Cure Alzheimer's Fund Cure Alzheimer's Fund

Modulation of Abeta Assembly and Cytotoxicity by a Fragment of Myelin Basic Protein

2008

We have identified myelin basic protein (MBP) as a novel factor in brain that can bind Abeta and potently inhibit its assembly into fibrils. In light of this novel finding the overall hypothesis of this proposal is that defined fragments of MBP can regulate Abeta assembly and modulate its cytotoxic properties. This will provide the basis for developing novel and potent Abeta assembly inhibitors.

Studies of APP and Abeta Translational William Van Nostrand

Funding to Date

$100,000

Focus

Studies of APP and Abeta, Translational

Researchers

William Van Nostrand, Ph.D.

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