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Christiane Wrann, D.V.M., Ph.D.

Associate Professor of Medicine, Harvard Medical School and Cardiovascular Research Center (CVRC); Faculty, McCance Center for Brain Health; Affiliate, Harvard Stem Cell Institute (HSCI), Massachusetts General Hospital

Dr. Wrann is an Associate Professor of Medicine at the Cardiovascular Research Center at Massachusetts General Hospital (MGH) and the Harvard Medical School in Boston. Dr. Wrann is also an affiliate of the Henry and Allison McCance Center for Brain Health and the Harvard Stem Cell Institute. She is the recipient of the K99/R00 Pathway to Independence Award from the NINDS and the Hassenfeld Cardiovascular Research Scholar Award. Her research focuses on the beneficial effects of exercise and metabolism on the brain, and specifically secreted factors in exercise as potential drug targets.

Dr. Wrann studied veterinary medicine at the University of Veterinary Medicine Hannover, the University of Cambridge, and Cornell University. She received her Ph.D. with Summa cum laude in Immunology from the University of Veterinary Medicine Hannover in 2008. She concluded her postdoctoral in the laboratory of Dr. Bruce Spiegelman at Dana-Farber Cancer Institute and Harvard Medical School. In April 2016 she joined the faculty of the CVRC to start her own laboratory. The goal of her current CureAlz-funded research is to investigate the role of the exercise hormone irisin in AD pathogenesis using an AD transgenic mouse model.

Lab: http://cvrc.massgeneral.org/faculty/christiane-wrann-dvm-phd/

Twitter @Wrannlab

 

Related Research:

Neuroprotective Effects of the Exercise Hormone Irisin in Alzheimer’s Disease Se Hoon Choi Christiane Wrann 2023-10-25 Neuroprotective Effects of the Exercise Hormone Irisin in Alzheimer’s Disease Se Hoon Choi Christiane Wrann 2022-06-23 Neuroprotective Effects of the Exercise Hormone Irisin in Alzheimer’s Disease Se Hoon Choi Christiane Wrann 2018-12-27

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Neuroprotective Effects of the Exercise Hormone Irisin in Alzheimer’s Disease 2023, 2024

$690,000
Neuroprotective Effects of the Exercise Hormone Irisin in Alzheimer’s Disease 2021, 2022

$700,000
Neuroprotective Effects of the Exercise Hormone Irisin in Alzheimer’s Disease 2018, 2020

$700,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Ouyang, A., Zhang, C., Adra, N., Tesh, R., Sun, H., Lei, D., Jing, J., Fan, P., Paixao, L., Ganglberger, W., Briggs, L., Salinas, J., Bevers, M. B., Wrann, C. D., Chemali, Z., Fricchione, G., Thomas, R. J., Rosand, J., Tanzi, R. E., & Westover, M. B. Effects of Aerobic Exercise on Brain Age and Health in Middle-Aged and Older Adults: A Single-Arm Pilot Clinical Trial, Life, July 8, 2024, Read More

Kim, E., Kim, H., Jedrychowski, M. P., Bakiasi, G., Park, J., Kruskop, J., Choi, Y., Kwak, S. S., Quinti, L., Kim, D. Y., Wrann, C. D., Spiegelman, B. M., Tanzi, R. E., & Choi, S. H. Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling, Neuron, September 8, 2023, Read More

Islam, M. R., Valaris, S., Young, M. F., Haley, E. B., Luo, R., Bond, S. F., Mazuera, S., Kitchen, R. R., Caldarone, B. J., Bettio, L. E. B., Christie, B. R., Schmider, A. B., Soberman, R. J., Besnard, A., Jedrychowski, M. P., Kim, H., Tu, H., Kim, E., Choi, S. H., Tanzi, R. E., … Wrann, C. D. Exercise hormone irisin is a critical regulator of cognitive function, Nature Metabolism, August 20, 2021, Read More

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