Current Understanding and Future Perspectives, International Journal of Molecular Sciences | Delle, C., Wang, X., & Nedergaard, M. | 2024-05-24 |
| The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people, Immunity & Ageing | Jacobs, T., Jacobson, S. R., Fortea, J., Berger, J. S., Vedvyas, A., Marsh, K., He, T., Gutierrez-Jimenez, E., Fillmore, N. R., Gonzalez, M., Figueredo, L., Gaggi, N. L., Plaska, C. R., Pomara, N., Blessing, E., Betensky, R., Rusinek, H., Zetterberg, H., Blennow, K., Glodzik, L., … Alzheimer’s Disease Neuroimaging Initiative | 2024-05-17 |
| γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome, Annals of Neurology | Chen, X. Q., Becker, A., Albay, R., Nguyen, P. D., Karachentsev, D., Roberts, A. J., Rynearson, K. D., Tanzi, R. E., & Mobley, W. C. | 2024-05-15 |
| Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer’s disease mouse models, Nature Communications | Wasén, C., Beauchamp, L. C., Vincentini, J., Li, S., LeServe, D. S., Gauthier, C., Lopes, J. R., Moreira, T. G., Ekwudo, M. N., Yin, Z., da Silva, P., Krishnan, R. K., Butovsky, O., Cox, L. M., & Weiner, H. L. | 2024-05-08 |
| Senolytics and cell senescence: historical and evolutionary perspectives, Evolution, Medicine, & Public Health | Finch C. E. | 2024-05-03 |
| Widespread White Matter Abnormalities in Concussed Athletes Detected by 7T Diffusion Magnetic Resonance Imaging, Journal of Neurotrauma | Gard, A., Kornaropoulos, E. N., Portonova Wernersson, M., Rorsman, I., Blennow, K., Zetterberg, H., Tegner, Y., De Maio, A., Markenroth Bloch, K., Björkman-Burtscher, I., Pessah-Rasmussen, H., Nilsson, M., & Marklund, N. | 2024-05-03 |
| Alterations of human CSF and serum-based mitophagy biomarkers in the continuum of Alzheimer disease, Autophagy | Veverová, K., Laczó, J., Katonová, A., Horáková, H., Matušková, V., Angelucci, F., Laczó, M., Nedelská, Z., Hort, J., Wang, H. L., Zhang, J., Shi, L., Fei Fang, E., & Vyhnálek, M. | 2024-05-02 |
| Cerebrospinal fluid reference proteins increase accuracy and interpretability of biomarkers for brain diseases, Nature Communications | Karlsson, L., Vogel, J., Arvidsson, I., Åström, K., Janelidze, S., Blennow, K., Palmqvist, S., Stomrud, E., Mattsson-Carlgren, N., & Hansson, O. | 2024-05-01 |
| Effects of Amyloid Beta (Aβ) Oligomers on Blood-Brain Barrier Using a 3D Microfluidic Vasculature-on-a-Chip Model, Applied Sciences | Uzoechi, S. C., Collins, B. E., Badeaux, C. J., Li, Y., Kwak, S. S., Kim, D. Y., Laskowitz, D. T., Lee, J. M., & Yun, Y. | 2024-05-01 |
| Nonlinear Relation between Body Mass Index and Long-Term Poststroke Functional Outcome-The Importance of Insulin Resistance, Inflammation, and Insulin-like Growth Factor-Binding Protein-1, International Journal of Molecular Sciences | Gadd, G., Åberg, D., Wall, A., Zetterberg, H., Blennow, K., Jood, K., Jern, C., Isgaard, J., Svensson, J., & Åberg, N. D. | 2024-04-30 |
| Genome-wide meta-analysis of short-tandem repeats for Parkinson’s disease risk using genotype imputation, Brain Communications | Ohlei, O., Paul, K., Nielsen, S. S., Gmelin, D., Dobricic, V., Altmann, V., Schilling, M., Bronstein, J. M., Franke, A., Wittig, M., Parkkinen, L., Hansen, J., Checkoway, H., Ritz, B., Bertram, L., & Lill, C. M. | 2024-04-23 |
| The P2X7 Receptor is a Master Regulator of Microparticle and Mitochondria Exchange in Mouse Microglia, Function | Falzoni, S., Vultaggio-Poma, V., Chiozzi, P., Tarantini, M., Adinolfi, E., Boldrini, P., Giuliani, A. L., Morciano, G., Tang, Y., Gorecki, D. C., & Di Virgilio, F. | 2024-04-17 |
| Plasma P-Tau217 for Predicting Alzheimer Dementia Among Community-Dwelling Older Adults, Neurology, Clinical practice | Yu, L., Wang, T., Hansson, O., Janelidze, S., Lamar, M., Arfanakis, K., Bennett, D. A., Schneider, J. A., & Boyle, P. A. | 2024-04-15 |
| Will cellular immunotherapies end neurodegenerative diseases?, Trends in Immunology | Boskovic, P., Gao, W., & Kipnis, J. | 2024-04-09 |
| Microglia and amyloid plaque formation in Alzheimer’s disease – Evidence, possible mechanisms, and future challenges, Journal of Neuroinflammation | Fruhwürth, S., Zetterberg, H., & Paludan, S. R. | 2024-04-04 |
| Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model, Science Translational Medicine | Hou, J., Chen, Y., Cai, Z., Heo, G. S., Yuede, C. M., … Holtzman, D. M. & Colonna, M. | 2024-04-03 |
| Fixel-based analysis reveals tau-related white matter changes in early stages of Alzheimer’s disease, The Journal of Neuroscience | Ahmadi, K., Pereira, J. B., Westen, D. V., Pasternak, O., Zhang, F., Nilsson, M., Stomrud, E., Spotorno, N., & Hansson, O. | 2024-04-02 |
| On the effect heterogeneity of established disease susceptibility loci for Alzheimer’s disease across different genetic ancestries, Alzheimer's & Dementia | Lee, S., Hecker, J., Hahn, G., Mullin, K., Alzheimer's Disease Neuroimaging Initiative (ADNI), Lutz, S. M., Tanzi, R. E., Lange, C., & Prokopenko, D. | 2024-04-02 |
| ER-stress response in retinal Müller glia occurs significantly earlier than amyloid pathology in the Alzheimer’s mouse brain and retina, Glia | Palko, S. I., Benoit, M. R., Yao, A. Y., Mohan, R., & Yan, R. | 2024-03-28 |
| Sex‐specific blood biomarkers linked to memory changes in middle‐aged adults: The Framingham Heart Study, Alzheimer's & Dementia | Ding, H., Liu, C., Li, Y., Ang, T. F. A., Devine, S., Liu, Y., Au, R., & Doraiswamy, P. M. | 2024-03-27 |
| Cryopreservation of cerebrospinal fluid cells preserves the transcriptional landscape for single-cell analysis, Journal of Neuroinflammation | Kodali, M. C., Antone, J., Alsop, E., Jayakumar, R., Parikh, K., Chiot, A., Sanchez-Molina, P., Ajami, B., Arnold, S. E., Jensen, K., Das, S., & Weinberg, M. S. | 2024-03-23 |
| Disease staging of Alzheimer’s disease using a CSF-based biomarker model, Nature Aging | Salvadó, G., Horie, K., Barthélemy, N. R., Vogel, J. W., Pichet Binette, A., Chen, C. D., Aschenbrenner, A. J., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Palmqvist, S., Stomrud, E., Janelidze, S., Ossenkoppele, R., Schindler, S. E., Bateman, R. J., & Hansson, O. | 2024-03-21 |
| Comparing a pre-defined versus deep learning approach for extracting brain atrophy patterns to predict cognitive decline due to Alzheimer’s disease in patients with mild cognitive symptoms, Alzheimer's Research & Therapy | Arvidsson, I., Strandberg, O., Palmqvist, S., Stomrud, E., Cullen, N., Janelidze, S., Tideman, P., Heyden, A., Åström, K., Hansson, O., & Mattsson-Carlgren, N. | 2024-03-19 |
| A Need for Refined Senescence Biomarkers and Measures of Senolytics in the Brain, Journal of Alzheimer's Disease | Orr M. E. | 2024-03-19 |
| Neurotoxic Microglial Activation via IFNγ-Induced Nrf2 Reduction Exacerbating Alzheimer’s Disease, Advanced Science | Kang, Y. J., Hyeon, S. J., McQuade, A., Lim, J., Baek, S. H., Diep, Y. N., Do, K. V., Jeon, Y., Jo, D. G., Lee, C. J., Blurton-Jones, M., Ryu, H., & Cho, H. | 2024-03-14 |
| A blood-based biomarker workflow for optimal tau-PET referral in memory clinic settings, Nature Communications | Brum, W. S., Cullen, N. C., Therriault, J., Janelidze, S., Rahmouni, N., Stevenson, J., Servaes, S., Benedet, A. L., Zimmer, E. R., Stomrud, E., Palmqvist, S., Zetterberg, H., Frisoni, G. B., Ashton, N. J., Blennow, K., Mattsson-Carlgren, N., Rosa-Neto, P., & Hansson, O. | 2024-03-14 |
| Serum neurofilament light for detecting disease activity in individual patients in multiple sclerosis: A 48-week prospective single-center study, Multiple Sclerosis | Johnsson, M., Stenberg, Y. T., Farman, H. H., Blennow, K., Zetterberg, H., Malmeström, C., Sandgren, S., Rosenstein, I., Lycke, J., Axelsson, M., & Novakova, L. | 2024-03-13 |
| A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer’s disease vulnerable neurons, Brain | Rodriguez-Rodriguez, P., Arroyo-Garcia, L. E., Tsagkogianni, C., Li, L., Wang, W., Végvári, Á., Salas-Allende, I., Plautz, Z., Cedazo-Minguez, A., Sinha, S. C., Troyanskaya, O., Flajolet, M., Yao, V., & Roussarie, J. P. | 2024-03-11 |
| Sex-specific associations of serum cortisol with brain biomarkers of Alzheimer’s risk, Scientific Reports | Mosconi, L., Williams, S., Carlton, C., Zarate, C., Boneu, C., Fauci, F., Ajila, T., Nerattini, M., Jett, S., Andy, C., Battista, M., Pahlajani, S., Osborne, J., Brinton, R. D., & Dyke, J. P. | 2024-03-06 |
| Plasma Biomarkers as Predictors of Progression to Dementia in Individuals with Mild Cognitive Impairment, Journal of Alzheimer's Disease | Nallapu, B. T., Petersen, K. K., Lipton, R. B., Davatzikos, C., Ezzati, A., & Alzheimer’s Disease Neuroimaging Initiative | 2024-03-05 |
| Potential impact of unblinding on observed treatment effects in Alzheimer’s disease trials, Alzheimer's & Dementia | Wolters, F. J., & Labrecque, J. A. | 2024-02-21 |
| Highly Accurate Blood Test for Alzheimer’s Disease Comparable or Superior to Clinical CSF Tests, Nature Medicine | Barthélemy, N. R., Salvadó, G., Schindler, S., He, Y., Janelidze, S., Collij, L. E., Saef, B., Henson, R. L., Chen, C. D., Gordon, B. A., Li, Y., La Joie, R., Benzinger, T. L. S., Morris, J. C., Mattsson-Carlgren, N., Palmqvist, S., Ossenkoppele, R., Rabinovici, G. D., Stomrud, E., Bateman, R. J. & Hansson, O. | 2024-02-21 |
| HuM195 and its single-chain variable fragment increase Aβ phagocytosis in microglia via elimination of CD33 inhibitory signaling, Molecular Psychiatry | Wong, E., Malviya, M., Jain, T., Liao, G. P., Kehs, Z., Chang, J. C., Studer, L., Scheinberg, D. A., & Li, Y. M. | 2024-02-21 |
| Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner, Molecular Neurodegeneration | Bosch, M. E., Dodiya, H. B., Michalkiewicz, J., Lee, C., Shaik, S. M., Weigle, I. Q., Zhang, C., Osborn, J., Nambiar, A., Patel, P., Parhizkar, S., Zhang, X., Laury, M. L., Mondal, P., Gomm, A., Schipma, M. J., Mallah, D., Butovsky, O., Chang, E. B., Tanzi, R. E., Gilbert, J. A., Holtzman, D. M. & Sisodia, S. S. | 2024-02-17 |
| Dementia in the Ancient Greco-Roman World Was Minimally Mentioned, Journal of Alzheimer's Disease | Finch, C. E., & Burstein, S. M. | 2024-02-13 |
| PFASs May Risk Alzheimer’s Disease, The Journals of Gerontology. Series A | Wang, H. L., & Fang, E. F. | 2024-02-13 |
| The Relationship between p-tau217, p-tau231, and p-tau205 in the Human Brain Is Affected by the Cellular Environment and Alzheimer’s Disease Pathology, Cells | Wennström, M., Schultz, N., Gallardo, P. M., The Netherlands Brain Bank, Serrano, G. E., Beach, T. G., Bose, S., & Hansson, O. | 2024-02-11 |
| Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer’s disease, Acta Neuropathologica Communications | Raulin, A. C., Doss, S. V., Heckman, M. G., Craver, E. C., Li, Z., Ikezu, T. C., Sekiya, H., Liu, C. C., Martens, Y. A., Rosenberg, C. L., Kuchenbecker, L. A., DeTure, M., Reichard, R. R., Nguyen, A. T., Constantopoulos, E., Larsen, R. A., Kounaves, E. K., Murray, M. E., Dickson, D. W., Petersen, R. C., Bu, G., Kanekiyo, T. | 2024-02-09 |
| Effects of certain pre-analytical factors on the performance of plasma phospho-tau217, Alzheimer's Research & Therapy | Bali, D., Hansson, O., & Janelidze, S. | 2024-02-08 |
| Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative diseases, Brain | Nilsson, J., Pichet Binette, A., Palmqvist, S., Brum, W. S., Janelidze, S., Ashton, N. J., Spotorno, N., Stomrud, E., Gobom, J., Zetterberg, H., Brinkmalm, A., Blennow, K., & Hansson, O. | 2024-02-07 |
| Identification of direct connections between the dura and the brain, Nature | Smyth, L. C. D., Xu, D., Okar, S. V., Dykstra, T., Rustenhoven, J., Papadopoulos, Z., … Kipnis, J. | 2024-02-07 |
| Diffusion weighted magnetic resonance spectroscopy revealed neuronal specific microstructural alterations in Alzheimer’s disease, Brain Communications | Spotorno, N., Najac, C., Strandberg, O., Stomrud, E., van Westen, D., Nilsson, M., Ronen, I., & Hansson, O. | 2024-02-01 |
| Epigenetic dysregulation in Alzheimer’s disease peripheral immunity, Neuron | Ramakrishnan, A., Piehl, N., Simonton, B., Parikh, M., Zhang, Z., Teregulova, V., van Olst, L., & Gate, D. | 2024-01-31 |
| Disruption of hippocampal neuregulin 1-ErbB4 signaling contributes to the hippocampus-dependent cognitvie impariment induced by isoflurane in aged mice, Anesthesiology | Li, X. M., Su, F., Ji, M. H., Zhang, G. F., Qiu, L. L., Jia, M., Gao, J., Xie, Z., & Yang, J. J. | 2014-07-01 |
| Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3 beta activation in young mice, Anesthesiology | Tao, G., Zhang, J., Zhang, L., Dong, Y., Yu, B., Crosby, G., Culley, D. J., Zhang, Y., & Xie, Z. | 2014-09-01 |
| Anaesthetic Neurotoxicity and Neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar, British Journal of Anaesthesia | Jevtovic-Todorovic, V., Absalom, A. R., Blomgren, K., Brambrink, A., Crosby, G., Culley, D. J., Fiskum, G., Giffard, R. G., Herold, K. F., Loepke, A. W., Ma, D., Orser, B. A., Planel, E., Slikker, W., Jr, Soriano, S. G., Stratmann, G., Vutskits, L., Xie, Z., & Hemmings, H. C., Jr. | 2013-08-01 |
| Isoflurane induces endoplasmic reticulum stress and caspase actication through ryanodine receptors, British Journal of Anaesthesia | Wang, H., Dong, Y., Zhang, J., Xu, Z., Wang, G., Swain, C. A., Zhang, Y., & Xie, Z. | 2014-04-03 |
| Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells, British Journal of Anaesthesia | Zhang, L., Zhang, J., Yang, L., Dong, Y., Zhang, Y., & Xie, Z. | 2013-04-19 |
| Neurotoxicity of General Anesthetics: an update, Current Pharmaceutical Design | Vlisides, P., & Xie, Z. | 2012-12-01 |
| Different effects of anesthetic isoflurane on caspase-3 activation and cytosol cytochorne mice levels between m neural progenitor cells and neurons, Frontiers in Cellular Neuroscience | Zhang, Y., Pan, C., Wu, X., Dong, Y., Culley, D. J., Crosby, G., Li, T., & Xie, Z. | 2014-01-30 |
| Surgery plus anesthesia induces loss of attention in mice, Frontiers in Cellular Neuroscience | Ren, Q., Peng, M., Dong, Y., Zhang, Y., Chen, M., Yin, N., Marcantonio, E. R., & Xie, Z. | 2015-09-08 |
| Surgical incision-induced nociception causes cognitive impairment and reduction in synaptic NMDA recptor 2B in mice, Journal of Neuroscience | Zhang, X., Xin, X., Dong, Y., Zhang, Y., Yu, B., Mao, J., & Xie, Z. | 2013-11-06 |
| Perioperative cognitive decline in aging population, MAYO Clinic Proceedings | Terrando, N., Brzezinski, M., Degos, V., Eriksson, L. I., Kramer, J. H., Leung, J. M., Miller, B. L., Seeley, W. W., Vacas, S., Weiner, M. W., Yaffe, K., Young, W. L., Xie, Z., & Maze, M. | 2011-09-01 |
| Anesthetic sevoflurane reduces levels of hippocalcin and postsynaptic density protein 95, Molecular Neurobiology | Zhang, J., Dong, Y., Zhou, C., Zhang, Y., & Xie, Z. | 2014-05-29 |
| Vitamin C attenuates isoflurane-induced caspase-3 activation and cognitive impairment, Molecular Neurobiology | Cheng, B., Zhang, Y., Wang, A., Dong, Y., & Xie, Z. | 2014-11-04 |
| Sleep disturbance induces neuroinflammation and impariment of learning and memory, Neurobiology of Disease | Zhu, B., Dong, Y., Xu, Z., Gompf, H. S., Ward, S. A., Xue, Z., Miao, C., Zhang, Y., Chamberlin, N. L., & Xie, Z. | 2012-12-01 |
| Anesthetic isoflurante increases phosphorylated tau levels mediated by caspase activation and A beta generation, PLoS One | Dong, Y., Wu, X., Xu, Z., Zhang, Y., & Xie, Z. | 2012-06-20 |
| General anesthetics and beta-amyloid protein, Progress in Neuro-Psychopharmacology & Biological Psychiatry | Xie, Z., & Xu, Z. | 2012-08-13 |
| Hybrid PET/MRI Enables High-Spatial Resolution, Quantitative Imaging of Amyloid Plaques in an Alzheimer’s Disease Mouse Model, Scientific Reports | Frost, G. R., Longo, V., Li, T., Jonas, L. A., Judenhofer, M., Cherry, S., Koutcher, J., Lekaye, C., Zanzonico, P., & Li, Y. M. | 2020-06-25 |
| γ-Secretase Inhibitors and Modulators: Mechanistic Insights Into the Function and Regulation of γ-Secretase, Seminars in Cell & Developmental Biology | Nie, P., Vartak, A., & Li, Y. M. | 2020-04-02 |
| Evidence that the “Lid” domain of nicastrin is not essential for regulating secretase activity, Journal of Biological Chemistry | Zhang, X., Sullivan, E., Scimeca, M., Wu, X., Li, Y. M., & Sisodia, S. S. | 2016-02-17 |
| Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of gamma-secrtase using synthetic antibodies, Proceedings of the National Academy of Sciences of the United States of America | Zhang, X., Hoey, R. J., Lin, G., Koide, A., Leung, B., Ahn, K., Dolios, G., Paduch, M., Ikeuchi, T., Wang, R., Li, Y. M., Koide, S., & Sisodia, S. S. | 2012-05-14 |
| Therapeutic TVs for Crossing Barriers in the Brain, Cell | Zhao, Z., & Zlokovic, B. V. | 2020-07-23 |
| Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo, Frontiers in Aging Neuroscience | Nelson, A. R., Sagare, M. A., Wang, Y., Kisler, K., Zhao, Z., & Zlokovic, B. V. | 2020-04-29 |
| Endothelial Tip Cell Finds Its Way with Piezo1, Neuron | Zhao, Z., & Zlokovic, B. V. | 2020-10-14 |
| Blood-Brain Barrier: From Physiology to Disease and Back, Physiological Reviews | Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. | 2019-01-01 |
| Prion Protein Antagonists Rescue Alzheimer’s Amyloid-Beta Related Cognitive Deficits, Trends in Molecular Medicine | Sagare, A. P., Sweeney, M. D., Nelson, A. R., Zhao, Z., & Zlokovic, B. V. | 2019-02-01 |
| Can prehospital “plasma supplement” neutralize the systemic storm in severe trauma?, Cell Reports Medicine | Zhao, Z., & Zlokovic, B. V. | 2021-12-21 |
| Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier, Molecular Neurodegeneration | Kisler, K., Sagare, A. P., Lazic, D., Bazzi, S., Lawson, E., Hsu, C. J., Wang, Y., Ramanathan, A., Nelson, A. R., Zhao, Z., & Zlokovic, B. V. | 2023-01-27 |
| Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism, Molecular Neurodegeneration | Ma, Q., Zhao, Z., Sagare, A. P., Wu, Y., Wang, M., Owens, N. C., Verghese, P. B., Herz, J., Holtzman, D. M., & Zlokovic, B. V. | 2018-10-19 |
| Inflammatory pain may induce cognitive impairment through an interlukin-6 dependent and postsynaptic density-95 associated mechanism, Anesthesia & Analgesia | Yang, L., Xin, X., Zhang, J., Zhang, L., Dong, Y., Zhang, Y., Mao, J., & Xie, Z. | 2014-05-30 |
| 2-Deoxy-D-Glucose Enhances Anesthetic Effects in Mice, Anesthesia & Analgesia | Wang, H., Xu, Z., Wu, A., Dong, Y., Zhang, Y., Yue, Y., & Xie, Z. | 2015-02-01 |
| Propofol Enhances Hemoglobin-induced cytotoxicity in Neurons, Anesthesia & Analgesia | Yuan, J., Cui, G., Li, W., Zhang, X., Wang, X., Zheng, H., Zhang, J., Xiang, S., & Xie, Z. | 2016-01-14 |
| Glucose May Attenuate Isoflurane-Induced Caspase-3 Activation in H4 Human Neuroglioma Cells, Anesthesia & Analgesia | Sun, Y., Zhang, Y., Cheng, B., Dong, Y., Pan, C., Li, T., & Xie, Z. | 2014-07-26 |
| Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment, Anesthesiology | Shen, X., Dong, Y., Xu, Z., Wang, H., Miao, C., Soriano, S. G., Sun, D., Baxter, M. G., Zhang, Y., & Xie, Z. | 2013-03-01 |
| Sevoflurane anesthesia in pregnant mice induces neurotoxicity in fetal and offspring mice, Anesthesiology | Zheng, H., Dong, Y., Xu, Z., Crosby, G., Culley, D. J., Zhang, Y., & Xie, Z. | 2013-03-01 |
| Effects of Anesthetic Isoflurane and Desflurane on Human Cerebrospinal Fluid Aβ and τ Level, Anesthesiology | Zhang, B., Tian, M., Zheng, H., Zhen, Y., Yue, Y., Li, T., Li, S., Marcantonio, E. R., & Xie, Z. | 2013-07-01 |
| Cancer prognosis: can anesthesia play a role?, Anesthesiology | Xie Z. | 2013-09-01 |
| Myelin basic protein binds to and inhibits the fibrillar assembly of Abeta42 in vitro., Biochemistry | Hoos, M. D., Ahmed, M., Smith, S. O., & Van Nostrand, W. E. | 2009-04-22 |
| Fine mapping of the amyloid β-protein binding site on myelin basic protein, Biochemistry | Kotarba, A. E., Aucoin, D., Hoos, M. D., Smith, S. O., & Van Nostrand, W. E. | 2013-04-04 |
| Mechanism of Nucleated conformational conversion of A beta 42, Biochemistry | Fu, Z., Aucoin, D., Davis, J., Van Nostrand, W. E., & Smith, S. O. | 2015-06-12 |
| Degradation of amyloid beta protein by purified myelin basic protein, Journal of Biological Chemistry | Liao, M. C., Ahmed, M., Smith, S. O., & Van Nostrand, W. E. | 2009-08-19 |
| N-terminal Domain of Myelin Basic Protein Inhibits Amyloid beta-Protein Fibril Assembly, Journal of Biological Chemistry | Liao, M. C., Hoos, M. D., Aucoin, D., Ahmed, M., Davis, J., Smith, S. O., & Van Nostrand, W. E. | 2010-08-31 |
| Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils., Nature Structural & Molecular Biology | Ahmed, M., Davis, J., Aucoin, D., Sato, T., Ahuja, S., Aimoto, S., Elliott, J. I., Van Nostrand, W. E., & Smith, S. O. | 2010-04-11 |
| Small molecule amyloid-beta protein precurosr processing modulators lower amyloid beta peptide levels via cKit signaling, Journal of Alzheimer's Disease | Chen, C. D., Zeldich, E., Khodr, C., Camara, K., Tung, T. Y., Lauder, E. C., Mullen, P., Polanco, T. J., Liu, Y. Y., Zeldich, D., Xia, W., Van Nostrand, W. E., Brown, L. E., Porco, J. A., & Abraham, C. R. | 2019-02-12 |
| PanomiR: a systems biology framework for analysis of multi-pathway targeting by miRNAs, Briefings in Bioinformatics | Naderi Yeganeh, P., Teo, Y. Y., Karagkouni, D., Pita-Juárez, Y., Morgan, S. L., Slack, F. J., Vlachos, I. S., & Hide, W. A. | 2023-11-20 |
| The relative resistance of children to sepsis mortality: from pathways to drug candidates, Molecular Systems Biology | Joachim, R. B., Altschuler, G. M., Hutchinson, J. N., Wong, H. R., Hide, W. A., & Kobzik, L. | 2018-05-01 |
| Central regulation of stress-evoked peripheral immune responses, Nature Reviews Neuroscience | Chan, K. L., Poller, W. C., Swirski, F. K., & Russo, S. J. | 2023-08-25 |
| Glial control of synapse number in healthy and diseased brain, Frontiers in Cellular Neuroscience | Lee, E., & Chung, W. S. | 2019-02-13 |
| γ-Secretase fanning the fire of innate immunity, Biochemical Society Transactions | Liu, C., Nikain, C., & Li, Y. M. | 2023-08-31 |
| γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors, Frontiers in Aging Neuroscience | Wong, E., Frost, G. R., & Li, Y. M. | 2020-12-02 |
| Friend, Foe or Both? Immune Activity in Alzheimer’s Disease, Frontiers in Aging Neuroscience | Frost, G. R., Jonas, L. A., & Li, Y. M. | 2019-12-10 |
| The role of astrocytes in amyloid production and Alzheimer’s disease, Open Biology | Frost, G. R., & Li, Y. M. | 2017-12-13 |
| Functional insight into LOAD-associated microglial response genes, Open Biology | Jonas, L. A., Jain, T., & Li, Y. M. | 2022-01-26 |
| Versatility of presenilin 1, Proceedings of the National Academy of Sciences of the United States of America | Frost, G. R., Wong, E., & Li, Y. M. | 2017-06-23 |
| Recent developments of small molecule γ-secretase modulators for Alzheimer’s disease, RSC Medicinal Chemistry | Mekala, S., Nelson, G., & Li, Y. M. | 2020-08-27 |
| Gamma-Secretase and its modulators: Twenty years and beyond, Neuroscience Letters | Xia W. | 2019-02-11 |
| Three dimensional human neuro-spherod model of Alzheimer’s disease based on differentiated induced pluripotent stem cells, PLoS One | Lee, H. K., Velazquez Sanchez, C., Chen, M., Morin, P. J., Wells, J. M., Hanlon, E. B., & Xia, W. | 2016-09-29 |
| Diagnosis of Alzheimer’s disease using laser-induced breakdown spectroscopy and machine learning, Spectrochimica Acta Part B: Atomic Spectroscopy | Gaudiuso, R., Ewusi-Annan, E., Xia, W., & Melikechi, N. | 2020-07-15 |
| The Acyl-coenzyme A: cholesterol Acyltransferase Inhibitor CI-1011 Reverses Diffuse Brain Amyloid pathology in aged amyloid precursor protein transgenic mice, Journal of Neuropathology & Experimental Neurology | Huttunen, H. J., Havas, D., Peach, C., Barren, C., Duller, S., Xia, W., Frosch, M. P., Hutter-Paier, B., Windisch, M., & Kovacs, D. M. | 2010-08-01 |
| Reticulon 1 and 3 are essential for axonal growth and synaptic maintenance associated with the intellectual development, Human Molecular Genetics | Zhou, J., Shi, Q., Ge, Y. Y., He, W., Hu, X., Xia, W., & Yan, R. | 2023-05-25 |
| OCIAD1 contributes to neurodegeneration in Alzheimer’s disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages, eBioMedicine | Li, X., Wang, L., Cykowski, M., He, T., Liu, T., Chakranarayan, J., Rivera, A., Zhao, H., Powell, S., Xia, W., & Wong, S. T. C. | 2020-01-10 |
| Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer’s disease., Alzheimer's & Dementia | Jun, G. R., You, Y., Zhu, C., Meng, G., Chung, J., Panitch, R., Hu, J., Xia, W., Alzheimer's Disease Genetics Consortium, Bennett, D. A., Foroud, T. M., Wang, L. S., Haines, J. L., Mayeux, R., Pericak-Vance, M. A., Schellenberg, G. D., Au, R., Lunetta, K. L., Ikezu, T., Stein, T. D., … Farrer, L. A. | 2022-02-09 |
| Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids, Methods | Muraoka, S., Lin, W., Chen, M., Hersh, S. W., Emili, A., Xia, W., & Ikezu, T. | 2020-02-05 |
| Proteomic and biological profiling of extracellular vesicles from Alzheimer’s disease human brain tissues, Alzheimer's & Dementia | Muraoka, S., DeLeo, A. M., Sethi, M. K., Yukawa-Takamatsu, K., Yang, Z., Ko, J., Hogan, J. D., Ruan, Z., You, Y., Wang, Y., Medalla, M., Ikezu, S., Chen, M., Xia, W., Gorantla, S., Gendelman, H. E., Issadore, D., Zaia, J., & Ikezu, T. | 2020-04-17 |
| Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain, Annual Review of Neuroscience | Fu, X. D., & Mobley, W. C. | 2023-07-10 |
| Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders, Annual Review of Pharmacology and Toxicology | Bartesaghi, R., Vicari, S., & Mobley, W. C. | 2022-01-06 |
| Local TrkB signaling: themes in development and neural plasticity, Cell and Tissue Research | Johnstone, A., & Mobley, W. | 2020-09-16 |
| Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses, Frontiers in Neuroscience | Chen, X. Q., & Mobley, W. C. | 2019-05-07 |
| Alzheimer’s disease pathogenesis: insights from molecular and cellular biolgoy studies of oligomeric A beta and Tau species, Frontiers in Neuroscience | Chen, X. Q., & Mobley, W. C. | 2019-06-21 |
| Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome, Neurobiology of Disease | Kleschevnikov, A. M., Yu, J., Kim, J., Lysenko, L. V., Zeng, Z., Yu, Y. E., & Mobley, W. C. | 2017-03-22 |
| Down syndrome conitive phenotypes modeled in mice trisomic for all HAS 21 Homologues, PLoS One | Belichenko, P. V., Kleschevnikov, A. M., Becker, A., Wagner, G. E., Lysenko, L. V., Yu, Y. E., & Mobley, W. C. | 2015-07-31 |
| Soluble SORLA enhances neurite outgrowth and regeneration through activation of the EGF Receptor/ERK signaling axis, Journal of Neuroscience | Stupack, J., Xiong, X. P., Jiang, L. L., Zhang, T., Zhou, L., Campos, A., Ranscht, B., Mobley, W., Pasquale, E. B., Xu, H., & Huang, T. Y. | 2020-06-29 |
| Dementia in Down Syndrome, Lancet Neurology | Ballard, C., Mobley, W., Hardy, J., Williams, G., & Corbett, A. | 2016-04-11 |
| Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease, Neurology | Ikonomovic, M. D., Klunk, W. E., Abrahamson, E. E., Wuu, J., Mathis, C. A., Scheff, S. W., Mufson, E. J., & DeKosky, S. T. | 2011-07-05 |
| Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia, Molecular Psychiatry | Ledo, J. H., Liebmann, T., Zhang, R., Chang, J. C., Azevedo, E. P., Wong, E., Silva, H. M., Troyanskaya, O. G., Bustos, V., & Greengard, P. | 2020-08-13 |
| Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles, Journal of Biological Chemistry | Guo, J. L., & Lee, V. M. | 2011-03-03 |
| In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice, Journal of Neuroscience | Yamada, K., Cirrito, J. R., Stewart, F. R., Jiang, H., Finn, M. B., Holmes, B. B., Binder, L. I., Mandelkow, E. M., Diamond, M. I., Lee, V. M., & Holtzman, D. M. | 2011-09-14 |
| Tau pathology spreads in S19 tau transgenic mice following locus coeruleus (LC) injections of synthestic tau fibrils is determined by the LC’s afferent and efferent connections, Acta Neuropathologica | Iba, M., McBride, J. D., Guo, J. L., Zhang, B., Trojanowski, J. Q., & Lee, V. M. | 2015-07-07 |
| Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzhiemer’s like tauopathy, Journal of Neuroscience | Iba, M., Guo, J. L., McBride, J. D., Zhang, B., Trojanowski, J. Q., & Lee, V. M. | 2013-01-16 |
| Aging induces an NLRP3 inflammasome-dependent expansion of adipose B cells that impair metabolic homeostasis, Cell Metabolism | Camell, C. D., Günther, P., Lee, A., Goldberg, E. L., Spadaro, O., Youm, Y. H., Bartke, A., Hubbard, G. B., Ikeno, Y., Ruddle, N. H., Schultze, J., & Dixit, V. D. | 2019-11-14 |
| IL-33 causes thermogenic failure in aging by dysfunctional adipose ILC2, Cell Metabolism | Goldberg, E. L., Shchukina, I., Youm, Y. H., Ryu, S., Tsusaka, T., Young, K. C., Camell, C. D., Dlugos, T., Artyomov, M. N., & Dixit, V. D. | 2021-09-01 |
| When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging, Cell Metabolism | Mihaylova, M. M., Chaix, A., Delibegovic, M., Ramsey, J. J., Bass, J., Melkani, G., Singh, R., Chen, Z., Ja, W. W., Shirasu-Hiza, M., Latimer, M. N., Mattison, J. A., Thalacker-Mercer, A. E., Dixit, V. D., Panda, S., & Lamming, D. W. | 2023-06-30 |
| Loss of Nucleobindin-2 causes insulin resistance in obesity without impacting satiety or adiposity, Cell Reports | Ravussin, A., Youm, Y. H., Sander, J., Ryu, S., Nguyen, K., Varela, L., Shulman, G. I., Sidorov, S., Horvath, T. L., Schultze, J. L., & Dixit, V. D. | 2018-07-31 |
| Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice, eLife | Ryu, S., Shchukina, I., Youm, Y. H., Qing, H., Hilliard, B., Dlugos, T., Zhang, X., Yasumoto, Y., Booth, C. J., Fernández-Hernando, C., Suárez, Y., Khanna, K., Horvath, T. L., Dietrich, M. O., Artyomov, M., Wang, A., & Dixit, V. D. | 2021-06-21 |
| Dietary Regulation of Immunity, Immunity | Lee, A. H., & Dixit, V. D. | 2020-09-15 |
| The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging, Immunity | Ryu, S., Sidorov, S., Ravussin, E., Artyomov, M., Iwasaki, A., Wang, A., & Dixit, V. D. | 2022-08-12 |
| Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity, Journal of Clinical Investigation | Ryu, S., Spadaro, O., Sidorov, S., Lee, A. H., Caprio, S., Morrison, C., Smith, S. R., Ravussin, E., Shchukina, I., Artyomov, M. N., Youm, Y. H., & Dixit, V. D. | 2023-10-02 |
| Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing, Nature | Camell, C. D., Sander, J., Spadaro, O., Lee, A., Nguyen, K. Y., Wing, A., Goldberg, E. L., Youm, Y. H., Brown, C. W., Elsworth, J., Rodeheffer, M. S., Schultze, J. L., & Dixit, V. D. | 2017-09-27 |
| Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome, Nature Aging | Shchukina, I., Bagaitkar, J., Shpynov, O., … Dixit, V. D., … Artyomov, M. N. | 2021-11-23 |
| Caloric restriction in humans reveals immunometabolic regulators of health span, Science | Spadaro, O., Youm, Y., Shchukina, I., Ryu, S., Sidorov, S., Ravussin, A., Nguyen, K., Aladyeva, E., Predeus, A. N., Smith, S. R., Ravussin, E., Galban, C., Artyomov, M. N., & Dixit, V. D. | 2022-02-10 |
| Proteomic Profiling of Mouse Brains Exposed to Blast-Induced Mild Traumatic Brain Injury Reveals Changes in Axonal Proteins and Phosphorylated Tau, Journal of Alzheimer's Disease | Chen, M., Song, H., Cui, J., Johnson, C. E., Hubler, G. K., DePalma, R. G., Gu, Z., & Xia, W. | 2018-10-30 |
| Proteomic Profiling of Plasma and Brain Tissue from Alzheimer’s Disease Patients Reveals Candidate Network of Plasma Biomarkers, Journal of Alzheimer's Disease | Chen, M., & Xia, W. | 2020-06-30 |
| Multi-Focal Neuronal Ultrastructural Abnormalities and Synaptic Alterations in Mice after Low-Intensity Blast Exposure, Journal of Neurotrauma | Konan, L. M., Song, H., Pentecost, G., Fogwe, D., Ndam, T., Cui, J., Johnson, C. E., Grant, D., White, T., Chen, M., Xia, W., Cernak, I., DePalma, R. G., & Gu, Z. | 2019-03-13 |
| Common Proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer’s patients, Journal of Proteomics | Chen, M., Lee, H. K., Moo, L., Hanlon, E., Stein, T., & Xia, W. | 2018-04-27 |
| Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles, Aging and Disease | Muraoka, S., Lin, W., Takamatsu-Yukawa, K., Hu, J., Ikezu, S., DeTure, M. A., Dickson, D. W., Emili, A., & Ikezu, T. | 2021-09-01 |
| Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons, Brain | Ruan, Z., Pathak, D., Venkatesan Kalavai, S., Yoshii-Kitahara, A., Muraoka, S., Bhatt, N., Takamatsu-Yukawa, K., Hu, J., Wang, Y., Hersh, S., Ericsson, M., Gorantla, S., Gendelman, H. E., Kayed, R., Ikezu, S., Luebke, J. I., & Ikezu, T. | 2020-11-27 |
| Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study, Cells | Muraoka, S., Jedrychowski, M. P., Yanamandra, K., Ikezu, S., Gygi, S. P., & Ikezu, T. | 2020-08-25 |
| Proteomic Profiling of Extracellular Vesicles Isolated from Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy, Frontiers in Neuroscience | Muraoka, S., Jedrychowski, M. P., Tatebe, H., DeLeo, A. M., Ikezu, S., Tokuda, T., Gygi, S. P., Stern, R. A., & Ikezu, T. | 2019-10-09 |
| Activated Human Astrocyte-Derived Extracellular Vesicles Modulate Neuronal Uptake, Differentiation and Firing, Journal of Extracellular Vesicles | You, Y., Borgmann, K., Edara, V. V., Stacy, S., Ghorpade, A., & Ikezu, T. | 2019-12-26 |
| Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer’s Disease Mouse Models., Journal of Proteome Research | Muraoka, S., Jedrychowski, M. P., Iwahara, N., Abdullah, M., Onos, K. D., Keezer, K. J., Hu, J., Ikezu, S., Howell, G. R., Gygi, S. P., & Ikezu, T. | 2021-02-03 |
| P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice, Molecular Neurodegeneration | Ruan, Z., Delpech, J. C., Venkatesan Kalavai, S., Van Enoo, A. A., Hu, J., Ikezu, S., & Ikezu, T. | 2020-08-18 |
| Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model, Molecular Neurodegeneration | Clayton, K., Delpech, J. C., Herron, S., Iwahara, N., Ericsson, M., Saito, T., Saido, T. C., Ikezu, S., & Ikezu, T. | 2021-03-22 |
| Emerging Role of Extracellular Vesicles in Neurodegenerative Disorders, Neurobiology of Disease | You, Y., & Ikezu, T. | 2019-06-20 |
| Cre-inducible Adeno Associated Virus-mediated Expression of P301L mutant tau causes motor deficits and neuronal degeneration in substantia nigra, Neuroscience | You, Y., Botros, M. B., Enoo, A. A. V., Bockmiller, A., Herron, S., Delpech, J. C., & Ikezu, T. | 2019-11-02 |
| Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice, Science Translational Medicine | Delpech, J. C., Pathak, D., Varghese, M., Kalavai, S. V., Hays, E. C., Hof, P. R., Johnson, W. E., Ikezu, S., Medalla, M., Luebke, J. I., & Ikezu, T. | 2021-09-15 |
| Transcriptional and Epigenetic Regulation of Microglia in Health and Disease, Trends in Molecular Medicine | Yeh, H., & Ikezu, T. | 2018-12-12 |
| Neuroimmune crosstalk through extracellular vesicles in health and disease, Trends in Neurosciences | Delpech, J. C., Herron, S., Botros, M. B., & Ikezu, T. | 2019-03-26 |
| Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models, Acta Neuropathologica Communications | Ikezu, S., Ingraham Dixie, K. L., Koro, L., Watanabe, T., Kaibuchi, K., & Ikezu, T. | 2020-02-04 |
| TIA1 regulates the generation and response to toxic tau oligomers, Acta Neuropathologica | Jiang, L., Ash, P. E. A., Maziuk, B. F., Ballance, H. I., Boudeau, S., Abdullatif, A. A., Orlando, M., Petrucelli, L., Ikezu, T., & Wolozin, B. | 2019-02-11 |
| Reducing the RNA binding protein T1A1 protects against tau-mediated neurodegeneration in vivo, Nature Neuroscience | Apicco, D. J., Ash, P. E. A., Maziuk, B., LeBlang, C., Medalla, M., Al Abdullatif, A., Ferragud, A., Botelho, E., Ballance, H. I., Dhawan, U., Boudeau, S., Cruz, A. L., Kashy, D., Wong, A., Goldberg, L. R., Yazdani, N., Zhang, C., Ung, C. Y., Tripodis, Y., Kanaan, N. M., Ikezu, T., Cottone, P., Leszyk, J., Li, H., Luebke, J., Bryant, C. D., & Wolozin, B. | 2018-01-01 |
| APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia, Science Translational Medicine | Liu, C. C., Murray, M. E., Li, X., Zhao, N., Wang, N., Heckman, M. G., Shue, F., Martens, Y., Li, Y., Raulin, A. C., Rosenberg, C. L., Doss, S. V., Zhao, J., Wren, M. C., Jia, L., Ren, Y., Ikezu, T. C., Lu, W., Fu, Y., Caulfield, T., Trottier, Z.A., Knight, J., Chen, Y., Linares, C., Wang, X., Kurti, A., Asmann, Y.W., Wszolek, Z.K., Smith, G.E., Vemuri, P., Kantarci, K., Knopman, D.S., Lowe, V.J., Jack, C.R. Jr, Parisi, J.E., Ferman, T.J., Boeve, B.F., Graff-Radford, N.R., Petersen, R.C., Younkin, S.G., Fryer, J.D., Wang, H., Han, X., Frieden, C., Dickson, D.W., Ross, O.A., Bu, G. | 2021-09-29 |
| Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice, Acta Neuropathologica Communications | Yukawa, K., Yamamoto-Mcguire, S., Cafaro, L., Hong, C., Kamme, F., Ikezu, T., & Ikezu, S. | 2023-10-19 |
| Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels, ASC Chemical Biology | Bustos, V. H., Sunkari, Y. K., Sinha, A., Pulina, M., Bispo, A., Hopkins, M., Lam, A., Kriegsman, S. F., Mui, E., Chang, E., Jedlicki, A., Rosenthal, H., Flajolet, M., & Sinha, S. C. | 2023-12-11 |
| Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression, Brain | Yamazaki, Y., Shinohara, M., Shinohara, M., Yamazaki, A., Murray, M. E., Liesinger, A. M., Heckman, M. G., Lesser, E. R., Parisi, J. E., Petersen, R. C., Dickson, D. W., Kanekiyo, T., & Bu, G. | 2019-02-15 |
| Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function, Nature Neuroscience | Liu, C. C., Zhao, J., Fu, Y., … Kanekiyo, T., Fryer, J. D., … Bu, G. | 2022-08-01 |
| Clinicopathologic Factors Associated With Reversion to Normal Cognition in Patients With Mild Cognitive Impairment, Neurology | Li, Z., Heckman, M. G., Kanekiyo, T., Martens, Y. A., Day, G. S., Vassilaki, M., Liu, C. C., Bennett, D. A., Petersen, R. C., Zhao, N., & Bu, G. | 2022-05-17 |
| ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids, Science Advances | You, Y., Zhang, Z., Sultana, N., Ericsson, M., Martens, Y. A., Sun, M., Kanekiyo, T., Ikezu, S., Shaffer, S. A., & Ikezu, T. | 2023-09-15 |
| Chronic progressive neurodegeneration in a transgenic mouse model of Prion disease, Frontiers in Neuroscience | Fainstein, N., Dori, D., Frid, K., Fritz, A. T., Shapiro, I., Gabizon, R., & Ben-Hur, T. | 2016-11-11 |
| Resident brain neural precursor cells develop age-dependent loss of therapeutic functions in Alzhiemer’s mice, Neurobiology of Aging | Fainstein N, Dan-Goor N, Ben-Hur T. | 2018-08-06 |
| Intra-hippocampal transplantation of neural precursor cells with transgenic over-expression of IL-1 receptor antagonist rescues memory and neurogenesis impairments in an Alzheimer’s disease model, Neuropsychopharmacology | Ben-Menachem-Zidon, O., Ben-Menahem, Y., Ben-Hur, T., & Yirmiya, R. | 2013-08-19 |
