Kim, J. J., Hebisch, M., Kwak, S. S., Zheng, M., Nuli, S., Bae, J. S., Brand, E., Tanzi, R. E., Irimia, D., & Kim, D. Y. Cryopreserving 3D cell culture models of Alzheimer’s disease in hydrogel microbeads, Scientific Reports, April 12, 2025, Read More

Bai, P., Mondal, P., Liu, Y., Gomm, A., Suen, C., Yang, L., Zhu, B., Sun, H., Ran, C., Shen, S., Tanzi, R. E., Zhang, C., & Wang, C. HDAC11 displays neuropathological alterations and offers as a novel drug target for Alzheimer’s disease, Alzheimer's & Dementia, March 20, 2025, Read More

Willett, J. D. S., Waqas, M., Choi, Y., Ngai, T., Mullin, K., Tanzi, R. E., & Prokopenko, D. Identification of 16 novel Alzheimer’s disease loci using multi-ancestry meta-analyses, Alzheimer's & Dementia, February 25, 2025, Read More

Ma, X., Prokopenko, D., Wang, N., Aikawa, T., Choi, Y., Zhang, C., Lei, D., Ren, Y., Kawatani, K., Starling, S. C., Perkerson, R. B., Roy, B., Quintero, A. C., Parsons, T. M., Pan, Y., Li, Z., Wang, M., Bao, H., Han, X., Bu, G., Tanzi, R. E., Kanekiyo, T. Alzheimer’s disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice, Neurobiology of Disease, January 27, 2025, Read More

Zellmer, J. C., Lomoio, S., Tanzi, R. E., & Bhattacharyya, R. Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer’s Disease (AD), Journal of Visualized Experiments, January 10, 2025, Read More

Naderi Yeganeh, P., Kwak, S. S., Jorfi, M., Koler, K., Kalatturu, T., von Maydell, D., Liu, Z., Guo, K., Choi, Y., Park, J., Abarca, N., Bakiasi, G., Cetinbas, M., Sadreyev, R., Griciuc, A., Quinti, L., Choi, S. H., Xia, W., Tanzi, R. E., Hide, W., Kim, D. Y. Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease, Neuron, November 27, 2024, Read More

Lin, C., Tian, Y., Tanzi, R. E., & Jorfi, M. Approaches for studying neuroimmune interactions in Alzheimer’s disease, Trends in Immunology, November 12, 2024, Read More

Ngai, T., Willett, J., Waqas, M., Fishbein, L. H., Choi, Y., Hahn, G., Mullin, K., Lange, C., Hecker, J., Tanzi, R. E., & Prokopenko, D. Assessing polyomic risk to predict Alzheimer’s disease using a machine learning model, Alzheimer's & Dementia, November 7, 2024, Read More

Perrin, F., Anderson, L. C., Mitchell, S. P. C., Sinha, P., Turchyna, Y., Maesako, M., Houser, M. C. Q., Zhang, C., Wagner, S. L., Tanzi, R. E., & Berezovska, O. PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer’s disease, Acta Neuropathologica Communications, October 21, 2024, Read More

Lin, C. J., Jaafar, N., & Tanzi, R. E. Protocol to characterize mouse dural mast cells by flow cytometry and immunofluorescence, STAR Protocols, October 7, 2024, Read More

Pavlou, G., Spitz, S., Pramotton, F. M., Tsai, A., Li, B. M., Wang, X., Barr, O. M., Ko, E. C., Zhang, S., Ashley, S. J., Maaser-Hecker, A., Choi, S. H., Jorfi, M., Tanzi, R. E., & Kamm, R. D. Engineered 3D human neurovascular model of Alzheimer’s disease to study vascular dysfunction, Biomaterials, September 28, 2024, Read More

Biby, S., Mondal, P., Xu, Y., Gomm, A., Kaur, B., Namme, J. N., Wang, C., Tanzi, R. E., Zhang, S., & Zhang, C. Functional Characterization of an Arylsulfonamide-Based Small-Molecule Inhibitor of the NLRP3 Inflammasome, ACS Chemical Neuroscience, September 19, 2024, Read More

Hall, C. K., Barr, O. M., Delamare, A., Burkholder, A., Tsai, A., Tian, Y., Felix E Ellett, Li, B. M., Tanzi, R. E., & Jorfi, M. Profiling migration of human monocytes in response to chemotactic and barotactic guidance cues, Cell Reports Methods, September 16, 2024, Read More

