Dr. John F. Crary is a board-certified neuropathologist and internationally recognized Alzheimer’s disease researcher whose work bridges human pathology, genetics, and artificial intelligence. He defined Primary Age-Related Tauopathy (PART), helping clarify how age-related neurofibrillary changes intersect withAlzheimer’s disease. His lab discovered JADE1 as a genetic driver of tauopathy and pioneered AI-based digital pathology tools, including HistoAge, to extract new biological insights from human brain tissue. As Director of the Neuropathology Brain Bank at Mount Sinai, Dr. Crary leads one of the nation’s major Alzheimer’s disease tissue programs and is advancing next-generation iPSC-derived brain organoid models to uncover early mechanisms of tau injury. His work has significantly shaped our understanding of tau biology, brain aging, and the pathways leading to Alzheimer’s disease.

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