| Combined treatment with phenolics (-)-epigallocatecin-3 gallate and ferulic acid improves cognition and reduces Alzhiemer-like pathology in mice, Journal of Biological Chemistry | Mori, T., Koyama, N., Tan, J., Segawa, T., Maeda, M., & Town, T. | 2018-12-18 |
| Gallic Acid is a Dual α/β-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice, Journal of Biological Chemistry | Mori, T., Koyama, N., Yokoo, T., Segawa, T., Maeda, M., Sawmiller, D., Tan, J., & Town, T. | 2020-09-10 |
| Let’s make microglia great again in neurodegenerative disorders, Journal of Neural Transmission | Guillot-Sestier, M. V., & Town, T. | 2017-10-12 |
| Mouse Brain Transcriptome Responses to Inhaled Nanoparticulate Matter Differed by Sex and APOE in Nrf2-Nfkb Interactions, eLife | Haghani, A., Cacciottolo, M., Doty, K. R., D'Agostino, C., Thorwald, M., Safi, N., Levine, M. E., Sioutas, C., Town, T. C., Forman, H. J., Zhang, H., Morgan, T. E., & Finch, C. E. | 2020-06-24 |
| Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment, Journal of Clinical Investigation | Jiang, L. L., Zhu, B., Zhao, Y., Li, X., Liu, T., Pina-Crespo, J., Zhou, L., Xu, W., Rodriguez, M. J., Yu, H., Cleveland, D. W., Ravits, J., Da Cruz, S., Long, T., Zhang, D., Huang, T. Y., & Xu, H. | 2019-05-21 |
| Atlas of the aging mouse brain reveals white matter as vulnerable foci, Cell | Hahn, O., Foltz, A. G., Atkins, M., Kedir, B., Moran-Losada, P., Guldner, I. H., Munson, C., Kern, F., Pálovics, R., Lu, N., Zhang, H., Kaur, A., Hull, J., Huguenard, J. R., Grönke, S., Lehallier, B., Partridge, L., Keller, A., & Wyss-Coray, T. | 2023-08-08 |
| CD22 Blockade restores homeostatic microglial phagocytosis in ageing brains, Nature | Pluvinage, J. V., Haney, M. S., Smith, B. A. H., Sun, J., Iram, T., Bonanno, L., Li, ... Wyss-Coray, T. | 2019-04-03 |
| Clonally Expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease, Nature | Gate, D., Saligrama, N., Leventhal, O., Yang, A. C., Unger, … Wyss-Coray, T. | 2020-01-08 |
| Undulating changes in human plasma proteome profiles across the lifespan, Nature Medicine | Lehallier, B., Gate, D., Schaum, N., Nanasi, T., Lee, S. E., ... Wyss-Coray, T. | 2019-12-05 |
| Lipid-droplet accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain, Nature Neuroscience | Marschallinger, J., Iram, T., Zardeneta, M., Lee, S. E., ... Wyss-Coray, T. | 2020-01-20 |
| CD4(+) T cells contribute to neurodegeneration in Lewy body dementia, Science | Gate, D., Tapp, E., Leventhal, O., Shahid, M., ... Wyss-Coray, T. | 2021-10-14 |
| Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy, Aging and Disease | Muraoka, S., DeLeo, A. M., Yang, Z., Tatebe, H., Yukawa-Takamatsu, K., Ikezu, S., Tokuda, T., Issadore, D., Stern, R. A., & Ikezu, T. | 2021-09-01 |
| Transcriptomic profiling of sporadic Alzheimer’s disease patients, Molecular Brain | Caldwell, A. B., Anantharaman, B. G., Ramachandran, S., Nguyen, P., Liu, Q., Trinh, I., Galasko, D. R., Desplats, P. A., Wagner, S. L., & Subramaniam, S. | 2022-10-12 |
| Dedifferentiation and neuronal repression define familial Alzheimer’s disease., Science Advances | Caldwell, A. B., Liu, Q., Schroth, G. P., Galasko, D. R., Yuan, S. H., Wagner, S. L., & Subramaniam, S. | 2020-11-13 |
| Gamma-Secretase Partitioning Into Lipid Bilayers Remodels Membrane Microdomains After Direct Insertion, Langmuir | Barros, M., Houlihan, W. J., Paresi, C. J., Brendel, M., Rynearson, K. D., Lee, C. W., Prikhodko, O., Cregger, C., Chang, G., Wagner, S. L., Gilchrist, M. L., & Li, Y. M. | 2020-05-20 |
| Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzhiemer’s disease, Proceedings of the National Academy of Sciences of the United States of America | Andrew, R. J., Fernandez, C. G., Stanley, M., Jiang, H., Nguyen, P., Rice, R. C., Buggia-Prévot, V., De Rossi, P., Vetrivel, K. S., Lamb, R., Argemi, A., Allaert, E. S., Rathbun, E. M., Krause, S. V., Wagner, S. L., Parent, A. T., Holtzman, D. M., & Thinakaran, G. | 2017-10-23 |
| A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of gamma-secretase, Journal of Biological Chemistry | Zhang, X., Hoey, R., Koide, A., Dolios, G., Paduch, M., Nguyen, P., Wu, X., Li, Y., Wagner, S. L., Wang, R., Koide, S., & Sisodia, S. S. | 2014-10-28 |
| Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders, Molecular Neurodegeneration | Huang, Y., Liu, B., Sinha, S. C., Amin, S., & Gan, L. | 2023-11-08 |
| Reduction of synaptojanin1 ameliorates synaptic and behaviorla impariments in a mouse model of Alzheimer’s disease, Journal of Neuroscience | McIntire, L. B., Berman, D. E., Myaeng, J., Staniszewski, A., Arancio, O., Di Paolo, G., & Kim, T. W. | 2012-10-31 |
| Linking Lipids to Alzheimer’s Disease: cholesterol and beyond, Nature Reviews Neuroscience | Di Paolo, G., & Kim, T. W. | 2011-05-30 |
| ABCA7 and Pathogenic Pathways of Alzheimer’s Disease, Brain Sciences | Aikawa, T., Holm, M. L., & Kanekiyo, T. | 2018-02-05 |
| Cryo‐EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms, The EMBO Journal | Le, L. T. M., Thompson, J. R., Dehghani-Ghahnaviyeh, S., Pant, S., Dang, P. X., French, J. B., Kanikeyo, T., Tajkhorshid, E., & Alam, A. | 2022-12-09 |
| The low-density lipoprotein receptor-related protein 1 and amyloid-beta clearance in Alzheimer’s disease, Frontiers in Aging Neuroscience | Kanekiyo, T., & Bu, G. | 2014-05-20 |
| Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins, Molecular Neurodegeneration | Oatman, S. R., Reddy, J. S., Quicksall, Z., … Kanekiyo, T., … Bu, G., … Ertekin-Taner, N. | 2023-01-07 |
| APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids, Stem Cell Research & Therapy | Zhao, J., Ikezu, T. C., Lu, W., Macyczko, J. R., Li, Y., Lewis-Tuffin, L. J., Martens, Y. A., Ren, Y., Zhu, Y., Asmann, Y. W., Ertekin-Taner, N., Kanekiyo, T., & Bu, G. | 2023-08-21 |
| Generation and validation of APOE knockout human iPSC-derived cerebral organoids, STAR Protocols | Martens, Y. A., Xu, S., Tait, R., Li, G., Zhao, X. C., Lu, W., Liu, C. C., Kanekiyo, T., Bu, G., & Zhao, J. | 2021-06-05 |
| Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease, Proceedings of the National Academy of Sciences of the United States of America | Baker, S. K., Chen, Z. L., Norris, E. H., Revenko, A. S., MacLeod, A. R., & Strickland, S. | 2018-09-25 |
| An antibody against HK blocks Alzheimer’s disease peptide beta-amyloid-induced bradykinin release in human plasma, Proceedings of the National Academy of Sciences of the United States of America | Chen, Z. L., Singh, P., Wong, J., Horn, K., Strickland, S., & Norris, E. H. | 2019-11-12 |
| Cerebral amyloid angiopathy-linked beta-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen, Proceedings of the National Academy of Sciences of the United States of America | Cajamarca, S. A., Norris, E. H., van der Weerd, L., Strickland, S., & Ahn, H. J. | 2020-06-09 |
| Editorial: New Insights on Neuron and Astrocyte Function from Cutting Edge Optical Techniques, Frontiers in Cellular Neuroscience | Antic, S. D., Baker, B. J., & Canepari, M. | 2019-10-15 |
| Studying Synaptically Evoked Cortical Responses ex vivo With Combination of a Single Neuron Recording (Whole-Cell) and Population Voltage Imaging (Genetically Encoded Voltage Indicator), Frontiers in Neuroscience | Jang, J., Zhu, M. H., Jogdand, A. H., & Antic, S. D. | 2021-10-27 |
| Imaging of Evoked Cortical Depolarizations Using Either ASAP2s, or chi-VSFP, or Di-4-Anepps, or Autofluorescence Optical Signals, Journal of Integrative Neuroscience | Milicevic, K. D., Zhu, M. H., Barbeau, B. L., Baser, O., Erol, Z. Y., Liu, L. X., Lin, M. Z., & Antic, S. D. | 2023-11-06 |
| In Vitro Testing of Voltage Indicators: Archon1, ArcLightD, ASAP1, ASAP2s, ASAP3b, Bongwoori-Pos6, BeRST1, FlicR1 and Chi-VSFP-Butterfly, eNeuro | Milosevic, M. M., Jang, J., McKimm, E. J., Zhu, M. H., & Antic, S. D. | 2020-08-14 |
| Population imaging discrepancies between a genetically-encoded calcium indicator (GECI) versus a genetically-encoded voltage indicator (GEVI), Scientific Reports | Zhu, M. H., Jang, J., Milosevic, M. M., & Antic, S. D. | 2021-03-05 |
| Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE, Nature Neuroscience | Parhizkar, S., Arzberger, T., Brendel, M., Kleinberger, G., Deussing, M., Focke, C., Nuscher, B., Xiong, M., Ghasemigharagoz, A., Katzmarski, N., Krasemann, S., Lichtenthaler, S. F., Müller, S. A., Colombo, A., Monasor, L. S., Tahirovic, S., Herms, J., Willem, M., Pettkus, N., Butovsky, O., Bartenstein, P., Edbauer, D., Rominger, A., Erturk, A., Grathwohl, S. A., Neher, J. J., Holtzman, D., Meyer-Leuhmann, M., & Haass, C. | 2019-02-01 |
| CSF p-tau increase in response to A beta-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles, Acta Neuropathologica | Kaeser, S. A., Häsler, L. M., Lambert, M., Bergmann, C., Bottelbergs, A., Theunis, C., Mercken, M., & Jucker, M. | 2021-12-28 |
| Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae, Nature Communications | Rother, C., Uhlmann, R. E., Müller, S. A., Schelle, J., … Kaeser, S. A., … Jucker, M. | 2022-11-28 |
| A neuronal blood marker is associated with mortality in old age, Nature Aging | Kaeser, S. A., Lehallier, B., Thinggaard, M., Häsler, L. M., Apel, A., Bergmann, C., Berdnik, D., Jeune, B., Christensen, K., Grönke, S., Partridge, L., Wyss-Coray, T., Mengel-From, J., & Jucker, M. | 2021-02-11 |
| The molecular identity of the TLQP-21 peptide receptor, Cellular and Molecular Life Sciences | Sahu, B. S., Nguyen, M. E., Rodriguez, P., Pallais, J. P., Ghosh, V., Razzoli, M., Sham, Y. Y., Salton, S. R., & Bartolomucci, A. | 2021-10-09 |
| Role of VGF/BDNF/TrkB Autoregulatory Feedback Loop in Rapid-Acting Antidepressant Efficacy, Journal of Molecular Neuroscience | Jiang, C., Lin, W. J., & Salton, S. R. | 2019-07-18 |
| An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function, Translational Psychiatry | Lin, W. J., Zhao, Y., Li, Z., Zheng, S., Zou, J. L., Warren, N. A., Bali, P., Wu, J., Xing, M., Jiang, C., Tang, Y., Salton, S. R., & Ye, X. | 2021-07-08 |
| Cellular prion protein mediates the toxicity of beta-amyloid oligomers implications for Alzheimer Disease, Archives of Neurology | Nygaard, H. B., & Strittmatter, S. M. | 2009-11-01 |
| Beta-amyloid oligomers and cellular prion protein in Alzheimer’s disease, Journal of Molecular Medicine | Gunther, E. C., & Strittmatter, S. M. | 2009-12-04 |
| Memory impairment in transgenic Alzheimer mice requires cellular prion protein, Journal of Neuroscience | Gimbel, D. A., Nygaard, H. B., Coffey, E. E., Gunther, E. C., Laurén, J., Gimbel, Z. A., & Strittmatter, S. M. | 2010-05-05 |
| Converging multi-modality datasets to build efficient drug repositioning pipelines against Alzheimer’s disease and related dementias, Medical Reviews | Yin, Z., & Wong, S. T. C. | 2022-02-14 |
| Effect of potent gamma-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers., JAMA Neurology | Liu, Q., Waltz, S., Woodruff, G., Ouyang, J., Israel, M. A., Herrera, C., Sarsoza, F., Tanzi, R. E., Koo, E. H., Ringman, J. M., Goldstein, L. S., Wagner, S. L., & Yuan, S. H. | 2014-12-01 |
| Blood will out: vascular contributions to Alzheimer’s disease, Journal of Clinical Investigation | Strickland S. | 2018-02-01 |
| A critical role for plasminogen in inflammation, Journal of Experimental Medicine | Baker, S. K., & Strickland, S. | 2020-03-11 |
| The Alzheimer’s disease peptide beta-amyloid promotes thrombin generation through activation of coagulation factor XII, Journal of Thrombosis and Haemostasis | Zamolodchikov, D., Renné, T., & Strickland, S. | 2016-02-29 |
| Activation of the factor XII-driven contact system in Alzheimer’s disease patient and mouse model plasma, Proceedings of the National Academy of Sciences of the United States of America | Zamolodchikov, D., Chen, Z. L., Conti, B. A., Renné, T., & Strickland, S. | 2015-03-16 |
| Depletion of coagulation factor XII ameliorates brain pathology and cogntive impairment in Alzheimer disease mice, Blood | Chen, Z. L., Revenko, A. S., Singh, P., MacLeod, A. R., Norris, E. H., & Strickland, S. | 2017-05-04 |
| Abnormal clotting of the intrinsic contact pathway in Alzhiemer’s disease patients is related to cognitive ability, Blood Advances | Suidan, G. L., Singh, P. K., Patel-Hett, S., Chen, Z. L., Volfson, D., Yamamoto-Imoto, H., Norris, E. H., Bell, R. D., & Strickland, S. | 2018-04-26 |
| Anti-HK antibody reveals critical roles of a 20-residue HK region for Aβ-induced plasma contact system activation, Blood Advances | Chen, Z. L., Singh, P. K., Horn, K., Strickland, S., & Norris, E. H. | 2022-05-24 |
| Interactions of beta-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer’s disease, Current Opinion in Hematology | Ahn, H. J., Chen, Z. L., Zamolodchikov, D., Norris, E. H., & Strickland, S. | 2017-09-01 |
| Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits, Glia | Farfara, D., Feierman, E., Richards, A., Revenko, A. S., MacLeod, R. A., Norris, E. H., & Strickland, S. | 2019-03-18 |
| Increased Contact System Activation in Mild Cognitive Impairment Patients with Impaired Short-Term Memory, Journal of Alzheimer's Disease | Singh, P. K., Chen, Z. L., Strickland, S., & Norris, E. H. | 2020-09-01 |
| Plasminogen mediates communication between the peripheral and central immune system during systemic immune challenge with lipopolysaccharide, Journal of Neuroinflammation | Baker, S. K., Chen, Z. L., Norris, E. H., & Strickland, S. | 2019-08-28 |
| Increased plasma bradykinin level is associated with cognitive impairment in Alzheimer’s patients, Neurobiology of Disease | Singh, P. K., Chen, Z. L., Ghosh, D., Strickland, S., & Norris, E. H. | 2020-03-12 |
| Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides, Angewandte Chemie (International ed. in English) | Meier, M., Kennedy-Darling, J., Choi, S. H., Norstrom, E. M., Sisodia, S. S., & Ismagilov, R. F. | 2009-01-30 |
| Regulation of hippocampal progenitor cell survival, proliferation, and dendritic development by BDNF, Molecular Neurodegeneration | Choi, S. H., Li, Y., Parada, L. F., & Sisodia, S. S. | 2009-12-21 |
| Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia, Cell Reports | Ruan, Z., Takamatsu-Yukawa, K., Wang, Y., Ushman, M. L., Labadorf, A. T., Ericsson, M., Ikezu, S., & Ikezu, T. | 2022-05-10 |
| Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications, Journal of Extracellular Vesicles | Zhang, Z., Yu, K., You, Y., Jiang, P., Wu, Z., DeTure, M. A., Dickson, D. W., Ikezu, S., Peng, J., & Ikezu, T. | 2023-08-10 |
| Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia, Acta Neuropathologica Communications | Shi, H., Yin, Z., Koronyo, Y., Fuchs, D. T., Sheyn, J., Davis, M. R., Wilson, J. W., Margeta, M. A., Pitts, K. M., Herron, S., Ikezu, S., Ikezu, T., Graham, S. L., Gupta, V. K., Black, K. L., Mirzaei, M., Butovsky, O., & Koronyo-Hamaoui, M. | 2022-09-08 |
| Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease, Nature Neuroscience | Yin, Z., Herron, S., Silveira, S., Kleemann, K., ... Ikezu, S., Ikezu, T., Butovsky, O. | 2023-06-08 |
| Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation, Neuron | Choi, S. H., Veeraraghavalu, K., Lazarov, O., Marler, S., Ransohoff, R. M., Ramirez, J. M., & Sisodia, S. S. | 2008-08-28 |
| Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells., Proceedings of the National Academy of Sciences of the United States of America | Veeraraghavalu, K., & Sisodia, S. S. | 2013-05-14 |
| DNA-based fluorescent probes of NOS2 activity in live brains, Proceedings of the National Academy of Sciences of the United States of America | Veetil, A. T., Zou, J., Henderson, K. W., Jani, M. S., Shaik, S. M., Sisodia, S. S., Hale, M. E., & Krishnan, Y. | 2020-06-17 |
| Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer’s transgenic mice, Scientific Reports | Dodiya, H. B., Frith, M., Sidebottom, A., Cao, Y., Koval, J., Chang, E., & Sisodia, S. S. | 2020-05-18 |
| Activation and intrinsic gamma-secretase activity of presenilin 1, Proceedings of the National Academy of Sciences of the United States of America | Ahn, K., Shelton, C. C., Tian, Y., Zhang, X., Gilchrist, M. L., Sisodia, S. S., & Li, Y. M. | 2010-11-29 |
| Generation of iPSC lines from archived non-cryoprotected biobanked dura mater, Acta Neuropathologica Communications | Sproul, A. A., Vensand, L. B., Dusenberry, C. R., Jacob, S., Vonsattel, J. P., Paull, D. J., Shelanski, M. L., Crary, J. F., & Noggle, S. A. | 2014-01-07 |
| Characterization of a subpopulation of developing cortical interneuons from human iPSCs within serum-free embryoid bodies, American Journal of Physiology-Cell Physiology | Nestor, M. W., Jacob, S., Sun, B., Prè, D., Sproul, A. A., Hong, S. I., Woodard, C., Zimmer, M., Chinchalongporn, V., Arancio, O., & Noggle, S. A. | 2014-11-12 |
| A time course analysis of the electrophysiological properties of neurons differentiated from human induced pluripotent stem cells (iPSCs), PLoS One | Prè, D., Nestor, M. W., Sproul, A. A., Jacob, S., Koppensteiner, P., Chinchalongporn, V., Zimmer, M., Yamamoto, A., Noggle, S. A., & Arancio, O. | 2014-07-29 |
| Deficiency of TYROBP, an adaptor protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology, Acta Neuropathologica | Haure-Mirande, J. V., Audrain, M., Fanutza, T., Kim, S. H., Klein, W. L., Glabe, C., Readhead, B., Dudley, J. T., Blitzer, R. D., Wang, M., Zhang, B., Schadt, E. E., Gandy, S., & Ehrlich, M. E. | 2017-06-13 |
| Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces β-Amyloid Load in Males and Females, Cells | Pan, A. L., Audrain, M., Sakakibara, E., Joshi, R., Zhu, X., Wang, Q., Wang, M., Beckmann, N. D., Schadt, E. E., Gandy, S., Zhang, B., Ehrlich, M. E., & Salton, S. R. | 2022-12-01 |
| Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease, Nature Communications | Beckmann, N. D., Lin, W. J., Wang, M., … Gandy, S., Tu, Z., Ehrlich, M. E., Zhang, B., Schadt, E. E. | 2020-08-07 |
| VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice, Molecular Neurodegenration | El Gaamouch, F., Audrain, M., Lin, W. J., Beckmann, N., Jiang, C., Hariharan, S., Heeger, P. S., Schadt, E. E., Gandy, S., Ehrlich, M. E., & Salton, S. R. | 2020-01-10 |
| Characterization and molecular profiling of PSEN1 familial Alzheimer’s disease iPSC-derived neural progenitors, PLoS One | Sproul, A. A., Jacob, S., Pre, D., Kim, S. H., Nestor, M. W., Navarro-Sobrino, M., Santa-Maria, I., Zimmer, M., Aubry, S., Steele, J. W., Kahler, D. J., Dranovsky, A., Arancio, O., Crary, J. F., Gandy, S., & Noggle, S. A. | 2014-01-08 |
| Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes, Journal of Neuroscience | Lane, R. F., St George-Hyslop, P., Hempstead, B. L., Small, S. A., Strittmatter, S. M., & Gandy, S. | 2012-10-10 |
| Editorial: Multifaceted Interactions Between Immunity and the Diseased Brain, Frontiers in Cellular Neuroscience | Funk, K. E., Montagne, A., Falcao, A. M., & Da Mesquita, S. | 2022-06-08 |
| Charting the meningeal lymphatic network, Journal of Experimental Medicine | Da Mesquita S. | 2022-07-05 |
| Current views on meningeal lymphatics and immunity in aging and Alzheimer’s disease, Molecular Neurodegeneration | Rego, S., Sanchez, G., & Da Mesquita, S. | 2023-08-14 |
| Axonal Transport of APP and the spatial regulation of APP cleavage and function in neuronal cells, Experimental Brain Research | Brunholz, S., Sisodia, S., Lorenzo, A., Deyts, C., Kins, S., & Morfini, G. | 2011-09-30 |
| Microbial Immuno-Communication in Neurodegenerative Diseases, Frontiers in Neuroscience | Main, B. S., & Minter, M. R. | 2017-03-23 |
| Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone neuronal progenitors via cell-autonomous mechanisms involving Notch signaling, Journal of Neuroscience | Veeraraghavalu, K., Choi, S. H., Zhang, X., & Sisodia, S. S. | 2010-05-19 |
| A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2, Journal of Neuroscience | Zhang, X., Garbett, K., Veeraraghavalu, K., Wilburn, B., Gilmore, R., Mirnics, K., & Sisodia, S. S. | 2012-06-20 |
| Differential release of ss-Amyloid from Dendrite versus Axon-targeted APP, Journal of Neuroscience | DeBoer, S. R., Dolios, G., Wang, R., & Sisodia, S. S. | 2014-09-14 |
| Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation, and survival of adult hippocampal progenitors., Molecular Neurodegeneration | Veeraraghavalu, K., Choi, S. H., Zhang, X., & Sisodia, S. S. | 2013-10-20 |
| Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome, Molecular Neurodegeneration | Shaik, S. M., Cao, Y., Gogola, J. V., Dodiya, H. B., Zhang, X., Boutej, H., Han, W., Kriz, J., & Sisodia, S. S. | 2023-12-16 |
| Cell-targetable DNA nanocapsules for spatiotemporal release of caged bioactive small molecules, Nature Nanotechnology | Veetil, A. T., Chakraborty, K., Xiao, K., Minter, M. R., Sisodia, S. S., & Krishnan, Y. | 2017-08-21 |
| Heterogeneity of CNS Myeloid Cells and their roles in Neurodegeneration, Nature Neuroscience | Prinz, M., Priller, J., Sisodia, S. S., & Ransohoff, R. M. | 2011-09-27 |
| Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single cell imaging, Nature Neuroscience | Füger, P., Hefendehl, J. K., Veeraraghavalu, K., Wendeln, A. C., Schlosser, C., Obermüller, U., Wegenast-Braun, B. M., Neher, J. J., Martus, P., Kohsaka, S., Thunemann, M., Feil, R., Sisodia, S. S., Skodras, A., & Jucker, M. | 2017-08-28 |
| Open peer commentary on “Prescribing anti‐amyloid immunotherapies to treat Alzheimer’s disease: Fully informing patient decisions”, Alzheimer's & Dementia | Gandy S. | 2023-11-20 |
| Alzheimer’s disease: new data highlights nonneuronal cell types and the necessity for presymptomatic prevention strategies., Biological Psychiatry | Gandy S. | 2013-11-28 |
| Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast, Journal of Alzheimer's Disease | Bharadwaj, P. R., Verdile, G., Barr, R. K., Gupta, V., Steele, J. W., Lachenmayer, M. L., Yue, Z., Ehrlich, M. E., Petsko, G., Ju, S., Ringe, D., Sankovich, S. E., Caine, J. M., Macreadie, I. G., Gandy, S., & Martins, R. N. | 2012-11-14 |
| Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzhiemer’s amyloid beta peptide, Journal of Neuroscience | Lane, R. F., Steele, J. W., Cai, D., Ehrlich, M. E., Attie, A. D., & Gandy, S. | 2013-04-17 |
| A consecutive case series experience with [18 F] florbetapir PET imaging in an urban dementia center: impact on quality of life, decision making, and disposition, Molecular Neurodegeneration | Mitsis, E. M., Bender, H. A., Kostakoglu, L., Machac, J., Martin, J., Woehr, J. L., Sewell, M. C., Aloysi, A., Goldstein, M. A., Li, C., Sano, M., & Gandy, S. | 2014-02-03 |
| Chronic traumatic encephalopathy: clinical biomarker correlations and current concepts in pathogenesis, Molecular Neurodegeneration | Gandy, S., Ikonomovic, M. D., Mitsis, E., Elder, G., Ahlers, S. T., Barth, J., Stone, J. R., & DeKosky, S. T. | 2014-09-17 |
| News & views: anti-amyloid antibodies and novel emerging approaches to Alzheimer’s disease in 2023, Molecular Neurodegeneration | Gandy S. | 2023-09-25 |
| Latrepirdine stimulates autophagy and reduces accumulation of alpha-synuclein in cells and in mouse brain, Molecular Psychiatry | Steele, J. W., Ju, S., Lachenmayer, M. L., Liken, J., … Gandy, S. | 2012-08-07 |
| Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer’s mouse model, Molecular Psychiatry | Steele, J. W., Lachenmayer, M. L., … Gandy, S. | 2012-07-31 |
| Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer’s brain molecular pathology, Molecular Psychiatry | Readhead, B., Haure-Mirande, J. V., Zhang, B., Haroutunian, V., Gandy, S., Schadt, E. E., Dudley, J. T., & Ehrlich, M. E. | 2015-11-10 |
| Amyloid-beta Oligomers: Possible Roles as Key Neurotoxins in Alzheimer’s Disease, Mount Sinai Journal of Medicine | Lublin, A. L., & Gandy, S. | 2010-01-25 |
| Acute and traumatic encephalopathies: pathogenesis and biomarkers, Nature Reviews Neurology | DeKosky, S. T., Blennow, K., Ikonomovic, M. D., & Gandy, S. | 2013-04-01 |
| Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and severe head injury, Translational Psychiatry | Mitsis, E. M., Riggio, S., … Gandy, S. | 2014-09-16 |
| miR155, TREM2, INPP5D: Disease stage and cell type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy, Journal of Neuroinflammation | Gandy, S., & Ehrlich, M. E. | 2023-09-25 |
| Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer A beta oligomer mouse, Molecular Psychiatry | Kim, S. H., Steele, J. W., Lee, S. W., Clemenson, G. D., Carter, T. A., Treuner, K., Gadient, R., Wedel, P., Glabe, C., Barlow, C., Ehrlich, M. E., Gage, F. H., & Gandy, S. | 2014-08-12 |
| Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau, Molecular Psychiatry | Audrain, M., Haure-Mirande, J. V., Wang, M., Kim, S. H., Fanutza, T., Chakrabarty, P., Fraser, P., St George-Hyslop, P. H., Golde, T. E., Blitzer, R. D., Schadt, E. E., Zhang, B., Ehrlich, M. E., & Gandy, S. | 2018-10-03 |
| Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer’s disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels, Alzheimer's & Dementia | Ruiz, H. H., Chi, T., Shin, A. C., Lindtner, C., Hsieh, W., Ehrlich, M., Gandy, S., & Buettner, C. | 2016-02-28 |
| Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage, Journal of Experimental Medicine | Rustenhoven, J., Pavlou, G., Storck, S. E., Dykstra, T., Du, S., Wan, Z., Quintero, D., Scallan, J. P., Smirnov, I., Kamm, R. D., & Kipnis, J. | 2023-04-07 |
| Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-beta(42) in Alzheimer’s disease., Brain | Shinohara, M., Koga, S., Konno, T., Nix, J., Shinohara, M., Aoki, N., Das, P., Parisi, J. E., Petersen, R. C., Rosenberry, T. L., Dickson, D. W., & Bu, G. | 2017-11-17 |
| Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer’s disease, Alzheimer's & Dementia | Liu, C. C., Yamazaki, Y., Heckman, M. G., Martens, Y. A., Jia, L., Yamazaki, A., Diehl, N. N., Zhao, J., Zhao, N., DeTure, M., Davis, M. D., Felton, L. M., Qiao, W., Li, Y., Li, H., Fu, Y., Wang, N., Wren, M., Aikawa, T., Holm, M. L., Oue, H., Linares, C., Allen, M., Carrasquillo, M.M., Murray, M.E., Petersen, R.C., Ertekin-Taner, N., Dickson, D.W., Kanekiyo, T., Bu, G. | 2020-08-22 |
| Human sialoglycan ligands for immune inhibitory Siglecs, Molecular Aspects of Medicine | Gonzalez-Gil, A., Li, T. A., Kim, J., & Schnaar, R. L. | 2022-08-11 |
| Functional analysis of CX3CR1 in human induced pluripotent stem (iPS) cell-derived microglia-like cells, European Journal of Neuroscience | Murai, N., Mitalipova, M., & Jaenisch, R. | 2020-09-14 |
| Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain, Proceedings of the National Academy of Sciences of the United States of America | Svoboda, D. S., Barrasa, M. I., Shu, J., Rietjens, R., Zhang, S., Mitalipova, M., Berube, P., Fu, D., Shultz, L. D., Bell, G. W., & Jaenisch, R. | 2019-11-26 |
| Targeting the beta secretase BACE1 for Alzheimer’s disease therapy, Lancet Neurology | Yan, R., & Vassar, R. | 2014-02-17 |
| Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer’s disease, Neuroscience & Behavioral Reviews | Yan, R., Fan, Q., Zhou, J., & Vassar, R. | 2016-04-01 |
| Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects, Journal of Neurochemistry | Vassar, R., Kuhn, P. H., Haass, C., Kennedy, M. E., Rajendran, L., Wong, P. C., & Lichtenthaler, S. F. | 2014-04-19 |
| Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased amyloid beta generation in Alzheimer’s disease, Acta Neuropathologica | Sadleir, K. R., Kandalepas, P. C., Buggia-Prévot, V., Nicholson, D. A., Thinakaran, G., & Vassar, R. | 2016-03-18 |
| Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase, Molecular Neurodegeneration | Buggia-Prévot, V., Fernandez, C. G., Riordan, S., Vetrivel, K. S., Roseman, J., Waters, J., Bindokas, V. P., Vassar, R., & Thinakaran, G. | 2014-01-04 |
| A function for EHD family proteins in unidirectional retrograde dendritic transprt of BACE1 and Alzheimer’s disease Ab production, Cell Reports | Buggia-Prévot, V., Fernandez, C. G., Udayar, V., Vetrivel, K. S., Elie, A., Roseman, J., Sasse, V. A., Lefkow, M., Meckler, X., Bhattacharyya, S., George, M., Kar, S., Bindokas, V. P., Parent, A. T., Rajendran, L., Band, H., Vassar, R., & Thinakaran, G. | 2013-12-26 |
| Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity, Molecular Neurodegeneration | Upadhyay, A., Chhangani, D., Rao, N. R., Kofler, J., Vassar, R., Rincon-Limas, D. E., & Savas, J. N. | 2023-09-14 |
| Aberrant glial activation and synaptic defects in CaMKIIα-iCre and nestin-Cre transgenic mouse models, Scientific Reports | Alia, A. O., Jeon, S., Popovic, J., Salvo, M. A., Sadleir, K. R., Vassar, R., & Cuddy, L. K. | 2022-12-21 |
| The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease, Nature | Hur, J. Y., Frost, G. R., Wu, X., Crump, C., Pan, S. J., Wong, E., … Vassar, R., … Greengard, P., ... Li, Y. M. | 2020-09-02 |
| Synapto-depressive effects of amyloid beta require PICK1, European Journal of Neuroscience | Alfonso, S., Kessels, H. W., Banos, C. C., Chan, T. R., Lin, E. T., Kumaravel, G., Scannevin, R. H., Rhodes, K. J., Huganir, R., Guckian, K. M., Dunah, A. W., & Malinow, R. | 2014-04-08 |
| Cellular Pharmacology of Protein Kinase M zeta (PKM zeta) Contrasts with Its in Vitro Profile IMPLICATIONS FOR PKM zeta AS A MEDIATOR OF MEMORY, Journal of Biological Chemistry | Wu-Zhang, A. X., Schramm, C. L., Nabavi, S., Malinow, R., & Newton, A. C. | 2012-02-29 |
| Engineering a memory with LTD and LTP, Nature | Nabavi, S., Fox, R., Proulx, C. D., Lin, J. Y., Tsien, R. Y., & Malinow, R. | 2014-06-01 |
| Metabotropic NMDA receptor function is required for beta-amyloid-induced synaptic depression, Proceedings of the National Academy of Sciences of the United States of America | Kessels, H. W., Nabavi, S., & Malinow, R. | 2012-02-19 |
| Amyloid beta from axons and dendrites reduces local spine number and plasticity, Nature Neuroscience | Wei, W., Nguyen, L. N., Kessels, H. W., Hagiwara, H., Sisodia, S., & Malinow, R. | 2009-12-27 |
| In vitro microfluidic models for neurodegenerative disorders, Advanced Healthcare Materials | Osaki, T., Shin, Y., Sivathanu, V., Campisi, M., & Kamm, R. D. | 2017-09-07 |
| 3D Self-Organized microvasclar model of the human blood-brain barrier with endothelial cells, pericytes, and astrocytes, Biomaterials | Campisi, M., Shin, Y., Osaki, T., Hajal, C., Chiono, V., & Kamm, R. D. | 2018-07-12 |
| Microphysiological models of neurological disorders for drug development, Current Opinion in Biomedical Engineering | Offeddu, G. S., Shin, Y., Kamm, R. D. | 2020-03-01 |
| 3D Self-Organized Human Blood-Brain Barrier in a Microfluidic Chip, Methods in Molecular Biology | Campisi, M., Lim, S. H., Chiono, V., & Kamm, R. D. | 2020-12-20 |
| Engineered human blood-brain barrier microfluidic model for vascular permeability analyses, Nature Protocols | Hajal, C., Offeddu, G. S., Shin, Y., Zhang, S., Morozova, O., Hickman, D., Knutson, C. G., & Kamm, R. D. | 2022-01-07 |
| The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain, Science Advances | Hajal, C., Shin, Y., Li, L., Serrano, J. C., Jacks, T., & Kamm, R. D. | 2021-06-23 |
| Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes, Neuron | Pulido, R. S., Munji, R. N., Chan, T. C., Quirk, C. R., Weiner, G. A., Weger, B. D., Rossi, M. J., Elmsaouri, S., Malfavon, M., Deng, A., Profaci, C. P., Blanchette, M., Qian, T., Foreman, K. L., Shusta, E. V., Gorman, M. R., Gachon, F., Leutgeb, S., & Daneman, R. | 2020-09-25 |
| Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies, Brain | Young, A. L., Vogel, J. W., Robinson, J. L., McMillan, C. T., Ossenkoppele, R., Wolk, D. A., Irwin, D. J., Elman, L., Grossman, M., Lee, V. M., Lee, E. B., & Hansson, O. | 2023-05-08 |
| The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling, Journal of Biological Chemistry | Gayen, M., Benoit, M. R., Fan, Q., Hudobenko, J., & Yan, R. | 2022-09-24 |
| BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides, Molecular Neurodegeneration | Zhou, J., Singh, N., Galske, J., Hudobenko, J., Hu, X., & Yan, R. | 2023-05-04 |
| BACE1 controls synaptic function through modulating release of synaptic vesicles, Molecular Psychiatry | Das, B., Singh, N., Yao, A. Y., Zhou, J., He, W., Hu, X., & Yan, R. | 2021-06-22 |
| Exploration of C-terminal CX3CL1 for reducing age-dependent neurodegeneration, Neural Regeneration Research | Hudobenko, J., Gayen, M., Benoit, M. R., Singh, N., & Yan, R. | 2023-04-20 |
| Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance, Science Advances | Singh, N., Das, B., Zhou, J., Hu, X., & Yan, R. | 2022-07-20 |
| The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer’s amyloid pathology, Journal of Experimental Medicine | Fan, Q., Gayen, M., Singh, N., Gao, F., He, W., Hu, X., Tsai, L. H., & Yan, R. | 2019-06-17 |
| Evoked Cortical Depolarizations Before and After the Amyloid Plaque Accumulation: Voltage Imaging Study, Journal of Alzheimer's Disease | Zhu, M. H., Jogdand, A. H., Jang, J., Nagella, S. C., Das, B., Milosevic, M. M., Yan, R., & Antic, S. D. | 2022-07-04 |
| The Retromer supports AMPA Receptor Trafficking During LTP, Neuron | Temkin, P., Morishita, W., Goswami, D., Arendt, K., Chen, L., & Malenka, R. | 2017-04-05 |
| ACAT Inhibition and amyloid beta reduction, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids | Bhattacharyya, R., & Kovacs, D. M. | 2010-08-01 |
| Palmitoylation of Amyloid Precursor Protein regulates amyloidogenic processing in lipid rafts, Journal of Neuroscience | Bhattacharyya, R., Barren, C., & Kovacs, D. M. | 2013-07-03 |
| Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway, The FASEB Journal | Huttunen, H. J., Peach, C., Bhattacharyya, R., Barren, C., Pettingell, W., Hutter-Paier, B., Windisch, M., Berezovska, O., & Kovacs, D. M. | 2009-07-22 |
| In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues, EMBO Molecular Medicine | Young, L. E. A., Conroy, L. R., Clarke, H. A., Hawkinson, T. R., Bolton, K. E., Sanders, W. C., Chang, J. E., Webb, M. B., Alilain, W. J., Vander Kooi, C. W., Drake, R. R., Andres, D. A., Badgett, T. C., Wagner, L. M., Allison, D. B., Sun, R. C., & Gentry, M. S. | 2022-09-05 |
| Gys1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model, Neurotherapeutics | Donohue, K. J., Fitzsimmons, B., Bruntz, R. C., Markussen, K. H., Young, L. E. A., Clarke, H. A., Coburn, P. T., Griffith, L. E., Sanders, W., Klier, J., Burke, S. N., Maurer, A. P., Minassian, B. A., Sun, R. C., Kordasiewisz, H. B., & Gentry, M. S. | 2023-09-12 |
| APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge, Cell Reports | Lee, S., Devanney, N. A., Golden, L. R., Smith, C. T., Schwartz, J. L., Walsh, A. E., Clarke, H. A., Goulding, D. S., Allenger, E. J., Morillo-Segovia, G., Friday, C. M., Gorman, A. A., Hawkinson, T. R., MacLean, S. M., Williams, H. C., Sun, R. C., Morganti, J. M., & Johnson, L. A. | 2023-03-03 |
| Data-driven models of dominantly-inherited Alzheimer’s disease progression, Brain | Oxtoby, N. P., Young, A. L., Cash, D. M., Benzinger, T. L. S., Fagan, A. M., Morris, J. C., Bateman, R. J., Fox, N. C., Schott, J. M., & Alexander, D. C. | 2018-03-22 |
| Single-subject grey matter network trajectories over the disease course of autosomal dominant Alzheimer’s disease, Brain Communications | Vermunt, L., Dicks, E., Wang, G., Dincer, A., Flores, S., Keefe, S. J., … Morris. J., C., … Bateman, R. J., ... Dominantly Inherited Alzheimer Network (DIAN) | 2020-07-15 |
| Tau Positron Emission Tomography in Autosomal Dominant Alzheimer Disease Small Windows, Big Picture, JAMA Neurology | McDade, E., & Bateman, R. J. | 2018-05-01 |
| SILK Studies – Capturing the Turnover of Proteins Linked to Neurodegenerative Diseases, Nature Reviews Neurology | Paterson, R. W., Gabelle, A., Lucey, B. P., Barthélemy, N. R., Leckey, C. A., Hirtz, C., Lehmann, S., Sato, C., Patterson, B. W., West, T., Yarasheski, K., Rohrer, J. D., Wildburger, N. C., Schott, J. M., Karch, C. M., Wray, S., Miller, T. M., Elbert, D. L., Zetterberg, H., Fox, N. C., … Bateman, R. J. | 2019-06-20 |
| The case for low-level BACE1 inhibition for the prevention of Alzheimer disease, Nature Reviews Neurology | McDade, E., Voytyuk, I., Aisen, P., Bateman, R. J., Carrillo, M. C., De Strooper, B., Haass, C., Reiman, E. M., Sperling, R., Tariot, P. N., Yan, R., Masters, C. L., Vassar, R., & Lichtenthaler, S. F. | 2021-09-21 |
| Amyloid beta dynamics are regulated by orexin and the sleep wake cycle, Science | Kang, J. E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. | 2009-11-13 |
| Disruption of the sleep-wake cycle and diurnal fluctuations of amyloid-beta in mice with Alzheimer’s disease pathology, Science Translational Medicine | Roh, J. H., Huang, Y., Bero, A. W., Kasten, T., Stewart, F. R., Bateman, R. J., & Holtzman, D. M. | 2012-09-05 |
| Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid, Nature | Drieu, A., Du, S., Storck, S. E., Rustenhoven, J., Papadopoulos, Z., Dykstra, T., Zhong, F., Kim, K., Blackburn, S., Mamuladze, T., Harari, O., Karch, C. M., Bateman, R. J., Perrin, R., Farlow, M., Chhatwal, J., Dominantly Inherited Alzheimer Network, Hu, S., Randolph, G. J., Smirnov, I., … Kipnis, J. | 2022-11-09 |
| The structure of amyloid-β dimers in Alzheimer’s disease brain: a step forward for oligomers, Brain | Bateman, R. J., Mawuenyega, K. G., & Wildburger, N. C. | 2019-04-29 |
| Synaptic proteostasis in Parkinson’s disease, Current Opinion in Neurobiology | Nachman, E., & Verstreken, P. | 2022-02-01 |
| Presynaptic Autophagy and the Connection With Neurotransmission, Frontiers in Cell and Developmental Biology | Decet, M., & Verstreken, P. | 2021-12-17 |
| Reduced levels of the tyrosine phosphatase STEP block beta-amyloid-mediated GluA1/GluA2 receptor internalization, Journal of Neurochemistry | Zhang, Y., Kurup, P., Xu, J., Anderson, G. M., Greengard, P., Nairn, A. C., & Lombroso, P. J. | 2011-09-21 |
| A beta-mediated NMDA receptor endocytosis in Alzheimer’s disease involves ubiquitination of the tyrosine phosphatase STEP61, Journal of Neuroscience | Kurup, P., Zhang, Y., Xu, J., Venkitaramani, D. V., Haroutunian, V., Greengard, P., Nairn, A. C., & Lombroso, P. J. | 2010-04-28 |
| A functional mouse retroposed gene Rps23r1 reduces Alzhiemer’s beta amyloid levels and tau phosphorylation, Neuron | Zhang, Y. W., Liu, S., Zhang, X., Li, W. B., Chen, Y., Huang, X., Sun, L., Luo, W., Netzer, W. J., Threadgill, R., Wiegand, G., Wang, R., Cohen, S. N., Greengard, P., Liao, F. F., Li, L., & Xu, H. | 2009-11-12 |