Godoy-Lugo, J. A., Thorwald, M. A., Cacciottolo, M., D'Agostino, C., Chakhoyan, A., Sioutas, C., Tanzi, R. E., Rynearson, K. D., & Finch, C. E. Air pollution amyloidogenesis is attenuated by the gamma-secretase modulator GSM-15606, Alzheimer's & Dementia, August 12, 2024, Read More

Arnold, S. E., Hendrix, S., Nicodemus-Johnson, J., Knowlton, N., Williams, V. J., Burns, J. M., Crane, M., McManus, A. J., Vaishnavi, S. N., Arvanitakis, Z., Neugroschl, J., Bell, K., Trombetta, B. A., Carlyle, B. C., Kivisäkk, P., Dodge, H. H., Tanzi, R. E., Yeramian, P. D., & Leslie, K. Biological effects of sodium phenylbutyrate and taurursodiol in Alzheimer’s disease, Alzheimer's & Dementia, August 9, 2024, Read More

Sun, Z., Kwon, J. S., Ren, Y., Chen, S., Walker, C. K., Lu, X., Cates, K., Karahan, H., Sviben, S., Fitzpatrick, J. A. J., Valdez, C., Houlden, H., Karch, C. M., Bateman, R. J., Sato, C., Mennerick, S. J., Diamond, M. I., Kim, J., Tanzi, R. E., Holtzman, D. M., Yoo, A. S. Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming, Science, August 8, 2024, Read More

Mathys, H., Boix, C. A., Akay, L. A., Xia, Z., Davila-Velderrain, J., Ng, A. P., Jiang, X., Abdelhady, G., Galani, K., Mantero, J., Band, N., James, B. T., Babu, S., Galiana-Melendez, F., Louderback, K., Prokopenko, D., Tanzi, R. E., Bennett, D. A., Tsai, L. H., & Kellis, M. Single-cell multiregion dissection of Alzheimer’s disease, Nature, July 24, 2024, Read More

Kim, E., Tanzi, R. E., & Choi, S. H. Therapeutic potential of exercise-hormone irisin in Alzheimer’s disease, Neural Regeneration Research, July 10, 2024, Read More

Ouyang, A., Zhang, C., Adra, N., Tesh, R., Sun, H., Lei, D., Jing, J., Fan, P., Paixao, L., Ganglberger, W., Briggs, L., Salinas, J., Bevers, M. B., Wrann, C. D., Chemali, Z., Fricchione, G., Thomas, R. J., Rosand, J., Tanzi, R. E., & Westover, M. B. Effects of Aerobic Exercise on Brain Age and Health in Middle-Aged and Older Adults: A Single-Arm Pilot Clinical Trial, Life, July 8, 2024, Read More

Bai, P., Lan, Y., Liu, Y., Mondal, P., Gomm, A., Xu, Y., Wang, Y., Wang, Y., Kang, L., Pan, L., Bagdasarian, F. A., Hallisey, M., Varela, B., Choi, S. H., Gomperts, S. N., Wey, H. Y., Shen, S., Tanzi, R. E., Wang, C., & Zhang, C. Development of a New Positron Emission Tomography Imaging Radioligand Targeting RIPK1 in the Brain and Characterization in Alzheimer’s Disease, Advanced Science, June 25, 2024, Read More

Hahn, G., Prokopenko, D., Hecker, J., Lutz, S. M., Mullin, K., Sejour, L., Hide, W., Vlachos, I., DeSantis, S., Tanzi, R. E., & Lange, C. Prediction of disease-free survival for precision medicine using cooperative learning on multi-omic data, Briefings in Bioinformatics, June 5, 2024, Read More

Chen, X. Q., Becker, A., Albay, R., Nguyen, P. D., Karachentsev, D., Roberts, A. J., Rynearson, K. D., Tanzi, R. E., & Mobley, W. C. γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome, Annals of Neurology, May 15, 2024, Read More

Lee, S., Hecker, J., Hahn, G., Mullin, K., Alzheimer's Disease Neuroimaging Initiative (ADNI), Lutz, S. M., Tanzi, R. E., Lange, C., & Prokopenko, D. On the effect heterogeneity of established disease susceptibility loci for Alzheimer’s disease across different genetic ancestries, Alzheimer's & Dementia, April 2, 2024, Read More

