Two previously unknown mutations in the ADAM10 gene have been identified; this gene is linked to late-onset Alzheimer’s disease. The research suggests that the ADAM10 gene codes for an enzyme that helps to prevent the formation of the amyloid plaques seen in Alzheimer’s. A mutation of the ADAM10 gene diminishes activity of this enzyme, leading to increased buildup of amyloid into the plaque bundles. Identifying this potential trigger of Alzheimer’s pathology has made possible new therapeutic targets for the disease.

Rudy Tanzi, Ph.D., and Jaehong Suh, Ph.D., Massachusetts General Hospital