| CDK5 is essential for adult hippocampal neurogenesis, Proceedings of the National Academy of Sciences of the United States of America | Lagace, D. C., Benavides, D. R., Kansy, J. W., Mapelli, M., Greengard, P., Bibb, J. A., & Eisch, A. J. | 2008-11-18 |
| Gleevec shifts APP processing from a beta-cleavage to a nonamyloidogenic cleavage, Proceedings of the National Academy of Sciences of the United States of America | Netzer, W. J., Bettayeb, K., Sinha, S. C., Flajolet, M., Greengard, P., & Bustos, V. | 2017-01-23 |
| δ-COP modulates Aβ peptide formation via retrograde trafficking of APP, Proceedings of the National Academy of Sciences of the United States of America | Bettayeb, K., Chang, J. C., Luo, W., Aryal, S., Varotsis, D., Randolph, L., Netzer, W. J., Greengard, P., & Flajolet, M. | 2016-04-25 |
| Three-dimensional study of Alzheimer’s disease hallmarks using iDISCO clearing method, Cell Reports | Liebmann, T., Renier, N., Bettayeb, K., Greengard, P., Tessier-Lavigne, M., & Flajolet, M. | 2016-07-14 |
| Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development, PLoS One | Ledo, J. H., Zhang, R., Mesin, L., Mourão-Sá, D., Azevedo, E. P., Troyanskaya, O. G., Bustos, V., & Greengard, P. | 2020-08-21 |
| C99 selectively accumulates in vulnerable neurons in Alzheimer’s disease, Alzheimer's & Dementia | Pulina, M. V., Hopkins, M., Haroutunian, V., Greengard, P., & Bustos, V. | 2020-01-06 |
| Short-term treatment with dabigatran alters protein expression patterns in a late-stage tau-based Alzheimer’s disease mouse model, Biochemistry and Biophysics Reports | Iannucci, J., Johnson, S. L., Majchrzak, M., Barlock, B. J., Akhlaghi, F., Seeram, N. P., Sen, A., & Grammas, P. | 2020-11-19 |
| High Glucose and Hypoxia-Mediated Damage to Human Brain Microvessel Endothelial Cells Induces an Altered, Pro-Inflammatory Phenotype in BV-2 Microglia In Vitro, Cellular and Molecular Neurobiology | Iannucci, J., Rao, H. V., & Grammas, P. | 2020-11-02 |
| Dabigatran reduces thrombin-induced neuroinflammation and AD markers in vitro: Therapeutic relevance for Alzheimer’s disease, Cerebral Circulation - Cognition and Behavior | Bihaqi, S. W., Rao, H. V., Sen, A., & Grammas, P. | 2021-05-06 |
| Isoform-Specific Effects of Apolipoprotein E on Markers of Inflammation and Toxicity in Brain Glia and Neuronal Cells In Vitro, Current Issues in Molecular Biology | Iannucci, J., Sen, A., & Grammas, P. | 2021-05-27 |
| Thrombin, a Mediator of Coagulation, Inflammation, and Neurotoxicity at the Neurovascular Interface: Implications for Alzheimer’s Disease, Frontiers in Neuroscience | Iannucci, J., Renehan, W., & Grammas, P. | 2020-07-24 |
| Sex Differences in Metabolic Indices and Chronic Neuroinflammation in Response to Prolonged High-Fat Diet in ApoE4 Knock-In Mice, International Journal of Molecular Sciences | Mattar, J. M., Majchrzak, M., Iannucci, J., Bartman, S., Robinson, J. K., & Grammas, P. | 2022-04-01 |
| Thrombin Signaling Contributes to High Glucose-Induced Injury of Human Brain Microvascular Endothelial Cells., Journal of Alzheimer's disease | Vittal Rao, H., Bihaqi, S. W., Iannucci, J., Sen, A., & Grammas, P. | 2021-01-05 |
| Genome-Wide Association Study of Alzheimer’s Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery Dataset, Frontiers in Aging Neuroscience | Homann, J., Osburg, T., Ohlei, O., Dobricic, V., Deecke, L., Bos, I., Vandenberghe, R., Gabel, S., Scheltens, P., Teunissen, C. E., Engelborghs, S., Frisoni, G., Blin, O., Richardson, J. C., Bordet, R., Lleó, A., Alcolea, D., Popp, J., Clark, C., Peyratout, G., Martinez-Lage, P., Tainta, M., Dobson, R.J.B., Legido-Quigley, C., Sleegers, K., Van Broeckhoven, C., Wittig, M., Franke, A., Lill, C.M., Blennow, K., Zetterberg, H., Lovestone, S., Streffer, J., Kate, M., Vos, S. J. B., Barkhof, F., Visser, P. J., & Bertram, L. | 2022-03-21 |
| Combined Connectomics, MAPT Gene Expression, and Amyloid Deposition to Explain Regional Tau Deposition in Alzheimer Disease, Annals of Neurology | Zheng, L., Rubinski, A., Denecke, J., Luan, Y., Smith, R., Strandberg, O., Stomrud, E., Ossenkoppele, R., Svaldi, D. O., Higgins, I. A., Shcherbinin, S., Pontecorvo, M. J., Hansson, O., Franzmeier, N., Ewers, M., & Alzheimer's Disease Neuroimaging Initiative | 2023-10-14 |
| Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis, Brain | Bocancea, D. I., Svenningsson, A. L., van Loenhoud, A. C., Groot, C., Barkhof, F., Strandberg, O., Smith, R., Alzheimer’s Disease Neuroimaging Initiative, La Joie, R., Rosen, H. J., Pontecorvo, M. J., Rabinovici, G. D., van der Flier, W. M., Hansson, O., & Ossenkoppele, R. | 2023-03-27 |
| Interactions between vascular burden and amyloid-β pathology on trajectories of tau accumulation, Brain | Coomans, E. M., van Westen, D., Pichet Binette, A., Strandberg, O., Spotorno, N., Serrano, G. E., Beach, T. G., Palmqvist, S., Stomrud, E., Ossenkoppele, R., & Hansson, O. | 2023-09-18 |
| Mitochondrial Ca2+ Signaling and Bioenergetics in Alzheimer’s Disease, Biomedicines | Arnst, N., Redolfi, N., Lia, A., Bedetta, M., Greotti, E., & Pizzo, P. | 2022-11-24 |
| Mitochondrial Ca2+ signaling and Alzheimer’s disease: Too much or too little?, Cell Calcium | Garcia-Casas, P., Rossini, M., Filadi, R., & Pizzo, P. | 2023-05-11 |
| Key Signalling Molecules in Aging and Neurodegeneration, Cells | Filadi, R., & Pizzo, P. | 2022-02-28 |
| Microglia signatures and their role in health and disease, Nature Reviews Neuroscience | Butovsky, O., & Weiner, H. L. | 2018-09-11 |
| TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury, EMBO Reports | Mazaheri, F., Snaidero, N., Kleinberger, G., Madore, C., Daria, A., Werner, G., Krasemann, S., Capell, A., Trümbach, D., Wurst, W., Brunner, B., Bultmann, S., Tahirovic, S., Kerschensteiner, M., Misgeld, T., Butovsky, O., & Haass, C. | 2017-05-08 |
| The TREM2-APOE Pathway drives the transcriptional phenotype of dysfunctional microglia in Neurodegenerative Diseases, Immunity | Krasemann, S., Madore, C., Cialic, R., Baufeld, C., ... Ulrich, J. D., … Lemere, C., Ikezu, T., ... Holtzman, D. M. … Haass, C., Butovsky, O. | 2017-09-19 |
| Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia, Neuron | Wang, C., Xiong, M., Gratuze, M., Bao, X., Shi, Y., Andhey, P. S., Manis, M., Schroeder, C., Yin, Z., Madore, C., Butovsky, O., Artyomov, M., Ulrich, J. D., & Holtzman, D. M. | 2021-04-07 |
| Sex-specific effects of microbiome perturbations on cerebral amyloid beta amyloidosis and microglia phenotypes, Journal of Experimental Medicine | Dodiya, H. B., Kuntz, T., Shaik, S. M., Baufeld, C., Leibowitz, J., Zhang, X., Gottel, N., Zhang, X., Butovsky, O., Gilbert, J. A., & Sisodia, S. S. | 2019-05-16 |
| Higher plasma beta-synuclein indicates early synaptic degeneration in Alzheimer’s disease, Alzheimer's & Dementia | Oeckl, P., Janelidze, S., Halbgebauer, S., Stomrud, E., Palmqvist, S., Otto, M., & Hansson, O. | 2023-04-27 |
| Age-related and amyloid-beta-independent tau deposition and its downstream effects, Brain | Wuestefeld, A., Pichet Binette, A., Berron, D., Spotorno, N., van Westen, D., Stomrud, E., Mattsson-Carlgren, N., Str|berg, O., Smith, R., Palmqvist, S., Glenn, T., Moes, S., Honer, M., Arfanakis, K., Barnes, L. L., Bennett, D. A., Schneider, J. A., Wisse, L. E. M., & Hansson, O. | 2023-04-21 |
| Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer’s disease, Brain | Spotorno, N., Strandberg, O., Stomrud, E., Janelidze, S., Blennow, K., Nilsson, M., van Westen, D., & Hansson, O. | 2023-12-21 |
| Anterior cingulate sulcation is associated with onset and survival in frontotemporal dementia, Brain Communications | Harper, L., de Boer, S., Lindberg, O., Lätt, J., Cullen, N., Clark, L., Irwin, D., Massimo, L., Grossman, M., Hansson, O., Pijnenburg, Y., McMillan, C. T., & Santillo, A. F. | 2023-10-10 |
| MRI BrainAGE demonstrates increased brain aging in systemic lupus erythematosus patients, Frontiers in Aging Neuroscience | Kuchcinski, G., Rumetshofer, T., Zervides, K. A., Lopes, R., Gautherot, M., Pruvo, J. P., Bengtsson, A. A., Hansson, O., Jönsen, A., & Sundgren, P. C. M. | 2023-10-20 |
| Plasma IAPP-Autoantibody Levels in Alzheimer’s Disease Patients Are Affected by APOE4 Status, International Journal of Molecular Sciences | Pocevičiūtė, D., Roth, B., Schultz, N., Nuñez-Diaz, C., Janelidze, S., The Netherl|s Brain Bank, Olofsson, A., Hansson, O., & Wennström, M. | 2023-02-14 |
| A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases, Nature Aging | Brum, W. S., Cullen, N. C., Janelidze, S., Ashton, N. J., Zimmer, E. R., Therriault, J., Benedet, A. L., Rahmouni, N., Tissot, C., Stevenson, J., Servaes, S., Triana-Baltzer, G., Kolb, H. C., Palmqvist, S., Stomrud, E., Rosa-Neto, P., Blennow, K., & Hansson, O. | 2023-08-31 |
| DOPA decarboxylase is an emerging biomarker for Parkinsonian disorders including preclinical Lewy body disease, Nature Aging | Pereira, J. B., Kumar, A., Hall, S., Palmqvist, S., Stomrud, E., Bali, D., Parchi, P., Mattsson-Carlgren, N., Janelidze, S., & Hansson, O. | 2023-09-18 |
| The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases, Nature Communications | Smith, R., Capotosti, F., Schain, M., Ohlsson, … Hansson, O. | 2023-10-27 |
| Cognitive effects of Lewy body pathology in clinically unimpaired individuals, Nature Medicine | Palmqvist, S., Rossi, M., Hall, S., Quadalti, C., Mattsson-Carlgren, N., Dellavalle, S., Tideman, P., Pereira, J. B., Nilsson, M. H., Mammana, A., Janelidze, S., Baiardi, S., Stomrud, E., Parchi, P., & Hansson, O. | 2023-07-18 |
| Clinical effects of Lewy body pathology in cognitively impaired individuals, Nature Medicine | Quadalti, C., Palmqvist, S., Hall, S., Rossi, M., Mammana, A., Janelidze, S., Dellavalle, S., Mattsson-Carlgren, N., Baiardi, S., Stomrud, E., Hansson, O., & Parchi, P. | 2023-07-18 |
| Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau, Molecular Psychiatry | Van Egroo, M., Riphagen, J. M., Ashton, N. J., Janelidze, S., Sperling, R. A., Johnson, K. A., Yang, H. S., Bennett, D. A., Blennow, K., Hansson, O., Zetterberg, H., & Jacobs, H. I. L. | 2023-04-05 |
| Blood biomarkers for Alzheimer’s disease in clinical practice and trials, Nature Aging | Hansson, O., Blennow, K., Zetterberg, H., & Dage, J. | 2023-05-18 |
| The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer’s disease: a literature review, Alzheimer's Research & Therapy | Brand, A. L., Lawler, P. E., Bollinger, J. G., Li, Y., Schindler, S. E., Li, M., Lopez, S., Ovod, V., Nakamura, A., Shaw, L. M., Zetterberg, H., Hansson, O., & Bateman, R. J. | 2022-12-27 |
| Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer’s amyloid beta (42) from isolated intact nerve terminals, Journal of Neuroscience | Kim, S. H., Fraser, P. E., Westaway, D., St George-Hyslop, P. H., Ehrlich, M. E., & Gandy, S. | 2010-03-17 |
| PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain, Science Translational Medicine | Schaler, A. W., Runyan, A. M., Clelland, C. L., Sydney, E. J., Fowler, S. L., Figueroa, H. Y., Shioda, S., Santa-Maria, I., Duff, K. E., & Myeku, N. | 2021-05-26 |
| Amyloid-beta levels are significantly reduced and spatial memory defects are rescued in a novel neuroserpin-deficient Alzhiemer’s disease transgenic mouse model, Journal of Neurochemistry | Fabbro, S., Schaller, K., & Seeds, N. W. | 2011-07-18 |
| Neuroserpin up-regulation in the Alzheimer’s disease brain is associated with elevated throid hormone receptor-beta 1 and HuD expression, Neurochemistry International | Subhadra, B., Schaller, K., & Seeds, N. W. | 2013-09-11 |
| Diversity of amyloid-beta proteoforms in the Alzheimer’s disease brain, Scientific Reports | Wildburger, N. C., Esparza, T. J., LeDuc, R. D., Fellers, R. T., Thomas, P. M., Cairns, N. J., Kelleher, N. L., Bateman, R. J., & Brody, D. L. | 2017-08-25 |
| Solble Amyloid-beta aggregates from human Alzheimr’s disease brains, Scientific Reports | Esparza, T. J., Wildburger, N. C., Jiang, H., Gangolli, M., Cairns, N. J., Bateman, R. J., & Brody, D. L. | 2016-12-05 |
| Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy, Acta Neuropathologica Communications | Kempthorne, L., Yoon, H., Madore, C., Smith, S., Wszolek, Z. K., Rademakers, R., Kim, J., Butovsky, O., & Dickson, D. W. | 2020-05-19 |
| Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder, Brain, Behavior, and Immunity | Guneykaya, D., Ugursu, B., Logiacco, F., Popp, O., Feiks, M. A., Meyer, N., Wendt, S., Semtner, M., Cherif, F., Gauthier, C., Madore, C., Yin, Z., Çınar, Ö., Arslan, T., Gerevich, Z., Mertins, P., Butovsky, O., Kettenmann, H., & Wolf, S. A. | 2023-03-29 |
| Sex-specific transcriptome of spinal microglia in neuropathic pain due to peripheral nerve injury, Glia | Fiore, N. T., Yin, Z., Guneykaya, D., Gauthier, C. D., Hayes, J. P., D'Hary, A., Butovsky, O., & Moalem-Taylor, G. | 2022-01-20 |
| Microglia, Lifestyle Stress, and Neurodegeneration, Immunity | Madore, C., Yin, Z., Leibowitz, J., & Butovsky, O. | 2020-01-07 |
| Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4., Investigative Ophtalmology & Visual Science | Margeta, M. A., Letcher, S. M., Igo, R. P., Jr, Cooke Bailey, J. N., Pasquale, L. R., Haines, J. L., Butovsky, O., Wiggs, J. L., & NEIGHBORHOOD consortium | 2020-07-01 |
| Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease, Journal of Clinical Investigation | Roy, E. R., Wang, B., Wan, Y. W., Chiu, G., Cole, A., Yin, Z., Propson, N. E., Xu, Y., Jankowsky, J. L., Liu, Z., Lee, V. M., Trojanowski, J. Q., Ginsberg, S. D., Butovsky, O., Zheng, H., & Cao, W. | 2020-03-09 |
| Differential contribution of microglia and monocytes in neurodegenerative diseases, Journal of Neural Transmission | Baufeld, C., O'Loughlin, E., Calcagno, N., Madore, C., & Butovsky, O. | 2017-10-23 |
| Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis, Immunity | Kiss, M. G., Mindur, J. E., Yates, A. G., … Nahrendorf, M., … Swirski, F.K. & McAlpine, C. S. | 2023-05-08 |
| Beyond the sleep-amyloid interactions in Alzheimer’s disease pathogenesis, Journal of Neurophysiology | Ning, S., & Jorfi, M. | 2019-03-13 |
| The interplay between microglial states and major risk factors in Alzheimer’s disease through the eyes of single-cell RNA sequencing: beyond black and white, Journal of Neurophysiology | von Maydell, D., & Jorfi, M. | 2019-08-31 |
| Designed inhibitors to reduce amyloid virulence and cytotoxicity and combat neurodegenerative and infectious diseases, Current Opinion in Chemical Biology | Indig, R. Y., & L|au, M. | 2023-05-15 |
| Differential fibril morphologies and thermostability determine functional roles of Staphylococcus aureus PSMα1 and PSMα3, Frontiers in Molecular Biosciences | Rayan, B., Barnea, E., Khokhlov, A., Upcher, A., & Landau, M. | 2023-07-04 |
| What can AlphaFold do for antimicrobial amyloids?, Proteins | Ragonis-Bachar, P., Axel, G., Blau, S., Ben-Tal, N., Kolodny, R., & Landau, M. | 2023-10-19 |
| Effective anti-Alzheimer A beta therapy involves depletion of specific A beta oligomer subtypes, Neurology Neuroimmunology & Neuroinflammation | Knight, E. M., Kim, S. H., Kottwitz, J. C., Hatami, A., Albay, R., Suzuki, A., Lublin, A., Alberini, C. M., Klein, W. L., Szabo, P., Relkin, N. R., Ehrlich, M., Glabe, C. G., Gandy, S., & Steele, J. W. | 2016-05-10 |
| Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer’s APP/PSEN1 mice by gene targeting of diabetes/Alzheimer’s-related Sorcs1, Acta Neuropathologica Communications | Knight, E. M., Ruiz, H. H., Kim, S. H., Harte, J. C., Hsieh, W., Glabe, C., Klein, W. L., Attie, A. D., Buettner, C., Ehrlich, M. E., & Gandy, S. | 2016-02-25 |
| Days to criterion as an indicator of toxicity associated with Human Alzheimer Amyloid-beta Oligomers, Annals of Neurology | Gandy, S., Simon, A. J., Steele, J. W., Lublin, A. L., Lah, J. J., Walker, L. C., Levey, A. I., Krafft, G. A., Levy, E., Checler, F., Glabe, C., Bilker, W. B., Abel, T., Schmeidler, J., & Ehrlich, M. E. | 2010-08-01 |
| Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2, Molecular Neurodegeneration | Haure-Mirande, J. V., Audrain, M., Ehrlich, M. E., & Gandy, S. | 2022-08-24 |
| Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden, Molecular Psychiatry | T., Kim, S. H., Heja, S., Readhead, B., Dudley, J. T., Blitzer, R. D., Schadt, E. E., Zhang, B., Gandy, S., & Ehrlich, M. E. | 2018-10-03 |
| Intranasal Peptide Therapeutics: A Promising Avenue for Overcoming the Challenges of Traditional CNS Drug Development, Cells | Bose, M., Farias Quipildor, G., Ehrlich, M. E., & Salton, S. R. | 2022-11-16 |
| Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo, Molecular Neurodegeneration | Steele, J. W., Kim, S. H., Cirrito, J. R., Verges, D. K., Restivo, J. L., Westaway, D., Fraser, P., Hyslop, P. S., Sano, M., Bezprozvanny, I., Ehrlich, M. E., Holtzman, D. M., & Gandy, S. | 2009-12-17 |
| Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism, Journal of Experimental Medicine | Song, W. M., Joshita, S., Zhou, Y., Ulland, T. K., Gilfillan, S., & Colonna, M. | 2018-01-10 |
| Brain Parenchymal and Extraparenchymal Macrophages in Development, Homeostasis, and Disease, Journal of Immunology | Brioschi, S., Zhou, Y., & Colonna, M. | 2020-01-15 |
| Microglia in Alzheimer’s Diseases: a target for immunotherapy, Journal of Leukocye Biology | Wang, S., & Colonna, M. | 2019-02-06 |
| Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia, Nature Immunology | Zhou, Y., Tada, M., Cai, Z., |hey, P. S., Swain, A., Miller, K. R., Gilfillan, S., Artyomov, M. N., Takao, M., Kakita, A., & Colonna, M. | 2023-01-19 |
| TREM2 variants: new keys to decipher Alzheimer disease pathogenesis, Nature Reviews Neuroscience | Colonna, M., & Wang, Y. | 2016-02-25 |
| Regulation of microglial survival and proliferation in health and disease, Seminars in Immunology | Ulland, T. K., Wang, Y., & Colonna, M. | 2015-03-28 |
| Fifty Shades of Microglia, Trends in Neurosciences | Brioschi, S., Peng, V., & Colonna, M. | 2019-04-18 |
| TREM2 maintains Microglial metabolic fitness in Alzheimer’s Disease, Cell | Ulland, T. K., Song, W. M., Huang, S. C., Ulrich, J. D., Sergushichev, A., Beatty, W. L., Loboda, A. A., Zhou, Y., Cairns, N. J., Kambal, A., Loginicheva, E., Gilfillan, S., Cella, M., Virgin, H. W., Unanue, E. R., Wang, Y., Artyomov, M. N., Holtzman, D. M., & Colonna, M. | 2017-08-10 |
| APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread, Cell | Chen, Y., Song, S., Parhizkar, S., Lord, J., Zhu, Y., Strickland, M. R., Wang, C., Park, J., Tabor, G. T., Jiang, H., Li, K., Davis, A. A., Yuede, C. M., Colonna, M., Ulrich, J. D., & Holtzman, D. M. | 2023-12-11 |
| Targeting innate immunity for neurodegenerative disorders of the central nervous system., Journal of Neurochemistry | Andreasson, K. I., Bachstetter, A. D., Colonna, M., Ginhoux, F., Holmes, C., Lamb, B., Landreth, G., Lee, D. C., Low, ... Town, T., … Colonna, M. , ... Van Eldik, L. J. | 2016-09-01 |
| Alzheimer’s disease: From immunotherapy to immunoprevention, Cell | Jucker, M., & Walker, L. C. | 2023-09-19 |
| Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer’s disease, Brain | Vöglein, J., Paumier, K., Jucker, M., Preische, O., McDade, E., Hassenstab, J., Benzinger, T. L., Noble, J. M., Berman, S. B., Graff-Radford, N. R., Ghetti, B., Farlow, M. R., Chhatwal, J., Salloway, S., Xiong, C., Karch, C. M., Cairns, N., Mori, H., Schofield, P. R., Masters, C. L., … Dominantly Inherited Alzheimer Network | 2019-03-20 |
| Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzhiemer’s disease and PART, Acta Neuropathologica | Kaufman, S. K., Del Tredici, K., Thomas, T. L., Braak, H., & Diamond, M. I. | 2018-05-11 |
| Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue, Acta Neuropathologica Communications | Kaufman, S. K., Thomas, T. L., Del Tredici, K., Braak, H., & Diamond, M. I. | 2017-06-07 |
| Anatomic survey of seeding in Alzheimer’s disease brains reveals unexpected patterns, Acta Neuropathologica Communications | Stopschinski, B. E., Del Tredici, K., Estill-Terpack, S. J., Ghebremdehin, E., Yu, F. F., Braak, H., & Diamond, M. I. | 2021-10-11 |
| Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus alpha synuclein and beta amyloid aggregates, Journal of Biological Chemistry | Stopschinski, B. E., Holmes, B. B., Miller, G. M., Manon, V. A., Vaquer-Alicea, J., Prueitt, W. L., Hsieh-Wilson, L. C., & Diamond, M. I. | 2018-07-06 |
| A synthetic heparinoid blocks Tau aggregate cell uptake and amplification, Journal of Biological Chemistry | Stopschinski, B. E., Thomas, T. L., Nadji, S., Darvish, E., Fan, L., Holmes, B. B., Modi, A. R., Finnell, J. G., Kashmer, O. M., Estill-Terpack, S., Mirbaha, H., Luu, H. S., & Diamond, M. I. | 2020-01-23 |
| The dual fates of exogenous tau seeds: lysosomal clearance vs. cytoplasmic amplification, Journal of Biological Chemistry | Kolay, S., Vega, A. R., Dodd, D. A., Perez, V. A., Kashmer, O. M., White, C. L., 3rd, & Diamond, M. I. | 2022-05-05 |
| Seed-competent tau monomer initiates pathology in a tauopathy mouse model, Journal of Biological Chemistry | Mirbaha, H., Chen, D., Mullapudi, V., Terpack, S. J., White, C. L., 3rd, Joachimiak, L. A., & Diamond, M. I. | 2022-06-22 |
| Tau prion strains dictate patterns of cell pathology, progression rate, and regional vulnerability in vivo, Neuron | Kaufman, S. K., Sanders, D. W., Thomas, T. L., Ruchinskas, A. J., Vaquer-Alicea, J., Sharma, A. M., Miller, T. M., & Diamond, M. I. | 2016-11-23 |
| Precise and Efficient Scarless genome editing in stem cells using CORRECT, Nature Protocols | Kwart, D., Paquet, D., Teo, S., & Tessier-Lavigne, M. (2017). Precise and efficient scarless ge | 2017-02-01 |
| Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9, Nature | Paquet, D., Kwart, D., Chen, A., Sproul, A., Jacob, S., Teo, S., Olsen, K. M., Gregg, A., Noggle, S., & Tessier-Lavigne, M. | 2016-04-27 |
| A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP beta-CTFs nto A beta, Neuron | Kwart, D., Gregg, A., Scheckel, C., Murphy, E. A., Paquet, D., Duffield, M., Fak, J., Olsen, O., Darnell, R. B., & Tessier-Lavigne, M. | 2019-08-12 |
| The microglia response to neurodegenerative disease, Advances in Immunology | Song, W. M., & Colonna, M. | 2018-05-09 |
| Disease-associated microglia: a universal immune sensor of neurodegeneration, Cell | Deczkowska, A., Keren-Shaul, H., Weiner, A., Colonna, M., Schwartz, M., & Amit, I. | 2018-05-17 |
| Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination, Cell Reports | Hou, J., Zhou, Y., Cai, Z., Terekhova, M., Swain, A., |hey, P. S., Guimaraes, R. M., Ulezko Antonova, A., Qiu, T., Sviben, S., Strout, G., Fitzpatrick, J. A. J., Chen, Y., Gilfillan, S., Kim, D. H., Van Dyken, S. J., Artyomov, M. N., & Colonna, M. | 2023-03-21 |
| Spontaneous and induced adaptive immune responses in Alzheimer’s disease: new insights into old observations, Current Opinion in Immunology | Chen, Y., & Colonna, M. | 2022-07-12 |
| TREM2-Dependent Effects on Microglia in Alzheimer’s Disease, Frontiers in Aging Neuroscience | Zhou, Y., Ulland, T. K., & Colonna, M. | 2018-07-09 |
| A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages, Immunity | Brioschi, S., Belk, J. A., Peng, V., Molgora, M., Rodrigues, P. F., Nguyen, K. M., Wang, S., Du, S., Wang, W. L., Grajales-Reyes, G. E., Ponce, J. M., Yuede, C. M., Li, Q., Baer, J. M., DeNardo, D. G., Gilfillan, S., Cella, M., Satpathy, A. T., & Colonna, M. | 2023-02-14 |
| TREM2 sustains microglial expansion during aging and response to demyelination, Journal of Clinical Investigation | Poliani, P. L., Wang, Y., Fontana, E., Robinette, M. L., Yamanishi, Y., Gilfillan, S., & Colonna, M. | 2015-04-20 |
| Anti-human TREM2 Induces Microglia Proliferation and Reduces Pathology in an Alzheimer’s Disease Model, Journal of Experimental Medicine | Wang, S., Mustafa, M., Yuede, C. M., Salazar, S. V., Kong, P., Long, H., Ward, M., Siddiqui, O., Paul, R., Gilfillan, S., Ibrahim, A., Rhinn, H., Tassi, I., Rosenthal, A., Schwabe, T., & Colonna, M. | 2020-06-24 |
| Sex-driven Modifiers of Alzheimer Risk: A Multimodality Brain Imaging Study, Neurology | Rahman, A., Schelbaum, E., Hoffman, K., Diaz, I., Hristov, H., Andrews, R., Jett, S., Jackson, H., Lee, A., Sarva, H., Pahlajani, S., Matthews, D., Dyke, J., de Leon, M. J., Isaacson, R. S., Brinton, R. D., & Mosconi, L. | 2020-06-24 |
| Association of Reproductive History With Brain MRI Biomarkers of Dementia Risk in Midlife, Neurology | Schelbaum, E., Loughlin, L., Jett, S., Zhang, C., Jang, G., Malviya, N., Hristov, H., Pahlajani, S., Isaacson, R., Dyke, J. P., Kamel, H., Brinton, R. D., & Mosconi, L. | 2021-11-03 |
| Increased Alzheimer’s Risk during the menopause transition: a 3-year longitudinal brain imaging study, PLoS One | Mosconi, L., Rahman, A., Diaz, I., Wu, X., Scheyer, O., Hristov, H. W., Vallabhajosula, S., Isaacson, R. S., de Leon, M. J., & Brinton, R. D. | 2018-12-12 |
| Effects of sex and APOE ε4 genotype on brain mitochondrial high-energy phosphates in midlife individuals at risk for Alzheimer’s disease: A 31Phosphorus MR spectroscopy study, PLoS One | Jett, S., Dyke, J. P., Boneu Yepez, C., Zarate, C., Carlton, C., Schelbaum, E., Jang, G., Pahlajani, S., Williams, S., Diaz Brinton, R., & Mosconi, L. | 2023-02-14 |
| Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition, Scientific Reports | Mosconi, L., Berti, V., Dyke, J., Schelbaum, E., Jett, S., Loughlin, L., Jang, G., Rahman, A., Hristov, H., Pahlajani, S., Andrews, R., Matthews, D., Etingin, O., Ganzer, C., de Leon, M., Isaacson, R., & Brinton, R. D. | 2021-06-09 |
| Sex and menopause impact 31P-Magnetic Resonance Spectroscopy brain mitochondrial function in association with 11C-PiB PET amyloid-beta load, Scientific Reports | Jett, S., Dyke, J. P., Andy, C., Schelbaum, E., Jang, G., Boneu Yepez, C., Pahlajani, S., Diaz, I., Diaz Brinton, R., & Mosconi, L. | 2022-12-21 |
| Age- and glaucoma-induced changes to the ocular glymphatic system, Neurobiology of Disease | Wang, X., Delle, C., Peng, W., Plá, V., Giannetto, M., Kusk, P., Sigurdsson, B., Sakurai, S., Sweeney, A., Sun, Q., Du, T., Libby, R. T., & Nedergaard, M. | 2023-10-12 |
| An Ocular Glymphatic Clearance System Removes β-Amyloid From the Rodent Eye, Science Translational Medicine | Wang, X., Lou, N., Eberhardt, A., Yang, Y., Kusk, P., Xu, Q., Förstera, B., Peng, S., Shi, M., Ladrón-de-Guevara, A., Delle, C., Sigurdsson, B., Xavier, A. L. R., Ertürk, A., Libby, R. T., Chen, L., Thrane, A. S., & Nedergaard, M. | 2020-03-25 |
| The glymphatic pathway in neurological disorders, The Lancet Neurology | Rasmussen, M. K., Mestre, H., & Nedergaard, M. | 2018-11-01 |
| Vascular dysfunction — The disregarded partner of Alzheimer’s disease, Alzheimer's & Dementia | Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., Jacobs, R. E., Doubal, F. N., Ramirez, J., Black, S. E., Nedergaard, M., Benveniste, H., Dichgans, M., Iadecola, C., Love, S., Bath, P. M., … Zlokovic, B. V. | 2019-01-01 |
| Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology, Cell | Mathys, H., Peng, Z., Boix, C. A., … Kellis, M. & Tsai, L. H. | 2023-09-28 |
| Epigenomic dissection of Alzheimer’s disease pinpoints causal variants and reveals epigenome erosion, Cell | Xiong, X., James, B. T., Boix, C. A., Park, Y. P., Galani, K., Victor, M. B., Sun, N., Hou, L., Ho, L. L., Mantero, J., Scannail, A. N., Dileep, V., Dong, W., Mathys, H., Bennett, D. A., Tsai, L. H., & Kellis, M. | 2023-09-28 |
| Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration, Cell | Dileep, V., Boix, C. A., Mathys, H., Marco, A., Welch, G. M., Meharena, H. S., Loon, A., Jeloka, R., Peng, Z., Bennett, D. A., Kellis, M., & Tsai, L. H. | 2023-09-28 |
| Human microglial state dynamics in Alzheimer’s disease progression, Cell | Sun, N., Victor, M. B., Park, Y. P., Xiong, X., Scannail, A. N., Leary, N., Prosper, S., Viswanathan, S., Luna, X., Boix, C. A., James, B. T., Tanigawa, Y., Galani, K., Mathys, H., Jiang, X., Ng, A. P., Bennett, D. A., Tsai, L. H., & Kellis, M. | 2023-09-28 |
| Single-Cell Transcriptomic Analysis of Alzheimer’s Disease, Nature | Mathys, H., Davila-Velderrain, J., Peng, Z., Gao, F., Mohammadi, S., Young, J. Z., Menon, M., He, L., Abdurrob, F., Jiang, X., Martorell, A. J., Ransohoff, R. M., Hafler, B. P., Bennett, D. A., Kellis, M., & Tsai, L. H. | 2019-05-01 |
| Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes, Nature Medicine | Blanchard, J. W., Bula, M., Davila-Velderrain, J., Akay, L. A., Zhu, L., Frank, A., Victor, M. B., Bonner, J. M., Mathys, H., Lin, Y. T., Ko, T., Bennett, D. A., Cam, H. P., Kellis, M., & Tsai, L. H. | 2020-06-08 |
| Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble, Nature Neuroscience | Marco, A., Meharena, H. S., Dileep, V., Raju, R. M., Davila-Velderrain, J., Zhang, A. L., Adaikkan, C., Young, J. Z., Gao, F., Kellis, M., & Tsai, L. H. | 2020-10-05 |
| MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration, Science Translational Medicine | Barker, S. J., Raju, R. M., Milman, N. E. P., Wang, J., Davila-Velderrain, J., Gunter-Rahman, F., Parro, C. C., Bozzelli, P. L., Abdurrob, F., Abdelaal, K., Bennett, D. A., Kellis, M., & Tsai, L. H. | 2021-11-03 |
| BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1, Science Advances | Singh, N., Benoit, M. R., Zhou, J., Das, B., Davila-Velderrain, J., Kellis, M., Tsai, L. H., Hu, X., & Yan, R. | 2022-06-17 |
| Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields, Cell | Grossman, N., Bono, D., Dedic, N., Kodandaramaiah, S. B., Rudenko, A., Suk, H. J., Cassara, A. M., Neufeld, E., Kuster, N., Tsai, L. H., Pascual-Leone, A., & Boyden, E. S. | 2017-06-01 |
| REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease, Cell Reports | Meyer, K., Feldman, H. M., Lu, T., Drake, D., Lim, E. T., Ling, K. H., Bishop, N. A., Pan, Y., Seo, J., Lin, Y. T., Su, S. C., Church, G. M., Tsai, L. H., & Yankner, B. A. | 2019-01-29 |
| Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity, Cell Stem Cell | Victor, M. B., Leary, N., Luna, X., Meharena, H. S., Scannail, A. N., Bozzelli, P. L., Samaan, G., Murdock, M. H., von Maydell, D., Effenberger, A. H., Cerit, O., Wen, H. L., Liu, L., Welch, G., Bonner, M., & Tsai, L. H. | 2022-08-04 |
| In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory, Current Opinion in Neurobiology | Watson, L. A., & Tsai, L. H. | 2017-12-23 |
| Three-dimensional chromatin organization in brain function and dysfunction, Current Opinion in Neurobiology | Dileep, V., & Tsai, L. H. | 2021-06-07 |
| Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function, Genes & Development | Akay, L. A., Effenberger, A. H., & Tsai, L. H. | 2021-02-01 |
| iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss, Glia | Penney, J., Ralvenius, W. T., Loon, A., Cerit, O., Dileep, V., Milo, B., Pao, P. C., Woolf, H., & Tsai, L. H. | 2023-11-15 |
| Modeling Alzheimer’s Disease With iPSC-derived Brain Cells, Molecular Psychiatry | Penney, J., Ralvenius, W. T., & Tsai, L. H. | 2019-08-07 |
| The road to restoring neural circuits for the treatment of Alzheiemer’s disease, Nature | Canter, R. G., Penney, J., & Tsai, L. H. | 2016-11-10 |
| Insights into Alzheimer’s disease from single-cell genomic approaches, Nature Neuroscience | Murdock, M. H., & Tsai, L. H. | 2023-01-02 |
| APOE4 causes widespread molecular and cellular alterations associated with Alzheimer’s disease phenotypes in human iPSC-derived brain cell types., Neuron | Lin, Y. T., Seo, J., Gao, F., Feldman, H. M., Wen, H. L., Penney, J., Cam, H. P., Gjoneska, E., Raja, W. K., Cheng, J., Rueda, R., Kritskiy, O., Abdurrob, F., Peng, Z., Milo, B., Yu, C. J., Elmsaouri, S., Dey, D., Ko, T., Yankner, B. A., … Tsai, L. H. | 2018-06-27 |
| Single-cell dissection of the human brain vasculature, Nature | Garcia, F. J., Sun, N., Lee, H., Godlewski, B., Mathys, H., Galani, K., Zhou, B., Jiang, X., Ng, A. P., Mantero, J., Tsai, L. H., Bennett, D. A., Sahin, M., Kellis, M., & Heiman, M. | 2022-02-14 |
| Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer’s disease., Nature Aging | Sun, N., Akay, L. A., Murdock, M. H., Park, Y., Galiana-Melendez, F., Bubnys, A., Galani, K., Mathys, H., Jiang, X., Ng, A. P., Bennett, D. A., Tsai, L. H., & Kellis, M. | 2023-06-01 |
| Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience, Nature Neuroscience | Udeochu, J. C., Amin, S., … Tsai, L. H., Subhash, S. C., & Gan, L. | 2023-04-24 |
| Sex and Gender Driven Modifiers of Alzheimer’s: The Role for Estrogenic Control Across Age, Race, Medical, and Lifestyle Risk, Frontiers in Aging Neuroscience | Rahman, A., Jackson, H., Hristov, H., Isaacson, R. S., Saif, N., Shetty, T., Etingin, O., Henchcliffe, C., Brinton, R. D., & Mosconi, L. | 2019-11-15 |
| Endogenous and Exogenous Estrogen Exposures: How Women’s Reproductive Health Can Drive Brain Aging and Inform Alzheimer’s Prevention, Frontiers in Aging Neuroscience | Jett, S., Malviya, N., Schelbaum, E., Jang, G., Jahan, E., Clancy, K., Hristov, H., Pahlajani, S., Niotis, K., Loeb-Zeitlin, S., Havryliuk, Y., Isaacson, R., Brinton, R. D., & Mosconi, L. | 2022-03-09 |
| Ovarian steroid hormones: A long overlooked but critical contributor to brain aging and Alzheimer’s disea, Frontiers in Aging Neuroscience | Jett, S., Schelbaum, E., Jang, G., Boneu Yepez, C., Dyke, J. P., Pahlajani, S., Diaz Brinton, R., & Mosconi, L. | 2022-07-19 |
| Vitamin D supplementation is associated with slower epigenetic aging, GeroScience | Vetter, V. M., Sommerer, Y., Kalies, C. H., Spira, D., Bertram, L., & Demuth, I. | 2022-05-13 |
| Common signatures of differential microRNA expression in Parkinson’s and Alzheimer’s disease brains, Brain Communications | Dobricic, V., Schilling, M., Farkas, I., Gveric, D. O., Ohlei, O., Schulz, J., Middleton, L., Gentleman, S. M., Parkkinen, L., Bertram, L., & Lill, C. M. | 2022-10-28 |
| The gut microbiota is an emerging target for improving brain health during ageing, Gut Microbiome | Boehme, M., Guzzetta, K. E., Wasén, C., & Cox, L. M. | 2022-12-12 |
| TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss, Neuron | Paolicelli, R. C., Jawaid, A., Henstridge, C. M., Valeri, A., Merlini, M., Robinson, J. L., Lee, E. B., Rose, J., Appel, S., Lee, V. M., Trojanowski, J. Q., Spires-Jones, T., Schulz, P. E., & Rajendran, L. | 2017-07-19 |
| The endolysosomal pathway and ALS/FTD, Trends in Neurosciences | Todd, T. W., Shao, W., Zhang, Y. J., & Petrucelli, L. | 2023-10-10 |
| Alzheimer’s Genetics in the GWAS Era: A Continuing Story of ‘Replications and Refutations’, Current Neurology and Neuroscience Reports | Bertram L. | 2011-03-30 |
| Distinguishing true from false positives in genomic studies: p values, European Journal of Epidemiology | Broer, L., Lill, C. M., Schuur, M., Amin, N., Roehr, J. T., Bertram, L., Ioannidis, J. P., & van Duijn, C. M. | 2013-02-01 |
| Systematic Analysis of Candidate Genes for Alzheimer’s Disease in a French, Genome-Wide Association Study, Journal of Alzheimer's Disease | Laumet, G., Chouraki, V., Grenier-Boley, B., Legry, V., Heath, S., Zelenika, D., Fievet, N., Hannequin, D., Delepine, M., Pasquier, F., Hanon, O., Brice, A., Epelbaum, J., Berr, C., Dartigues, J. F., Tzourio, C., Campion, D., Lathrop, M., Bertram, L., Amouyel, P., … Lambert, J. C. | 2010-06-13 |
| Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29,000 subjects, Journal of Medical Genetics | Lill, C. M., Liu, T., Schjeide, B. M., Roehr, J. T., Akkad, D. A., Damotte, V., Alcina, A., Ortiz, M. A., … Bertram, L., Zipp, F. | 2012-09-01 |
| Genome-wide significant associations of ANKRD55 rs6859219 and multiple sclerosis risk, Journal of Medical Genetics | Lill, C. M., Schjeide, B. M., Graetz, C., Liu, T., Damotte, V., Akkad, D. A., Blaschke, P., Gerdes, L. A., Kroner, A., Luessi, F., Cournu-Rebeix, I., Hoffjan, S., Winkelmann, A., Touze, E., Pico, F., Corcia, P., Otaegui, D., Antigüedad, A., Alcina, A., Comabella, M., … Bertram, L. | 2013-01-12 |
| Impact of Parkinson’s disease risk loci on age at onset, Movement Disorders | Lill, C. M., Hansen, J., Olsen, J. H., Binder, H., Ritz, B., & Bertram, L. | 2015-04-25 |
| Genetic variants in PSEN2 and correlation to CSF beta-amyloid 42 levels in AD, Neurobiology of Aging | Lebedeva, E., Stingl, J. C., Thal, D. R., Ghebremedhin, E., Strauss, J., Özer, E., Bertram, L., von Einem, B., Tumani, H., Otto, M., Riepe, M. W., Högel, J., Ludolph, A. C., & von Arnim, C. A. | 2010-09-20 |
| Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample, Neurogenetics | Lill, C. M., Schjeide, B. M., Akkad, D. A., Blaschke, P., Winkelmann, A., Gerdes, L. A., Hoffjan, S., Luessi, F., … Bertram, L., Zipp, F. | 2012-11-18 |
| Assessment of micro-RNA-related SNP effects in the 3′ untranslated region of the IL22RA2 risk locus in multiple sclerosis, Neurogenetics | Lill, C. M., Schilling, M., Ansaloni, S., Schröder, J., Jaedicke, M., … Bertram, L. | 2014-03-18 |
| Call for participation in the neurogenetics consortium within the Human Variome Project, Neurogenetics | Haworth, A., Bertram, L., … Sobrido, M. J. | 2011-06-01 |
| Serum iron levels and the risk of Parkinson Disease: A mendelian randomization study., PLoS Medicine | Pichler, I., Del Greco M, F., Gögele, M., Lill, C. M., Bertram, L., Do, C. B., Eriksson, N., Foroud, T., Myers, R. H., PD GWAS Consortium, Nalls, M., Keller, M. F., International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium 2, Benyamin, B., Whitfield, J. B., Genetics of Iron Status Consortium, Pramstaller, P. P., Hicks, A. A., Thompson, J. R., … Minelli, C. | 2013-06-04 |
| Quantifying Selective Reporting and the Proteus Phenomenon for Multiple Datasets with Similar Bias, PLoS One | Pfeiffer, T., Bertram, L., & Ioannidis, J. P. | 2011-03-29 |
| Synopsis of preterm birth genetic association studies: the preterm birth genetics knowledge base (PTBGene), Public Health Genomics | Dolan, S. M., Hollegaard, M. V., Merialdi, M., Betran, A. P., Allen, T., Abelow, C., Nace, J., Lin, B. K., Khoury, M. J., Ioannidis, J. P., Bagade, S., Zheng, X., Dubin, R. A., Bertram, L., Velez Edwards, D. R., & Menon, R. | 2010-05-20 |
| Towards Unveiling the Genetics of Neurodegenerative Diseases, Seminars in Neurology | Lill, C. M., & Bertram, L. | 2012-01-21 |