Bosch, M. E., Dodiya, H. B., Michalkiewicz, J., Lee, C., Shaik, S. M., Weigle, I. Q., Zhang, C., Osborn, J., Nambiar, A., Patel, P., Parhizkar, S., Zhang, X., Laury, M. L., Mondal, P., Gomm, A., Schipma, M. J., Mallah, D., Butovsky, O., Chang, E. B., Tanzi, R. E., Gilbert, J. A., Holtzman, D. M. & Sisodia, S. S. Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner, Molecular Neurodegeneration, February 17, 2024, Read More

Saha, P., Weigle, I. Q., Slimmon, N., Poli, P. B., Patel, P., Zhang, X., Cao, Y., Michalkiewicz, J., Gomm, A., Zhang, C., Tanzi, R. E., Dylla, N., Al-Hendy, A., & Sisodia, S. S. Early modulation of the gut microbiome by female sex hormones alters amyloid pathology and microglial function, Scientific Reports, January 21, 2024, Read More

Mondal, P., Bai, P., Gomm, A., Bakiasi, G., Lin, C. J., Wang, Y., Choi, S. H., Tanzi, R. E., Wang, C., & Zhang, C. Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer’s Disease Neuropathology, Advanced Science, November 21, 2023, Read More

Bai, P., Liu, Y., Yang, L., Ding, W., Mondal, P., Sang, N., Liu, G., Lu, X., Ho, T. T., Zhou, Y., Wu, R., Birar, V. C., Wilks, M. Q., Tanzi, R. E., Lin, H., Zhang, C., Li, W., Shen, S., & Wang, C. Development and Pharmacochemical Characterization Discover a Novel Brain-Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice, Journal of Medicinal Chemistry, November 16, 2023, Read More

Ko, E. C., Spitz, S., Pramotton, F. M., Barr, O. M., Xu, C., Pavlou, G., Zhang, S., Tsai, A., Maaser-Hecker, A., Jorfi, M., Choi, S. H., Tanzi, R. E., & Kamm, R. D. Accelerating the in vitro emulation of Alzheimer’s disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture model, Frontiers in Bioengineering and Biotechnology, October 9, 2023, Read More

Neumann, A., Ohlei, O., Küçükali, F., Bos, I. J., Timsina, J., Vos, S., Prokopenko, D., Tijms, B. M., Andreasson, U., Blennow, K., Vandenberghe, R., Scheltens, P., Teunissen, C. E., Engelborghs, S., Frisoni, G. B., Blin, O., Richardson, J. C., Bordet, R., Lleó, A., Alcolea, D., … EMIF-AD & ADNI study group Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning, Genome Medicine, October 4, 2023, Read More

Yin, Z., Rosenzweig, N., … Ikezu, T., … Tanzi, R., E., … Holtzman, D., M., & Butovsky, O. APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints, Nature Immunology, September 25, 2023, Read More

Lin, C. J., Herisson, F., Le, H., Jaafar, N., Chetal, K., Oram, M. K., Flynn, K. L., Gavrilles, E. P., Sadreyev, R. I., Schiffino, F. L., & Tanzi, R. E. Mast cell deficiency improves cognition and enhances disease-associated microglia in 5XFAD mice, Cell Reports, September 13, 2023, Read More

Kim, E., Kim, H., Jedrychowski, M. P., Bakiasi, G., Park, J., Kruskop, J., Choi, Y., Kwak, S. S., Quinti, L., Kim, D. Y., Wrann, C. D., Spiegelman, B. M., Tanzi, R. E., & Choi, S. H. Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling, Neuron, September 8, 2023, Read More

Jorfi, M., Park, J., Hall, C. K., Lin, C. J., Chen, M., von Maydell, D., Kruskop, J. M., Kang, B., Choi, Y., Prokopenko, D., Irimia, D., Kim, D. Y., & Tanzi, R. E. Infiltrating CD8+ T cells exacerbate Alzheimer’s disease pathology in a 3D human neuroimmune axis model, Nature Neuroscience, August 24, 2023, Read More

Linnoila, J., Jalali Motlagh, N., Jachimiec, G., Lin, C. J., Küllenberg, E., Wojtkiewicz, G., Tanzi, R., & Chen, J. W. Optimizing animal models of autoimmune encephalitis using active immunization, Frontiers in Immunology, July 12, 2023, Read More

Chen, X. Q., Sawa, M., Becker, A., Karachentsev, D., Zuo, X., Rynearson, K. D., Tanzi, R. E., & Mobley, W. C. Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator, Annals of Neurology, April 11, 2023, Read More

Liu, G., Mondal, P., Sang, N., Li, Z., Ding, W., Yang, L., Liu, Y., Birar, V. C., Gomm, A., Tanzi, R. E., Zhang, C., Shen, S., Wang, C., Lu, X., & Bai, P. Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors, European Journal of Medicinal Chemistry, March 31, 2023, Read More