| Relationship Between 5 Epigenetic Clocks, Telomere Length, and Functional Capacity Assessed in Older Adults: Cross-Sectional and Longitudinal Analyses, The Journals of Gerontology: Series A | Vetter, V. M., Kalies, C. H., Sommerer, Y., Spira, D., Drewelies, J., Regitz-Zagrosek, V., Bertram, L., Gerstorf, D., & Demuth, I. | 2022-01-15 |
| Epigenetic aging and perceived psychological stress in old age, Translational Psychiatry | Vetter, V. M., Drewelies, J., Sommerer, Y., Kalies, C. H., Regitz-Zagrosek, V., Bertram, L., Gerstorf, D., & Demuth, I. | 2022-09-26 |
| The pursuit of susceptibility genes for Alzhiemer’s disease: progress and prospects, Trends in Genetics | Sleegers, K., Lambert, J. C., Bertram, L., Cruts, M., Amouyel, P., & Van Broeckhoven, C. | 2010-01-18 |
| Seven-CpG DNA Methylation Age Determined by Single Nucleotide Primer Extension and Illumina’s Infinium MethylationEPIC Array Provide Highly Comparable Results, Frontiers in Genetics | Vetter, V. M., Kalies, C. H., Sommerer, Y., Bertram, L., & Demuth, I. | 2022-01-17 |
| The Endosomal-Lysosomal Pathway is Dysregulated by APOE4 Expression in Vivo, Frontiers in Neuroscience | Nuriel, T., Peng, K. Y., Ashok, A., Dillman, A. A., Figueroa, H. Y., Apuzzo, J., Ambat, J., Levy, E., Cookson, M. R., Mathews, P. M., & Duff, K. E. | 2017-12-12 |
| Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology, Nature Communications | Nuriel, T., Angulo, S. L., Khan, U., Ashok, A., Chen, Q., Figueroa, H. Y., Emrani, S., Liu, L., Herman, M., Barrett, G., Savage, V., Buitrago, L., Cepeda-Prado, E., Fung, C., Goldberg, E., Gross, S. S., Hussaini, S. A., Moreno, H., Small, S. A., & Duff, K. E. | 2017-11-13 |
| A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology, Nature Neuroscience | Fu, H., Possenti, A., Freer, R., Nakano, Y., Hernandez Villegas, N. C., Tang, M., Cauhy, P. V. M., Lassus, B. A., Chen, S., Fowler, S. L., Figueroa, H. Y., Huey, E. D., Johnson, G. V. W., Vendruscolo, M., & Duff, K. E. | 2018-12-17 |
| Targeting the 26S Proteasome to Protect against Proteotoxic Diseases, Trends in Molecular Medicine | Myeku, N., & Duff, K. E. | 2017-12-09 |
| Selective vulnerability in neurodegenerative diseases, Nature Neuroscience | Fu, H., Hardy, J., & Duff, K. E. | 2018-09-24 |
| Neuronal activity enhances tau propagation and tau pathology in vivo, Nature Neuroscience | Wu, J. W., Hussaini, S. A., Bastille, I. M., Rodriguez, G. A., Mrejeru, A., Rilett, K., Sanders, D. W., Cook, C., Fu, H., Boonen, R. A., Herman, M., Nahmani, E., Emrani, S., Figueroa, Y. H., Diamond, M. I., Clelland, C. L., Wray, S., & Duff, K. E. | 2016-06-20 |
| APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice, Scientific Reports | Area-Gomez, E., Larrea, D., Pera, M., Agrawal, R. R., Guilfoyle, D. N., Pirhaji, L., Shannon, K., Arain, H. A., Ashok, A., Chen, Q., Dillman, A. A., Figueroa, H. Y., Cookson, M. R., Gross, S. S., Fraenkel, E., Duff, K. E., & Nuriel, T. | 2020-03-09 |
| Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice, Translational Psychiatry | Miranda, A. M., Ashok, A., Chan, R. B., Zhou, B., Xu, Y., McIntire, L. B., Area-Gomez, E., Di Paolo, G., Duff, K. E., Oliveira, T. G., & Nuriel, T. | 2022-03-29 |
| African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants, Neurology Genetics | Schindler, S. E., Cruchaga, C., Joseph, A., McCue, L., Farias, F. H. G., Wilkins, C. H., Deming, Y., Henson, R. L., Mikesell, R. J., Piccio, L., Llibre-Guerra, J. J., Moulder, K. L., Fagan, A. M., Ances, B. M., Benzinger, T. L. S., Xiong, C., Holtzman, D. M., & Morris, J. C. | 2021-03-04 |
| Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light, Neurology | Schindler, S. E., Karikari, T. K., Ashton, N. J., Henson, R. L., Yarasheski, K. E., West, T., Meyer, M. R., Kirmess, K. M., Li, Y., Saef, B., Moulder, K. L., Bradford, D., Fagan, A. M., Gordon, B. A., Benzinger, T. L. S., Balls-Berry, J., Bateman, R. J., Xiong, C., Zetterberg, H., Blennow, K., … Morris, J. C. | 2022-04-21 |
| Liver-ing in your head rent free: peripheral ApoE4 drives CNS pathology, Molecular Neurodegeneration | Golden, L. R., & Johnson, L. A. | 2022-10-04 |
| The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease, Alzheimer's & Dementia | Lill, C. M., Rengmark, A., Pihlstrøm, L., Fogh, I., Shatunov, A., Sleiman, P. M., Wang, L. S., Liu, T., Lassen, C. F., Meissner, E., Alexopoulos, P., Calvo, A., Chio, A., Dizdar, N., Faltraco, F., Forsgren, L., Kirchheiner, J., Kurz, A., Larsen, J. P., Liebsch, M., … Bertram, L. | 2015-04-30 |
| Cohort profile: follow-up of a Berlin Aging Study II (BASE-II) subsample as part of the GendAge study, BMJ Open | Demuth, I., Banszerus, V., Drewelies, J., Düzel, S., Seeland, U., Spira, D., Tse, E., Braun, J., Steinhagen-Thiessen, E., Bertram, L., Thiel, A., Lindenberger, U., Regitz-Zagrosek, V., Gerstorf, D., & Additional BASE-II/GendAge investigators | 2021-07-23 |
| MANBA, CXCR5, SOX8, RPS6KB1, ZBTB46 are genetic risk loci for multiple sclerosis, Brain | International Multiple Sclerosis Genetics Consortium, Lill, C. M., Schjeide, B. M., Graetz, C., Ban, M., Alcina, A., Ortiz, M. A., Pérez, J., Damotte, V., Booth, D., Lopez de Lapuente, A., Broer, L., Schilling, M., Akkad, D. A., Aktas, O., Alloza, I., Antigüedad, A., Arroyo, R., Blaschke, P., Buttmann, M., … Bertram, L., Zipp, F. | 2013-06-04 |
| Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition, and biomarkers, Brain Imaging and Behavior | Shen, L., Thompson, P. M., Potkin, S. G., Bertram, L., Farrer, L. A., Foroud, T. M., Green, R. C., … Alzheimer’s Disease Neuroimaging Initiative | 2013-10-05 |
| Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase, Journal of Pharmacology and Experimental Therapeutics | Lazo, J. S., Isbell, K. N., Vasa, S. A., Llaneza, D. C., Rastelli, E. J., Wipf, P., & Sharlow, E. R. | 2023-02-23 |
| Structure of the complex of an iminopyridinedione PTP4A3 phosphatase inhibitor with human serum albumin, Molecular Pharmacology | Czub, M. P., Boulton, A. M., Rastelli, E. J., Tasker, N. R., Maskrey, T. S., Blanco, I. K., McQueeney, K. E., Bushweller, J. H., Minor, W., Wipf, P., Sharlow, E. R., & Lazo, J. S. | 2020-09-25 |
| New Approaches to Difficult Drug Discovery, SLAS Discovery | Lazo, J. S., McQueeney, K. E., & Sharlow, E. R. | 2017-07-26 |
| Functional characterization of the dural sinuses as a neuroimmune interface, Cell | Rustenhoven, J., Drieu, A., Mamuladze, T., de Lima, K. A., Dykstra, T., Wall, M., Papadopoulos, Z., Kanamori, M., Salvador, A. F., Baker, W., Lemieux, M., Da Mesquita, S., Cugurra, A., Fitzpatrick, J., Sviben, S., Kossina, R., Bayguinov, P., Townsend, R. R., Zhang, Q., Erdmann-Gilmore, P., … Kipnis, J. | 2021-01-27 |
| Cerebrovascular Anomalies: Perspectives From Immunology and Cerebrospinal Fluid Flow, Circulation Research | Rustenhoven, J., Tanumihardja, C., & Kipnis, J. | 2021-06-25 |
| Immune Cells and CNS physiology: microglia and beyond, Journal of Experimental Medicine | Norris, G. T., & Kipnis, J. | 2018-11-30 |
| Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease, Nature | Da Mesquita, S., Louveau, A., Vaccari, A., Smirnov, I., Cornelison, R. C., Kingsmore, K. M., Contarino, C., Onengut-Gumuscu, S., Farber, E., Raper, D., Viar, K. E., Powell, R. D., Baker, W., Dabhi, N., Bai, R., Cao, R., Hu, S., Rich, S. S., Munson, J. M., Lopes, M. B., … Kipnis, J. | 2018-07-25 |
| Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels, Nature Neuroscience | Mazzitelli, J. A., Smyth, L. C. D., Cross, K. A., Dykstra, T., Sun, J., Du, S., Mamuladze, T., Smirnov, I., Rustenhoven, J., & Kipnis, J. | 2022-03-17 |
| Lymphatics in Neurological Disorders: a neuro-lympho-vascular component of multiple sclerosis and Alzheimer’s disease?, Neuron | Louveau, A., Da Mesquita, S., & Kipnis, J. | 2016-09-07 |
| The meningeal lymphatic system: a new player in neurophysiology, Neuron | Da Mesquita, S., Fu, Z., & Kipnis, J. | 2018-10-24 |
| Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology, Scientific Advances | Da Mesquita, S., Herz, J., Wall, M., Dykstra, T., de Lima, K. A., Norris, G. T., Dabhi, N., Kennedy, T., Baker, W., & Kipnis, J. | 2021-05-21 |
| Skull bone marrow channels as immune gateways to the central nervous system, Nature Neuroscience | Mazzitelli, J. A., Pulous, F. E., Smyth, L. C. D., Kaya, Z., Rustenhoven, J., Moskowitz, M. A., Kipnis, J., & Nahrendorf, M. | 2023-11-23 |
| 3D Miniaturization of Human Organs for Drug Discovery, Advanced Healthcare Materials | Park, J., Wetzel, I., Dréau, D., & Cho, H. | 2017-09-08 |
| Dynamic DNA methylation in the right place at the right time, Science | Luo, C., Hajkova, P., & Ecker, J. R. | 2018-09-28 |
| Integrative systems biology characterizes immune-mediated neurodevelopmental changes in murine Zika virus microcephaly, iScience | Fujimura, K., Guise, A. J., Nakayama, T., Schlaffner, C. N., Meziani, A., Kumar, M., Cheng, L., Vaughan, D. J., Kodani, A., Van Haren, S., Parker, K., Levy, O., Durbin, A. F., Bosch, I., Gehrke, L., Steen, H., Mochida, G. H., & Steen, J. A. | 2023-05-19 |
| A simple, time- and cost-effective, high-throughput depletion strategy for deep plasma proteomics, Science Advances | Viode, A., van Zalm, P., Smolen, K. K., Fatou, B., Stevenson, D., Jha, M., Levy, O., Steen, J., Steen, H., & IMPACC Network | 2023-03-29 |
| An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function., EMBO Molecular Medicine | Schlepckow, K., Kleinberger, G., Fukumori, A., Feederle, R., Lichtenthaler, S. F., Steiner, H., & Haass, C. | 2017-08-30 |
| P62 accumulates through neuroanatomical circuits in response to tauopathy propagation, Acta Neuropathologica Communications | Blaudin de Thé, F. X., Lassus, B., Schaler, A. W., Fowler, S. L., Goulbourne, C. N., Jeggo, R., Mannoury la Cour, C., Millan, M. J., & Duff, K. E. | 2021-11-02 |
| Culture shock: microglial heterogeneity, activation, and disrupted single-cell microglial networks in vitro, Molecular Neurodegeneration | Cadiz, M. P., Jensen, T. D., Sens, J. P., Zhu, K., Song, W. M., Zhang, B., Ebbert, M., Chang, R., & Fryer, J. D. | 2022-03-28 |
| Widespread choroid plexus contamination in sampling and profiling of brain tissue, Molecular Psychiatry | Olney, K. C., Todd, K. T., Pallegar, P. N., Jensen, T. D., Cadiz, M. P., Gibson, K. A., Barnett, J. H., de Ávila, C., Bouchal, S. M., Rabichow, B. E., Ding, Z., Wojtas, A. M., Wilson, M. A., & Fryer, J. D. | 2022-01-05 |
| APOE2 is associated with longevity independent of Alzheimer’s disease, eLife | Shinohara, M., Kanekiyo, T., Tachibana, M., Kurti, A., Shinohara, M., Fu, Y., Zhao, J., Han, X., Sullivan, P. M., Rebeck, G. W., Fryer, J. D., Heckman, M. G., & Bu, G. | 2020-10-19 |
| Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation, Acta Neuropathologica Communications | Wojtas, A. M., Carlomagno, Y., Sens, J. P., Kang, S. S., Jensen, T. D., Kurti, A., Baker, K. E., Berry, T. J., Phillips, V. R., Castanedes, M. C., Awan, A., DeTure, M., De Castro, C. H. F., Librero, A. L., Yue, M., Daughrity, L., Jansen-West, K. R., Cook, C. N., Dickson, D. W., Petrucelli, L., Fryer, J. D. | 2020-12-01 |
| Astrocyte-derived clusterin suppresses amyloid formation in vivo, Molecular Neurodegeneration | Wojtas, A. M., Sens, J. P., Kang, S. S., Baker, K. E., Berry, T. J., Kurti, A., Daughrity, L., Jansen-West, K. R., Dickson, D. W., Petrucelli, L., Bu, G., Liu, C. C., & Fryer, J. D. | 2020-11-27 |
| Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function, Neuron | Yamazaki, Y., Liu, C. C., Yamazaki, A., Shue, F., Martens, Y. A., Chen, Y., Qiao, W., Kurti, A., Oue, H., Ren, Y., Li, Y., Aikawa, T., Cherukuri, Y., Fryer, J. D., Asmann, Y. W., Kim, B. Y. S., Kanekiyo, T., & Bu, G. | 2020-12-14 |
| Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease, Nature Immunology | Liu, C. C., Wang, N., Chen, Y., Inoue, Y., … Fryer, J. D., … Bu, G. | 2023-10-19 |
| Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology, Cell Reports | Wood, J. I., Wong, E., Joghee, R., Balbaa, A., Vitanova, K. S., Stringer, K. M., Vanshoiack, A., Phelan, S. J., Launchbury, F., Desai, S., Tripathi, T., Hanrieder, J., Cummings, D. M., Hardy, J., & Edwards, F. A. | 2022-11-22 |
| Wakefulness and loss of awareness: brain and brainstem interactio in the vegetative state, Neurology | Silva, S., Alacoque, X., Fourcade, O., Samii, K., Marque, P., Woods, R., Mazziotta, J., Chollet, F., & Loubinoux, I. | 2010-01-26 |
| Increased soluble TREM2 in cerebospinal fluid is associated with reduced cognitvie and clinical decline, Science Translational Medicine | Ewers, M., Franzmeier, N., Suárez-Calvet, M., Morenas-Rodriguez, E., Caballero, M. A. A., Kleinberger, G., Piccio, L., Cruchaga, C., Deming, Y., Dichgans, M., Trojanowski, J. Q., Shaw, L. M., Weiner, M. W., Haass, C., & Alzheimer’s Disease Neuroimaging Initiative | 2019-08-28 |
| The Alzheimer’s disease risk factor INPP5D restricts neuroprotective microglial responses in amyloid beta-mediated pathology, Alzheimer's & Dementia | Samuels, J. D., Moore, K. A., Ennerfelt, H. E., Johnson, A. M., Walsh, A. E., Price, R. J., & Lukens, J. R. | 2023-04-15 |
| SYK coordinates neuroprotective microglial responses in neurodegenerative disease, Cell | Ennerfelt, H., Frost, E. L., Shapiro, D. A., Holliday, C., Zengeler, K. E., Voithofer, G., Bolte, A. C., Lammert, C. R., Kulas, J. A., Ulland, T. K., & Lukens, J. R. | 2022-10-17 |
| Microglia rely on SYK signalling to mount neuroprotective responses in models of Alzheimer’s disease and multiple sclerosis, Clinical and Translational Medicine | Ennerfelt, H., & Lukens, J. R. | 2023-01-11 |
| How neurons die in Alzheimer’s disease: Implications for neuroinflammation, Current Opinion in Neurobiology | Mangalmurti A, Lukens JR. | 2022-06-10 |
| The innate immune response in tauopathies, European Journal of Immunoogy | Johnson, A. M., & Lukens, J. R. | 2023-03-18 |
| An introduction to neuroimmunology, Immunological Reviews | Lukens, J. R., & Williams, J. L. | 2022-08-30 |
| Emerging roles for ITAM and ITIM receptor signaling in microglial biology and Alzheimer’s disease-related amyloidosis, Journal of Neurochemistry | Samuels, J. D., Lukens, J. R., & Price, R. J. | 2023-10-11 |
| CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer’s disease mouse model, Proceedings of the National Academy of Sciences of the United States of America | Ennerfelt, H., Holliday, C., Shapiro, D. A., Zengeler, K. E., Bolte, A. C., Ull|, T. K., & Lukens, J. R. | 2023-06-05 |
| A potent selective allosteric PTP4A3 phosphatase inhibitor enhances microvascular barrier function and inhibits human tumor cell growth, The FASEB Journal | Lazo, J. S., McQueeney, K. E., Salamoun. J. M., Barabutis, N., Catravas, J.D., Wipf, P. | 2018-04-01 |
| Small molecule targeting of PTPs in Cancer, International Journal of Biochemistry & Cell Biology | Lazo, J. S., McQueeney, K. E., Burnett, J. C., Wipf, P., & Sharlow, E. R. | 2017-09-21 |
| Cellular Control of Brain Capillary Blood Flow: In vivo imaging veritas, Trends in Neurosciences | Grutzendler, J., & Nedergaard, M. | 2019-06-26 |
| Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy, Nature | Chen, X., Firulyova, M., Manis, M., Herz, J., Smirnov, I., Aladyeva, E., Wang, C., Bao, X., Finn, M. B., Hu, H., Shchukina, I., Kim, M. W., Yuede, C. M., Kipnis, J., Artyomov, M. N., Ulrich, J. D., & Holtzman, D. M. | 2023-03-08 |
| Unraveling the lymphatic system in the spinal cord meninges: a critical element in protecting the central nervous system, Cellular and Molecular Life Sciences | Gonuguntla, S., & Herz, J. | 2023-11-20 |
| TREM2 Function in Alzheimer’s Disease and Neurodegeneration, ACS Chemical Neuroscience | Ulrich, J. D., & Holtzman, D. M. | 2016-02-08 |
| Selective reduction of astrocyte apoE3 and apoE4 strongly reduces A beta accumulation and plaque-related pathology in a mouse model of amyloidosi, Molecular Neurodegeneration | Mahan, T. E., Wang, C., Bao, X., Choudhury, A., Ulrich, J. D., & Holtzman, D. M. | 2022-02-02 |
| In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis, Molecular Neurodegeneration | Ulrich, J. D., Burchett, J. M., Restivo, J. L., Schuler, D. R., Verghese, P. B., Mahan, T. E., Landreth, G. E., Castellano, J. M., Jiang, H., Cirrito, J. R., & Holtzman, D. M. | 2013-04-19 |
| APoE facilitates the microglia response to amyloid plaque pathology, Journal of Experimental Medicine | Ulrich, J. D., Ulland, T. K., Mahan, T. E., Nyström, S., Nilsson, K. P., Song, W. M., Zhou, Y., Reinartz, M., Choi, S., Jiang, H., Stewart, F. R., Anderson, E., Wang, Y., Colonna, M., & Holtzman, D. M. | 2018-02-26 |
| Elucidating the role of TREM2 in Alzheimer’s Disease, Neuron | Ulrich, J. D., Ulland, T. K., Colonna, M., & Holtzman, D. M. | 2017-04-19 |
| TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy, Proceedings of the National Academy of Sciences of the United States of America | Leyns, C. E. G., Ulrich, J. D., Finn, M. B., Stewart, F. R., Koscal, L. J., Remolina Serrano, J., Robinson, G. O., Anderson, E., Colonna, M., & Holtzman, D. M. | 2017-10-09 |
| Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis, Neuron | Roussarie, J. P., Yao, V., Rodriguez-Rodriguez, P., Oughtred, R., Rust, J., Plautz, Z., Kasturia, S., Albornoz, C., Wang, W., Schmidt, E. F., Dannenfelser, R., Tadych, A., Brichta, L., Barnea-Cramer, A., Heintz, N., Hof, P. R., Heiman, M., Dolinski, K., Flajolet, M., Troyanskaya, O. G., … Greengard, P. | 2020-06-29 |
| Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer’s Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals, Cell Systems | Hark, T. J., Rao, N. R., Castillon, C., Basta, T., Smukowski, S., Bao, H., Upadhyay, A., Bomba-Warczak, E., Nomura, T., O'Toole, E. T., Morgan, G. P., Ali, L., Saito, T., Guillermier, C., Saido, T. C., Steinhauser, M. L., Stowell, M. H. B., Chapman, E. R., Contractor, A., & Savas, J. N. | 2020-12-15 |
| Using stable isotope labeling to advance our understanding of Alzheimer’s disease etiology and pathology, Journal of Neurochemistry | Hark, T. J., & Savas, J. N. | 2021-02-02 |
| Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in App Knock-in Mice, Journal of Proteome Research | Rao, N. R., & Savas, J. N. | 2021-06-09 |
| Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease, Journal of Visualized Experiments | Goldman, C., Suhy, N., Schwarz, J. E., Sartori, E. R., Rooklin, R. B., Schuldt, B. R., Mesentier-Louro, L. A., & Blanchard, J. W. | 2023-10-20 |
| Modeling the Blood-Brain Barrier Using Human-Induced Pluripotent Stem Cells, Methods in Molecular Biology | Mesentier-Louro, L. A., Suhy, N., Broekaart, D., Bula, M., Pereira, A. C., & Blanchard, J. W. | 2023-06-11 |
| APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes, Nature | Blanchard, J. W., Akay, L. A., Davila-Velderrain, J., von Maydell, D., … Kellis, M., Tsai, L. H. | 2022-11-16 |
| CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease, Nature Aging | Barthélemy, N. R., Saef, B., Li, Y., Gordon, B. A., He, Y., Horie, K., Stomrud, E., Salvadó, G., Janelidze, S., Sato, C., Ovod, V., Henson, R. L., Fagan, A. M., Benzinger, T. L. S., Xiong, C., Morris, J. C., Hansson, O., Bateman, R. J., & Schindler, S. E. | 2023-03-13 |
| Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models, Translational Psychiatry | Cacciottolo, M., Wang, X., Driscoll, I., Woodward, N., Saffari, A., Reyes, J., Serre, M. L., Vizuete, W., Sioutas, C., Morgan, T. E., Gatz, M., Chui, H. C., Shumaker, S. A., Resnick, S. M., Espeland, M. A., Finch, C. E., & Chen, J. C. | 2017-01-01 |
| Inhibition of PKC delta reduces amyloid-beta levels and reverses Alzheimer’s disease phenotypes, Journal of Experimental Medicine | Du, Y., Zhao, Y., Li, C., Zheng, Q., Tian, J., Li, Z., Huang, T. Y., Zhang, W., & Xu, H. | 2018-05-08 |
| Arginine Methyltransferase PRMT8 provides cellular stress tolerance in aging motoneurons, Journal of Neuroscience | Simandi Z, Pajer K, Karolyi K, Sieler T, Jiang LL, Kolostyak Z, Sari Z, Fekecs Z, Pap A, Patsalos A, Contreras GA, Reho B, Papp Z, Guo X, Horvath A, Kiss G, Keresztessy Z, Vámosi G, Hickman J, Xu H, Dormann D, Hortobagyi T, Antal M, Nógrádi A, Nagy L. | 2018-08-29 |
| ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating gamma-secretase activity, Nature Communications | Zhu, B., Jiang, L., Huang, T., Zhao, Y., Liu, T., Zhong, Y., Li, X., Campos, A., Pomeroy, K., Masliah, E., Zhang, D., & Xu, H. | 2017-11-13 |
| Elevated TREM2 gene dosage reprograms microglia responsivity and ameliorates pathologicla phenotypes in Alzheimer’s disease models, Neuron | Lee, C. Y. D., Daggett, A., Gu, X., Jiang, L. L., Langfelder, P., Li, X., Wang, N., Zhao, Y., Park, C. S., Cooper, Y., Ferando, I., Mody, I., Coppola, G., Xu, H., & Yang, X. W. | 2018-03-07 |
| TREM2 is a receptor for beta-amyloid that mediates microglia function, Neuron | Zhao, Y., Wu, X., Li, X., Jiang, L. L., Gui, X., Liu, Y., Sun, Y., Zhu, B., Piña-Crespo, J. C., Zhang, M., Zhang, N., Chen, X., Bu, G., An, Z., Huang, T. Y., & Xu, H. | 2018-03-07 |
| Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 experssion, Cell Reports | Zhuang, K., Huang, C., Leng, L., Zheng, H., Gao, Y., Chen, G., Ji, Z., Sun, H., Hu, Y., Wu, D., Shi, M., Li, H., Zhao, Y., Zhang, Y., Xue, M., Bu, G., Huang, T. Y., Xu, H., & Zhang, J. | 2018-07-17 |
| SNX27 Deletion causes hydrocephalus by impairing ependymal cell differentiation and ciliogenesis, Journal of Neuroscience | Wang X, Zhou Y, Wang J, Tseng IC, Huang T, Zhao Y, Zheng Q, Gao Y, Luo H, Zhang X, Bu G, Hong W, Xu H. | 2016-12-14 |
| TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway, Frontiers in Aging Neuroscience | Zhong L, Zhang ZL, Li X, Liao C, Mou P, Wang T, Wang Z, Wang Z, Wei M, Xu H, Bu G, Chen XF. | 2017-06-21 |
| Trem2 deletion enhances tau dispersion and pathology through microglia exosomes, Molecular Neurodegeneration | Zhu B, Liu Y, Hwang S, Archuleta K, Huang H, Campos A, Murad R, Piña-Crespo J, Xu H, Huang TY. | 2022-09-02 |
| Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques, Immunity | Roy ER, Chiu G, Li S, Propson NE, Kanchi R, Wang B, Coarfa C, Zheng H, Cao W. | 2022-05-10 |
| Complement C3aR depletion reverses HIF-1α–induced metabolic impairment and enhances microglial response to Aβ pathology, Journal of Clinical Investigation | Gedam, M., Comerota, M. M., Propson, N. E., Chen, T., Jin, F., Wang, M. C., & Zheng, H. | 2023-06-15 |
| Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease, Molecular Neurodegeneration | Comerota, M. M., Gedam, M., Xiong, W., Jin, F., Deng, L., Wang, M. C., Wang, J., & Zheng, H. | 2023-08-15 |
| TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy, Nature Neuroscience | Wang, B., Martini-Stoica, H., Qi, C., Lu, T. C., Wang, S., Xiong, W., Qi, Y., Xu, Y., Sardiello, M., Li, H., & Zheng, H. | 2023-11-20 |
| Sensory processing deficits and related cortical pathological changes in Alzheimer’s disease, Frontiers in Aging Neuroscience | Zhang, N. K., Zhang, S. K., Zhang, L. I., Tao, H. W., & Zhang, G. W. | 2023-08-15 |
| Identification and Prioritization of PET Neuroimaging Targets for Microglial Phenotypes Associated with Microglial Activity in Alzheimer’s Disease, ACS Chemical Neuroscience | Bartolo, N. D., Mortimer, N., Manter, M. A., Sanchez, N., Riley, M., O'Malley, T. T., & Hooker, J. M. | 2022-12-06 |
| Analysis of brain region-specific mRNA synthesis and stability by utilizing adult mouse brain slice culture, STAR Protocols | Dzhala, V., Fowler, A. J., DiMarzio, B. A., Staley, K. J., & Suh, J. | 2022-06-17 |
| PLD3 affects axonal spheroids and network defects in Alzheimer’s disease, Nature | Yuan, P., Zhang, M., Tong, L., Morse, T. M., McDougal, R. A., Ding, H., Chan, D., Cai, Y., & Grutzendler, J. | 2022-11-30 |
| Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo, Science Advances | Damisah, E. C., Hill, R. A., Rai, A., Chen, F., Rothlin, C. V., Ghosh, S., & Grutzendler, J. | 2020-06-26 |
| TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques, Journal of Experimental Medicine | Wang, Y., Ulland, T. K., Ulrich, J. D., Song, W., Tzaferis, J. A., Hole, J. T., Yuan, P., Mahan, T. E., Shi, Y., Gilfillan, S., Cella, M., Grutzendler, J., DeMattos, R. B., Cirrito, J. R., Holtzman, D. M., & Colonna, M. | 2016-04-18 |
| Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease, Molecular Neurodegeneration | Inoue, Y., Shue, F., Bu, G., & Kanekiyo, T. | 2023-07-11 |
| ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism, Molecular Psychiatry | Kawatani, K., Holm, M. L., Starling, S. C., Martens, Y. A., Zhao, J., Lu, W., Ren, Y., Li, Z., Jiang, P., Jiang, Y., Baker, S. K., Wang, N., Roy, B., Parsons, T. M., Perkerson, R. B., 3rd, Bao, H., Han, X., Bu, G., & Kanekiyo, T. | 2023-12-22 |
| Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice, Neurobiology of Aging | Rogers, J. T., Liu, C. C., Zhao, N., Wang, J., Putzke, T., Yang, L., Shinohara, M., Fryer, J. D., Kanekiyo, T., & Bu, G. | 2017-02-09 |
| ABCA7 Haplodeficiency Distrubs Microglial immune Responses in the Mouse Brain, Proceedings of the National Academy of Sciences of the United States of America | Aikawa T, Ren Y, Yamazaki Y, Tachibana M, Johnson MR, Anderson CT, Martens YA, Holm ML, Asmann YW, Saito T, Saido TC, Fitzgerald ML, Bu G, Kanekiyo T. | 2019-11-05 |
| Astrocytic LRP1 Mediates Brain A beta Clearance and Impacts Amyloid Deposition, Journal of Neuroscience | Liu, C. C., Hu, J., Zhao, N., Wang, J., Wang, N., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M., & Bu, G. | 2017-04-12 |
| Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid beta clearance and aggregation in Alzheimer’s disease, Science Translational Medicine | Liu, C. C., Zhao, N., Yamaguchi, Y., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M., & Bu, G. | 2016-03-30 |
| Mimicry of Central-Peripheral Immunity in Alzheimer’s Disease and Discovery of Neurodegenerative Roles in neutrophil, Frontiers in Immunology | Park, J., Baik, S. H., Mook-Jung, I., Irimia, D., & Cho, H. | 2019-09-25 |
| Elucidating the interactive roles of glia in Alzheimer’s disease using established and newly developed experimental models, Frontiers in Neurology | Chun, H., Marriott, I., Lee, C. J., & Cho, H. | 2018-09-26 |
| Therapeutic nanoplatforms and delivery strategies for neurological disorders, Nano Convergence | Kang, Y. J., Cutler, E. G., & Cho, H. | 2018-11-30 |
| sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer’s disease and associate with neuronal injury markers, EMBO Molecular Medicine | Suárez-Calvet, M., Kleinberger, G., Araque Caballero, M. Á., Brendel, M., Rominger, A., Alcolea, D., Fortea, J., Lleó, A., Blesa, R., Gispert, J. D., Sánchez-Valle, R., Antonell, A., Rami, L., Molinuevo, J. L., Brosseron, F., Traschütz, A., Heneka, M. T., Struyfs, H., Engelborghs, S., Sleegers, K., Van Broeckhove, C., Zetterberg, H., Nellgard, B., Blennow, K., Crispin, A., Ewers, M., & Haass, C. | 2016-03-03 |
| The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance, and neuronal survival in mice, Proceedings of the National Academy of Sciences of the United States of America | Minis, A., Rodriguez, J. A., Levin, A., Liu, K., Govek, E. E., Hatten, M. E., & Steller, H. | 2019-11-21 |
| TREM2 in CNS homeostasis and neurodegenerative disease, Molecular Neurodegeneration | Painter, M. M., Atagi, Y., Liu, C. C., Rademakers, R., Xu, H., Fryer, J. D., & Bu, G. | 2015-09-04 |
| The retromer complex and sorting nexins in neurodegenerative diseases, Frontiers in Aging Neuroscience | Zhang, H., Huang, T., Hong, Y., Yang, W., Zhang, X., Luo, H., Xu, H., & Wang, X. | 2018-03-26 |
| Appoptosin mediates lesions induced by oxidative stress through the JNK-FoxO1 Pathway, Frontiers in Aging Neuroscience | Zhang, C., Tan, Z., Xie, Y., Zhao, Y., Huang, T. Y., Lu, Z., Luo, H., Can, D., Xu, H., Zhang, Y. W., & Zhang, X. | 2019-09-04 |
| Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases, Frontiers in Aging Neuroscience | Zheng, Q., Huang, T., Zhang, L., Zhou, Y., Luo, H., Xu, H., & Wang, X. | 2016-12-15 |
| SNX8 Enhances Non-Amyloidogenic APPP Trafficking and Attenuates A beta Accumulation and Memory Deficits in an AD mouse, Frontiers in Cellular Neuroscience | Xie, Y., Niu, M., Ji, C., Huang, T. Y., Zhang, C., Tian, Y., Shi, Z., Wang, C., Zhao, Y., Luo, H., Can, D., Xu, H., Zhang, Y. W., & Zhang, X. | 2019-09-06 |
| SORLA attenuates EphA4 signaling and amyloid beta-induced neurodegeneration, Journal of Experimental Medicine | Huang, T. Y., Zhao, Y., Jiang, L. L., Li, X., Liu, Y., Sun, Y., Piña-Crespo, J. C., Zhu, B., Masliah, E., Willnow, T. E., Pasquale, E. B., & Xu, H. | 2017-12-04 |
| Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer’s disease, Neuron | Liu, C. C., Tsai, C. W., Deak, F., Rogers, J., Penuliar, M., Sung, Y. M., Maher, J. N., Fu, Y., Li, X., Xu, H., Estus, S., Hoe, H. S., Fryer, J. D., Kanekiyo, T., & Bu, G. | 2014-09-18 |
| ApoE and Aβ in Alzheimer’s disease: accidental encounters or partners?, Neuron | Kanekiyo, T., Xu, H., & Bu, G. | 2014-02-19 |
| Low-density lipoprotein receptor-related protein 1 (LRP1) regulates the stability and function of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor in neurons, PLoS One | Gan, M., Jiang, P., McLean, P., Kanekiyo, T., & Bu, G. | 2014-12-12 |
| Soluble TREM2 induces inflammatory responses and enhnaces microglial survival, Journal of Experimental Medicine | Zhong, L., Chen, X. F., Wang, T., Wang, Z., Liao, C., Wang, Z., Huang, R., Wang, D., Li, X., Wu, L., Jia, L., Zheng, H., Painter, M., Atagi, Y., Liu, C. C., Zhang, Y. W., Fryer, J. D., Xu, H., & Bu, G. | 2017-03-06 |
| Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2), Molecular Neurodegeneration | Zhong, L., Wang, Z., Wang, D., Wang, Z., Martens, Y. A., Wu, L., Xu, Y., Wang, K., Li, J., Huang, R., Can, D., Xu, H., Bu, G., & Chen, X. F. | 2018-03-27 |
| The role of APOE in cerebrovascular dysfunction, Acta Neuropathologica | Tai, L. M., Thomas, R., Marottoli, F. M., Koster, K. P., Kanekiyo, T., Morris, A. W., & Bu, G. (2016). | 2016-02-16 |
| Apolipoprotein E regulates lipid metabolism and alpha-synuclein pathology in human iPSC-derived cerebral organoids, Acta Neuropathologica | Zhao, J., Lu, W., Ren, Y., Fu, Y., Martens, Y. A., Shue, F., Davis, M. D., Wang, X., … Kanekiyo, T., Bu, G. | 2021-08-28 |
| Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer’s disease, Acta Neuropathologica Communications | Reddy, J. S., Allen, M., Ho, C. C. G., Oatman, S. R., İş, Ö., Quicksall, Z. S., Wang, X., Jin, J., Patel, T. A., Carnwath, T. P., Nguyen, T. T., Malphrus, K. G., Lincoln, S. J., Carrasquillo, M. M., Crook, J. E., Kanekiyo, T., Murray, M. E., Bu, G., Dickson, D. W., & Ertekin-Taner, N. | 2021-05-21 |
| ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components, Arteriosclerosis, Thrombosis, and Vascular Biology | Yamazaki, Y., Shinohara, M., Yamazaki, A., Ren, Y., Asmann, Y. W., Kanekiyo, T., & Bu, G. | 2019-10-31 |
| Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-beta pathology in amyloid model mice, Experimental Neurology | Tachibana M, Yamazaki Y, Liu CC, Bu G, Kanekiyo T. | 2017-10-26 |
| ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation, Frontiers in Neuroscience | Aikawa, T., Ren, Y., Holm, M. L., Asmann, Y. W., Alam, A., Fitzgerald, M. L., Bu, G., & Kanekiyo, T. | 2021-04-07 |
| APOE epsilon 4/ epsilon 4 diminishes neurotrophic function of human iPSC-derived astrocytes, Human Molecular Genetics | Zhao J, Davis MD, Martens YA, Shinohara M, Graff-Radford NR, Younkin SG, Wszolek ZK, Kanekiyo T, Bu G. | 2017-04-21 |
| 5-HT3 Antagonist Ondansetron Increases apoE Secretion by Modulating the LXR-ABCA1 Pathway, International Journal of Molecular Sciences | Shinohara, M., Shinohara, M., Zhao, J., Fu, Y., Liu, C. C., Kanekiyo, T., & Bu, G. | 2019-03-25 |
| LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4, JCI Insight | Oue, H., Yamazaki, Y., Qiao, W., Yuanxin, C., Ren, Y., Kurti, A., … Bu, G., & Kanekiyo, T. | 2023-04-10 |
| Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA protein-mediated pathway, Journal of Biological Chemistry | Casey, C. S., Atagi, Y., Yamazaki, Y., Shinohara, M., Tachibana, M., Fu, Y., Bu, G., & Kanekiyo, T. | 2015-04-22 |
| Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies, Journal of Lipid Research | Shinohara, M., Tachibana, M., Kanekiyo, T., & Bu, G. | 2017-04-04 |
| LRP1 modulates the microglial immune response via regulation of JNK and NF-kappa B signaling pathways, Journal of Neuroinflammation | Yang, L., Liu, C. C., Zheng, H., Kanekiyo, T., Atagi, Y., Jia, L., Wang, D., N'songo, A., Can, D., Xu, H., Chen, X. F., & Bu, G. | 2016-12-08 |
| Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain, Journal of Neuroscience | Liu, C. C., Hu, J., Tsai, C. W., Yue, M., Melrose, H. L., Kanekiyo, T., & Bu, G. | 2015-04-08 |
| ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer’s Neuronal Pathology, Journal of Neuroscience | Sakae, N., Liu, C. C., Shinohara, M., Frisch-Daiello, J., Ma, L., … Bu, G & Kanekiyo, T. | 2016-03-30 |
| Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells, Molecular Neurodegeneration | Wren, M. C., Zhao, J., Liu, C. C., Murray, M. E., Atagi, Y., Davis, M. D., Fu, Y., Okano, H. J., Ogaki, K., Strongosky, A. J., Tacik, P., Rademakers, R., Ross, O. A., Dickson, D. W., Wszolek, Z. K., Kanekiyo, T., & Bu, G. | 2015-09-15 |
| APP-Mediated signaling prevents memory decline in Alzheimer’s disease mouse model, Cell Reports | Deyts, C., Clutter, M., Pierce, N., Chakrabarty, P., Ladd, T. B., Goddi, A., Rosario, A. M., Cruz, P., Vetrivel, K., Wagner, S. L., Thinakaran, G., Golde, T. E., & Parent, A. T. | 2019-04-30 |
| Microglia use TAM receptors to detect and engulf amyloid β plaques, Nature Immunology | Huang, Y., Happonen, K. E., Burrola, P. G., O'Connor, C., Hah, N., Huang, L., Nimmerjahn, A., & Lemke, G. | 2021-04-15 |
| How macrophages deal with death, Nature Reviews Immunology | Lemke G. | 2019-04-24 |
| Early death in a mouse model of Alzheimer’s disease exacerbated by microglial loss of TAM receptor signaling, Proceedings of the National Academy of Sciences of the United States of America | Huang, Y., & Lemke, G. | 2022-10-03 |
| Adaptable toolbox to characterize Alzheimer’s disease pathology in mouse models, STAR Protocols | Huang, Y., & Lemke, G. | 2022-12-16 |
| APOE2 eases cognitve declne during aging: clinical and pre-clinival evaluations, Annals of Neurology | Shinohara M, Kanekiyo T, Yang L, Linthicum D, Shinohara M, Fu Y, Price L, Frisch-Daiello JL, Han X, Fryer JD, Bu G. | 2016-03-29 |
| Lipoproteins in the Central Nervous System: From Biology to Pathobiology, Annual Review of Biochemistry | Raulin AC, Martens YA, Bu G. | 2022-03-18 |
| Apolipoprotein E, Receptors, and Modulation of Alzhiemer’s disease, Biological Psychiatry | Zhao N, Liu CC, Qiao W, Bu G. | 2017-03-14 |
| The AD Knowledge Portal: A Repository for Multi-Omic Data on Alzheimer’s Disease and Aging, Current Protocols in Human Genetics | Greenwood AK, Montgomery KS, Kauer N, Woo KH, Leanza ZJ, Poehlman WL, Gockley J, Sieberts SK, Bradic L, Logsdon BA, Peters MA, Omberg L, Mangravite LM. | 2020-10-21 |
| Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2), Journal of Biological Chemistry | Atagi, Y., Liu, C. C., Painter, M. M., Chen, X. F., Verbeeck, C., Zheng, H., Li, X., Rademakers, R., Kang, S. S., Xu, H., Younkin, S., Das, P., Fryer, J. D., & Bu, G. | 2015-09-15 |
| APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease, Molecular Neurodegeneration | Li, Z., Shue, F., Zhao, N., Shinohara, M., & Bu, G. | 2020-11-04 |
| ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies, Molecular Neurodegeneration | Raulin, A. C., Doss, S. V., Trottier, Z. A., Ikezu, T. C., Bu, G., & Liu, C. C. | 2022-11-08 |
| Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination, Molecular Neurodegeneration | Wang, N., Wang, M., Jeevaratnam, S., Rosenberg, C., Ikezu, T. C., Shue, F., Doss, S. V., Alnobani, A., Martens, Y. A., Wren, M., Asmann, Y. W., Zhang, B., Bu, G., & Liu, C. C. | 2022-11-23 |
| APOE ε2 is associated with increased tau pathology in primary tauopathy, Nature Communications | Zhao, N., Liu, C. C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff-Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R., Murray, M. E., Koga, S., … Bu, G. | 2018-10-22 |
| Apolipoprotein E and Alzheimer’s disease: pathobiology and targeting strategies, Nature Reviews Neurology | Yamazaki, Y., Zhao, N., Caulfield, T. R., Liu, C. C., & Bu, G. | 2019-07-31 |
| ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer’s disease, Neurobiology of Aging | Li, Y., Macyczko, J. R., Liu, C. C., & Bu, G. | 2022-03-22 |
| Apolipoprotein E4 impairs neuronal insulin signaling by trapping insulin receptor in the endosomes, Neuron | Zhao, N., Liu, C. C., Van Ingelgom, A. J., Martens, Y. A., Linares, C., Knight, J. A., Painter, M. M., Sullivan, P. M., & Bu, G. | 2017-09-27 |
| ApoE4 Accelerates Early Seeding of Amyloid Pathology, Neuron | Liu, C. C., Zhao, N., Fu, Y., Wang, N., Linares, C., Tsai, C. W., & Bu, G. | 2017-12-06 |
| An assay to evaluate the capacity of cholesterol acceptors using BODIPY-cholesterol in cells, STAR Protocols | Raulin, A. C., Liu, C. C., & Bu, G. | 2023-03-17 |
| A Novel Link between Trafficking and Lewy body disorder, The Lancet Neurology | Ross, O. A., & Bu, G. | 2018-06-07 |
| SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers, Neurobiology of Disease | Norambuena, A., Sun, X., Wallrabe, H., Cao, R., Sun, N., Pardo, E., Shivange, N., Wang, D. B., Post, L. A., Ferris, H. A., Hu, S., Periasamy, A., & Bloom, G. S. | 2022-04-20 |
| Alzheimer disease A tale of two prions, Prion | Nussbaum, J. M., Seward, M. E., & Bloom, G. S. | 2012-09-10 |
| Selective Detection of Misfolded Tau From Postmortem Alzheimer’s Disease Brains, Frontiers in Aging Neuroscience | Wu, L., Wang, Z., Lad, S., Gilyazova, N., Dougharty, D. T., Marcus, M., Henderson, F., Ray, W. K., Siedlak, S., Li, J., Helm, R. F., Zhu, X., Bloom, G. S., Wang, S. J., Zou, W. Q., & Xu, B. | 2022-07-20 |
| Prion-like behavior and tau-dependent cytotoxicity of pyroglutamylated amyloid-beta, Nature | Nussbaum, J. M., Schilling, S., Cynis, H., Silva, A., Swanson, E., Wangsanut, T., Tayler, K., Wiltgen, B., Hatami, A., Rönicke, R., Reymann, K., Hutter-Paier, B., Alexandru, A., Jagla, W., Graubner, S., Glabe, C. G., Demuth, H. U., & Bloom, G. S. | 2012-05-02 |
| Reduced brain insulin signaling: A seminal process in Alzheimer’s disease pathogenesis, Neuropharmacology | Bloom, G. S., Lazo, J. S., & Norambuena, A. | 2017-09-27 |
| A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype, Neurobiology of Aging | Porterfield, V., Khan, S. S., Foff, E. P., Koseoglu, M. M., Blanco, I. K., Jayaraman, S., Lien, E., McConnell, M. J., Bloom, G. S., Lazo, J. S., & Sharlow, E. R. | 2020-02-19 |
| Dietary salt promotes cognitive impairment through tau phosphorylation, Nature | Faraco, G., Hochrainer, K., Segarra, S. G., Schaeffer, S., Santisteban, M. M., Menon, A., Jiang, H., Holtzman, D. M., Anrather, J., & Iadecola, C. | 2019-10-23 |
| Traumatic brain injury increases cortical glutamate network activity by compromising GABAergic Control, Cerebral Cortex | Cantu, D., Walker, K., Andresen, L., Taylor-Weiner, A., Hampton, D., Tesco, G., & Dulla, C. G. | 2014-03-07 |
| Molecular Mechanism of cognitive dysfunction following traumatic brain injury, Frontiers in Aging Neuroscience | Walker, K. R., & Tesco, G. | 2013-07-09 |
| Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice, Journal of Cerebral Blood Flow & Metabolism | Mannix, R. C., Zhang, J., Park, J., Zhang, X., Bilal, K., Walker, K., Tanzi, R. E., Tesco, G., & Whalen, M. J. | 2010-06-30 |
| Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1, Journal of Neuroscience | Walker, K. R., Kang, E. L., Whalen, M. J., Shen, Y., & Tesco, G. | 2012-07-25 |
| Pathophysiology of neurodegenerative diseases: An interplay among axonal transport failure, oxidative stress, and inflammation?, Seminars in Immunology | Tesco, G., & Lomoio, S. | 2022-06-30 |
| Significance of transcytosis in Alzheimer’s disease: BACE1 takes the scenic route to axons, BioEssays | Buggia-Prévot, V., & Thinakaran, G. | 2015-06-30 |
| Aberrant accrual of BIN1 near Alzheimer’s disease amyloid deposits in trasngenic models, Brain Pathology | De Rossi, P., Andrew, R. J., Musial, T. F., Buggia-Prevot, V., Xu, G., Ponnusamy, M., Ly, H., Krause, S. V., Rice, R. C., de l'Estoile, V., Valin, T., Salem, S., Despa, F., Borchelt, D. R., Bindokas, V. P., Nicholson, D. A., & Thinakaran, G. | 2018-12-27 |
| A paired RNAi and RabGAP Overexpression screen identifies Rab11 as a regulator of beta-amyloid production, Cell Reports | Udayar, V., Buggia-Prévot, V., Guerreiro, R. L., Siegel, G., Rambabu, N., Soohoo, A. L., Ponnusamy, M., Siegenthaler, B., Bali, J., AESG, Simons, M., Ries, J., Puthenveedu, M. A., Hardy, J., Thinakaran, G., & Rajendran, L. | 2013-12-26 |
| Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and locatlization to white matter tracts, Molecular Neurodegeneration | De Rossi, P., Buggia-Prévot, V., Clayton, B. L., Vasquez, J. B., van Sanford, C., Andrew, R. J., Lesnick, R., Botté, A., Deyts, C., Salem, S., Rao, E., Rice, R. C., Parent, A., Kar, S., Popko, B., Pytel, P., Estus, S., & Thinakaran, G. | 2016-08-03 |
| APP Receptor? To be or not to be, Trends in Pharmacological Sciences | Deyts, C., Thinakaran, G., & Parent, A. T. | 2016-01-31 |
| Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation, Cell Reports | De Rossi, P., Nomura, T., Andrew, R. J., Masse, N. Y., Sampathkumar, V., Musial, T. F., Sudwarts, A., Recupero, A. J., Le Metayer, T., Hansen, M. T., Shim, H. N., Krause, S. V., Freedman, D. J., Bindokas, V. P., Kasthuri, N., Nicholson, D. A., Contractor, A., & Thinakaran, G. | 2020-03-10 |
| Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by “molecular tweezers” — from the test tube to animal models, Current Pharmaceutical Design | Attar, A., & Bitan, G. | 2014-05-01 |
| Molecular tweezers targeting transthyretin amyloidosis, Neurotherapeutics | Ferreira, N., Pereira-Henriques, A., Attar, A., Klärner, F. G., Schrader, T., Bitan, G., Gales, L., Saraiva, M. J., & Almeida, M. R. | 2014-04-01 |
| A shortened Barnes Maze Protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer’s disease, PLoS One | Attar, A., Liu, T., Chan, W. T., Hayes, J., Nejad, M., Lei, K., & Bitan, G. | 2013-11-13 |
| Modulators of amyloid protein aggregation and toxicity: EGCG and CLR01, Translational Neuroscience | Attar, A., Rahimi, F., & Bitan, G. | 2013-12-20 |
| Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers, Alzheimer's & Dementia | Sun, X., Eastman, G., Shi, Y., Saibaba, S., Oliveira, A. K., Lukens, J. R., Norambuena, A., Thompson, J. A., Purdy, M. D., Dryden, K., Pardo, E., Mandell, J. W., & Bloom, G. S. | 2023-12-09 |
| Bidirectional modulation of Alzhiemer’s phenotype by alpha-synuclein in mice and primary neurons, Acta Neuropathologica | Khan, S. S., LaCroix, M., Boyle, G., Sherman, M. A., Brown, J. L., Amar, F., Aldaco, J., Lee, M. K., Bloom, G. S., & Lesné, S. E. | 2018-10-01 |
| Localization, induction, and cellular effects of tau phosphorylated at threonine 217, Alzheimer's & Dementia | Rajbanshi, B., Guruacharya, A., M|ell, J. W., & Bloom, G. S. | 2023-01-12 |
| mTOR and neuronal cell cycle re-entry: how impaired brain insulin signaling promotes Alzheimer’s disease, Alzheimer's & Dementia | Rajbanshi, B., Guruacharya, A., Mandell, J. W., & Bloom, G. S. | 2017-02-01 |
| N-methyl-D-aspartate receptor-mediated calciuym influx connects amyloid-beta oligomers to ectopic neuronal cell cycle re-entry in Alzheimer’s Disease, Alzheimer's & Dementia | Kodis, E. J., Choi, S., Swanson, E., Ferreira, G., & Bloom, G. S. | 2018-10-01 |
| Dysregulation of mTOR by tau in Alzheimer’s disease, Cytoskeleton | Bloom, G. S., & Norambuena, A. | 2023-08-28 |
| A half-century of tau, Cytoskeleton | Bloom, G. S., & Baas, P. W. | 2023-08-28 |
| Tau: the center of a signaling nexus in Alzheimer’s disease, Frontiers in Neuroscience | Khan, S. S., & Bloom, G. S. | 2016-02-09 |
| Amyloid-beta and Tau: the trigger and bullet in Alzheimer’s disease pathogenesis, JAMA Neurology | Bloom, G. S. | 2014-04-01 |
| A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer’s Disease Transgenic Mice, Journal of Alzheimer's Disease | Kuwar, R., Rolfe, A., Di, L., Blevins, H., Xu, Y., Sun, X., Bloom, G. S., Zhang, S., & Sun, D. | 2021-01-01 |
| Extracellular Tau Oligomers Damage the Axon Initial Segment, Journal of Alzheimer's Disease | Best, M. N., Lim, Y., Ferenc, N. N., Kim, N., Min, L., Wang, D. B., Sharifi, K., Wasserman, A. E., McTavish, S. A., Siller, K. H., Jones, M. K., Jenkins, P. M., Mandell, J. W., & Bloom, G. S. | 2023-05-09 |
| Intraneuronal Tau Misfolding Induced by Extracellular Amyloid-beta Oligomers, Journal of Alzheimer's Disease | Rudenko, L. K., Wallrabe, H., Periasamy, A., Siller, K. H., Svindrych, Z., Seward, M. E., Best, M. N., & Bloom, G. S. | 2019-10-15 |
| Extracellular tau oligomers induce invasion of endogenous tau into the somatodendritic compartment and axonal transport dysfunction, Journal of Alzhiemer's Disease | Swanson, E., Breckenridge, L., McMahon, L., Som, S., McConnell, I., & Bloom, G. S. | 2017-01-01 |
| Alzheimer’s disease as a metabolic disorder, Lipids | Bloom, G. S., & Norambuena, A. | 2018-08-01 |
| A unifying hypothesis for Alzheimer’s disease: from plaques to neurodegeneration, Trends in Neurosciences | Edwards, F. E. | 2019-05-01 |
| Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia, Molecular Neurodegeneration | Benitez, D. P., Jiang, S., Wood, J., Wang, R., Hall, C. M., Peerboom, C., Wong, N., Stringer, K. M., Vitanova, K. S., Smith, V. C., Joshi, D., Saito, T., Saido, T. C., Hardy, J., Hanrieder, J., De Strooper, B., Salih, D. A., Tripathi, T., Edwards, F. A., & Cummings, D. M. | 2021-07-15 |
| Following spatial Aβ aggregation dynamics in evolving Alzheimer’s disease pathology by imaging stable isotope labeling kinetics, Science Advances | Michno, W., Stringer, K. M., Enzlein, T., Passarelli, M. K., Escrig, S., Vitanova, K., Wood, J., Blennow, K., Zetterberg, H., Meibom, A., Hopf, C., Edwards, F. A., & Hanrieder, J. | 2021-06-16 |
| P2 Receptors: Novel Disease Markers and Metabolic Checkpoints in Immune Cells, Biomolecules | Vultaggio-Poma, V., & Di Virgilio, F. | 2022-07-14 |
| Extracellular ATP: A powerful inflammatory mediator in the central nervous system, Neuropharmacology | Di Virgilio, F., Vultaggio-Poma, V., Falzoni, S., & Giuliani, A. L. | 2022-11-15 |
| Extracellular ATP: A powerful inflammatory mediator in the central nervous system, Neuropharmacology | Di Virgilio, F., Vultaggio-Poma, V., Falzoni, S., & Giuliani, A. L. | 2023-02-15 |
| Fetal bovine serum contains biologically available ATP, Purinergic Signaling | Vultaggio-Poma, V., Scussel Bergamin, L., Falzoni, S., Tarantini, M., Giuliani, A. L., Sandonà, D., Polverino De Laureto, P., & Di Virgilio, F. | 2023-04-19 |
| Unorthodox localization of P2X7 receptor in subcellular compartments of skeletal system cells, Frontiers in Cell and Developmental Biology | Penolazzi, L., Notarangelo, M. P., Lambertini, E., Vultaggio-Poma, V., Tarantini, M., Di Virgilio, F., & Piva, R. | 2023-05-04 |
| The Coming of Age of the P2X7 Receptor in Diagnostic Medicine, International Journal of Molecular Sciences | Di Virgilio, F., Vultaggio-Poma, V., Falzoni, S., & Giuliani, A. L. | 2023-05-30 |
| Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology, Nature Communications | Baglietto-Vargas, D., Forner, S., Cai, L., Martini, A. C., Trujillo-Estrada, L., Swarup, V., ... LaFerla, F. M. | 2021-04-23 |
| Intracranial arteriosclerosis and the risk of dementia: A population-based cohort study, Alzheimer's & Dementia | van den Beukel, T. C., Wolters, F. J., Siebert, U., Spiering, W., Ikram, M. A., Vernooij, M. W., de Jong, P. A., & Bos, D. | 2023-10-09 |
| Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar A beta by multiple endoproteolytic cleavages within the beta-sheet domain, Proceedings of the National Academy of Sciences of the United States of America | Solé-Domènech, S., Rojas, A. V., Maisuradze, G. G., Scheraga, H. A., Lobel, P., & Maxfield, F. R. | 2018-02-13 |
| Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in vitro Phosphorylated Tau and their Modulation by Potential Inhibitors, ACS Chemical Biology | Despres, C., Di, J., Cantrelle, F. X., Li, Z., Huvent, I., Chambraud, B., Zhao, J., Chen, J., Chen, S., Lippens, G., Zhang, F., Linhardt, R., Wang, C., Klärner, F. G., Schrader, T., Landrieu, I., Bitan, G., & Smet-Nocca, C. | 2019-05-02 |
| Modulation of amyloid beta-protein (A beta) assembly by homologous C-terminal fragments strategy for inhibiting Amyloid beta toxicity, ACS Chemical Neuroscience | Li, H., Rahimi, F., & Bitan, G. | 2016-07-05 |
| The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice, Alzheimer's Research & Therapy | Di, J., Siddique, I., Li, Z., Malki, G., Hornung, S., Dutta, S., Hurst, I., Ishaaya, E., Wang, A., Tu, S., Boghos, A., Ericsson, I., Klärner, F. G., Schrader, T., & Bitan, G. | 2021-01-04 |
| Tranilast binds to A beta monomers and promotes A beta fibrillation, Biochemistry | Connors, C. R., Rosenman, D. J., Lopes, D. H., Mittal, S., Bitan, G., Sorci, M., Belfort, G., Garcia, A., & Wang, C. | 2013-05-31 |
| Safety and pharmacological characterization of the molecular tweezer CLR01- a broad spectrum inhibitor of amyloid protein’s toxicity, BMC Pharmacology and Toxicology | Attar, A., Chan, W. T., Klärner, F. G., Schrader, T., & Bitan, G. | 2014-04-16 |
| Protection of primary neurons and mouse brain from Alzheimer’s pathology by molecular tweezers, Brain | Attar, A., Ripoli, C., Riccardi, E., Maiti, P., Li Puma, D. D., Liu, T., Hayes, J., Jones, M. R., Lichti-Kaiser, K., Yang, F., Gale, G. D., Tseng, C. H., Tan, M., Xie, C. W., Straudinger, J. L., Klärner, F. G., Schrader, T., Frautschy, S. A., Grassi, C., & Bitan, G. | 2012-11-24 |
| Molecular tweezers for lysine and arginine — powerful inhibitors of pathologic protein aggregation, Chemical Communications | Schrader, T., Bitan, G., & Klärner, F. G. | 2016-08-22 |
| Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: strategies and mechanisms, ChemMedChem | Liu, T., & Bitan, G. | 2012-02-09 |
| Effects of cerebral amyloid angiopathy on the brain vasculome, Aging Cell | Deng, W., Guo, S., van Veluw, S. J., Yu, Z., Chan, S. J., Takase, H., Arai, K., Ning, M., Greenberg, S. M., Lo, E. H., & Bacskai, B. J. | 2022-07-18 |
| Striatal fibrinogen extravasation and vascular degeneration correlate with motor dysfunction in an aging mouse model of Alzheimer’s disease, Frontiers in Aging Neuroscience | Berk-Rauch, H. E., Choudhury, A., Richards, A. T., Singh, P. K., Chen, Z. L., Norris, E. H., Strickland, S., & Ahn, H. J. | 2023-03-09 |
| Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer’s Disease, Neurobiology of Aging | Tataryn, N. M., Singh, V., Dyke, J. P., Berk-Rauch, H. E., Clausen, D. M., Aronowitz, E., Norris, E. H., Strickland, S., & Ahn, H. J. | 2021-07-28 |
| Spreading of Tau Protein Does Not Depend on Aggregation Propensity, Journal of Molecular Neuroscience | Rodrigues, S., Anglada-Huguet, M., Hochgräfe, K., Kaniyappan, S., Wegmann, S., & Mandelkow, E. M. | 2023-08-22 |
| Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau, Journal of Biological Chemistry | Wischhof, L., Adhikari, A., Mondal, M., Marsal-Cots, A., Biernat, J., Mandelkow, E. M., Mandelkow, E., Ehninger, D., Nicotera, P., & Bano, D. | 2022-02-24 |
| The release and trans-synaptic transmission of Tau via exosomes, Molecular Neurodegeneration | Wang, Y., Balaji, V., Kaniyappan, S., Krüger, L., Irsen, S., Tepper, K., Chandupatla, R., Maetzler, W., Schneider, A., Mandelkow, E., & Mandelkow, E. M. | 2017-01-13 |
| FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments, Molecular Neurodegeneration | Kaniyappan, S., Tepper, K., Biernat, J., Chandupatla, R. R., Hübschmann, S., Irsen, S., Bicher, S., Klatt, C., Mandelkow, E. M., & Mandelkow, E. | 2020-07-16 |
| A comprehensive AI-driven analysis of large-scale omic datasets reveals novel dual-purpose targets for the treatment of cancer and aging, Aging Cell | Pun, F. W., Leung, G. H. D., Leung, H. W., Rice, J., Schmauck-Medina, T., Lautrup, S., Long, X., Liu, B. H. M., Wong, C. W., Ozerov, I. V., Aliper, A., Ren, F., Rosenberg, A. J., Agrawal, N., Izumchenko, E., Fang, E. F., & Zhavoronkov, A. | 2023-10-27 |
| Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer’s disease, Alzheimer's & Dementia | Knapskog, A. B., Aksnes, M., Edwin, T. H., Ueland, P. M., Ulvik, A., Fang, E. F., Eldholm, R. S., Halaas, N. B., Saltvedt, I., Giil, L. M., & Watne, L. O. | 2023-06-02 |
| Editorial: Mitophagy in health and disease, volume II, Frontiers in Cell and Developmental Biology | Fang, E. F., Tavernarakis, N., & Palikaras, K. | 2023-06-29 |
| Chemical mitophagy modulators: Drug development strategies and novel regulatory mechanisms, Pharmacological Research | Dong, Y., Zhuang, X. X., Wang, Y. T., Tan, J., Feng, D., Li, M., Zhong, Q., Song, Z., Shen, H. M., Fang, E. F., & Lu, J. H. | 2023-06-20 |
| Tissue-specific macrophage responses to remote injury impact the outcome of subsequent local immune challenges, Immunity | Hoyer, F. F., Naxerova, K., Schloss, M. J., Hulsmans, M., Nair, A. V., Dutta, P., Calcagno, D. M., Herisson, F., Anzai, A., Sun, Y., Wojtkiewicz, G., Rohde, D., Frodermann, V., Vandoorne, K., Courties, G., Iwamoto, Y., Garris, C. S., Williams, D. L., Breton, S., Brown, D., Whalen, M., Libby, P., Pittet, M. J., King, K. R., Weissleder, R., Swirski, F. K., & Nahrendorf, M., | 2019-11-19 |
| Direct Vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration, Nature Neuroscience | Herisson, F., Frodermann, V., Courties, G., Rohde, D., Sun, Y., Vandoorne, K., Wojtkiewicz, G. R., Masson, G. S., Vinegoni, C., Kim, J., Kim, D. E., Weissleder, R., Swirski, F. K., Moskowitz, M. A., & Nahrendorf, M. | 2018-08-27 |
| A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro, Alzheimer’s Research & Therapy | Aillaud, I., Kaniyappan, S., Chandupatla, R. R., Ramirez, L. M., Alkhashrom, S., Eichler, J., Horn, A. H. C., Zweckstetter, M., Mandelkow, E., Sticht, H., & Funke, S. A. | 2022-01-21 |
| A current view on Tau protein phosphorylation in Alzheimer’s disease., Current Opinion in Neurobiology | Wegmann, S., Biernat, J., & Mandelkow, E. | 2021-04-20 |
| Tau and Membranes: Interactions That Promote Folding and Condensation, Frontiers in Cell and Developmental Biology | Sallaberry, C. A., Voss, B. J., Majewski, J., Biernat, J., Mandelkow, E., Chi, E. Y., & Vander Zanden, C. M. | 2021-09-21 |
| Microfluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer’s Disease, Methods in Molecular Biology | Kaniyappan, S., Balaji, V., Wang, Y., & Mandelkow, E. | 2022-10-31 |
| Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice, Alzheimer's & Dementia | Anglada-Huguet, M., Rodrigues, S., Hochgräfe, K., Mandelkow, E., & Mandelkow, E. M. | 2021-04-19 |
| Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems, Autophagy | Balaji, V., Kaniyappan, S., Mandelkow, E., Wang, Y., & Mandelkow, E. M. | 2018-09-01 |
| Fragmentation of functional resting state brain networks in a transgenic mouse model of tau pathology: A metabolic connectivity study using [18F]FDG-PET, Experimental Neurology | Endepols, H., Anglada-Huguet, M., Mandelkow, E., Neumaier, B., Mandelkow, E. M., & Drzezga, A. | 2023-12-03 |
| Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy, International Journal of Molecular Sciences | Anglada-Huguet, M., Endepols, H., Sydow, A., Hilgers, R., Neumaier, B., Drzezga, A., Kaniyappan, S., Mandelkow, E., & Mandelkow, E. M. | 2023-05-25 |
| Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study, Molecular Neurodegeneration | Endepols, H., Anglada-Huguet, M., Mandelkow, E., Schmidt, Y., Krapf, P., Zlatopolskiy, B. D., Neumaier, B., Mandelkow, E. M., & Drzezga, A. | 2022-03-21 |
| Emerging drug discovery ecosystems, SLAS Discovery | Sharlow, E. R. | 2023-05-30 |
| Benefits of Strategic Small-Scale Targeted Screening, Assay and Drug Development Technologies | Sharlow, E. R. | 2016-08-01 |
| Revisiting repurposing, Assay and Drug Development Technologies | Sharlow, E. R. | 2016-12-01 |
| A Small molecule screen exposes mTOR signaling pathway involvement in radiation-induced apoptosis, ACS Chemical Biology | Sharlow, E. R., Leimgruber, S., Lira, A., McConnell, M. J., Norambuena, A., Bloom, G. S., Epperly, M. W., Greenberger, J. S., & Lazo, J. S. | 2016-05-14 |
| The Promise and Perils of Compound Discovery Screening with Inducible Pluripotent Cell-Derived Neurons, Assay and Drug Development Technologies | Sharlow, E. R., Koseoglu, M. M., Bloom, G. S., & Lazo, J. S. | 2020-02-14 |
| Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations, FEBS Journal | Sharlow, E. R., Llaneza, D. C., Tewari, B. P., Mingledorff, G. A., Mendelson, A. J., Sontheimer, H., Bloom, G. S., & Lazo, J. S. | 2023-07-10 |
| Aberrant neuronal cell-cycle re-entry: the pathological confluence fo Alzheimer’s disease and brain insulin resistance, and its relation to cancer., Journal of Alzheimer's Disease | Koseoglu, M. M., Norambuena, A., Sharlow, E. R., Lazo, J. S., & Bloom, G. S. | 2019-01-08 |
| Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer’s Disease and Brain Insulin Resistance, and Its Relation to Cancer, Journal of Alzheimer's Disease | Koseoglu, M. M., Norambuena, A., Sharlow, E. R., Lazo, J. S., & Bloom, G. S. | 2019-01-08 |
| High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons, SLAS Discovery | Sharlow, E. R., Llaneza, D. C., Grever, W. E., Mingledorff, G. A., Mendelson, A. J., Bloom, G. S., & Lazo, J. S. | 2022-10-20 |
| Transcriptome and Translatome Regulation of Pathogenesis in Alzheimer’s Disease Model Mice, Journal of Alzheimer's Disease | Eastman, G., Sharlow, E. R., Lazo, J. S., Bloom, G. S., & Sotelo-Silveira, J. R. | 2022-03-08 |
| Disease-modifying effects of M-1 muscarinic acetylcholine receptor activation in an Alzheimer’s disease mouse model, ACS Chemical Neuroscience | Lebois, E. P., Schroeder, J. P., Esparza, T. J., Bridges, T. M., Lindsley, C. W., Conn, P. J., Brody, D. L., Daniels, J. S., & Levey, A. I. | 2017-06-21 |
| Use of Repetitive Transcranial Magnetic Stimulation in the Treatment of Neuropsychiatric and Neurocognitive Symptoms Associated With Concussion in Military Populations, Journal of Head Trauma Rehabilitation | Oberman, L. M., Exley, S., Philip, N. S., Siddiqi, S. H., Adamson, M. M., & Brody, D. L. | 2020-11-25 |
| Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid beta accumulation and independently accelerates the development of tau abnormalities, Journal of Neuroscience | Tran, H. T., LaFerla, F. M., Holtzman, D. M., & Brody, D. L. | 2011-06-29 |
| Traumatic brain injury reduces solubl extracellular amyloid-beta in mice: a methodologically novel combined microdialysis-controlled cortical impact study, Neurobiology of Disease | Schwetye, K. E., Cirrito, J. R., Esparza, T. J., Mac Donald, C. L., Holtzman, D. M., & Brody, D. L. | 2010-12-01 |
| Amyloid-beta dynamics correlate with neurological status in the injured human brain, Science | Brody, D. L., Magnoni, S., Schwetye, K. E., Spinner, M. L., Esparza, T. J., Stocchetti, N., Zipfel, G. J., & Holtzman, D. M. | 2008-08-29 |
| Non-canonical soluble amyloid beta aggregates and plaque buffering: controversies and future direction for target discovery in Alzheier’s disease., Alzheimer's Research & Therapy | Brody, D. L., Jiang, H., Wildburger, N., & Esparza, T. J. | 2017-08-17 |
| New Perspectives on Immune Involvement in Parkinson’s Disease Pathogenesis, Journal of Parkinson's disease | Gate D. | 2022-09-27 |
| Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment, Cell | Piehl, N., van Olst, L., Ramakrishnan, A., Teregulova, V., Simonton, B., Zhang, Z., Tapp, E., Channappa, D., Oh, H., Losada, P. M., Rutledge, J., Trelle, A. N., Mormino, E. C., Elahi, F., Galasko, D. R., Henderson, V. W., Wagner, A. D., Wyss-Coray, T., & Gate, D. | 2022-12-13 |
| C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death, Journal of Neuroscience | Kanmert, D., Cantlon, A., Muratore, C. R., Jin, M., O'Malley, T. T., Lee, G., Young-Pearse, T. L., Selkoe, D. J., & Walsh, D. M. | 2015-07-20 |
| The Familial British dementia mutation promates formation of neurotoxic cystine cross-linked amyloid Bri (Abri) Oligomers, Journal of Biological Chemistry | Cantlon, A., Frigerio, C. S., Freir, D. B., Boland, B., Jin, M., & Walsh, D. M. | 2015-07-03 |
| Tau immunization: a cautionary tale?, Neurobiology of Aging | Mably, A. J., Kanmert, D., Mc Donald, J. M., Liu, W., Caldarone, B. J., Lemere, C. A., O'Nuallain, B., Kosik, K. S., & Walsh, D. M. | 2015-03-01 |
| Alzheimer’s secretases regulate voltage-gated sodium channels, Neuroscience Letters | Kovacs, D. M., Gersbacher, M. T., & Kim, D. Y. | 2010-12-10 |
| BACE1 and presenilin/gamma-secretase regulate proteolytic processing of KCNE1 and 2, auxilary subunits of voltage-gated potassium channels, The FASEB Journal | Sachse, C. C., Kim, Y. H., Agsten, M., Huth, T., Alzheimer, C., Kovacs, D. M., & Kim, D. Y. | 2013-03-15 |
| Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H 2 O 2- production, Nature Neuroscience | Chun, H., Im, H., Kang, Y. J., Kim, Y., Shin, J. H., Won, W., Lim, J., Ju, Y., Park, Y. M., Kim, S., Lee, S. E., Lee, J., Woo, J., Hwang, Y., Cho, H., Jo, S., Park, J. H., Kim, D., Kim, D. Y., Seo, J. S., Gwag, B. J., Kim, Y. S., Park K. D., Kaang, B. K., Cho, H., Ryu, H., & Lee, C. J. | 2020-11-16 |
| Three-Dimensional Models of the Human Brain Development and Disease, Advanced Healthcare Materials | Jorfi, M., D'Avanzo, C., Kim, D. Y., & Irimia, D. | 2017-08-28 |
| Isoflurane facilitates synaptic NMDA receptor endocytosis in mice primary neurons, Current Molecular Medicine | Dong, Y., Wu, X., Zhang, G., Xu, Z., Zhang, Y., Gautam, V., Kovacs, D. M., Wu, A., Yue, Y., & Xie, Z. | 2013-05-01 |
| Emerging roles of innate and adaptive immunity in Alzheimer’s disease, Immunity | Chen, X., & Holtzman, D. M. | 2022-12-13 |
| Microglia derived APOE-dependent neurodegneration in a tauopathy mouse model, Journal of Experimental Medicine | Shi, Y., Manis, M., Long, J., Wang, K., Sullivan, P. M., Remolina Serrano, J., Hoyle, R., & Holtzman, D. M. | 2019-11-04 |
| Antibody Therapeutics targeting Abeta and Tau, Cold Spring Harbor Perspectives in Medicine | Gallardo, G., & Holtzman, D. M. | 2017-10-01 |
| Astrocytic α2-Na+/K+ ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model, Science Translational Medicine | Mann, C. N., Devi, S. S., Kersting, C. T., Bleem, A. V., Karch, C. M., Holtzman, D. M., & Gallardo, G. | 2022-02-16 |
| Hallmarks of neurodegenerative diseases, Cell | Wilson, D. M., 3rd, Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. | 2023-02-16 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease, Nature Medicine | Zhou, Y., Song, W. M., Andhey, P. S., Swain, A., Levy, T., Miller, K. R., Poliani, P. L., Cominelli, M., Grover, S., Gilfillan, S., Cella, M., Ulland, T. K., Zaitsev, K., Miyashita, A., Ikeuchi, T., Sainouchi, M., Kakita, A., Bennett, D. A., Schneider, J. A., Nichols, M. R., Beausoleil, S. A., Ulrich, J., Holtzman, D. M., Artyomov, M. N., & Colonna, M. | 2020-01-13 |
| Driving cessation over a 24-hour period: dementia severity and cerebrospinal fluid markers, Alzheimer's & Dementia | Stout, S. H., Babulal, G. M., Ma, C., Carr, D. B., Head, D. M., Grant, E. A., Williams, M. M., Holtzman, D. M., Fagan, A. M., Morris, J. C., & Roe, C. M. | 2018-05-01 |
| NIA-AA staging of preclinical Alzhiemer disease: discordance and concordance of CSF and imaging biomarkers, Neurobiology of Aging | Vos, S. J. B., Gordon, B. A., Su, Y., Visser, P. J., Holtzman, D. M., Morris, J. C., Fagan, A. M., & Benzinger, T. L. S. | 2016-04-04 |
| Cognitively unimpaired HIV-positive subjects do not have icreased C-11 PiB A case-control study, Neurology | Ances, B. M., Christensen, J. J., Teshome, M., Taylor, J., Xiong, C., Aldea, P., Fagan, A. M., Holtzman, D. M., Morris, J. C., Mintun, M. A., & Clifford, D. B. | 2010-07-13 |
| Amyloid beta concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis, Alzheimer's & Dementia | Ovod, V., Ramsey, K. N., Mawuenyega, K. G., Bollinger, J. G., Hicks, T., Schneider, T., Sullivan, M., Paumier, K., Holtzman, D. M., Morris, J. C., Benzinger, T., Fagan, A. M., Patterson, B. W., & Bateman, R. J. | 2017-07-19 |
| Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy, Nature | Da Mesquita, S., Papadopoulos, Z., Dykstra, T., Brase, L., Farias, F. G., Wall, M., Jiang, H., Kodira, C. D., de Lima, K. A., Herz, J., Louveau, A., Goldman, D. H., Salvador, A. F., Onengut-Gumuscu, S., Farber, E., Dabhi, N., Kennedy, T., Milam, M. G., Baker, W., Smirnov, I., Rich, S. S., Dominantly Inherited Alzheimer Network, Benitez, B. A., Karch, C. M., Perrin, R. J., Farlow, M., Chhatwal, J. P., Holtzman, D. M., Cruchaga, C., Harari, O., & Kipnis, J. | 2021-04-28 |
| TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways, Cell | Wang, S., Sudan, R., Peng, V., Zhou, Y., Du, S., Yuede, C. M., Lei, T., Hou, J., Cai, Z., Cella, M., Nguyen, K., Poliani, P. L., Beatty, W. L., Chen, Y., Cao, S., Lin, K., Rodrigues, C., Ellebedy, A. H., Gilfillan, S., Brown, G. D., Holtzman, D. M., Brioschi, S., & Colonna, M. | 2022-10-27 |
| Altered microglial response to A beta plaques in APPPS1-21 mice heterozygous for TREM2, Molecular Neurodegeneration | Ulrich, J. D., Finn, M. B., Wang, Y., Shen, A., Mahan, T. E., Jiang, H., Stewart, F. R., Piccio, L., Colonna, M., & Holtzman, D. M. | 2014-06-03 |
| TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model, Cell | Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., Gilfillan, S., Krishnan, G. M., Sudhakar, S., Zinselmeyer, B. H., Holtzman, D. M., Cirrito, J. R., & Colonna, M. | 2015-03-12 |
| TREM2 Function Impedes Tau Seeding in Neuritic Plaques, Nature Neuroscience | Leyns, C. E. G., Gratuze, M., Narasimhan, S., Jain, N., Koscal, L. J., Jiang, H., Manis, M., Colonna, M., Lee, V. M. Y., Ulrich, J. D., & Holtzman, D. M. | 2019-06-01 |
| Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype, Analytical Biochemistry | Lawler, P. E., Bollinger, J. G., Schindler, S. E., Hodge, C. R., Iglesias, N. J., Krishnan, V., Coulton, J. B., Li, Y., Holtzman, D. M., & Bateman, R. J. | 2023-04-16 |
| Amyloid beta oligomerization in Alzheimer’s dementia versus high pathology controls, Annals of Neurology | Esparza, T. J., Zhao, H., Cirrito, J. R., Cairns, N. J., Bateman, R. J., Holtzman, D. M., & Brody, D. L. | 2013-01-01 |
| CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease, Nature Medicine | Horie, K., Salvadó, G., Barthélemy, N. R., Janelidze, S., Li, Y., He, Y., Saef, B., Chen, C. D., Jiang, H., Strandberg, O., Pichet Binette, A., Palmqvist, S., Sato, C., Sachdev, P., Koyama, A., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Mattsson-Carlgren, N., … Bateman, R. J. | 2023-07-13 |
| The binding of apolipoprotein E to oligomers and fibrils of amyloid-beta alters the kinetics of amyloid aggregation, Biochemistry | Garai, K., Verghese, P. B., Baban, B., Holtzman, D. M., & Frieden, C. | 2014-09-25 |
| Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system, Brain Research | Zeng, C., Pan, F., Jones, L. A., Lim, M. M., Griffin, E. A., Sheline, Y. I., Mintun, M. A., Holtzman, D. M., & Mach, R. H. | 2010-03-01 |
| Alzhiemer’s Disease: an update on pathobiology and treatment strategies, Cell | Long, J. M., & Holtzman, D. M. | 2019-09-26 |
| Is there a link between the sleep-wake cycle and Alzheimer’s pathology, Future Neurology | Roh, J. H., & Holtzman, D. M. | 2015-05-01 |
| Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer’s disease transgenic mice, Journal of Alzheimers Disease | Cao, C., Cirrito, J. R., Lin, X., Wang, L., Verges, D. K., Dickson, A., Mamcarz, M., Zhang, C., Mori, T., Arendash, G. W., Holtzman, D. M., & Potter, H. | 2009-07-01 |
| Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of A beta amyloidosis, Journal of Experimental Medicine | Kim, J., Eltorai, A. E., Jiang, H., Liao, F., Verghese, P. B., Kim, J., Stewart, F. R., Basak, J. M., & Holtzman, D. M. | 2012-11-19 |
| Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease, Journal of Experimental Medicine | Roh, J. H., Jiang, H., Finn, M. B., Stewart, F. R., Mahan, T. E., Cirrito, J. R., Heda, A., Snider, B. J., Li, M., Yanagisawa, M., de Lecea, L., & Holtzman, D. M. | 2014-11-24 |
| Characterizing the Appearance and Growth of Amyloid plaques in APP/PS1 Mice, Journal of Neuroscience | Yan, P., Bero, A. W., Cirrito, J. R., Xiao, Q., Hu, X., Wang, Y., Gonzales, E., Holtzman, D. M., & Lee, J. M. | 2009-08-26 |
| Opposing synaptic regulation of amyloid-beta metabolism by NMDA Receptors in vivo, Journal of Neuroscience | Verges, D. K., Restivo, J. L., Goebel, W. D., Holtzman, D. M., & Cirrito, J. R. | 2011-08-03 |
| Effects of CD2-associated protein deficiency on amyloid-beta in neuroblastoma cells and in an APP transgenic mouse model., Molecular Neurodegeneration | Liao, F., Jiang, H., Srivatsan, S., Xiao, Q., Lefton, K. B., Yamada, K., Mahan, T. E., Lee, J. M., Shaw, A. S., & Holtzman, D. M. | 2015-03-19 |
| Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy, Molecular Neurodegenration | Xiong, M., Wang, C., Gratuze, M., Saadi, F., Bao, X., Bosch, M. E., Lee, C., Jiang, H., Serrano, J. R., Gonzales, E. R., Kipnis, M., & Holtzman, D. M. | 2023-03-16 |
| Emerging diagnostics and therapeutics for Alzheimer disease, Nature Medicine | Self, W. K., & Holtzman, D. M. | 2023-09-04 |
| Neuronal activity regulates the regional vulnerability to amyloid-beta deposition, Nature Neuroscience | Bero, A. W., Yan, P., Roh, J. H., Cirrito, J. R., Stewart, F. R., Raichle, M. E., Lee, J. M., & Holtzman, D. M. | 2011-06-01 |
| Interplay between Innate immunity and Alzheimer’s disease: APOE ad TREM2 in the spotlight, Nature Reviews Immunology | Shi, Y., & Holtzman, D. M. | 2018-08-23 |
| Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis, Neuron | Chen, Y., Strickland, M. R., Soranno, A., & Holtzman, D. M. | 2020-11-10 |
| Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum, NeuroReport | Lim, M. M., Xu, J., Holtzman, D. M., & Mach, R. H. | 2011-07-13 |
| Current status of amyloid-targeting immunotherapies for Alzheimer’s disease, Science Translational Medicine | Tabor, G. T., & Holtzman, D. M. | 2023-11-08 |
| APOE mediated neuroinflammation and neurodegeneration in Alzheimer’s disease, Seminars in Immunology | Parhizkar, S., & Holtzman, D. M. | 2022-02-26 |
| Minocycline reduces spontaneous hemorrhage in mouse models of cerebral amyloid angiopathy, Stroke | Yan, P., Zhu, A., Liao, F., Xiao, Q., Kraft, A., Gonzales, E., Perez, R., Greenberg, S. M., Holtzman, D., & Lee, J. M. | 2015-06-01 |
| On the Recombination Rate Estimation in the Presence of Populaion Substructure, PLoS One | Hecker, J., Prokopenko, D., Lange, C., & Fier, H. L. | 2015-12-30 |
| A novel locus for exertional dyspnoea in childhood asthma, The European respiratory journal | Lee, S., Lasky-Su, J. A., Lange, C., Kim, W., Kumar, P. L., McDonald, M. N., Vaz Fragoso, C. A., Laurie, C., Raby, B. A., Celedón, J. C., Cho, M. H., Won, S., Weiss, S. T., Hecker, J., & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium | 2021-02-04 |
| Novel recessive locus for body mass index in childhood asthma, Thorax | Lee, S., Lasky-Su, J., Won, S., Laurie, C., Celedón, J. C., Lange, C., Weiss, S., & Hecker, J. | 2021-04-22 |
| Exosomes neutralize synaptic-plasticity-disrupting activity of A beta assemblies in vivo, Molecular Brain | An, K., Klyubin, I., Kim, Y., Jung, J. H., Mably, A. J., O'Dowd, S. T., Lynch, T., Kanmert, D., Lemere, C. A., Finan, G. M., Park, J. W., Kim, T. W., Walsh, D. M., Rowan, M. J., & Kim, J. H. | 2013-11-13 |
| Further understanding the connection between Alzheimer’s disease and Down syndrome, Alzheimer's & Dementia | Snyder, H. M., Bain, L. J., Brickman, A. M., Carrillo, M. C., Esbensen, A. J., Espinosa, J. M., Fernandez, F., Fortea, J., Hartley, S. L., Head, E., Hendrix, J., Kishnani, P. S., Lai, F., Lao, P., Lemere, C., Mobley, W., Mufson, E. J., Potter, H., Zaman, S. H., Granholm, A. C., … Rafii, M. S. | 2020-06-16 |
| ApoE mimetic improves pathology and memory in a model of Alzheimer’s disease, Brain Research | Krishnamurthy, K., Cantillana, V., Wang, H., Sullivan, P. M., Kolls, B. J., Ge, X., Lin, Y., Mace, B., & Laskowitz, D. T. | 2020-01-30 |
| Implicating endothelial cell senescence to dysfunction in the ageing and diseased brain, Basic & Clinical Pharmacology & Toxicology | Graves, S. I., & Baker, D. J. | 2020-03-11 |
| Insights from In Vivo Studies of Cellular Senescence, Cells | Prieto, L. I., Graves, S. I., & Baker, D. J. | 2020-04-13 |
| Untangling senescent and damage-associated microglia in the aging and diseased brain, FEBS Journal | Ng, P. Y., McNeely, T. L., & Baker, D. J. | 2021-12-14 |
| Cellular senescence in ageing: from mechanisms to therapeutic opportunities, Nature Reviews Molecular Cell Biology | Di Micco, R., Krizhanovsky, V., Baker, D., & d'Adda di Fagagna, F. | 2021-08-06 |
| Corpora amylacea are associated with tau burden and cognitive status in Alzheimer’s disease, Acta Neuropathologica Communications | Wander, C. M., Tsujimoto, T. H. M., Ervin, J. F., Wang, C., Maranto, S. M., Bhat, V., Dallmeier, J. D., Wang, S. J., Lin, F. C., Scott, W. K., Holtzman, D. M., & Cohen, T. J. | 2022-08-08 |
| Altered sleep and EEG power in the P301S tau transgenic mouse model, Annals of Clinical and Translational Neurology | Holth, J. K., Mahan, T. E., Robinson, G. O., Rocha, A., & Holtzman, D. M. | 2017-03-01 |
| Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans, Biomedicines | Sommerer, Y., Dobricic, V., Schilling, M., Ohlei, O., Bartrés-Faz, D., Cattaneo, G., Demuth, I., Düzel, S., Franzenburg, S., Fuß, J., Lindenberger, U., Pascual-Leone, Á., Sabet, S. S., Solé-Padullés, C., Tormos, J. M., Vetter, V. M., Wesse, T., Franke, A., Lill, C. M., & Bertram, L. | 2022-11-03 |
| Using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts, GeroScience | Drewelies, J., Hueluer, G., Duezel, S., Vetter, V. M., Pawelec, G., Steinhagen-Thiessen, E., Wagner, G. G., Lindenberger, U., Lill, C. M., Bertram, L., Gerstorf, D., & Demuth, I. | 2022-09-24 |
| Genome-wide analysis furthers decoding of Alzheimer disease genetics, Nature Reviews Neurology | Lill, C. M., & Bertram, L. | 2022-05-27 |
| Genetic associations with learning over 100 days of practice, npj Science of Learning | Youn, C., Grotzinger, A. D., Lill, C. M., Bertram, L., Schmiedek, F., Lövdén, M., Lindenberger, U., Nivard, M., Harden, K. P., & Tucker-Drob, E. M. | 2022-05-04 |
| Differential microRNA expression analyses across two brain regions in Alzheimer’s disease, Translational Psychiatry | Dobricic, V., Schilling, M., Schulz, J., Zhu, L. S., Zhou, C. W., Fuß, J., Franzenburg, S., Zhu, L. Q., Parkkinen, L., Lill, C. M., & Bertram, L. | 2022-08-29 |
| A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests, Bioinformatics | Hecker, J., Townes, F. W., Kachroo, P., Laurie, C., Lasky-Su, J., Ziniti, J., Cho, M. H., Weiss, S. T., Laird, N. M., & Lange, C. | 2020-12-26 |
| Utilizing the Jaccard index to reveal population stratification data: a simulation study and an application ot the 1000 Genome Project, Bioinformatics | Prokopenko, D., Hecker, J., Silverman, E. K., Pagano, M., Nöthen, M. M., Dina, C., Lange, C., & Fier, H. L. | 2016-05-01 |
| Identification of genetic outliers due to sub-structure and cryptic relationships, Bioinformatics | Schlauch, D., Fier, H., & Lange, C. | 2017-03-03 |
| PolyGEE: A generalized estimating equation approach to the efficient and robust estimation of polygenic effects in large-scale association studies, Biostatistics | Hecker, J., Prokopenko, D., Lange, C., & Fier, H. L. | 2018-07-01 |
| A consistent pattern of slide effects in Illumina DNA methylation BeadChip array data, Epigenetics | Hecker, J., Lee, S., Kachroo, P., Prokopenko, D., Maaser-Hecker, A., Lutz, S. M., Hahn, G., Irizarry, R., Weiss, S. T., DeMeo, D. L., & Lange, C. | 2023-09-23 |
| Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma, European Respiratory Journal | Lee, S., Prokopenko, D., Kelly, R. S., Lutz, S., Ann Lasky-Su, J., Cho, M. H., Laurie, C., Celedón, J. C., Lange, C., Weiss, S. T., Hecker, J., & DeMeo, D. L. | 2023-01-06 |
| Family-based tests for associating haplotypes with general phenotype data, Genetic Epidemiology | Hecker, J., Xu, X., Townes, F. W., Loehlein Fier, H., Corcoran, C., Laird, N., & Lange, C. | 2017-11-21 |
| Unsupervised cluster analysis of SARS-CoV-2 genomes reflects its geographic progression and identifies distinct genetic subgroups of SARS-CoV-2 virus, Genetic Epidemiology | Hahn, G., Lee, S., Weiss, S. T., & Lange, C. | 2021-01-08 |
| Selection bias when inferring the effect direction in Mendelian randomization, Genetic Epidemiology | Lutz, S. M., Voorhies, K., Wu, A. C., Hokanson, J., Vansteelandt, S., & Lange, C. | 2022-05-02 |
| A Comparison of Popular TDT-generalizations for family-based association analysis, Genetic Epidemiology | Hecker, J., Laird, N., & Lange, C. | 2019-01-04 |
| A flexible and nearly optimal sequential testing approach to randomized testing: QUICK-STOP, Genetic Epidemiology | Hecker, J., Ruczinski, I., Cho, M. H., Silverman, E. K., Coull, B., & Lange, C. | 2019-11-11 |
| The effects of misspecification of the mediator and outcome in mediation analysis, Genetic Epidemiology | Lutz, S. M., Sordillo, J. E., Hokanson, J. E., Chen Wu, A., & Lange, C. | 2020-03-13 |
| Integrating mulitple correlated phenotypes for genetic association analysis by maximizing heritability, Human Heredity | Zhou, J. J., Cho, M. H., Lange, C., Lutz, S., Silverman, E. K., & Laird, N. M. | 2015-06-20 |
| An interaction of the 17q12-21 locus with mold exposure in childhood asthma, Pediatric Allergy and Immunology | Lee, S., Lasky-Su, J., Kim, W., Won, S., Laurie, C., Celedón, J. C., Lange, C., Weiss, S. T., & Hecker, J. | 2020-09-18 |
| Using Network Methodology to infer population substructure, PLoS One | Prokopenko, D., Hecker, J., Silverman, E., Nöthen, M. M., Schmid, M., Lange, C., & Loehlein Fier, H. | 2015-06-22 |
| Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E, Molecular Neurodegeneration | Robert, J., Button, E. B., Martin, E. M., McAlary, L., Gidden, Z., Gilmour, M., Boyce, G., Caffrey, T. M., Agbay, A., Clark, A., Silverman, J. M., Cashman, N. R., & Wellington, C. L. | 2020-03-25 |
| An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases, Molecular Neurodegeneration | Robert, J., Weilinger, N. L., Cao, L. P., Cataldi, S., Button, E. B., Stukas, S., Martin, E. M., Seibler, P., Gilmour, M., Caffrey, T. M., Rowe, E. M., Fan, J., MacVicar, B., Farrer, M. J., & Wellington, C. L. | 2020-11-19 |
| Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia, Molecular Neurodegenration | Poliakova, T., & Wellington, C. L. | 2023-11-16 |
| Assessing the importance of interleukin-6 in COVID-19, The Lancet Respiratory Medicine | Chen, L. Y. C., Hoiland, R. L., Stukas, S., Wellington, C. L., & Sekhon, M. S. | 2021-02-09 |
| Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer’s disease., Alzheimer's & Dementia | Gispert, J. D., Suárez-Calvet, M., Monté, G. C., Tucholka, A., Falcon, C., Rojas, S., Rami, L., Sánchez-Valle, R., Lladó, A., Kleinberger, G., Haass, C., & Molinuevo, J. L. | 2016-07-13 |
| The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism, EMBO Journal | Kleinberger, G., Brendel, M., Mracsko, E., Wefers, B., Groeneweg, L., Xiang, X., Focke, C., Deußing, M., Suárez-Calvet, M., Mazaheri, F., Parhizkar, S., Pettkus, N., Wurst, W., Feederle, R., Bartenstein, P., Mueggler, T., Arzberger, T., Knuesel, I., Rominger, A., & Haass, C. | 2017-05-30 |
| TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance, EMBO Molecular Medicine | Xiang, X., Werner, G., Bohrmann, B., Liesz, A., Mazaheri, F., Capell, A., Feederle, R., Knuesel, I., Kleinberger, G., & Haass, C. | 2016-07-08 |
| Asymmetry of fibrillar plaque burden in amyloid mouse models, Journal of Nuclear Medicine | Sacher, C., Blume, T., Beyer, L., Biechele, G., Sauerbeck, J., Eckenweber, F., Deussing, M., Focke, C., Parhizkar, S., Lindner, S., Gildehaus, F. J., von Ungern-Sternberg, B., Baumann, K., Tahirovic, S., Kleinberger, G., Willem, M., Haass, C., Bartenstein, P., Cumming, P., Rominger, A., Herms, J., & Brendel, M. | 2020-05-15 |
| CSF glial biomarkers YKL40 and sTREM2 are associated with longitudinal volume and diffusivity changes in cognitively unimpaired individuals, NeuroImage: Clinical | Falcon, C., Monté-Rubio, G. C., Grau-Rivera, O., Suárez-Calvet, M., Sánchez-Valle, R., Rami, L., Bosch, B., Haass, C., Gispert, J. D., & Molinuevo, J. L. | 2019-04-01 |
| Specific Inhibition of beta-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein, Cell Reports | Ben Halima, S., Mishra, S., Raja, K. M. P., Willem, M., Baici, A., Simons, K., Brüstle, O., Koch, P., Haass, C., Caflisch, A., & Rajendran, L. | 2016-02-25 |
| Opposite microglial activations stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism, EMBO Molecular Medicine | Götzl, J. K., Brendel, M., Werner, G., Parhizkar, S., Sebastian Monasor, L., Kleinberger, G., Colombo, A. V., Deussing, M., Wagner, M., Winkelmann, J., Diehl-Schmid, J., Levin, J., Fellerer, K., Reifschneider, A., Bultmann, S., Bartenstein, P., Rominger, A., Tahirovic, S., Smith, S. T., Madore, C., Butovsky, O., Capell, A., & Haass, C. | 2019-06-01 |
| Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury, Science Translational Medicine | Suárez-Calvet, M., Araque Caballero, M. Á., Kleinberger, G., Bateman, R. J., Fagan, A. M., Morris, J. C., Levin, J., Danek, A., Ewers, M., & Haass, C. | 2016-12-14 |
| Signatures of glial activity can be detected in the CSF proteome, Proceedings of the National Academy of Sciences of the United States of America | Eninger, T., Müller, S. A., Bacioglu, M., Schweighauser, M., Lambert, M., Maia, L. F., Neher, J. J., Hornfeck, S. M., Obermüller, U., Kleinberger, G., Haass, C., Kahle, P. J., Staufenbiel, M., Ping, L., Duong, D. M., Levey, A. I., Seyfried, N. T., Lichtenthaler, S. F., Jucker, M., & Kaeser, S. A. | 2022-06-06 |
| Role of estrogen in women’s Alzheimer’s disease risk as modified by APOE, Journal of Neuroendocrinology | Valencia-Olvera, A. C., Maldonado Weng, J., Christensen, A., LaDu, M. J., & Pike, C. J. | 2022-10-20 |
| APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer’s disease mice, Journal of Neuroinflammation | Stephen, T. L., Breningstall, B., Suresh, S., McGill, C. J., & Pike, C. J. | 2022-12-01 |
| Effects of APOE Genotype and Western Diet on Metabolic Phenotypes in Female Mice, Metabolites | Christensen, A., & Pike, C. J. | 2023-02-16 |
| APOE, Genotype, and Sex affect microglial interactions with plaques in Alzheimer’s disease mice, Acta Neuropathologica Communications | Stephen, T. L., Cacciottolo, M., Balu, D., Morgan, T. E., LaDu, M. J., Finch, C. E., & Pike, C. J. | 2019-05-21 |
| Transcriptome-wide Association Study in Frontotemporal Dementia Identifies New Disease Loci by In Silico Analysis, Biological Psychiatry | Lill C. M. | 2021-04-15 |
| MicroRNAs as Molecular Biomarkers for Parkinson’s Disease Progression, Movement Disorders | Schilling, M., & Lill, C. M. | 2021-07-05 |
| Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer’s disease, Alzheimer's Research & Therapy | Sommerer, Y., Dobricic, V., Schilling, M., Ohlei, O., Sabet, S. S., Wesse, T., Fuß, J., Franzenburg, S., Franke, A., Parkkinen, L., Lill, C. M., & Bertram, L. | 2023-05-06 |
| Positron Emission Tomography Imaging of Fibrillar Parenchymal and Vascular Amyloid-beta in TgCRND8 Mice, ACS Chemical Neuroscience | McLean, D., Cooke, M. J., Albay, R., 3rd, Glabe, C., & Shoichet, M. S. | 2013-03-19 |
| The anti-amyloid beta monoclonal antibody 4G8 recognizes a generic sequence-independent epitope associated with alpha-synuclein and islet amyloid polypeptide amyloid fibrils, Journal of Alzheimer's Disease | Hatami, A., Monjazeb, S., & Glabe, C. | 2016-12-01 |
| Epitomic Characterization of the specificity of the Anti-Amyloid A beta Monoclonal Antibodies 6E10 and 4G8, Journal of Alzheimer's Disease | Baghallab, I., Reyes-Ruiz, J. M., Abulnaja, K., Huwait, E., & Glabe, C. | 2018-11-05 |
| Monoclonal antibodies against A beta 42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer’s disease brain, Journal of Biological Chemistry | Hatami, A., Albay, R., 3rd, Monjazeb, S., Milton, S., & Glabe, C. | 2014-10-03 |
| Familial Alzheimer’s Disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid-beta peptide, Journal of Biological Chemistry | Hatami, A., Monjazeb, S., Milton, S., & Glabe, C. G. | 2017-01-03 |
| An “epitomic” analysis of the specificity of conformation-dependent, anti-Aß amyloid monoclonal antibodies, Journal of Biological Chemistry | Reyes-Ruiz, J. M., Nakajima, R., Baghallab, I., Goldschmidt, L., Sosna, J., Mai Ho, P. N., Kumosani, T., Felgner, P. L., & Glabe, C. | 2020-12-14 |
| Structural Classification of Toxic Amyloid Oligomers, Journal of Biological Chemistry | Glabe C. G. | 2008-10-31 |
| Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer, Journal of Biological Chemistry | Kayed, R., Pensalfini, A., Margol, L., Sokolov, Y., Sarsoza, F., Head, E., Hall, J., & Glabe, C. | 2009-02-13 |
| Fibrillar Oligomers Nucleate the Oligomerization of Monomeric Amyloid beta but Do Not Seed Fibril Formation, Journal of Biological Chemistry | Wu, J. W., Breydo, L., Isas, J. M., Lee, J., Kuznetsov, Y. G., Langen, R., & Glabe, C. | 2009-12-15 |
| Systematic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing A deposition and tau pathology in 3xTg AD mice, Journal of Neurochemistry | Rasool, S., Martinez-Coria, H., Wu, J. W., LaFerla, F., & Glabe, C. G. | 2013-08-01 |
| Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers, Molecular Neurodegeneration | Kayed, R., Head, E., Sarsoza, F., Saing, T., Cotman, C. W., Necula, M., Margol, L., Wu, J., Breydo, L., Thompson, J. L., Rasool, S., Gurlo, T., Butler, P., & Glabe, C. G. | 2007-09-26 |
| Conformational dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar A beta oligomers, Molecular Neurodegeneration | Kayed, R., Canto, I., Breydo, L., Rasool, S., Lukacsovich, T., Wu, J., Albay, R., 3rd, Pensalfini, A., Yeung, S., Head, E., Marsh, J. L., & Glabe, C. | 2010-12-13 |
| Early long-term administration of CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in FXFAD mouse models of Alzheimer’s disease., Molecular Neurodegeneration | Sosna, J., Philipp, S., Albay, R., 3rd, Reyes-Ruiz, J. M., Baglietto-Vargas, D., LaFerla, F. M., & Glabe, C. G. | 2018-03-01 |
| Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques, Neurobiology of Disease | Pensalfini, A., Albay, R., 3rd, Rasool, S., Wu, J. W., Hatami, A., Arai, H., Margol, L., Milton, S., Poon, W. W., Corrada, M. M., Kawas, C. H., & Glabe, C. G. | 2014-11-01 |
| Soluble fibrillar oligomer levels are elevated in Alzheimer’s disease brain and correlate with cognitive dysfunction, Neurobiology of Disease | Tomic, J. L., Pensalfini, A., Head, E., & Glabe, C. G. | 2009-09-01 |
| Development of a novel, sensitive translational immunoassay to detect plasma glial fibrillary acidic protein (GFAP) after murine traumatic brain injury, Alzheimer's Research & Therapy | Button, E. B., Cheng, W. H., Barron, C., Cheung, H., Bashir, A., Cooper, J., Gill, J., Stukas, S., Baron, D. C., Robert, J., Rowe, E. M., Cripton, P. A., & Wellington, C. L. | 2021-03-07 |
| The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19, Blood Advances | Hoiland, R. L., Fergusson, N. A., Mitra, A. R., Griesdale, D. E. G., Devine, D. V., Stukas, S., Cooper, J., Thiara, S., Foster, D., Chen, L. Y. C., Lee, A. Y. Y., Conway, E. M., Wellington, C. L., & Sekhon, M. S. | 2020-10-14 |
| Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome, Cell Reports Medicine | Chen, L. Y. C., Biggs, C. M., Jamal, S., Stukas, S., Wellington, C. L., & Sekhon, M. S. | 2021-04-19 |
| Confronting the controversy: Interleukin-6 and the COVID-19 cytokine storm syndrome, European Respiratory Journal | Chen, L. Y. C., Hoiland, R. L., Stukas, S., Wellington, C. L., & Sekhon, M. S. | 2020-10-01 |
| Neurotoxicity of Diesel Exhaust Particles, Journal of Alzheimer's disease | Shkirkova, K., Lamorie-Foote, K., Zhang, N., Li, A., Diaz, A., Liu, Q., Thorwald, M. A., Godoy-Lugo, J. A., Ge, B., D'Agostino, C., Zhang, Z., Mack, W. J., Sioutas, C., Finch, C. E., Mack, W. J., & Zhang, H. | 2022-10-11 |
| Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo, Journal of Neuroinflammation | Woodward, N. C., Levine, M. C., Haghani, A., Shirmohammadi, F., Saffari, A., Sioutas, C., Morgan, T. E., & Finch, C. E. | 2017-04-14 |
| Age, sex, and cerebral microbleeds in EFAD Alzheimer disease mice, Neurobiology of Aging | Cacciottolo, M., Morgan, T. E., & Finch, C. E. | 2021-02-28 |
| Female vulnerability to the effects of smoking on health outcomes in older people, PLoS One | Haghani, A., Arpawong, T. E., Kim, J. K., Lewinger, J. P., Finch, C. E., & Crimmins, E. | 2020-06-04 |
| The Exposome in Human Evolution from Dust to Diesel, Quarterly Review of Biology | Trumble, B. C., & Finch, C. E. | 2019-12-01 |
| Air Pollution alters C. elegans development and lifespan: responses to traffic-related nanoparticulate matter, The Journals of Gerontology: Series A | Haghani, A., Dalton, H. M., Safi, N., Shirmohammadi, F., Sioutas, C., Morgan, T. E., Finch, C. E., & Curran, S. P. | 2019-03-04 |
| Apolipoprotein E and Sex Bias in Cerebrovascular aging of men and mice, Trends in Neurosciences | Finch, C. E., & Shams, S. | 2016-08-18 |
| Interleukin-3 gets a fresh start in the brain, Genes & Immunity | Yates, A. G., Khamhoung, A., & McAlpine, C. S. | 2023-12-08 |
| Sleep exerts lasting effects on hematopoietic stem cell function and diversity, Journal of Experimental Medicine | McAlpine, C. S., Kiss, M. G., Zuraikat, F. M., Cheek, D., Schiroli, G., Amatullah, H., Huynh, P., Bhatti, M. Z., Wong, L. P., Yates, A. G., Poller, W. C., Mindur, J. E., Chan, C. T., Janssen, H., Downey, J., Singh, S., Sadreyev, R. I., Nahrendorf, M., Jeffrey, K. L., Scadden, D. T., Naxerova, K., St-Onge, M., & Swirski, F.K. | 2022-09-21 |
| Monocytes re-enter the bone marrow during fasting and alter the host response to infection, Immunity | Janssen, H., Kahles, F., Liu, D., Downey, J., Koekkoek, L. L., Roudko, V., D'Souza, D., McAlpine, C. S., Halle, L., Poller, W. C., Chan, C. T., He, S., Mindur, J. E., Kiss, M. G., Singh, S., Anzai, A., Iwamoto, Y., Kohler, R. H., Chetal, K., Sadreyev, R. I., Weissleder, R., Kim-Schulze, S., Merad, M., Nahrendorf, M., & Swirski, F. K. | 2023-02-23 |
| Enhanced liver gene transfer and evasion of pre-existing humoral immunity with exosome-envelope AAV vectors, Blood Advances | Meliani, A., Boisgerault, F., Fitzpatrick, Z., Marmier, S., Leborgne, C., Collaud, F., Simon Sola, M., Charles, S., Ronzitti, G., Vignaud, A., van Wittenberghe, L., Marolleau, B., Jouen, F., Tan, S., Boyer, O., Christophe, O., Brisson, A. R., Maguire, C. A., & Mingozzi, F. | 2017-10-16 |
| Rescue of Hearing by Gene Delivery to inner-ear hair cells using exome associated AAV, Molecular Therapy | György, B., Sage, C., Indzhykulian, A. A., Scheffer, D. I., Brisson, A. R., Tan, S., Wu, X., Volak, A., Mu, D., Tamvakologos, P. I., Li, Y., Fitzpatrick, Z., Ericsson, M., Breakefield, X. O., Corey, D. P., & Maguire, C. A. | 2017-02-01 |
| Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate, Molecular Therapy - Methods & Clinical Development | Berezovskii, V. K., Born, R. T., O'Brien, M., Lafond, J. F., Arsenijevic, Y., Kenna, M. A., Maguire, C. A., & Corey, D. P. | 2018-11-18 |
| Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2, Molecular Therapy - Methods & Clinical Development | Prabhakar, S., Beauchamp, R. L., Cheah, P. S., Yoshinaga, A., Haidar, E. A., Lule, S., Mani, G., Maalouf, K., Stemmer-Rachamimov, A., Jung, D. H., Welling, D. B., Giovannini, M., Plotkin, S. R., Maguire, C. A., Ramesh, V., & Breakefield, X. O. | 2022-06-22 |
| Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection, Scientific Reports | Wassmer, S. J., Carvalho, L. S., György, B., Vandenberghe, L. H., & Maguire, C. A. | 2017-03-31 |
| Using mass spectrometry to validate mouse models of tauopathy, Molecular Neurodegenration | Yan, Y., & Cook, C. N. | 2023-04-05 |
| Reconstitution of the Alzheimer’s Disease Tau Core Structure from Recombinant Tau297-391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM, Biochemistry | Glynn, C., Chun, J. E., Donahue, C. C., Nadler, M. J. S., Fan, Z., & Hyman, B. T. | 2023-12-28 |
| APOE4 derived from astrocytes leads to blood-brain barrier impairment, Brain | Jackson, R. J., Meltzer, J. C., Nguyen, H., Commins, C., Bennett, R. E., Hudry, E., & Hyman, B. T. | 2021-12-27 |
| The Alzheimer Disease-Causing Presenilin-1 L435F Mutation Causes Increased Production of Soluble Aβ43 Species in Patient-Derived iPSC-Neurons, Closely Mimicking Matched Patient Brain Tissue, Journal of Neuropathology & Experimental Neurology | Oakley, D. H., Chung, M., Klickstein, N., Commins, C., Hyman, B. T., & Frosch, M. P. | 2020-04-04 |
| Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons, Journal of Neuroscience | Oakley, D. H., Klickstein, N., Commins, C., Chung, M., Dujardin, S., Bennett, R. E., Hyman, B. T., & Frosch, M. P. | 2021-04-23 |
| Virus vector mediated genetic modification of brain tumor stromal cells after intravenous delivery, Journal of Neuro-Oncology | Volak, A., LeRoy, S. G., Natasan, J. S., Park, D. J., Cheah, P. S., Maus, A., Fitzpatrick, Z., Hudry, E., Pinkham, K., Gandhi, S., Hyman, B. T., Mu, D., GuhaSarkar, D., Stemmer-Rachamimov, A. O., Sena-Esteves, M., Badr, C. E., & Maguire, C. A. | 2018-09-01 |
| Efficient Gene Transfer to the Central Nervous System by single-stranded Anc80L65, Molecular Therapy - Methods & Clinical Development | Hudry, E., Andres-Mateos, E., Lerner, E. P., Volak, A., Cohen, O., Hyman, B. T., Maguire, C. A., & Vandenberghe, L. H. | 2018-09-21 |
| A correlation map of genome-wide DNA methylation patterns between paired human brain and buccal samples, Clinical Epigenetics | Sommerer, Y., Ohlei, O., Dobricic, V., Oakley, D. H., Wesse, T., Sedghpour Sabet, S., Demuth, I., Franke, A., Hyman, B. T., Lill, C. M., & Bertram, L. | 2022-11-01 |
| Anti-ApoE Antibody given after plaque onset decreases A beta accumulation and improves brain function in a mouse model of a beta amyloidosis, Journal of Neuroscience | Liao, F., Hori, Y., Hudry, E., Bauer, A. Q., Jiang, H., Mahan, T. E., Lefton, K. B., Zhang, T. J., Dearborn, J. T., Kim, J., Culver, J. P., Betensky, R., Wozniak, D. F., Hyman, B. T., & Holtzman, D. M. | 2014-05-21 |
| ARMADA: Assessing reliable measurement in Alzheimer’s disease and cognitive aging project methods, Alzheimer's & Dementia | Weintraub, S., Karpouzian-Rogers, T., Peipert, J. D., Nowinski, C., Slotkin, J., Wortman, K., Ho, E., Rogalski, E., Carlsson, C., Giordani, B., Goldstein, F., Lucas, J., Manly, J. J., Rentz, D., Salmon, D., Snitz, B., Dodge, H. H., Riley, M., Eldes, F., Ustsinovich, V., & Gershon, R. | 2021-11-17 |
| Baseline characterization of the ARMADA (Assessing Reliable Measurement in Alzheimer’s Disease) study cohorts, Alzheimer's & Dementia | Karpouzian-Rogers, T., Ho, E., Novack, M., Chinkers, M., Bedjeti, K., Nowinski, C., Giordani, B., Gershon, R., & Weintraub, S. | 2022-11-17 |
| The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans, Alzheimer's & Dementia | Haghani, A., Thorwald, M., Morgan, T. E., & Finch, C. E. | 2020-11-20 |
| Amyloid futures in the expanding pathology of brain aging and dementia, Alzheimer's & Dementia | Thorwald, M. A., Silva, J., Head, E., & Finch, C. E. | 2022-12-19 |
| Does selection for short sleep duration explain huma vulnerability to Alzheimer’s disease?, Evolution, Medicine, and Public Health | Nesse, R. M., Finch, C. E., & Nunn, C. L. | 2017-01-24 |
| Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts, Free Radical Biology and Medicine | Cacciottolo, M., Morgan, T. E., Saffari, A. A., Shirmohammadi, F., Forman, H. J., Sioutas, C., & Finch, C. E. | 2019-12-26 |
| Air pollution, dementia, and lifespan in the socio-economic gradient of aging: perspective on human aging for planning future experimental studies, Frontiers in Aging | Finch C. E. | 2023-11-13 |
| APOE Alleles and Diet in Brain Aging and Alzheimer’s Disease, Frontiers in Aging Neuroscience | Yassine, H. N., & Finch, C. E. | 2020-06-10 |
| Urban Air Pollution Nanoparticles from Los Angeles: Recently Decreased Neurotoxicity, Journal of Alzheimer's Disease | Zhang, H., D'Agostino, C., Forman, H. J., Cacciottolo, M., Thorwald, M., Mack, W. J., Liu, Q., Shkirkova, K., Lamorie-Foote, K., Sioutas, C., Pirhadi, M., Mack, W. J., Morgan, T. E., & Finch, C. E. | 2021-06-29 |
| APOE4 Leads to Blood-Brain Barrier Dysfunction Predicting Cognitive Decline, Nature | Montagne, A., Nation, D. A., Sagare, A. P., Barisano, G., Sweeney, M. D., Chakhoyan, A., Pachicano, M., Joe, E., Nelson, A. R., D'Orazio, L. M., Buennagel, D. P., Harrington, M. G., Benzinger, T. L. S., Fagan, A. M., Ringman, J. M., Schneider, L. S., Morris, J. C., Reiman, E. M., Caselli, R. J., Chui, H. C., TCW, J., Chen, Y., Pa, J., Conti, P. S., Law, M., Toga, A.W., & Zlokovic, B. | 2020-04-29 |
| APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-β, Nature Aging | Montagne, A., Nikolakopoulou, A. M., Huuskonen, M. T., Sagare, A. P., Lawson, E. J., Lazic, D., Rege, S. V., Grond, A., Zuniga, E., Barnes, S. R., Prince, J., Sagare, M., Hsu, C. J., LaDu, M. J., Jacobs, R. E., & Zlokovic, B. V. | 2021-06-14 |
| Blood–brain barrier link to human cognitive impairment and Alzheimer’s disease, Nature Cardiovascular Research | Barisano, G., Montagne, A., Kisler, K., Schneider, J. A., Wardlaw, J. M., & Zlokovic, B. V. | 2022-02-07 |
| Microglia have a grip on brain microvasculature., Nature Communications | Kisler, K., Nikolakopoulou, A. M., & Zlokovic, B. V. | 2021-09-06 |
| Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction, Nature Medicine | Nation, D. A., Sweeney, M. D., Montagne, A., Sagare, A. P., D'Orazio, L. M., Pachicano, M., Sepehrband, F., Nelson, A. R., Buennagel, D. P., Harrington, M. G., Benzinger, T. L. S., Fagan, A. M., Ringman, J. M., Schneider, L. S., Morris, J. C., Chui, H. C., Law, M., Toga, A. W., & Zlokovic, B. V. | 2019-01-01 |
| The role of brain vasculature in neurodegenerative disorders, Nature Neuroscience | Sweeney, M. D., Kisler, K., Montagne, A., Toga, A. W., & Zlokovic, B. V. | 2018-10-01 |
| In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain, Nature Protocols | Kisler, K., Lazic, D., Sweeney, M. D., Plunkett, S., El Khatib, M., Vinogradov, S. A., Boas, D. A., Sakadži, S., & Zlokovic, B. V. | 2018-03-01 |
| Blood-brain barrier breakdown in Alzheimer’s disease and other neurodegenerative disorders, Nature Reviews Neurology | Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. | 2018-03-01 |
| A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice, Journal of Experimental Medicine | Barisano, G., Kisler, K., Wilkinson, B., Nikolakopoulou, A. M., Sagare, A. P., Wang, Y., Gilliam, W., Huuskonen, M. T., Hung, S. T., Ichida, J. K., Gao, F., Coba, M. P., & Zlokovic, B. V. | 2022-08-30 |
| Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop, Alzheimer's & Dementia | Zlokovic, B. V., Gottesman, R. F., Bernstein, K. E., Seshadri, S., McKee, A., Snyder, H., Greenberg, S. M., Yaffe, K., Schaffer, C. B., Yuan, C., Hughes, T. M., Daemen, M. J., Williamson, J. D., González, H. M., Schneider, J., Wellington, C. L., Katusic, Z. S., Stoeckel, L., Koenig, J. I., Corriveau, R. A., Fine, L., Galis, Z. G., Reis, J., Wright, J.D., & Chen, J. | 2020-10-08 |
| Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau, Acta Neuropathologica | Mate De Gerando, A., Welikovitch, L. A., Khasnavis, A., Commins, C., Glynn, C., Chun, J. E., Perbet, R., & Hyman, B. T. | 2023-06-21 |
| All the Tau We Cannot See, Annual Review of Medicine | Hyman, B. | 2023-01-27 |
| Identification and in vivo characterization of a brain-penetrating nanobody, Fluids and Barriers of the CNS | Wouters, Y., Jaspers, T., De Strooper, B., & Dewilde, M. | 2020-10-14 |
| Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics, Pharmaceutics | Rué, L., Jaspers, T., Degors, I. M. S., Noppen, S., Schols, D., De Strooper, B., & Dewilde, M. | 2023-06-16 |
| RNA binding proteins co-localize with small tau inclusions in tauopathy, Acta Neuropathologica | Maziuk, B. F., Apicco, D. J., Cruz, A. L., Jiang, L., Ash, P. E. A., da Rocha, E. L., Zhang, C., Yu, W. H., Leszyk, J., Abisambra, J. F., Li, H., & Wolozin, B. | 2018-08-01 |
| RNA Binding Proteins and the Genesis of Neurodegenerative Diseases, Advances in Experimental Medicine and Biology | Wolozin, B., & Apicco, D. | 2014-10-30 |
| The Pathophysiology of Tau and Stress Granules in Disease, Advances in Experimental Medicine and Biology | Cruz, A., Verma, M., & Wolozin, B. | 2020-02-25 |
| Disrupted in Dementia, Biological Psychiatry | Wolozin, B. | 2018-10-01 |
| Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology, Cell Death & Differentiation | Silva, J. M., Rodrigues, S., Sampaio-Marques, B., Gomes, P., Neves-Carvalho, A., Dioli, C., Soares-Cunha, C., Mazuik, B. F., Takashima, A., Ludovico, P., Wolozin, B., Sousa, N., & Sotiropoulos, I. | 2018-11-15 |
| Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity, Cell Reports | Vanderweyde, T., Apicco, D. J., Youmans-Kidder, K., Ash, P. E. A., Cook, C., Lummertz da Rocha, E., Jansen-West, K., Frame, A. A., Citro, A., Leszyk, J. D., Ivanov, P., Abisambra, J. F., Steffen, M., Li, H., Petrucelli, L., & Wolozin, B. | 2016-05-17 |
| Dysregulation of RNA Splicing in Tauopathies, Cell Reports | Apicco, D. J., Zhang, C., Maziuk, B., Jiang, L., Ballance, H. I., Boudeau, S., Ung, C., Li, H., & Wolozin, B. | 2019-12-24 |
| Dysregulation of RNA Binding Protein Aggregation in Neurodegenerative Disorders, Frontiers in Molecular Neuroscience | Maziuk, B., Ballance, H. I., & Wolozin, B. | 2017-04-04 |
| Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes, Human Molecular Genetics | Russo, A., Scardigli, R., La Regina, F., Murray, M. E., Romano, N., Dickson, D. W., Wolozin, B., Cattaneo, A., & Ceci, M. | 2017-04-15 |
| Directed evolution of a picomolar-affinity, high-specificity antibody targeting phosphorylated tau, Journal of Biological Chemistry | Li, D., Wang, L., Maziuk, B. F., Yao, X., Wolozin, B., & Cho, Y. K. | 2018-06-13 |
| Dioxins and related environmental contaminants increase TDP-43 levels, Molecular Neurodegeneration | Ash, P. E. A., Stanford, E. A., Al Abdulatif, A., Ramirez-Cardenas, A., Ballance, H. I., Boudeau, S., Jeh, A., Murithi, J. M., Tripodis, Y., Murphy, G. J., Sherr, D. H., & Wolozin, B. | 2017-05-05 |
| Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology, Toxicological Sciences | Ash, P. E. A., Dhawan, U., Boudeau, S., Lei, S., Carlomagno, Y., Knobel, M., Al Mohanna, L. F. A., Boomhower, S. R., Newland, M. C., Sherr, D. H., & Wolozin, B. | 2019-01-01 |
| Beneficial Association of Angiotensin-Converting Enzyme Inhibitors and Statins on the Occurrence of Possible Alzheimer’s Disease After Traumatic Brain Injury, Alzheimer's Research & Therapy | Li, M., Reisman, J., Morris-Eppolito, B., Qian, S. X., Kazis, L. E., Wolozin, B., Goldstein, L. E., & Xia, W. | 2020-03-27 |
| Bacillus Calmette–Guérin in Immuno-Regulation of Alzheimer’s Disease, Frontiers in Aging Neuroscience | Klein, B. Y., Greenblatt, C. L., Gofrit, O. N., & Bercovier, H. | 2022-06-27 |
| The small HDL particle hypothesis of Alzheimer’s disease, Alzheimer's & Dementia | Martinez, A. E., Weissberger, G., Kuklenyik, Z., He, X., Meuret, C., Parekh, T., Rees, J. C., Parks, B. A., Gardner, M. S., King, S. M., Collier, T. S., Harrington, M. G., Sweeney, M. D., Wang, X., Zlokovic, B. V., Joe, E., Nation, D. A., Schneider, L. S., Chui, H. C., Barr, J. R., Han, S.D., Krauss, R.M., & Yassine, H. N. | 2022-04-13 |
| On the intersection between systemic infection, brain vascular dysfunction and dementia, Brain | Huuskonen, M. T., Kisler, K., Sagare, A. P., & Zlokovic, B. V. | 2021-05-11 |
| Editorial for “MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure”, Journal of Magnetic Resonance Imaging | Huuskonen, M. T., Barisano, G., Chakhoyan, A., & Zlokovic, B. V. | 2021-07-31 |
| Identification and characterization of nanobodies targeting the EphA4 receptor, Journal of Biological Chemistry | Schoonaert, L., Rué, L., Roucourt, B., Timmers, M., Little, S., Chávez-Gutiérrez, L., Dewilde, M., Joyce, P., Curnock, A., Weber, P., Haustraete, J., Hassanzadeh-Ghassabeh, G., De Strooper, B., Van Den Bosch, L., Van Damme, P., Lemmens, R., & Robberecht, W. | 2017-07-07 |
| VHHs as tools for therapeutic protein delivery to the central nervous system, Fluids and Barriers of the CNS | Wouters, Y., Jaspers, T., Rué, L., Serneels, L., De Strooper, B., & Dewilde, M. | 2022-10-03 |
| 26S proteasomes become stably activated upon heat shock when ubiquitination and protein degradation increase, Proceedings of the National Academy of Sciences of the United States of America | Lee, D., & Goldberg, A. L. | 2022-06-21 |
| 26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation, Proceedings of the National Academy of Sciences of the United States of America | VerPlank, J. J. S., Lokireddy, S., Zhao, J., & Goldberg, A. L. | 2019-03-05 |
| Proteins containing ubiquitin-like (Ubl) domains not only bind to 26S proteasomes but also induce their activation, Proceedings of the National Academy of Sciences of the United States of America | Collins, G. A., & Goldberg, A. L. | 2020-03-03 |
| cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases, Proceedings of the National Academy of Sciences of the United States of America | VerPlank, J. J. S., Tyrkalska, S. D., Fleming, A., Rubinsztein, D. C., & Goldberg, A. L. | 2020-06-08 |
| ZFand5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation, Proceedings of the National Academy of Sciences of the United States of America | Lee, D., Takayama, S., & Goldberg, A. L. | 2018-09-25 |
| UBL domain of Usp14 and other proteins stimulates proteasome activities and protein degradation in cells (vol 115, pg E11642, 2018), Proceedings of the National Academy of Sciences of the United States of America | Kim, H. T., & Goldberg, A. L. | 2018-11-28 |
| Mechanisms That Activate 26S Proteasomes and Enhance Protein Degradation, Biomolecules | Goldberg, A. L., Kim, H. T., Lee, D., & Collins, G. A. | 2021-05-22 |
| Regulating protein breakdown through proteasome phosphorylation, Biochemical Journal | VerPlank, J. J. S., & Goldberg, A. L. | 2017-09-24 |
| Raising cGMP restores proteasome function and myelination in mice with a proteotoxic neuropathy, Brain | VerPlank, J. J. S., Gawron, J., Silvestri, N. J., Feltri, M. L., Wrabetz, L., & Goldberg, A. L. | 2021-08-11 |
| The Logic of the 26S Proteasome, Cell | Collins, G. A., & Goldberg, A. L. | 2017-05-18 |
| The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis, Journal of Biological Chemistry | Kim, H. T., & Goldberg, A. L. | 2017-06-09 |
| Mammalian Ddi2 is a shuttling factor containing a retroviral protease domain that influences binding of ubiquitylated proteins and proteasomal degradation, Journal of Biological Chemistry | Collins, G. A., Sha, Z., Kuo, C. L., Erbil, B., & Goldberg, A. L. | 2022-03-28 |
| Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies, Journal of Biological Chemistry | Sha, Z., Blyszcz, T., González-Prieto, R., Vertegaal, A. C. O., & Goldberg, A. L. | 2019-07-08 |
| Measurement of the Multiple Activities of 26S Proteasomes, Methods in Molecular Biology | Kim, H. T., Collins, G. A., & Goldberg, A. L. | 2018-09-22 |
| Meeting summary of The NYO3 5th NO-Age/AD meeting and the 1st Norway-UK joint meeting on ageing and dementia: recent progress on the mechanisms and interventional strategies, The Journals of Gerontology. Series A | Wang, H. L., Siow, R., Schmauck-Medina, T., … Fang, E. F. | 2024-01-30 |
| Biomarkers of Alzheimer’s disease and neurodegeneration in dried blood spots-A new collection method for remote settings, Alzheimer's & Dementia | Huber, H., Blennow, K., Zetterberg, H., Boada, M., Jeromin, A., Weninger, H., Nuñez-Llaves, R., Aguilera, N., Ramis, M., Simrén, J., Nilsson, J., Lantero-Rodriguez, J., Orellana, A., García-Gutiérrez, F., Morató, X., Ashton, N. J., & Montoliu-Gaya, L. | 2024-01-29 |
| Fast computation of the eigensystem of genomic similarity matrices, BMC Bioinformatics | Hahn, G., Lutz, S. M., Hecker, J., Prokopenko, D., Cho, M. H., Silverman, E. K., Weiss, S. T., & Lange, C. | 2024-01-25 |
| The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers’ Disease, International Journal of Biological Sciences | Hong, Y., Zhang, Z., Yangzom, T., Chen, A., Lundberg, B. C., Fang, E. F., Siller, R., Sullivan, G. J., Zeman, J., Tzoulis, C., Bindoff, L. A., & Liang, K. X. | 2024-01-25 |
| No increase of CD8+ TEMRA cells in the blood of healthy adults at high genetic risk of Alzheimer’s disease, Alzheimer's & Dementia | Deecke, L., Homann, J., Goldeck, D., Ohlei, O., Dobricic, V., Drewelies, J., Demuth, I., Pawelec, G., Bertram, L., & Lill, C. M. | 2024-01-25 |
| Early modulation of the gut microbiome by female sex hormones alters amyloid pathology and microglial function, Scientific Reports | Saha, P., Weigle, I. Q., Slimmon, N., Poli, P. B., Patel, P., Zhang, X., Cao, Y., Michalkiewicz, J., Gomm, A., Zhang, C., Tanzi, R. E., Dylla, N., Al-Hendy, A., & Sisodia, S. S. | 2024-01-21 |
| Alzheimer’s disease biomarker analysis using targeted mass spectrometry, Molecular & Cellular Proteomics | Gobom, J., Brinkmalm, A., Brinkmalm, G., Blennow, K., & Zetterberg, H. | 2024-01-20 |
| TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia, Science Translational Medicine | Marks, J. D., Ayuso, V. E., Carlomagno, Y., Yue, M., Todd, T. W., Hao, Y., Li, Z., McEachin, Z. T., Shantaraman, A., Duong, D. M., Daughrity, L. M., Jansen-West, K., Shao, W., Calliari, A., Bejarano, J. G., DeTure, M., … Petrucelli, L., Cook, C. N. | 2024-01-17 |
| Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations, Journal of Experimental Medicine | Cadiz, M. P., Gibson, K. A., Todd, K. T., Nascari, D. G., Massa, N., Lilley, M. T., Olney, K. C., Al-Amin, M. M., Jiang, H., Holtzman, D. M., & Fryer, J. D. | 2024-01-16 |
| Commonly disrupted pathways in brain and kidney in a pig model of systemic endotoxemia, Journal of Neuroinflammation | Olney, K. C., de Ávila, C., Todd, K. T., Tallant, L. E., Barnett, J. H., Gibson, K. A., Hota, P., Pandiane, A. S., Durgun, P. C., Serhan, M., Wang, R., Lind, M. L., Forzani, E., Gades, N. M., Thomas, L. F., & Fryer, J. D. | 2024-01-04 |
| Blocking of microglia-astrocyte proinflammatory signaling is beneficial following stroke, Frontiers in Molecular Neuroscience | Prescott, K., Münch, A. E., Brahms, E., Weigel, M. K., Inoue, K., Buckwalter, M. S., Liddelow, S. A., & Peterson, T. C. | 2024-01-04 |
| Deciphering microglia phenotypes in health and disease, Current Opinion in Genetics & Development | Balak, C. D., Han, C. Z., & Glass, C. K. | 2024-01-03 |
| Proteomic signaling of dual specificity phosphatase 4 (DUSP4) in Alzheimer’s disease, Biomolecules | Wang, E., Pan, A. L., Bagchi, P., Rangaraju, S., Seyfried, N. T., Ehrlich, M. E., Salton, S. R., & Zhang, B. | 2024-01-03 |
| Roles of NAD+ in Health and Aging, Cold Spring Harbor Perspectives in Medicine | Lautrup, S., Hou, Y., Fang, E. F., & Bohr, V. A. | 2024-01-02 |
| Non-mutational neoantigens in disease, Nature Immunology | Stern, L. J., Clement, C., Galluzzi, L., & Santambrogio, L. | 2024-01-02 |
| Global, regional, and national burden of HIV and other sexually transmitted infections in older adults aged 60–89 years from 1990 to 2019: results from the Global Burden of Disease Study 2019, The Lancet. Healthy Longevity | Fu, L., Tian, T., Wang, B., Lu, Z., Bian, J., Zhang, W., Wu, X., Li, X., Siow, R. C., Fang, E. F., He, N., & Zou, H. | 2024-01-01 |
| Editorial: Understanding human biology with iPSC derived cell types in the era of CRISPR technology, Fronetiers in Cell and Developmental Biology | Li, H., Przybyla, L., & Blanchard, J. W. | 2023-12-22 |
| Microglial APOE4: more is less and less is more, Molecular Neurodegeneration | Eskandari-Sedighi, G., & Blurton-Jones, M. | 2023-12-19 |
| Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers: A Secondary Analysis of a Randomized Clinical Trial, JAMA Neurology | Brum, W. S., Docherty, K. F., Ashton, N. J., Zetterberg, H., Hansson, O., McMurray, J. J. V., & Blennow, K. | 2023-12-18 |
| Physiological features of parvalbumin-expressing GABAergic interneurons contributing to high-frequency oscillations in the cerebral cortex, Current Research in Neurobiology | Milicevic, K. D., Barbeau, B. L., Lovic, D. D., Patel, A. A., Ivanova, V. O., & Antic, S. D. | 2023-12-16 |
| Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1–TFEB pathway to Huntington’s disease neurodegeneration, Nature Aging | Lee, S. W., Oh, Y. M., Victor, M. B., Yang, Y., Chen, S., Strunilin, I., Dahiya, S., Dolle, R. E., Pak, S. C., Silverman, G. A., Perlmutter, D. H., & Yoo, A. S. | 2023-12-08 |
| Plasma Biomarker Strategy for Selecting Patients With Alzheimer Disease for Antiamyloid Immunotherapies, JAMA Neurology | Mattsson-Carlgren, N., Collij, L. E., Stomrud, E., Pichet Binette, A., Ossenkoppele, R., Smith, R., Karlsson, L., Lantero-Rodriguez, J., Snellman, A., Strandberg, O., Palmqvist, S., Ashton, N. J., Blennow, K., Janelidze, S., & Hansson, O. | 2023-12-04 |
| Proteomic profiling of interferon-responsive reactive astrocytes in rodent and human, Glia | Prakash, P., Erdjument-Bromage, H., O'Dea, M. R., Munson, C. N., Labib, D., Fossati, V., Neubert, T. A., & Liddelow, S. A. | 2023-11-30 |
| Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer’s Disease Neuropathology, Advanced Science | Mondal, P., Bai, P., Gomm, A., Bakiasi, G., Lin, C. J., Wang, Y., Choi, S. H., Tanzi, R. E., Wang, C., & Zhang, C. | 2023-11-21 |
| Development and Pharmacochemical Characterization Discover a Novel Brain-Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice, Journal of Medicinal Chemistry | Bai, P., Liu, Y., Yang, L., Ding, W., Mondal, P., Sang, N., Liu, G., Lu, X., Ho, T. T., Zhou, Y., Wu, R., Birar, V. C., Wilks, M. Q., Tanzi, R. E., Lin, H., Zhang, C., Li, W., Shen, S., & Wang, C. | 2023-11-16 |
| Translating the Biology of Aging into New Therapeutics for Alzheimer’s Disease: Senolytics, Journal of Prevention of Alzheimer's Disease | Riessland, M., & Orr, M. E. | 2023-10-24 |
| Wasserstein HOG: Local Directionality Extraction via Optimal Transport, IEEE Transactions on Medical Imaging | Zhu, J., Veeraraghavan, H., Jiang, J., Oh, J. H., Norton, L., Deasy, J. O., & Tannenbaum, A. | 2023-10-24 |
| Accelerating the in vitro emulation of Alzheimer’s disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture model, Frontiers in Bioengineering and Biotechnology | Ko, E. C., Spitz, S., Pramotton, F. M., Barr, O. M., Xu, C., Pavlou, G., Zhang, S., Tsai, A., Maaser-Hecker, A., Jorfi, M., Choi, S. H., Tanzi, R. E., & Kamm, R. D. | 2023-10-09 |
| Tau Oligomer-Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease, JAMA Neurology | Taddei, R. N., Perbet, R., Mate de Gerando, A., Wiedmer, A. E., Sanchez-Mico, M., Connors Stewart, T., Gaona, A., Melloni, A., Amaral, A. C., Duff, K., Frosch, M. P., & Gómez-Isla, T. | 2023-10-09 |
| Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning, Genome Medicine | Neumann, A., Ohlei, O., Küçükali, F., Bos, I. J., Timsina, J., Vos, S., Prokopenko, D., Tijms, B. M., Andreasson, U., Blennow, K., Vandenberghe, R., Scheltens, P., Teunissen, C. E., Engelborghs, S., Frisoni, G. B., Blin, O., Richardson, J. C., Bordet, R., Lleó, A., Alcolea, D., … EMIF-AD & ADNI study group | 2023-10-04 |
| Etiology of Alzheimer’s Disease, Discovery Medicine | Zhang C. | 2023-10-01 |
| Spatial proteomics of hippocampal subfield-specific pathology in Alzheimer’s disease and primary age-related tauopathy, Alzheimer's & Dementia | Walker, J. M., Orr, M. E., Orr, T. C., ... Richardson, T. E. | 2023-09-30 |
| APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints, Nature Immunology | Yin, Z., Rosenzweig, N., … Ikezu, T., … Tanzi, R., E., … Holtzman, D., M., & Butovsky, O. | 2023-09-25 |
| Visualizing Fluid Flows via Regularized Optimal Mass Transport with Applications to Neuroscience, Journal of Scientific Computing | Chen, X., Tran, A. P., Elkin, R., Benveniste, H., & Tannenbaum, A. R. | 2023-09-19 |
| Mast cell deficiency improves cognition and enhances disease-associated microglia in 5XFAD mice, Cell Reports | Lin, C. J., Herisson, F., Le, H., Jaafar, N., Chetal, K., Oram, M. K., Flynn, K. L., Gavrilles, E. P., Sadreyev, R. I., Schiffino, F. L., & Tanzi, R. E. | 2023-09-13 |
| Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols, Nature Neuroscience | Frazel, P. W., Labib, D., Fisher, T., Brosh, R., Pirianian, N., Marchildon, A., Boeke, J. D., Fossati, V., & Liddelow, S. A. | 2023-09-11 |
| Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling, Neuron | Kim, E., Kim, H., Jedrychowski, M. P., Bakiasi, G., Park, J., Kruskop, J., Choi, Y., Kwak, S. S., Quinti, L., Kim, D. Y., Wrann, C. D., Spiegelman, B. M., Tanzi, R. E., & Choi, S. H. | 2023-09-08 |
| Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial, Nature Medicine | Gonzales, M. M., Garbarino, V. R., Kautz, T. F., Palavicini, J. P., Lopez-Cruzan, M., Dehkordi, S. K., Mathews, J. J., Zare, H., Xu, P., Zhang, B., Franklin, C., Habes, M., Craft, S., Petersen, R. C., Tchkonia, T., Kirkland, J. L., Salardini, A., Seshadri, S., Musi, N., & Orr, M. E. | 2023-09-07 |
| Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice, Nature Communications | Lee, J., Dimitry, J. M., Song, J. H., Son, M., Sheehan, P. W., King, M. W., Travis Tabor, G., Goo, Y. A., Lazar, M. A., Petrucelli, L., & Musiek, E. S. | 2023-08-25 |
| Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model, Nature Neuroscience | Jorfi, M., Park, J., Hall, C. K., Lin, C. J., Chen, M., von Maydell, D., Kruskop, J. M., Kang, B., Choi, Y., Prokopenko, D., Irimia, D., Kim, D. Y., & Tanzi, R. E. | 2023-08-24 |
| Molecular mechanism for activation of the 26S proteasome by ZFAND5, Molecular Cell | Lee, D., Zhu, Y., Colson, L., Wang, X., Chen, S., Tkacik, E., Huang, L., Ouyang, Q., Goldberg, A. L., & Lu, Y. | 2023-08-17 |
| Human microglia maturation is underpinned by specific gene regulatory networks, Immunity | Han, C. Z., Li, R. Z., Hansen, E., Trescott, S., Fixsen, B. R., Nguyen, C. T., Mora, C. M., Spann, N. J., Bennett, H. R., Poirion, O., Buchanan, J., Warden, A. S., Xia, B., Schlachetzki, J. C. M., Pasillas, M. P., Preissl, S., Wang, A., O'Connor, C., Shriram, S., Kim, R., … Coufal, N. G. | 2023-08-14 |
| Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration, Life Science Alliance | Drieu, A., Du, S., Kipnis, M., Bosch, M. E., Herz, J., Lee, C., Jiang, H., Manis, M., Ulrich, J. D., Kipnis, J., Holtzman, D. M., & Gratuze, M. | 2023-08-10 |
| Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro, Nature Immunology | Dolan, M. J., Therrien, M., Jereb, S., Kamath, T., Gazestani, V., Atkeson, T., Marsh, S. E., Goeva, A., Lojek, N. M., Murphy, S., White, C. M., Joung, J., Liu, B., Limone, F., Eggan, K., Hacohen, N., Bernstein, B. E., Glass, C. K., Leinonen, V., Blurton-Jones, M., … Stevens, B. | 2023-07-27 |
| APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading, Journal of Clinical Investigation | Wang, C., Nambiar, A., Strickland, M. R., Lee, C., Parhizkar, S., Moore, A. C., Musiek, E. S., Ulrich, J. D., & Holtzman, D. M. | 2023-07-17 |
| Optimizing animal models of autoimmune encephalitis using active immunization, Frontiers in Immunology | Linnoila, J., Jalali Motlagh, N., Jachimiec, G., Lin, C. J., Küllenberg, E., Wojtkiewicz, G., Tanzi, R., & Chen, J. W. | 2023-07-12 |
| SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity, Nature Immunology | Fixsen, B. R., Han, C. Z., Zhou, Y., Spann, N. J., Saisan, P., Shen, Z., Balak, C., Sakai, M., Cobo, I., Holtman, I. R., Warden, A. S., Ramirez, G., Collier, J. G., Pasillas, M. P., Yu, M., Hu, R., Li, B., Belhocine, S., Gosselin, D., Coufal, N. G., Ren, B., & Glass, C. K. | 2023-06-15 |
| Association of Alcohol Consumption with Cognition in Older Population: The A4 Study, Journal of Alzheimer's Disease | Nallapu, B. T., Petersen, K. K., Lipton, R. B., Grober, E., Sperling, R. A., & Ezzati, A. | 2023-06-13 |
| Geometric graph neural networks on multi-omics data to predict cancer survival outcomes, Computers in Biology and Medicine | Zhu, J., Oh, J. H., Simhal, A. K., Elkin, R., Norton, L., Deasy, J. O., & Tannenbaum, A. | 2023-06-09 |
| Clinical Utility of Tau Positron Emission Tomography in the Diagnostic Workup of Patients With Cognitive Symptoms, JAMA Neurology | Smith, R., Hägerström, D., Pawlik, D., Klein, G., Jögi, J., Ohlsson, T., Stomrud, E., & Hansson, O. | 2023-05-22 |
| Editorial: Advances and perspectives in neuroplacentology, Frontiers in Endocrinology | Vacher, C. M., Bonnin, A., Mir, I. N., & Penn, A. A. | 2023-05-19 |
| Biologic targets of prescription medications and risk of neurodegenerative disease in United States Medicare beneficiaries, PLoS One | Song, Y., Racette, B. A., Camacho-Soto, A., & Searles Nielsen, S. | 2023-05-17 |
| Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis, Nature Communications | Conroy, L. R., Clarke, H. A., Allison, D. B., Valenca, S. S., Sun, Q., Hawkinson, T. R., Young, L. E. A., Ferreira, J. E., Hammonds, A. V., Dunne, J. B., McDonald, R. J., Absher, K. J., Dong, B. E., Bruntz, R. C., Markussen, K. H., Juras, J. A., Alilain, W. J., Liu, J., Gentry, M. S., Angel, P. M., … Sun, R. C. | 2023-05-13 |
| Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport, JCI Insight | Ozturk, B., Koundal, S., Al Bizri, E., Chen, X., Gursky, Z. H., Dai, F., Lim, A. S., Heerdt, P., Kipnis, J., Tannenbaum, A., Lee, H., & Benveniste, H. | 2023-05-09 |
| FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity, Cell Metabolism | Wieder, N., Fried, J. C., Kim, C., Sidhom, E. H., Brown, M. R., Marshall, J. L., Arevalo, C., Dvela-Levitt, M., Kost-Alimova, M., Sieber, J., Gabriel, K. R., Pacheco, J., Clish, C., Abbasi, H. S., Singh, S., Rutter, J. C., Therrien, M., Yoon, H., Lai, Z. W., Baublis, A., Subramanian, R., Devkota, R., Small, J., Sreehanth, V., Han, My., Lim. D., Carprenter, A. E., Flannick, J., Finucane, H., Haigis, M.C., Claussnitzer, M., Sheu, E., Stevens, B., Wagner, B. K., Choudhary, A., Shaw, J. L., Pablo, J. L., & Greka, A. | 2023-05-02 |
| A predictive algorithm to identify ever smoking in medical claims-based epidemiologic studies, Annals of Epidemiology | Faust, I., Warden, M., Camacho-Soto, A., Racette, B. A., & Nielsen, S. S. | 2023-05-02 |
| Association of Stages of Objective Memory Impairment With Incident Symptomatic Cognitive Impairment in Cognitively Normal Individuals, Neurology | Grober, E., Petersen, K. K., Lipton, R. B., Hassenstab, J., Morris, J. C., Gordon, B. A., & Ezzati, A. | 2023-04-19 |
| Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator, Annals of Neurology | Chen, X. Q., Sawa, M., Becker, A., Karachentsev, D., Zuo, X., Rynearson, K. D., Tanzi, R. E., & Mobley, W. C. | 2023-04-11 |
| Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining, Genetics in Medicine | Wallace, B. C., Small, K., Brodley, C. E., Lau, J., Schmid, C. H., Bertram, L., Lill, C. M., Cohen, J. T., & Trikalinos, T. A. | 2012-04-05 |
| Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors, European Journal of Medicinal Chemistry | Liu, G., Mondal, P., Sang, N., Li, Z., Ding, W., Yang, L., Liu, Y., Birar, V. C., Gomm, A., Tanzi, R. E., Zhang, C., Shen, S., Wang, C., Lu, X., & Bai, P. | 2023-03-31 |
| Reproductive Markers in Alzheimer’s Disease Progression: The Framingham Heart Study, Journal of Prevention of Alzheimer's Disease | Ding, H., Li, Y., Ang, T. F. A., Liu, Y., Devine, S., Au, R., Doraiswamy, P. M., & Liu, C. | 2023-03-22 |
| Expanding the scope of health disparities research in Alzheimer’s disease and related dementias, Alzheimer's & Dementia | Akushevich, I., Kravchenko, J., Yashkin, A., Doraiswamy, P. M., Hill, C. V., & Alzheimer's Disease and Related Dementia Health Disparities Collaborative Group. | 2023-03-16 |
| N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model, Nature Communications | Suzzi, S., Croese, T., Ravid, A., Gold, O., Clark, A. R., Medina, S., Kitsberg, D., Adam, M., Vernon, K. A., Kohnert, E., Shapira, I., Malitsky, S., Itkin, M., Brandis, A., Mehlman, T., Salame, T. M., Colaiuta, S. P., Cahalon, L., Slyper, M., Greka, A., Habib, N., & Schwartz, M. | 2023-03-09 |
| Tracking cognition with the T-MoCA in a racially/ethnically diverse older adult cohor, Alzheimer's & Dementia | Wang, C., Nester, C. O., Chang, K., Rabin, L. A., Ezzati, A., Lipton, R. B., & Katz, M. J. | 2023-03-08 |
| The microglial immunoreceptor tyrosine-based motif-Syk signaling pathway is a promising target of immunotherapy for Alzheimer’s disease, Clinical and Translational Medicine | Wang, S., & Colonna, M. | 2023-02-11 |
| Mechanisms of Protein Trafficking and Quality Control in the Kidney and Beyond, Annual Reviews | Shaw, J. L., Pablo, J. L., & Greka, A. | 2023-02-10 |
| Modeling Huntington disease through microRNA-mediated neuronal reprogramming identifies age-associated autophagy dysfunction driving the onset of neurodegeneration, Autophagy | Oh, Y. M., Lee, S. W., & Yoo, A. S. | 2023-02-08 |
| Adult neurogenesis in Alzheimer’s disease, Hippocampus | Choi, S. H., & Tanzi, R. E. | 2023-02-07 |
| Adult hippocampal neurogenesis in Alzheimer’s disease: A roadmap to clinical relevance, Cell Stem Cell | Salta, E., Lazarov, O., Fitzsimons, C. P., Tanzi, R., Lucassen, P. J., & Choi, S. H. | 2023-02-02 |
| The neuroimmune axis of Alzheimer’s disease, Genome Medicine | Jorfi, M., Maaser-Hecker, A., & Tanzi, R. E. | 2023-01-26 |
| The Impact of the Cellular Environment and Aging on Modeling Alzheimer’s Disease in 3D Cell Culture Models, Advanced Science | Hebisch, M., Klostermeier, S., Wolf, K., Boccaccini, A. R., Wolf, S. E., Tanzi, R. E., & Kim, D. Y. | 2023-01-15 |
| Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with genetics, Frontiers in Molecular Neuroscience | Ramamurthy, E., Welch, G., Cheng, J., Yuan, Y., Gunsalus, L., Bennett, D. A., Tsai, L. H., & Pfenning, A. R. | 2023-01-06 |
| Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications, Pharmacological Reviews | Linares, G. R., Ivanova, M. I., Ichida, J., Weil, T., Münch, J., Sanchez-Garcia, E., Klärner, F. G., Schrader, T., & Bitan, G. | 2022-12-22 |
| Nutritional metabolism and cerebral bioenergetics in Alzheimer’s disease and related dementias, Alzheimer's & Dementia | Yassine, H. N., Self, W., Kerman, B. E., Santoni, G., Navalpur Shanmugam, N., Abdullah, L., Golden, L. R., Fonteh, A. N., Harrington, M. G., Gräff, J., Gibson, G. E., Kalaria, R., Luchsinger, J. A., Feldman, H. H., Swerdlow, R. H., Johnson, L. A., Albensi, B. C., Zlokovic, B. V., Tanzi, R., Cunnane, S., … Bowman, G. L. | 2022-12-08 |
| Sleep calibrates atherosclerotic cardiovascular disease, Nature Cardiovascular Research | Cohen, O., Shah, N. A., & McAlpine, C. S. | 2022-12-07 |
| Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer’s disease, Alzheimer's & Dementia | Castranio, E. L., Hasel, P., Haure-Mirande, J. V., Ramirez Jimenez, A. V., Hamilton, B. W., Kim, R. D., Glabe, C. G., Wang, M., Zhang, B., Gandy, S., Liddelow, S. A., & Ehrlich, M. E. | 2022-11-30 |
| Current Challenges and Solutions for Clinical Management and Care of People with HIV: Findings from the 12th Annual International HIV and Aging Workshop, AIDS Research and Human Retroviruses | Yu, X., Lobo, J. D., Sundermann, E., Baker, D. J., Tracy, R. P., Kuchel, G. A., Stephenson, K. E., Letendre, S. L., Brew, B., Cysique, L. A., Dale, S. K., Wallen, C., Kunisaki, K. M., Guaraldi, G., Milic, J., Winston, A., Moore, D. J., Margolick, J. B., & Erlandson, K. M. | 2022-11-23 |
| Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model, Nature Communications | Lordén, G., Wozniak, J. M., Doré, K., Dozier, L. E., Cates-Gatto, C., Patrick, G. N., Gonzalez, D. J., Roberts, A. J., Tanzi, R. E., & Newton, A. C. | 2022-11-23 |
| TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4, Neuron | Gratuze, M., Schlachetzki, J. C. M., D'Oliveira Albanus, R., Jain, N., Novotny, B., Brase, L., Rodriguez, L., Mansel, C., Kipnis, M., O'Brien, S., Pasillas, M. P., Lee, C., Manis, M., Colonna, M., Harari, O., Glass, C. K., Ulrich, J. D., & Holtzman, D. M. | 2022-11-10 |
| Sex‐specific biomarkers in Alzheimer’s disease progression: Framingham Heart Study, Alzheimer's & Dementia | Liu, C., Li, Y., Nwosu, A., Ang, T. F. A., Liu, Y., Devine, S., Au, R., & Doraiswamy, P. M. | 2022-11-03 |
| Associations of Stages of Objective Memory Impairment with Cerebrospinal Fluid and Neuroimaging Biomarkers of Alzheimer’s Disease, Journal of Prevention of Alzheimer's Disease | Petersen, K. K., Ezzati, A., Lipton, R. B., Gordon, B. A., Hassenstab, J., Morris, J. C., & Grober, E. | 2022-11-03 |
| Microglia states and nomenclature: A field at its crossroads, Neuron | Paolicelli, R. C., Sierra, A., Stevens, B., et al. | 2022-11-02 |
| The maximum entropy principle for compositional data, BMC Bioinformatics | Weistuch, C., Zhu, J., Deasy, J. O., & Tannenbaum, A. R. | 2022-10-29 |
| Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy, Nature Neuroscience | Oh, Y. M., Lee, S. W., Kim, W. K., Chen, S., Church, V. A., Cates, K., Li, T., Zhang, B., Dolle, R. E., Dahiya, S., Pak, S. C., Silverman, G. A., Perlmutter, D. H., & Yoo, A. S. | 2022-10-27 |
| Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration, Science Advances | Welch, G. M., Boix, C. A., Schmauch, E., Davila-Velderrain, J., Victor, M. B., Dileep, V., Bozzelli, P. L., Su, Q., Cheng, J. D., Lee, A., Leary, N. S., Pfenning, A. R., Kellis, M., & Tsai, L. H. | 2022-09-28 |
| Redefining microglia states: Lessons and limits of human and mouse models to study microglia states in neurodegenerative diseases, Seminars in Immunology | Yvanka de Soysa, T., Therrien, M., Walker, A. C., & Stevens, B. | 2022-09-22 |
| Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain, Physiology | Zhao, L., Tannenbaum, A., Bakker, E. N. T. P., & Benveniste, H. | 2022-09-15 |
| Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma, Immunity | Margeta, M. A., Yin, Z., Madore, C., Pitts, K. M., Letcher, S. M., Tang, J., Jiang, S., Gauthier, C. D., Silveira, S. R., Schroeder, C. M., Lad, E. M., Proia, A. D., Tanzi, R. E., Holtzman, D. M., Krasemann, S., Chen, D. F., & Butovsky, O. | 2022-08-16 |
| PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer’s disease risk, Scientific Reports | Lopatko Lindman, K., Jonsson, C., Weidung, B., Olsson, J., Pandey, J. P., Prokopenko, D., Tanzi, R. E., Hallmans, G., Eriksson, S., Elgh, F., & Lövheim, H. | 2022-08-02 |
| Repurposing the cardiac glycoside digoxin to stimulate myelin regeneration in chemically-induced and immune-mediated mouse models of multiple sclerosis, Glia | Titus, H. E., Xu, H., Robinson, A. P., Patel, P. A., Chen, Y., Fantini, D., Eaton, V., Karl, M., Garrison, E. D., Rose, I. V. L., Chiang, M. Y., Podojil, J. R., Balabanov, R., Liddelow, S. A., Miller, R. H., Popko, B., & Miller, S. D. | 2022-07-09 |
| Evolution of Human-specific Alleles Protecting Cognitive Function of Grandmothers, Molecular Biology and Evolution | Saha, S., Khan, N., Comi, T., Verhagen, A., Sasmal, A., Diaz, S., Yu, H., Chen, X., Akey, J. M., Frank, M., Gagneux, P., & Varki, A. | 2022-07-09 |
| Association of Depressive Symptoms and Cognition in Older Adults Without Dementia Across Different Biomarker Profiles, Journal of Alzheimer's disease | Rubin-Norowitz, M., Lipton, R. B., Petersen, K., Ezzati, A., & Alzheimer’s Disease Neuroimaging Initiative | 2022-06-28 |
| Most Pathways Can Be Related to the Pathogenesis of Alzheimer’s Disease, Frontiers in Aging Neuroscience | Morgan, S. L., Naderi, P., Koler, K., Pita-Juarez, Y., Prokopenko, D., Vlachos, I. S., Tanzi, R. E., Bertram, L., & Hide, W. A. | 2022-06-24 |
| Cholesterol and matrisome pathways dysregulated in astrocytes and microglia, Cell | Tcw, J., Qian, L., Pipalia, N. H., Chao, M. J., Liang, S. A., Shi, Y., Jain, B. R., Bertelsen, S. E., Kapoor, M., Marcora, E., Sikora, E., Andrews, E. J., Martini, A. C., Karch, C. M., Head, E., Holtzman, D. M., Zhang, B., Wang, M., Maxfield, F. R., Poon, W. W., & Goate, A. M. | 2022-06-23 |
| Predicting Amyloid Positivity in Cognitively Unimpaired Older Adults A Machine Learning Approach Using A4 Data, Neurology | Petersen, K. K., Lipton, R. B., Grober, E., Davatzikos, C., Sperling, R. A., & Ezzati, A. | 2022-06-14 |
| Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice, Cell Reports | Kiani Shabestari, S., Morabito, S., Danhash, E. P., McQuade, A., Sanchez, J. R., Miyoshi, E., Chadarevian, J. P., Claes, C., Coburn, M. A., Hasselmann, J., Hidalgo, J., Tran, K. N., Martini, A. C., Chang Rothermich, W., Pascual, J., Head, E., Hume, D. A., Pridans, C., Davtyan, H., Swarup, V., … Blurton-Jones, M. | 2022-06-14 |
| Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation, Cell | Fernández-Castañeda, A., Lu, P., Geraghty, A. C., Song, E., Lee, M. H., Wood, J., … Liddelow, S. A., … Monje, M. | 2022-06-13 |
| Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons, Cell Stem Cell | Capano, L. S., Sato, C., Ficulle, E., Yu, A., Horie, K., Kwon, J. S., Burbach, K. F., Barthélemy, N. R., Fox, S. G., Karch, C. M., Bateman, R. J., Houlden, H., Morimoto, R. I., Holtzman, D. M., Duff, K. E., & Yoo, A. S. | 2022-06-02 |
| Development of a potential PET probe for HDAC6 imaging in Alzheimer’s disease, Acta Pharmaceutica Sinica B | Bai, P., Mondal, P., Bagdasarian, F. A., Rani, N., Liu, Y., Gomm, A., Tocci, D. R., Choi, S. H., Wey, H. Y., Tanzi, R. E., Zhang, C., & Wang, C. | 2022-05-20 |
| Biological aging processes underlying cognitive decline and neurodegenerative disease, Journal of Clinical Investigation | Gonzales, M. M., Garbarino, V. R., Pollet, E., Palavicini, J. P., Kellogg, D. L., Jr, Kraig, E., & Orr, M. E. | 2022-05-16 |
| Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer’s disease, Phytomedicine | Liang, Y., Lee, D. Y. W., Zhen, S., Sun, H., Zhu, B., Liu, J., Lei, D., Lin, C. J., Zhang, S., Jacques, N. A., Quinti, L., Ran, C., Wang, C., Griciuc, A., Choi, S. H., Dai, R. H., Efferth, T., Tanzi, R. E., & Zhang, C. | 2022-05-13 |
| Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages, Acta Neuropathologica Communications | Taddei, R. N., Sanchez-Mico, M. V., Bonnar, O., Connors, T., Gaona, A., Denbow, D., Frosch, M. P., & Gómez-Isla, T. | 2022-05-09 |
| Proteomic Alterations and Novel Markers of Neurotoxic Reactive Astrocytes in Human Induced Pluripotent Stem Cell Models, Frontiers in Molecular Neuroscience | Labib, D., Wang, Z., Prakash, P., Zimmer, M., Smith, M. D., Frazel, P. W., Barbar, L., Sapar, M. L., Calabresi, P. A., Peng, J., Liddelow, S. A., & Fossati, V. | 2022-05-03 |
| Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis, Cancer Discovery | Kleffman, K., Levinson, G., Rose, I., Blumenberg, L. M., … Li, Y. M., … Liddelow, S.A., … Hernando, E. | 2022-05-02 |
| Infection and inflammation: New perspectives on Alzheimer’s disease, Brain, Behavior, & Immunity - Health | Whitson, H. E., Colton, C., El Khoury, J., Gate, D., Goate, A., Heneka, M. T., Kaddurah-Daouk, R., Klein, R. S., Shinohara, M. L., Sisodia, S., Spudich, S. S., Stevens, B., Tanzi, R., Ting, J. P., Garden, G., & Symposium Planning Committee members. | 2022-04-22 |
| Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer’s disease., Neuron | Sadick, J. S., O'Dea, M. R., Hasel, P., Dykstra, T., Faustin, A., & Liddelow, S. A. | 2022-04-04 |
| Rapid Biomarker Screening of Alzheimer’s Disease by Interpretable Machine Learning and Graphene-Assisted Raman Spectroscopy, ASC Nano | Wang, Z., Ye, J., Zhang, K., Ding, L., Granzier-Nakajima, T., Ranasinghe, J. C., Xue, Y., Sharma, S., Biase, I., Terrones, M., Choi, S. H., Ran, C., Tanzi, R. E., Huang, S. X., Zhang, C., & Huang, S. | 2022-03-25 |
| Neurotechnological Approaches to the Diagnosis and Treatment of Alzheimer’s Disease, Frontiers in Neuroscience | Ning, S., Jorfi, M., Patel, S. R., Kim, D. Y., & Tanzi, R. E. | 2022-03-24 |
| Associations of Stages of Objective Memory Impairment With Amyloid PET and Structural MRI The A4 Study, Neurology | Grober, E., Lipton, R. B., Sperling, R. A., Papp, K. V., Johnson, K. A., Rentz, D. M., Veroff, A. E., Aisen, P. S., & Ezzati, A. | 2022-03-29 |
| ApoE Cascade Hypothesis in the pathogenesis of Alzheimer’s disease and related dementias, Neuron | Martens, Y. A., Zhao, N., Liu, C. C., Kanekiyo, T., Yang, A. J., Goate, A. M., Holtzman, D. M., & Bu, G. | 2022-03-16 |
| Application of predictive models in boosting power of Alzheimer’s disease clinical trials: A post hoc analysis of phase 3 solanezumab trials, Alzheimer's & Dementia | Ezzati, A., Davatzikos, C., Wolk, D. A., Hall, C. B., Habeck, C., & Lipton, R. B. | 2022-03-14 |
| Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain, Nature Neuroscience | Marsh, S. E., Walker, A. J., Kamath, T., Dissing-Olesen, L., Hammond, T. R., de Soysa, T. Y., Young, A. M. H., Murphy, S., Abdulraouf, A., Nadaf, N., Dufort, C., Walker, A. C., Lucca, L. E., Kozareva, V., Vanderburg, C., Hong, S., Bulstrode, H., Hutchinson, P. J., Gaffney, D. J., Hafler, D. A., Franklin, R. J. M., Macosko, E. Z., & Stevens, B. | 2022-03-08 |
| Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer’s disease-associated genes: DTNB and DLG2, Molecular Psychiatry | Prokopenko, D., Lee, S., Hecker, J., Mullin, K., Morgan, S., Katsumata, Y., Alzheimer’s Disease Neuroimaging Initiative (ADNI), Weiner, M. W., Fardo, D. W., Laird, N., Bertram, L., Hide, W., Lange, C., & Tanzi, R. E. | 2022-03-04 |
| Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer’s disease-related neuropathology in cell models, Journal of Biological Chemistry | Zhang, S., Bai, P., Lei, D., Liang, Y., Zhen, S., Bakiasi, G., Pang, H., Choi, S. H., Wang, C., Tanzi, R. E., & Zhang, C. | 2022-03-03 |
| The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner, Scientific Reports | Bhattacharyya, R., Teves, C. A. F., Long, A., Hofert, M., & Tanzi, R. E. | 2022-03-03 |
| Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling, Acta Neuropathologica Communications | Walker, J. M., Kazempour Dehkordi, S., Fracassi, A., Vanschoiack, A., Pavenko, A., Taglialatela, G., Woltjer, R., Richardson, T. E., Zare, H., & Orr, M. E. | 2022-02-14 |
| The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer’s disease mouse model, Alzheimer's & Dementia | Claes, C., England, W. E., Danhash, E. P., Kiani Shabestari, S., Jairaman, A., Chadarevian, J. P., Hasselmann, J., Tsai, A. P., Coburn, M. A., Sanchez, J., Lim, T. E., Hidalgo, J. L. S., Tu, C., Cahalan, M. D., Lamb, B. T., Landreth, G. E., Spitale, R. C., Blurton-Jones, M., & Davtyan, H. | 2022-02-09 |
| Impact of sex and APOE ε4 on the association of cognitionand hippocampal volume in clinically normal, amyloid positive adults, Alzheimer's & Dementia | Petersen, K. K., Grober, E., Lipton, R. B., Sperling, R. A., Buckley, R. F., Aisen, P. S., & Ezzati, A. | 2022-02-09 |
| Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer’s disease brain, Journal of Extracellular Vesicles | You, Y., Muraoka, S., Jedrychowski, M. P., Hu, J., McQuade, A. K., Young-Pearse, T., Aslebagh, R., Shaffer, S. A., Gygi, S. P., Blurton-Jones, M., Poon, W. W., & Ikezu, T. | 2022-01-13 |
| Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer’s disease, Alzheimer's & Dementia | Caldwell, A. B., Liu, Q., Zhang, C., Schroth, G. P., Galasko, D. R., Rynearson, K. D., Tanzi, R. E., Yuan, S. H., Wagner, S. L., & Subramaniam, S. | 2022-01-27 |
| Microfluidic separation of axonal and somal compartments of neural progenitor cells differentiated in a 3D matrix, STAR Protocols | Lotlikar, M. S., Tarantino, M. B., Jorfi, M., Kovacs, D. M., Tanzi, R. E., & Bhattacharyya, R. | 2022-01-07 |
| A Smoothed Version of the Lassosum Penalty for Fitting Integrated Risk Models Using Summary Statistics or Individual-Level Data, Genes | Hahn, G., Prokopenko, D., Lutz, S. M., Mullin, K., Tanzi, R. E., Cho, M. H., Silverman, E. K., Lange, C., & On The Behalf Of The Nhlbi Trans-Omics For Precision Medicine TOPMed Consortium | 2022-01-06 |
| Turning the tide on Alzheimer’s disease: modulation of γ-secretase., Cell & Bioscience | Luo, J. E., & Li, Y. M. | 2022-01-04 |
| Gut microbiota-driven brain Aβ amyloidosis in mice requires microglia, Journal of Experimental Medicine | Dodiya, H. B., Lutz, H. L., Weigle, I. Q., Patel, P., Michalkiewicz, J., Roman-Santiago, C. J., Zhang, C. M., Liang, Y., Srinath, A., Zhang, X., Xia, J., Olszewski, M., Zhang, X., Schipma, M. J., Chang, E. B., Tanzi, R. E., Gilbert, J. A., & Sisodia, S. S. | 2022-01-03 |
| Single-cell delineation of lineage and genetic identity in the mouse brain, Nature | Bandler, R. C., Vitali, I., Delgado, R. N., Ho, M. C., Dvoretskova, E., Ibarra Molinas, J. S., Frazel, P. W., Mohammadkhani, M., Machold, R., Maedler, S., Liddelow, S. A., Nowakowski, T. J., Fishell, G., & Mayer, C. | 2021-12-15 |
| Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology, Nature Aging | Dehkordi, S. K., Walker, J., Sah, E., Bennett, E., Atrian, F., Frost, B., Woost, B., Bennett, R. E., Orr, T. C., Zhou, Y., Andhey, P. S., Colonna, M., Sudmant, P. H., Xu, P., Wang, M., Zhang, B., Zare, H., & Orr, M. E. | 2021-12-10 |
| Predictive value of ATN biomarker profiles in estimating disease progression in Alzheimer’s disease dementia, Alzheimer's & Dementia | Ezzati, A., Abdulkadir, A., Jack, C. R., Jr, Thompson, P. M., Harvey, D. J., Truelove-Hill, M., Sreepada, L. P., Davatzikos, C., Alzheimer's Disease Neuroimaging Initiative, & Lipton, R. B. | 2021-11-17 |
| Leveraging machine learning predictive biomarkers to augment the statistical power of clinical trials with baseline magnetic resonance imaging, Brain Communications | Lou, C., Habes, M., Illenberger, N. A., Ezzati, A., Lipton, R. B., Shaw, P. A., Stephens-Shields, A. J., Akbari, H., Doshi, J., Davatzikos, C., & Shinohara, R. T. | 2021-11-03 |
| Gut-microbiota-microglia-brain interactions in Alzheimer’s disease: knowledge-based, multi-dimensional characterization, Alzheimer's Research & Therapy | Wang, Q., Davis, P. B., Qi, X., Chen, S. G., Gurney, M. E., Perry, G., Doraiswamy, P. M., & Xu, R. | 2021-10-20 |
| Visualization of Receptor-Interacting Protein Kinase 1 (RIPK1) by Brain Imaging with Positron Emission Tomography, Journal of Medicinal Chemistry | Lan, Y., Bai, P., Liu, Y., Afshar, S., Striar, R., Rattray, A. K., Meyer, T. N., Langan, A. G., Posner, A. M., Shen, S., Tanzi, R. E., Zhang, C., & Wang, C. | 2021-10-15 |
| Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?, Neuronal Signaling | Lordén, C. & Newton A. C. | 2021-10-08 |
| Neurotoxic reactive astrocytes induce cell death via saturated lipids., Nature | Guttenplan, K. A., Weigel, M. K., Prakash, P., Wijewardhane, P. R., Hasel, P., Rufen-Blanchette, U., Münch, A. E., Blum, J. A., Fine, J., Neal, M. C., Bruce, K. D., Gitler, A. D., Chopra, G., Liddelow, S. A., & Barres, B. A. | 2021-10-06 |
| Lipid metabolism in sickness and in health:Emerging regulators of lipotoxicity, Molecular Cell | Yoon, H., Shaw, J. L., Haigis, M. C., & Greka, A. | 2021-09-16 |
| Patterning of interconnected human brain spheroids, Lab on a Chip | Kim, J. J., Jorfi, M., Tanzi, R. E., Kim, D. Y., Doyle, P. S., & Irimia, D. | 2021-09-14 |
| Exercise hormone irisin is a critical regulator of cognitive function, Nature Metabolism | Islam, M. R., Valaris, S., Young, M. F., Haley, E. B., Luo, R., Bond, S. F., Mazuera, S., Kitchen, R. R., Caldarone, B. J., Bettio, L. E. B., Christie, B. R., Schmider, A. B., Soberman, R. J., Besnard, A., Jedrychowski, M. P., Kim, H., Tu, H., Kim, E., Choi, S. H., Tanzi, R. E., … Wrann, C. D. | 2021-08-20 |
| Neuroinflammatory astrocyte subtypes in the mouse brain, Nature Neuroscience | Hasel, P., Rose, I. V. L., Sadick, J. S., Kim, R. D., & Liddelow, S. A. | 2021-08-19 |
| Comparing Performance of Different Predictive Models in Estimating Disease Progression in Alzheimer Disease, Alzheimer Disease and Associated Disorders | Ezzati, A., Zammit, A. R., & Lipton, R. B. | 2021-08-16 |
| Monitoring phagocytic uptake of amyloid beta into glial cell lysosomes in real time, Chemical Science | Prakash, P., Jethava, K. P., Korte, N., Izquierdo, P., Favuzzi, E., Rose, I. V. L., Guttenplan, K. A., Manchanda, P., Dutta, S., Rochet, J. C., Fishell, G., Liddelow, S. A., Attwell, D., & Chopra, G. | 2021-07-21 |
| Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease, Nature | McAlpine, C. S., Park, J., Griciuc, A., Kim, E., Choi, S. H., Iwamoto, Y., Kiss, M. G., Christie, K. A., Vinegoni, C., Poller, W. C., Mindur, J. E., Chan, C. T., He, S., Janssen, H., Wong, L. P., Downey, J., Singh, S., Anzai, A., Kahles, F., Jorfi, M., Feruglio, P.F., Sadreyev, R. I., Weissleder, R., Kleinstiver, B. P., Nahrendorf, M., Tanzi, R. E., & Swirski, F. K. | 2021-07-14 |
| Nuclei isolation of multiple brain cell types for omics interrogation, Nature Protocols | Nott, A., Schlachetzki, J. C. M., Fixsen, B. R., & Glass, C. K. | 2021-01-25 |
| Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults, Alzheimer's & Dementia | Yang, H. S., Zhang, C., Carlyle, B. C., Zhen, S. Y., Trombetta, B. A., Schultz, A. P., Pruzin, J. J., Fitzpatrick, C. D., Yau, W. W., Kirn, D. R., Rentz, D. M., Arnold, S. E., Johnson, K. A., Sperling, R. A., Chhatwal, J. P., & Tanzi, R. E. | 2021-06-23 |
| An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo, Journal of Experimental Medicine | Zhang, X., Zhang, C. M., Prokopenko, D., Liang, Y., Zhen, S. Y., Weigle, I. Q., Han, W., Aryal, M., Tanzi, R. E., & Sisodia, S. S. | 2021-06-07 |
| Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes, Cell Reports | Bhattacharyya, R., Black, S. E., Lotlikar, M. S., Fenn, R. H., Jorfi, M., Kovacs, D. M., & Tanzi, R. E. | 2021-05-18 |
| White matter hyperintensities and cognition across different Alzheimer’s biomarker profiles., Journal of the American Geriatrics Society | Lam, S., Lipton, R. B., Harvey, D. J., Zammit, A. R., Ezzati, A., & Alzheimer's Disease Neuroimaging Initiative | 2021-04-23 |
| Molecular imaging of NAD(+) -dependent deacetylase SIRT1 in the brain, Alzheimer's & Dementia | Xu, Y., Chen, Z., Wey, H. Y., Liang, Y., Tanzi, R. E., Zhang, C., & Wang, C. | 2021-04-15 |
| Whole-genome sequencing reveals new Alzheimer’s disease-associated rare variants in loci related to synaptic function and neuronal development, Alzheimer's & Dementia | Prokopenko, D., Morgan, S. L., Mullin, K., Hofmann, O., Chapman, B., Kirchner, R., Alzheimer's Disease Neuroimaging Initiative (ADNI), Amberkar, S., Wohlers, I., Lange, C., Hide, W., Bertram, L., & Tanzi, R. E. | 2021-04-02 |
| The role of innate immune genes in Alzheimer’s disease, Current Opinion in Neurology | Griciuc, A., & Tanzi, R. E. | 2021-04-01 |
| The AD tau core spontaneously self-assembles and recruits full-length tau to filaments, Cell Reports | Carlomagno, Y., Manne, S., DeTure, M., Prudencio, M., Zhang, Y. J., Hanna Al-Shaikh, R., Dunmore, J. A., Daughrity, L. M., Song, Y., Castanedes-Casey, M., Lewis-Tuffin, L. J., Nicholson, K. A., Wszolek, Z. K., Dickson, D. W., Fitzpatrick, A. W. P., Petrucelli, L., & Cook, C. N. | 2021-03-16 |
| The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration, Life | Sah, E., Krishnamurthy, S., Ahmidouch, M. Y., Gillispie, G. J., Milligan, C., & Orr, M. E. | 2021-03-11 |
| Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention, Journal of Experimental Medicine | Rynearson, K. D., Ponnusamy, M., Prikhodko, O., … Mobley, W. C., Thinakaran, G., Tanzi, R. E., Wagner, S. L. | 2021-03-02 |
| Evidence of the Cellular Senescence Stress Response in Mitotically Active Brain Cells-Implications for Cancer and Neurodegeneration, Life | Gillispie, G. J., Sah, E., Krishnamurthy, S., Ahmidouch, M. Y., Zhang, B., & Orr, M. E. | 2021-02-17 |
| Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs, Cell Stem Cell | Cates, K., McCoy, M. J., Kwon, J. S., Liu, Y., Abernathy, D. G., Zhang, B., Liu, S., Gontarz, P., Kim, W. K., Chen, S., Kong, W., Ho, J. N., Burbach, K. F., Gabel, H. W., Morris, S. A., & Yoo, A. S. | 2021-01-07 |
| Molecular imaging of Alzheimer’s disease–related gamma-secretase in mice and nonhuman primates, Journal of Experimental Medicine | Xu, Y., Wang, C., Wey, H. Y., Liang, Y., Chen, Z., Choi, S. H., Ran, C., Rynearson, K. D., Bernales, D. R., Koegel, R. E., Fiedler, S. A., Striar, R., Wagner, S. L., Tanzi, R. E., & Zhang, C. | 2020-12-07 |
| REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis, eLife | Griffin, P., Sheehan, P. W., Dimitry, J. M., Guo, C., Kanan, M. F., Lee, J., Zhang, J., & Musiek, E. S. | 2020-12-01 |
| Advancing Computerized Cognitive Training for MCI and Alzheimer’s Disease in a Pandemic and Post-pandemic World, Frontiers in Psychiatry | Bodner, K. A., Goldberg, T. E., Devanand, D. P., & Doraiswamy, P. M. | 2020-11-25 |
| Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings, Science Translational Medicine | Lomoio, S., Willen, R., Kim, W., Ho, K. Z., Robinson, E. K., Prokopenko, D., Kennedy, M. E., Tanzi, R. E., & Tesco, G. | 2020-11-18 |
| An Overview of Astrocyte Responses in Genetically Induced Alzheimer’s Disease Mouse Models, Cells | Spanos, F., & Liddelow, S. A. | 2020-11-04 |
| Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease, Nature Communications | McQuade, A., Kang, Y. J., Hasselmann, J., Jairaman, A., Sotelo, A., Coburn, M., Shabestari, S. K., Chadarevian, J. P., Fote, G., Tu, C. H., Danhash, E., Silva, J., Martinez, E., Cotman, C., Prieto, G. A., Thompson, L. M., Steffan, J. S., Smith, I., Davtyan, H., Cahalan, M., … Cho, H., Blurton-Jones, M. | 2020-10-23 |
| Abeta-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice, Science Translational Medicine | Cuddy, L. K., Prokopenko, D., Cunningham, E. P., Brimberry, R., Song, P., Kirchner, R., Chapman, B. A., Hofmann, O., Hide, W., Procissi, D., Hanania, T., Leiser, S. C., Tanzi, R. E., & Vassar, R. | 2020-09-30 |
| Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE, Journal of Experimental Medicine | Liu T, Zhu B, Liu Y, Zhang X, Yin J, Li X, Jiang L, Hodges AP, Rosenthal SB, Zhou L, Yancey J, McQuade A, Blurton-Jones M, Tanzi RE, Huang TY, Xu H. | 2020-09-17 |
| Genomic Mechanisms in Alzheimer’s Disease, Brain Pathology | Bertram, L., & Tanzi, R. E. | 2020-09-08 |
| Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators, Bioorganic and Medicinal Chemistry | Rynearson, K. D., Buckle, R. N., Herr, R. J., Mayhew, N. J., Chen, X., Paquette, W. D., Sakwa, S. A., Yang, J., Barnes, K. D., Nguyen, P., Mobley, W. C., Johnson, G., Lin, J. H., Tanzi, R. E., & Wagner, S. L. | 2020-09-01 |
| Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency, Nature | Zhang, J., Velmeshev, D., Hashimoto, K., Huang, Y. H., Hofmann, J. W., Shi, X., Chen, J., Leidal, A. M., Dishart, J. G., Cahill, M. K., Kelley, K. W., Liddelow, S. A., … Huang, E. J. | 2020-08-31 |
| Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?, Trends in Immunology | Liddelow, S. A., Marsh, S. E., & Stevens, B. | 2020-08-17 |
| Gene therapy for Alzheimer’s Disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation., Human Molecular Genetics | Griciuc, A., Federico, A. N., Natasan, J., Forte, A. M., McGinty, D., Nguyen, H., Volak, A., LeRoy, S., Gandhi, S., Lerner, E. P., Hudry, E., Tanzi, R. E., & Maguire, C. A. | 2020-08-17 |
| Upregulation of Alzheimer’s Disease Amyloid-beta Protein Precursor in Astrocytes Both in vitro and in vivo, Journal of Alzheimer's Disease | Liang, Y., Raven, F., Ward, J. F., Zhen, S., Zhang, S., Sun, H., Miller, S. J., Choi, S. H., Tanzi, R. E., & Zhang, C. | 2020-08-04 |
| Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model, Nature Communications | Guttenplan, K. A., Weigel, M. K., Adler, D. I., Couthouis, J., Liddelow, S. A., Gitler, A. D., & Barres, B. A. | 2020-07-27 |
| Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia, The EMBO Journal | Scott-Hewitt, N., Perrucci, F., Morini, R., Erreni, M., Mahoney, M., Witkowska, A., Carey, A., Faggiani, E., Schuetz, L. T., Mason, S., Tamborini, M., Bizzotto, M., Passoni, L., Filipello, F., Jahn, R., Stevens, B., & Matteoli, M. | 2020-07-13 |
| Non-invasive red-light optogenetic control of Drosophila cardiac function, Communications Biology | Men, J., Li, A., Jerwick, J., Li, Z., Tanzi, R. E., & Zhou, C. | 2020-06-29 |
| Neurotoxic Reactive Astrocytes Drive Neuronal Death After Retinal Injury, Cell Reports | Guttenplan, K. A., Stafford, B. K., El-Danaf, R. N., Adler, D. I., Münch, A. E., Weigel, M. K., Huberman, A. D., & Liddelow, S. A. | 2020-06-23 |
| Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease, Nature Medicine | Dujardin, S., Commins, C., Lathuiliere, A., Beerepoot, P., Fernandes, A. R., Kamath, T. V., De Los Santos, M. B., Klickstein, N., Corjuc, D. L., Corjuc, B. T., Dooley, P. M., Viode, A., Oakley, D. H., Moore, B. D., Mullin, K., Jean-Gilles, D., Clark, R., Atchison, K., Moore, R., Chibnik, L. B., Tanzi, R. E., … Hyman, B. T. | 2020-06-22 |
| CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes, Neuron | Barbar, L., Jain, T., Zimmer, M., Kruglikov, I., Sadick, J. S., Wang, M., Kalpana, K., Rose, I. V. L., Burstein, S. R., Rusielewicz, T., Nijsure, M., Guttenplan, K. A., di Domenico, A., Croft, G., Zhang, B., Nobuta, H., Hébert, J. M., Liddelow, S. A., & Fossati, V. | 2020-06-01 |
| Alternatives to Amyloid for Alzheimer’s Disease Therapies-A Symposium Report, Annals of the New York Academy of Sciences | Cable, J., Holtzman, D. M., Hyman, B. T., Tansey, M. G., Colonna, M., Kellis, M., Brinton, R. D., Albert, M., Wellington, C. L., Sisodia, S. S., & Tanzi, R. E. | 2020-05-29 |
| Amplified Protein Kinase C Signaling in Alzheimer’s Disease, The FASEB Journal | Lorden, G., Wosniak, J. M., Dozier, L. E., Patrick, G. N., Gonzalez, D. J., Roberts, A. J., & Newton, A. C. | 2020-04-18 |
| Generating Cell Type-Specific Protein Signatures from Non-symptomatic and Diseased Tissues, Annals of Biomedical Engineering | Sadick, J. S., Crawford, L. A., Cramer, H. C., 3rd, Franck, C., Liddelow, S. A., & Darling, E. M. | 2020-04-17 |
| Negative evidence for a role of APH1B T27I variant in Alzheimer’s disease, Human Molecular Genetics | Zhang, X., Zhang, C., Prokopenko, D., Liang, Y., Han, W., Tanzi, R. E., & Sisodia, S. S. | 2020-04-15 |
| Early Detection of Mild Cognitive Impairment (MCI) in an At-Home Setting, Journal of Prevention of Alzheimer's Disease | Sabbagh, M. N., Boada, M., Borson, S., Doraiswamy, P. M., Dubois, B., Ingram, J., Iwata, A., Porsteinsson, A. P., Possin, K. L., Rabinovici, G. D., Vellas, B., Chao, S., Vergallo, A., & Hampel, H. | 2020-04-06 |
| Identification of Novel Alzheimer’s Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data, Scientific Reports | Prokopenko, D., Hecker, J., Kirchner, R., Chapman, B. A., Hoffman, O., Mullin, K., Hide, W., Bertram, L., Laird, N., DeMeo, D. L., Lange, C., & Tanzi, R. E. | 2020-03-19 |
| Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease, Nature Communications | Kwak, S. S., Washicosky, K. J., Brand, E., von Maydell, D., Aronson, J., Kim, S., Capen, D. E., Cetinbas, M., Sadreyev, R., Ning, S., Bylykbashi, E., Xia, W., Wagner, S. L., Choi, S. H., Tanzi, R. E., & Kim, D. Y. | 2020-03-13 |
| Rationale for Early Diagnosis of Mild Cognitive Impairment (MCI) Supported by Emerging Digital Technologies, Journal of Prevention of Alzheimer's Disease | Sabbagh, M. N., Boada, M., Borson, S., Chilukuri, M., Doraiswamy, P. M., Dubois, B., Ingram, J., Iwata, A., Porsteinsson, A. P., Possin, K. L., Rabinovici, G. D., Vellas, B., Chao, S., Vergallo, A., & Hampel, H. | 2020-03-06 |
| Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome, Nature Communications | Arnold, M., Nho, K., Kueider-Paisley, A., Massaro, T., Huynh, K., Brauner, B., MahmoudianDehkordi, S., Louie, G., Moseley, M. A., Thompson, J. W., John-Williams, L. S., Tenenbaum, J. D., Blach, C., Chang, R., Brinton, R. D., Baillie, R., Han, X., Trojanowski, J. Q., Shaw, L. M., Martins, R., … Doraiswamy, P. M., ... Kastenmüller, G. | 2020-03-02 |
| Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains, Cell | Arakhamia, T., Lee, C. E., Carlomagno, Y., Duong, D. M., Kundinger, S. R., Wang, K., Williams, D., DeTure, M., Dickson, D. W., Cook, C. N., Seyfried, N. T., Petrucelli, L., & Fitzpatrick, A. W. P. | 2020-02-20 |
| The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer’s Disease, Journal of Alzheimer's Disease | Prikhodko, O., Rynearson, K. D., Sekhon, T., Mante, M. M., Nguyen, P. D., Rissman, R. A., Tanzi, R. E., & Wagner, S. L. | 2020-02-18 |
| A Curcumin Analog Reduces Levels of the Alzheimer’s Disease-Associated Amyloid-beta Protein by Modulating A beta PP Processing and Autophagy, Journal of Alzheimer's Disease | Wan, Y., Liang, Y., Liang, F., Shen, N., Shinozuka, K., Yu, J. T., Ran, C., Quan, Q., Tanzi, R. E., & Zhang, C. | 2019-11-26 |
| Brain cell type-specific enhancer-promoter interactome maps and disease risk association., Science | Nott, A., Holtman, I. R., Coufal, N. G., Schlachetzki, J. C. M., Yu, M., Hu, R., Han, C. Z., Pena, M., Xiao, J., Wu, Y., Keulen, Z., Pasillas, M. P., O'Connor, C., Nickl, C. K., Schafer, S. T., Shen, Z., Rissman, R. A., Brewer, J. B., Gosselin, D., Gonda, D. D., Levy, M. L., Rosenfeld, M.G., McVicker, G., Gage, F. H., & Glass, C. K. | 2019-11-14 |
| Significant Upregulation of Alzheimer’s beta-Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides, Angewandte Chemie (International ed. in English) | Ma, C., Su, J., Sun, Y., Feng, Y., Shen, N., Li, B., Liang, Y., Yang, X., Wu, H., Zhang, H., Herrmann, A., Tanzi, R. E., Liu, K., & Zhang, C. | 2019-11-04 |
| Lack of hepatic apoE does not influence early A beta deposition: observations from a new APOE knock-in model, Molecular Neurodegeneration | Huynh, T. V., Wang, C., Tran, A. C., Tabor, G. T., Mahan, T. E., Francis, C. M., Finn, M. B., Spellman, R., Manis, M., Tanzi, R. E., Ulrich, J. D., & Holtzman, D. M. | 2019-10-17 |
| Loss of Ataxin-1 Potentiates Alzheimer’s Pathogenesis by Elevating Cerebral BACE1 Transcription, Cell | Suh, J., Romano, D. M., Nitschke, L., Herrick, S. P., DiMarzio, B. A., Dzhala, V., Bae, J. S., Oram, M. K., Zheng, Y., Hooli, B., Mullin, K., Gennarino, V. A., Wasco, W., Schmahmann, J. D., Albers, M. W., Zoghbi, H. Y., & Tanzi, R. E. | 2019-08-22 |
| Blood Brain Barrier Dysfunction in a 3D in vitro model of Alzheimer’s Disease, Advanced Science | Shin, Y., Choi, S. H., Kim, E., Bylykbashi, E., Kim, J. A., Chung, S., Kim, D. Y., Kamm, R. D., & Tanzi, R. E. | 2019-08-12 |
| TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease, Neuron | Griciuc, A., Patel, S., Federico, A. N., Choi, S. H., Innes, B. J., Oram, M. K., Cereghetti, G., McGinty, D., Anselmo, A., Sadreyev, R. I., Hickman, S. E., El Khoury, J., Colonna, M., & Tanzi, R. E. | 2019-07-10 |
| Immune Signaling in Neurodegeneration, Immunity | Hammond, T. R., Marsh, S. E., & Stevens, B. | 2019-04-16 |
| TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice, Cell Reports | Zeng, J., Wang, Y., Luo, Z., Chang, L. C., Yoo, J. S., Yan, H., Choi, Y., Xie, X., Deverman, B. E., Gradinaru, V., Gupton, S. L., Zlokovic, B. V., Zhao, Z., & Jung, J. U. | 2019-04-09 |
| Modeling Adult-Onset Neurodegenerative Disorders with Human Neurons through Direct Neuronal Reprogramming, The FASEB Journal | Yoo, A. S. | 2019-04-01 |
| Low Evolutionary Selection Pressure in Senescence does not explain the persistence of amyloid-beta in the vertebrate genome, Frontiers in Aging Neuroscience | Moir, R. D., & Tanzi, R. E. | 2019-03-28 |
| Alzheimer’s disease risk genes: 29 and counting, Nature Reviews Neurology | Bertram, L., & Tanzi, R. E. | 2019-03-04 |
| Computational Causal Modeling of the Dynamic Biomarker Cascade in Alzheimer’s Disease, Computational and Mathematical Methods in Medicine | Petrella, J. R., Hao, W., Rao, A., & Doraiswamy, P. M. | 2019-02-03 |
| Quantitative Analysis of Neuronal Dendritic Arborization Complexity in Drosophila, Journal of Visualized Experiments | Wang, S., Tanzi, R. E., & Li, A. | 2019-01-07 |
| Special Issue on Stem Cell and Tissue Engineering in Development, Disease, and Repair, Developmental Dynamics | Shcheglovitov, A., Rao, M., & Yoo, A. | 2019-01-01 |
| Analysis of hidradenitis suppurativa-linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophages., Human Molecular Genetics | Li, A., Peng, Y., Taiclet, L. M., & Tanzi, R. E. (2019). | 2018-12-13 |
| Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment, Cell | Gibson, E. M., Nagaraja, S., Ocampo, A., Tam, L. T., Wood, L. S., Pallegar, P. N., Greene, J. J., Geraghty, A. C., Goldstein, A. K., Ni, L., Woo, P. J., Barres, B. A., Liddelow, S., Vogel, H., & Monje, M. | 2018-12-06 |
| A novel lysosome-to-micochondria signaling pathway disrupted by amyloid-beta oligomes, The EMBO Journal | Norambuena, A., Wallrabe, H., Cao, R., Wang, D. B., Silva, A., Svindrych, Z., Periasamy, A., Hu, S., Tanzi, R. E., Kim, D. Y., & Bloom, G. S. | 2018-10-22 |
| Distinct Cytokine Profiles in human brains resilient to Alzheimer’s pathology, Neuroiology of Disease | Barroeta-Espar, I., Weinstock, L. D., Perez-Nievas, B. G., Meltzer, A. C., Siao Tick Chong, M., Amaral, A. C., Murray, M. E., Moulder, K. L., Morris, J. C., Cairns, N. J., Parisi, J. E., Lowe, V. J., Petersen, R. C., Kofler, J., Ikonomovic, M. D., López, O., Klunk, W. E., … Gomez-Isla, T. | 2018-10-15 |
| The Antimicrobial protection hypothesis of Alzheimer’s disease, Alzheimer's & Dementia | Moir, R. D., Lathe, R., & Tanzi, R. E. | 2018-10-09 |
| New tricks for an ancient system: physiological and pathological roles of complement in the CNS, Molecular Immunology | Tenner, A. J., Stevens, B., & Woodruff, T. M. | 2018-10-01 |
| Combined Adult Neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model, Science | Choi, S. H., Bylykbashi, E., Chatila, Z. K., Lee, S. W., Pulli, B., Clemenson, G. D., Kim, E., Rompala, A., Oram, M. K., Asselin, C., Aronson, J., Zhang, C., Miller, S. J., Lesinski, A., Chen, J. W., Kim, D. Y., van Praag, H., Spiegelman, B. M., Gage, F. H., & Tanzi, R. E. | 2018-09-07 |
| Controversies about the subcellular localization and mechanisms of action of the Alzhiemer’s disease-protective CD33 splice variant, Acta Neuropathologica | Saha, S., Siddiqui, S. S., Khan, N., Verhagen, A., Jiang, W., Springer, S., Ghosh, P., & Varki, A. | 2019-08-22 |
| Mechanistic insights into MicroRNA-induced Neuronal Reprogramming of Human Adult Fibroblasts, Frontiers in Neuroscience | Lu, Y. L., & Yoo, A. S. | 2018-08-02 |
| Alzheimer’s disease beta-amyloid is rapidly seeded by herpesviridae to protet against brain infection, Neuron | Eimer, W. A., Vijaya Kumar, D. K., Navalpur Shanmugam, N. K., Rodriguez, A. S., Mitchell, T., Washicosky, K. J., György, B., Breakefield, X. O., Tanzi, R. E., & Moir, R. D. | 2018-07-11 |
| MicroRNAs Overcome cell fate barrier by reducing EH2-controlled REST stability during neuronal conversion of human adult fibroblastrs, Developmental Cell | Lee, S. W., Oh, Y. M., Lu, Y. L., Kim, W. K., & Yoo, A. S. | 2018-07-02 |
| Controversies and Future Directions of Ocular Biomarkers in Alzheimer Disease, JAMA Neurology | Ong, S. S., Doraiswamy, P. M., & Lad, E. M. | 2018-06-01 |
| A 3D Human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease, Nature Neuroscience | Park, J., Wetzel, I., Marriott, I., Dréau, D., D'Avanzo, C., Kim, D. Y., Tanzi, R. E., & Cho, H. | 2018-06-27 |
| LONGO: an R package for interactive gene length dependent analysis for neuronal identity, Bioinformatics | McCoy, M. J., Paul, A. J., Victor, M. B., Richner, M., Gabel, H. W., Gong, H., Yoo, A. S., & Ahn, T. H. | 2018-06-27 |
| iPSC-derived familial Alzheimer’s PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling, Molecular Neurodegeneration | Moreno, C. L., Della Guardia, L., Shnyder, V., Ortiz-Virumbrales, M., Kruglikov, I., Zhang, B., Schadt, E. E., Tanzi, R. E., Noggle, S., Buettner, C., & Gandy, S. | 2018-06-26 |
| Protein kinase Cα gain-of-function variant in Alzheimer’s disease displays enhanced catalysis by a mechanism that evades down-regulation, Proceedings of the National Academy of Sciences of the United States of America | Callender, J. A., Yang, Y., Lordén, G., Stephenson, N. L., Jones, A. C., Brognard, J., & Newton, A. C. | 2018-05-29 |
| Protein Kinase C alpha (PKC alpha) Gain-of-Function Variant in Alzheimer’s Disease Displays Enhanced Catalysis by a Mechanism that Evades Down-Regulation, Proceedings of the National Academy of Sciences of the United States of America | Callender, J. A., Yang, Y., Lordén, G., Stephenson, N. L., Jones, A. C., Brognard, J., & Newton, A. C. | 2018-05-29 |
| Sex Differences in cognitive decline in subjects with high likelihood of mild cognitive impairments due to Alzheimer’s disease, Scientific Reports | Sohn, D., Shpanskaya, K., Lucas, J. E., Petrella, J. R., Saykin, A. J., Tanzi, R. E., Samatova, N. F., & Doraiswamy, P. M. | 2018-05-10 |
| Rare Alzheimer’s Disease-Associated Protein Kinase C variant displays altered pharmacological profile in cellular environment, The FASEB Journal | Yang Y., Callender, J., & Newton A. C. | 2018-04-01 |
| Protein kinase C: perfectly balanced, Critical Reviews in Biochemistry and Molecular Biology | Newton A. C. | 2018-03-07 |
| Human Neurospheroid Arrays for in vitro studies of Alzheimer’s disease, Scientific Reports | Jorfi, M., D'Avanzo, C., Tanzi, R. E., Kim, D. Y., & Irimia, D. | 2018-02-05 |
| Striatal Neurons directly converted from Huntington’s disease patient fibroblast recapitulate age-associated disease phenotypes, Nature Neuroscience | Victor, M. B., Richner, M., Olsen, H. E., Lee, S. W., Monteys, A. M., Ma, C., Huh, C. J., Zhang, B., Davidson, B. L., Yang, X. W., & Yoo, A. S. | 2018-02-05 |
| Protein Kinase C as a tumor suppressor, Seminars in Cancer Biology | Newton A. C. | 2018-02-01 |
| Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid Beta Protein by Promoting microglial Phagocytosis, Scientific Reports | Zhang, C., Griciuc, A., Hudry, E., Wan, Y., Quinti, L., Ward, J., Forte, A. M., Shen, X., Ran, C., Elmaleh, D. R., & Tanzi, R. E. | 2018-01-18 |
| CRISPR/Cas9- Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN (N141l) neurons, Acta Neuropathologica Communications | Ortiz-Virumbrales, M., Moreno, C. L., Kruglikov, I., Marazuela, P., Sproul, A., Jacob, S., Zimmer, M., Paull, D., Zhang, B., Schadt, E. E., Ehrlich, M. E., Tanzi, R. E., Arancio, O., Noggle, S., & Gandy, S. | 2017-10-27 |
| Alzheimer’s disease: A matter of blood-brain barrier dysfunction?, Journal of Experimental Medicine | Montagne, A., Zhao, Z., & Zlokovic, B. V. | 2017-10-23 |
| ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy, Nature | Shi, Y., Yamada, K., Liddelow, S. A., Smith, S. T., Zhao, L., Luo, W., Tsai, R. M., Spina, S., Grinberg, L. T., Rojas, J. C., Gallardo, G., Wang, K., Roh, J., Robinson, G., Finn, M. B., Jiang, H., Sullivan, P. M., Baufeld, C., Wood, M. W., Sutphen, C., McCue, L., Xiong, C., Del-Aquila, J.L., Morris, J.C., Cruchage, C., Alzheimer's Disease Neuroimaging Initiative, Fagan, A.M., Miller, B.L., Boxer, A.L., Seeley, W.W., Butovsky, O., Barres, B.B., Paul, S.M., & Holtzman, D.M. | 2017-09-28 |
| MicroRNAs induce a permissive chromatin environment that enabels neuronal subtype-specific reprogramming of adult human fibroblasts, Cell Stem Cell | Abernathy, D. G., Kim, W. K., McCoy, M. J., Lake, A. M., Ouwenga, R., Lee, S. W., Xing, X., Li, D., Lee, H. J., Heuckeroth, R. O., Dougherty, J. D., Wang, T., & Yoo, A. S. | 2017-09-07 |
| Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease, Scientific Reports | Minter, M. R., Hinterleitner, R., Meisel, M., Zhang, C., Leone, V., Zhang, X., Oyler-Castrillo, P., Zhang, X., Musch, M. W., Shen, X., Jabri, B., Chang, E. B., Tanzi, R. E., & Sisodia, S. S. | 2017-09-05 |
| Soluble Gamma-secretase Modulators Attenuate Alzheimer’s beta amyloid pathology and induce conformational changes in presenili 1, eBioMedicine | Raven, F., Ward, J. F., Zoltowska, K. M., Wan, Y., Bylykbashi, E., Miller, S. J., Shen, X., Choi, S. H., Rynearson, K. D., Berezovska, O., Wagner, S. L., Tanzi, R. E., & Zhang, C. | 2017-09-04 |
| Characterizing Gene and Protein Crosstalks in Subjects at risk of developing Alzheimer’s disease: a new computational approach, Processes | Padmanabhan, K., Nudelman, K., Harenberg, S., Bello, G., Sohn, D., Shpanskaya, K., Tiwari Dikshit, P., Yerramsetty, P.S., Tanzi, R.E., Saykin, A.J., Petrella, J.R., Doraiswamy, P. M., Samatova, N. & Alzheimer's Disease Neuroimaging Initiative. | 2017-09-01 |
| Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease, Scientific Reports | Gamberger, D., Lavrač, N., Srivatsa, S., Tanzi, R. E., & Doraiswamy, P. M. | 2017-07-28 |
| Presymptomatic atrophy in autosomal dominant Alzheimer’s disease: a serial magnetic resonance imaging study, Alzheimer's & Dementia | Kinnunen, K. M., Cash, D. M., Poole, T., Frost, C., Benzinger, T. L. S., Ahsan, R. L., Leung, K. K., Cardoso, M. J., Modat, M., Malone, I. B., Morris, J. C., Bateman, R. J., Marcus, D. S., Goate, A., Salloway, S. P., Correia, S., Sperling, R. A., Chhatwal, J. P., Mayeux, R. P., Brickman, A. M., Martins, R. N., Farlow, M. R., Ghetti, B., Saykin, A. J., Jack, Jr., C. R., Schofield, P. R., McDade, E., Weiner, M. W., Ringman, J. M., Thompson, P. M., Masters, C. L., Rowe, C. C., Rossor, M. N., Ourselin, S., & Fox, N. C. | 2017-07-22 |
| Nanoplasmic fiber tip probe detects significant reduction of intracellular Alzheimer’s disease related oligomers by curcumin, Scientific Reports | Liang, F., Wan, Y., Schaak, D., Ward, J., Shen, X., Tanzi, R. E., Zhang, C., & Quan, Q. | 2017-07-18 |
| Pharmacological and Toxicological Properties of the Potent Oral gamma-secretase modulator BPN-15606, Journal of Pharmacology and Experimental Therapeutics | Wagner, S. L., Rynearson, K. D., Duddy, S. K., Zhang, C., Nguyen, P. D., Becker, A., Vo, U., Masliah, D., Monte, L., Klee, J. B., Echmalian, C. M., Xia, W., Quinti, L., Johnson, G., Lin, J. H., Kim, D. Y., Mobley, W. C., Rissman, R. A., & Tanzi, R. E. | 2017-07-01 |
| Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease, Nature Reviews Neuroscience | Kisler, K., Nelson, A. R., Montagne, A., & Zlokovic, B. V. | 0217-05-18 |
| On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows, Genetic Epidemiology | Loehlein Fier, H., Prokopenko, D., Hecker, J., Cho, M. H., Silverman, E. K., Weiss, S. T., Tanzi, R. E., & Lange, C. | 2017-04-20 |
| Silencing of the Drosophila ortholog of SOX5 leads to abnormal neuronal development and behavioral impairment, Human Molecular Genetics | Li, A., Hooli, B., Mullin, K., Tate, R. E., Bubnys, A., Kirchner, R., Chapman, B., Hofmann, O., Hide, W., & Tanzi, R. E. | 2017-02-10 |
| Mechanisms that synergistically regulate η-secretase processing of APP and Aη-α protein levels: relevance to pathogenesis and treatment of Alzheimer’s disease., Discovery Medicine | Ward, J., Wang, H., Saunders, A. J., Tanzi, R. E., & Zhang, C. | 2017-02-01 |
| Neurotoxic reactive astrocytes are induced by activated microglia, Nature | Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W. S., Peterson, T. C., Wilton, D. K., Frouin, A., Napier, B. A., Panicker, N., Kumar, M., Buckwalter, M. S., Rowitch, D. H., Dawson, V. L., Dawson, T. M., Stevens, B., Barres, B. A. | 2017-01-18 |
| Drosophila preparation and longitudinal imaging of heart function in vivo using optical coherence microsopy (OCM), Journal of Visualized Experiments | Men, J., Jerwick, J., Wu, P., Chen, M., Alex, A., Ma, Y., Tanzi, R. E., Li, A., & Zhou, C. | 2016-12-12 |
| 3D Culture Models of Alzheimer’s disease: a road map to a “cure-in-a-dish”, Molecular Neurodegeneration | Choi, S. H., Kim, Y. H., Quinti, L., Tanzi, R. E., & Kim, D. Y. | 2016-12-09 |
| Palmitoylated APP forms Dimers, Cleaved BACE1, PLoS One | Bhattacharyya, R., Fenn, R. H., Barren, C., Tanzi, R. E., & Kovacs, D. M. | 2016-11-22 |
| Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy, Cell Stem Cell | Liang, Q., Luo, Z., Zeng, J., Chen, W., Foo, S. S., Lee, S. A., Ge, J., Wang, S., Goldman, S. A., Zlokovic, B. V., Zhao, Z., & Jung, J. U. | 2016-11-03 |
| Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts, eLife | Huh, C. J., Zhang, B., Victor, M. B., Dahiya, S., Batista, L. F., Horvath, S., & Yoo, A. S. | 2016-09-20 |
| Alzheimer’s Disease-associated TREM2 variants exhibit either a decreased or increased lignad-dependent activation, Alzheimer's & Dementia | Song, W., Hooli, B., Mullin, K., Jin, S. C., Cella, M., Ulland, T. K., Wang, Y., Tanzi, R. E., & Colonna, M. | 2016-08-09 |
| Antibiotic-induced perturbation in gut microbial diversity influences neuro-inflammation and amylodiosis in a murine model of Alzheimer’s disease, Scientific Reports | Minter, M. R., Zhang, C., Leone, V., Ringus, D. L., Zhang, X., Oyler-Castrillo, P., Musch, M. W., Liao, F., Ward, J. F., Holtzman, D. M., Chang, E. B., Tanzi, R. E., & Sisodia, S. S. | 2016-07-16 |
| Pericytes of the neurovascular unit: key functions and signaling pathways, Nature Neuroscience | Sweeney, M. D., Ayyadurai, S., & Zlokovic, B. V. | 2016-05-26 |
| Amyloid-beta peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease, Science Translational Medicine | Kumar, D. K., Choi, S. H., Washicosky, K. J., Eimer, W. A., Tucker, S., Ghofrani, J., Lefkowitz, A., McColl, G., Goldstein, L. E., Tanzi, R. E., & Moir, R. D. | 2016-05-25 |
| Gain of Function mutations in protein kinase c alpha (PKC alpha) may promote synaptic defects in Alzheimer’s disease, Science Signaling | Alfonso, S. I., Callender, J. A., Hooli, B., Antal, C. E., Mullin, K., Sherman, M. A., Lesné, S. E., Leitges, M., Newton, A. C., Tanzi, R. E., & Malinow, R. | 2016-05-10 |
| Relevance of the COPI complex for Alzheimer’s disease progression in vivo, Proceedings of the National Academy of Sciences of the United States of America | Bettayeb, K., Hooli, B. V., Parrado, A. R., Randolph, L., Varotsis, D., Aryal, S., Gresack, J., Tanzi, R. E., Greengard, P., & Flajolet, M. | 2016-04-25 |
| Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer’s disease, Biochimica et Biophysica acta | Nelson, A. R., Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. | 2015-12-17 |
| Accelerating Stem Cell Trials for Alzheimer’s Disease, Lancet Neurology | Hunsberger, J. G., Rao, M., Kurtzberg, J., Bulte, J. W. M., Atala, A., LaFerla, F. M., Greely, H. T., Sawa, A., Gandy, S., Schneider, L. S., & Doraiswamy, P. M. | 2015-12-17 |
| Amyloid precursor protein translation is regulated by a 3′ UTR Guanine Quadruplex, PLoS One | Crenshaw, E., Leung, B. P., Kwok, C. K., Sharoni, M., Olson, K., Sebastian, N. P., Ansaloni, S., Schweitzer-Stenner, R., Akins, M. R., Bevilacqua, P. C., & Saunders, A. J. | 2015-11-30 |
| Optogenetic pacing in Drosophila melanogaster, Science Advances | Alex, A., Li, A., Tanzi, R. E., & Zhou, C. | 2015-10-09 |
| Alzheimer’s in 3D culture: Challenges and Perspectives, BioEssays | D'Avanzo, C., Aronson, J., Kim, Y. H., Choi, S. H., Tanzi, R. E., & Kim, D. Y. | 2015-10-01 |
| Massachusetts Alzheimer’s Disease Research Center: Progress and Challenges, Alzheimer's & Dementia | Hyman, B. T., Growdon, J. H., Albers, M. W., Buckner, R. L., Chhatwal, J., Gomez-Isla, M. T., Haass, C., Hudry, E., Jack, C. R., Jr, Johnson, K. A., Khachaturian, Z. S., Kim, D. Y., Martin, J. B., Nitsch, R. M., Rosen, B. R., Selkoe, D. J., Sperling, R. A., St George-Hyslop, P., Tanzi, R. E., Yap, L., Young, A. B., Phelps, C. H., & McCaffrey, P.M. | 2015-10-01 |
| A circadian clock gene, cry, affects heart morphogenesis and function in Drosophila as revealed by optical coherence microscopy, PLoS One | Alex, A., Li, A., Zeng, X., Tate, R. E., McKee, M. L., Capen, D. E., Zhang, Z., Tanzi, R. E., & Zhou, C. | 2015-09-08 |
| Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families, BMC Medical Genetics | Park, S., Lee, S., Lee, Y., Herold, C., Hooli, B., Mullin, K., Park, T., Park, C., Bertram, L., Lange, C., Tanzi, R., & Won, S. | 2015-08-19 |
| A 3D human neural cell culture system for modeling Alzheimer’s disease, Nature Protocols | Kim, Y. H., Choi, S. H., D'Avanzo, C., Hebisch, M., Sliwinski, C., Bylykbashi, E., Washicosky, K. J., Klee, J. B., Brüstle, O., Tanzi, R. E., & Kim, D. Y. | 2015-07-01 |
| Three dimensions of the amyloid hypothesis: time, space, and ‘wingmen’, Nature Neuroscience | Musiek, E. S., & Holtzman, D. M. | 2015-06-01 |
| Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance, Nature Neuroscience | Zhao, Z., Sagare, A. P., Ma, Q., Halliday, M. R., Kong, P., Kisler, K., Winkler, E. A., Ramanathan, A., Kanekiyo, T., Bu, G., Owens, N. C., Rege, S. V., Si, G., Ahuja, A., Zhu, D., Miller, C. A., Schneider, J. A., Maeda, M., Maed | 2015-05-25 |
| Gamma-Secretase modulators reduce endogenous amyloid beta (42) levels in human neural progenitor cells without altering neuronal differentiation, The FASEB Journal | D'Avanzo, C., Sliwinski, C., Wagner, S. L., Tanzi, R. E., Kim, D. Y., & Kovacs, D. M. | 2015-04-22 |
| Sleep, circadian rhythms and the pathogenesis of Alzheimer Disease, Experimental and Molecular Medicine | Musiek, E. S., Xiong, D. D., & Holtzman, D. M. | 2015-03-01 |
| A gamma secretase inhibitor, but not a gamma-secretase modulator, induced defects in BDNF Axonal trafficking and signaling: evidence for a role for APP, PLoS One | Weissmiller, A. M., Natera-Naranjo, O., Reyna, S. M., Pearn, M. L., Zhao, X., Nguyen, P., Cheng, S., Goldstein, L. S., Tanzi, R. E., Wagner, S. L., Mobley, W. C., & Wu, C. | 2015-02-24 |
| A three-dimensional human neural cell culture model of Alzheimer’s disease, Nature | Choi, S. H., Kim, Y. H., Hebisch, M., Sliwinski, C., Lee, S., D'Avanzo, C., Chen, H., Hooli, B., Asselin, C., Muffat, J., Klee, J. B., Zhang, C., Wainger, B. J., Peitz, M., Kovacs, D. M., Woolf, C. J., Wagner, S. L., Tanzi, R. E., & Kim, D. Y. | 2014-10-12 |
| The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk, Neurology | Hooli, B. V., Parrado, A. R., Mullin, K., Yip, W. K., Liu, T., Roehr, J. T., Qiao, D., Jessen, F., Peters, O., Becker, T., Ramirez, A., Lange, C., Bertram, L., & Tanzi, R. E. | 2014-10-07 |
| Cerebral vascular leak in a mouse model of amyloid neuropathology, Journal of Cerebral Blood Flow & Metabolism | Tanifum, E. A., Starosolski, Z. A., Fowler, S. W., Jankowsky, J. L., & Annapragada, A. V. | 2014-10-01 |
| Age-dependent, non-cell autonomous deposition of amyloid from synthesis of beta-amyloid by cells other than excitatory neurons, Journal of Neuroscience | Veeraraghavalu, K., Zhang, C., Zhang, X., Tanzi, R. E., & Sisodia, S. S. | 2014-03-05 |
| Soluble gamma-secretase modulators slectively inhibit the production of the 42 amino-acid amyloid beta peptide variant and augment the production of multiple carboxy-truncated amyloid beta species, Biochemistry | Wagner, S. L., Zhang, C., Cheng, S., Nguyen, P., Zhang, X., Rynearson, K. D., Wang, R., Li, Y., Sisodia, S. S., Mobley, W. C., & Tanzi, R. E. | 2014-01-22 |
| Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice, Scientific Reports | Xu, Z., Dong, Y., Wang, H., Culley, D. J., Marcantonio, E. R., Crosby, G., Tanzi, R. E., Zhang, Y., & Xie, Z. | 2014-01-20 |
| Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration, Journal of Clinical Investigation | Musiek, E. S., Lim, M. M., Yang, G., Bauer, A. Q., Qi, L., Lee, Y., Roh, J. H., Ortiz-Gonzalez, X., Dearborn, J. T., Culver, J. P., Herzog, E. D., Hogenesch, J. B., Wozniak, D. F., Dikranian, K., Giasson, B. I., Weaver, D. R., Holtzman, D. M., & Fitzgerald, G. A. | 2013-12-02 |
| ADAM10 Missense Mutations Potentiate beta-amyloid accumulation by impairing pro-domain chaperone function, Neuron | Suh, J., Choi, S. H., Romano, D. M., Gannon, M. A., Lesinski, A. N., Kim, D. Y., & Tanzi, R. E. | 2013-09-19 |
| Cerebrospinal fluid Abeta to Tau ratio and postoperative cognitive change, Annals of Surgery | Xie, Z., McAuliffe, S., Swain, C. A., Ward, S. A., Crosby, C. A., Zheng, H., Sherman, J., Dong, Y., Zhang, Y., Sunder, N., Burke, D., Washicosky, K. J., Tanzi, R. E., & Marcantonio, E. R. | 2013-08-01 |
| Rare autosomal copy number variations in early-onset familial Alzheimer’s disease, Molecular Psychiatry | Hooli, B. V., Kovacs-Vajna, Z. M., Mullin, K., Blumenthal, M. A., Mattheisen, M., Zhang, C., Lange, C., Mohapatra, G., Bertram, L., & Tanzi, R. E. | 2013-06-11 |
| Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta, Neuron | Griciuc, A., Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. H., Hyman, B. T., & Tanzi, R. E. | 2013-05-22 |
| Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography, Human Molecular Genetics | Li, A., Ahsen, O. O., Liu, J. J., Du, C., McKee, M. L., Yang, Y., Wasco, W., Newton-Cheh, C. H., O'Donnell, C. J., Fujimoto, J. G., Zhou, C., & Tanzi, R. E. | 2013-05-21 |
| Ubiquilin-1 modulates gamma-secretase-mediated epsilon-site cleavage in neuronal cells, Biochemsitry | Viswanathan, J., Haapasalo, A., Kurkinen, K. M., Natunen, T., Mäkinen, P., Bertram, L., Soininen, H., Tanzi, R. E., & Hiltunen, M. | 2013-05-10 |
| Origins of Alzheiemr’s disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid beta and tau involvement, Current Opinion in Neurology | Musiek, E. S., & Holtzman, D. M. | 2012-12-01 |
| Intravenous delivery of targeted liposomes to amyloid-beta in APP/PSEN1 transgenic mice, PLoS One | Tanifum, E. A., Dasgupta, I., Srivastava, M., Bhavane, R. C., Sun, L., Berridge, J., Pourgarzham, H., Kamath, R., Espinosa, G., Cook, S. C., Eriksen, J. L., & Annapragada, A. | 2012-10-31 |
| Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers, Biochimica et Biophysica Acta - General Subjects | Arai, H., Glabe, C., & Luecke, H. | 2012-08-24 |
| Developing the “Next Generation: of genetic association databases for complex diseases, Human Mutation | Lill, C. M., & Bertram, L. | 2012-07-12 |
| Chronic Traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model, Science Translational Medicine | Goldstein, L. E., Fisher, A. M., Tagge, C. A., Zhang, X. L., Velisek, L., Sullivan, J. A., Upreti, C., Kracht, J. M., Ericsson, M., Wojnarowicz, M. W., Goletiani, C. J., Maglakelidze, G. M., Casey, N., Moncaster, J. A., Minaeva, O., Moir, R. D., … Tanzi, R. E., ... McKee, A. C. | 2012-05-16 |
| The levels of water-soluble and triton-soluble A beta are increased in Alzheimer’s disease brain, Brain Research | McDonald, J. M., Cairns, N. J., Taylor-Reinwald, L., Holtzman, D., & Walsh, D. M. | 2012-04-23 |
| Role of common and rare APP DNA sequence variants in Alzheimer’s Disease, Neurology | Hooli, B. V., Mohapatra, G., Mattheisen, M., Parrado, A. R., Roehr, J. T., Shen, Y., Gusella, J. F., Moir, R., Saunders, A. J., Lange, C., Tanzi, R. E., & Bertram, L. | 2012-04-17 |
| Bidirectional relationship between functional connectivity and amyloid-beta deposition in mouse brain, Journal of Neuroscience | Bero, A. W., Bauer, A. Q., Stewart, F. R., White, B. R., Cirrito, J. R., Raichle, M. E., Culver, J. P., & Holtzman, D. M. | 2012-03-28 |
| The Zinc Dyshomeostasis Hypothesis of Alzheimer’s Disease, PLoS One | Craddock, T. J., Tuszynski, J. A., Chopra, D., Casey, N., Goldstein, L. E., Hameroff, S. R., & Tanzi, R. E. | 2012-03-23 |
| ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models, Science | Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., Brunden, K. R., Wilson, D. A., & Landreth, G. E. | 2012-03-23 |
| Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson’s Disease Genetics: the PDGene database, PLoS Genetics | Lill, C. M., Roehr, J. T., McQueen, M. B., Kavvoura, F. K., Bagade, S., Schjeide, B. M., Schjeide, L. M., Meissner, E., … Tanzi, R. E., ... Bertram, L. | 2012-03-15 |
| Anesthetics isoflurane and desflurane directly affect mitochondrial function, learning, and memory, Annals of Neurology | Zhang, Y., Xu, Z., Wang, H., Dong, Y., Shi, H. N., Culley, D. J., Crosby, G., Marcantonio, E. R., Tanzi, R. E., & Xie, Z. | 2012-02-24 |
| On the Meta-Analysis of Genome-Wide Association studies: a robust and efficient approach to combine population and family-based studies, Human Heredity | Won, S., Lu, Q., Bertram, L., Tanzi, R. E., & Lange, C. | 2012-01-18 |
| Functional Links between A beta toxicity, Endocytic trafficking, and Alzheimer’s disease risk factors in yeast, Science | Treusch, S., Hamamichi, S., Goodman, J. L., Matlack, K. E., Chung, C. Y., Baru, V., Shulman, J. M., Parrado, A., Bevis, B. J., Valastyan, J. S., Han, H., Lindhagen-Persson, M., Reiman, E. M., Evans, D. A., Bennett, D. A., Olofsson, A., DeJager, P. L., Tanzi, R. E., Caldwell, K. A., Caldwell, G. A., … Lindquist, S. | 2011-12-02 |
| Characterization of a Drosophila Alzheimer’s disease model: pharmacoogical rescue of cognitive defects, PLoS One | Chakraborty, R., Vepuri, V., Mhatre, S. D., Paddock, B. E., Miller, S., Michelson, S. J., Delvadia, R., Desai, A., Vinokur, M., Melicharek, D. J., Utreja, S., Khandelwal, P., Ansaloni, S., Goldstein, L. E., Moir, R. D., Lee, J. C., Tabb, L. P., Saunders, A. J., & Marenda, D. R. | 2011-06-06 |
| Changes in the expression of the Alzheimer’s disease-associated presenilin gene in Drosophila heart leads to cardiac dysfunction, Current Alzheimer Research | Li, A., Zhou, C., Moore, J., Zhang, P., Tsai, T. H., Lee, H. C., Romano, D. M., McKee, M. L., Schoenfeld, D. A., Serra, M. J., Raygor, K., Cantiello, H. F., Fujimoto, J. G., & Tanzi, R. E. | 2011-05-01 |
| Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking, Molecular and Cellular Biology | Sarajärvi, T., Tuusa, J. T., Haapasalo, A., Lackman, J. J., Sormunen, R., Helisalmi, S., Roehr, J. T., Parrado, A. R., Mäkinen, P., Bertram, L., Soininen, H., Tanzi, R. E., Petäjä-Repo, U. E., & Hiltunen, M. | 2011-04-04 |
| The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzhiemer Disease risk and cerebrospinal fluid biomarker levels, Archives of General Psychiatry | Schjeide, B. M., Schnack, C., Lambert, J. C., Lill, C. M., Kirchheiner, J., Tumani, H., Otto, M., Tanzi, R. E., Lehrach, H., Amouyel, P., von Arnim, C. A., & Bertram, L. | 2011-02-01 |
| Alzheimer’s disease-associated Ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation, Traffic | Viswanathan, J., Haapasalo, A., Böttcher, C., Miettinen, R., Kurkinen, K. M., Lu, A., Thomas, A., Maynard, C. J., Romano, D., Hyman, B. T., Berezovska, O., Bertram, L., Soininen, H., Dantuma, N. P., Tanzi, R. E., & Hiltunen, M. | 2011-01-07 |
| The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-alpha, IL-6, and IL-1 beta, Neurobiology of Aging | Wu, X., Lu, Y., Dong, Y., Zhang, G., Zhang, Y., Xu, Z., Culley, D. J., Crosby, G., Marcantonio, E. R., Tanzi, R. E., & Xie, Z. | 2010-12-28 |
| The Genetics of Alzheimer’s disease: back to the future, Neuron | Bertram, L., Lill, C. M., & Tanzi, R. E. | 2010-10-21 |
| Amyloid-beta Production Via Cleavage of Amyloid-beta Protein Precursor is Modulated by Cell Density, Journal of Alzheimer's Disease | Zhang, C., Browne, A., Divito, J. R., Stevenson, J. A., Romano, D., Dong, Y., Xie, Z., & Tanzi, R. E. | 2010-10-01 |
| Diabetes-associated SorCS1 regulates Alzheimer’s amyloid-beta metabolism: evidence for involvement of SorL1 and the Retromer Complex, Journal of Neuroscience | Lane, R. F., Raines, S. M., Steele, J. W., Ehrlich, M. E., Lah, J. A., Small, S. A., Tanzi, R. E., Attie, A. D., & Gandy, S. | 2010-09-29 |
| Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein, Journal of Biological Chemistry | Zhang, C., Browne, A., Child, D., & Tanzi, R. E. | 2010-09-10 |
| Alzheimer’s disease Amyloid-beta links lens and brain pathology in Down syndrome, PLoS One | Moncaster, J. A., Pineda, R., Moir, R. D., Lu, S., Burton, M. A., Ghosh, J. G., Ericsson, M., Soscia, S. J., Mocofanescu, A., Folkerth, R. D., Robb, R. M., Kuszak, J. R., Clark, J. I., Tanzi, R. E., Hunter, D. G., & Goldstein, L. E. | 2010-05-20 |
| The Alzheimer’s Disease-Associated Amyloid beta-Protein Is an Antimicrobial Peptide, PLoS One | Soscia, S. J., Kirby, J. E., Washicosky, K. J., Tucker, S. M., Ingelsson, M., Hyman, B., Burton, M. A., Goldstein, L. E., Duong, S., Tanzi, R. E., & Moir, R. D. | 2010-03-03 |
| Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy, Circulation | Gianni, D., Li, A., Tesco, G., McKay, K. M., Moore, J., Raygor, K., Rota, M., Gwathmey, J. K., Dec, G. W., Aretz, T., Leri, A., Semigran, M. J., Anversa, P., Macgillivray, T. E., Tanzi, R. E., & del Monte, F. | 2010-03-01 |
| Familial Alzhiemer’s Disease mutations in presenilin 1 do not alter levels of the secreted amyloid-protein precursor generated by beta-secretase cleavage, Current Alzheimer Research | Zhang, C., Browne, A., Kim, D. Y., & Tanzi, R. E. | 2010-02-01 |
| Loss of Function of ATXN1 Increases Amyloid beta-Protein Levels by Potentiating beta-Secretase Processing of beta-Amyloid Precursor Protein, Journal of Biological Chemistry | Zhang, C., Browne, A., Child, D., Divito, J. R., Stevenson, J. A., & Tanzi, R. E. | 2010-01-22 |
| CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid, Neuroscience Letters | Giedraitis, V., Glaser, A., Sarajärvi, T., Brundin, R., Gunnarsson, M. D., Schjeide, B. M., Tanzi, R. E., Helisalmi, S., Pirttilä, T., Kilander, L., Lannfelt, L., Soininen, H., Bertram, L., Ingelsson, M., & Hiltunen, M. | 2010-01-22 |
| Potential late-onset Alzheimer’s disease-associated mutations in the ADAM10 gene attenuate alpha-secretase activity, Human Molecular Genetics | Kim, M., Suh, J., Romano, D., Truong, M. H., Mullin, K., Hooli, B., Norton, D., Tesco, G., Elliott, K., Wagner, S. L., Moir, R. D., Becker, K. D., & Tanzi, R. E. | 2009-10-15 |
| Genome-wide association studies in Alzheimer’s Disease, Human Molecular Genetics | Bertram, L., & Tanzi, R. E. | 2009-10-15 |
| GAB2 as an Alzheimer Disease Susceptibility Gene, Archives of Neurology | Schjeide, B. M., Hooli, B., Parkinson, M., Hogan, M. F., DiVito, J., Mullin, K., Blacker, D., Tanzi, R. E., & Bertram, L. | 2009-02-01 |
| Assessment of Alzheimer’s disease case-control associations using family-based methods, Neurogenetics | Schjeide, B. M., McQueen, M. B., Mullin, K., DiVito, J., Hogan, M. F., Parkinson, M., Hooli, B., Lange, C., Blacker, D., Tanzi, R. E., & Bertram, L. | 2009-02-01 |
| The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta protein level in vivo, Annals of Neurology | Xie, Z., Culley, D. J., Dong, Y., Zhang, G., Zhang, B., Moir, R. D., Frosch, M. P., Crosby, G., & Tanzi, R. E. | 2008-11-11 |
| Genome-wide Association Analysis Reveals Putative Alzheimer’s Disease Susceptibility Loci in Addition to APOE, American Journal of Human Genetics | Bertram, L., Lange, C., Mullin, K., Parkinson, M., Hsiao, M., Hogan, M. F., Schjeide, B. M., Hooli, B., Divito, J., Ionita, I., Jiang, H., Laird, N., Moscarillo, T., Ohlsen, K. L., Elliott, K., Wang, X., Hu-Lince, D., Ryder, M., Murphy, A., Wagner, S. L., Blacker, D., … Tanzi, R. E. | 2008-10-30 |
| Spatial memory is intact in aged rats after propofol anesthesia, Anesthesia & Analgesia | Lee, I. H., Culley, D. J., Baxter, M. G., Xie, Z., Tanzi, R. E., & Crosby, G. | 2008-10-01 |
| Association of GSK3b with Alzheimer disease and frontotemporal dementia, Archives of Neurology | Schaffer, B. A., Bertram, L., Miller, B. L., Mullin, K., Weintraub, S., Johnson, N., Bigio, E. H., Mesulam, M., Wiedau-Pazos, M., Jackson, G. R., Cummings, J. L., Cantor, R. M., Levey, A. I., Tanzi, R. E., & Geschwind, D. H. | 2008-10-01 |
| Thirty years of Alzheimer’s disease genetics: the implications of systematic meta-analyses, Nature Reviews Neuroscience | Bertram, L., & Tanzi, R. E. | 2008-10-01 |
| Evaluation of the Potential Excess of Statistically Significant Findings in Published Genetic Association Studies: Application to Alzheimer’s Disease, American Journal of Epidemiology | Kavvoura, F. K., McQueen, M. B., Khoury, M. J., Tanzi, R. E., Bertram, L., & Ioannidis, J. P. | 2008-09-09 |