Choi, S. H., & Tanzi, R. E. Adult neurogenesis in Alzheimer’s disease, Hippocampus, February 7, 2023, Read More

Salta, E., Lazarov, O., Fitzsimons, C. P., Tanzi, R., Lucassen, P. J., & Choi, S. H. Adult hippocampal neurogenesis in Alzheimer’s disease: A roadmap to clinical relevance, Cell Stem Cell, February 2, 2023, Read More

Jorfi, M., Maaser-Hecker, A., & Tanzi, R. E. The neuroimmune axis of Alzheimer’s disease, Genome Medicine, January 26, 2023, Read More

Hebisch, M., Klostermeier, S., Wolf, K., Boccaccini, A. R., Wolf, S. E., Tanzi, R. E., & Kim, D. Y. The Impact of the Cellular Environment and Aging on Modeling Alzheimer’s Disease in 3D Cell Culture Models, Advanced Science, January 15, 2023, Read More

Yassine, H. N., Self, W., Kerman, B. E., Santoni, G., Navalpur Shanmugam, N., Abdullah, L., Golden, L. R., Fonteh, A. N., Harrington, M. G., Gräff, J., Gibson, G. E., Kalaria, R., Luchsinger, J. A., Feldman, H. H., Swerdlow, R. H., Johnson, L. A., Albensi, B. C., Zlokovic, B. V., Tanzi, R., Cunnane, S., … Bowman, G. L. Nutritional metabolism and cerebral bioenergetics in Alzheimer’s disease and related dementias, Alzheimer's & Dementia, December 8, 2022, Read More

Lordén, G., Wozniak, J. M., Doré, K., Dozier, L. E., Cates-Gatto, C., Patrick, G. N., Gonzalez, D. J., Roberts, A. J., Tanzi, R. E., & Newton, A. C. Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model, Nature Communications, November 23, 2022, Read More

Margeta, M. A., Yin, Z., Madore, C., Pitts, K. M., Letcher, S. M., Tang, J., Jiang, S., Gauthier, C. D., Silveira, S. R., Schroeder, C. M., Lad, E. M., Proia, A. D., Tanzi, R. E., Holtzman, D. M., Krasemann, S., Chen, D. F., & Butovsky, O. Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma, Immunity, August 16, 2022, Read More

Lopatko Lindman, K., Jonsson, C., Weidung, B., Olsson, J., Pandey, J. P., Prokopenko, D., Tanzi, R. E., Hallmans, G., Eriksson, S., Elgh, F., & Lövheim, H. PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer’s disease risk, Scientific Reports, August 2, 2022, Read More

Morgan, S. L., Naderi, P., Koler, K., Pita-Juarez, Y., Prokopenko, D., Vlachos, I. S., Tanzi, R. E., Bertram, L., & Hide, W. A. Most Pathways Can Be Related to the Pathogenesis of Alzheimer’s Disease, Frontiers in Aging Neuroscience, June 24, 2022, Read More

Bai, P., Mondal, P., Bagdasarian, F. A., Rani, N., Liu, Y., Gomm, A., Tocci, D. R., Choi, S. H., Wey, H. Y., Tanzi, R. E., Zhang, C., & Wang, C. Development of a potential PET probe for HDAC6 imaging in Alzheimer’s disease, Acta Pharmaceutica Sinica B, May 20, 2022, Read More

Liang, Y., Lee, D. Y. W., Zhen, S., Sun, H., Zhu, B., Liu, J., Lei, D., Lin, C. J., Zhang, S., Jacques, N. A., Quinti, L., Ran, C., Wang, C., Griciuc, A., Choi, S. H., Dai, R. H., Efferth, T., Tanzi, R. E., & Zhang, C. Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer’s disease, Phytomedicine, May 13, 2022, Read More

Whitson, H. E., Colton, C., El Khoury, J., Gate, D., Goate, A., Heneka, M. T., Kaddurah-Daouk, R., Klein, R. S., Shinohara, M. L., Sisodia, S., Spudich, S. S., Stevens, B., Tanzi, R., Ting, J. P., Garden, G., & Symposium Planning Committee members. Infection and inflammation: New perspectives on Alzheimer’s disease, Brain, Behavior, & Immunity - Health, April 22, 2022, Read More

Wang, Z., Ye, J., Zhang, K., Ding, L., Granzier-Nakajima, T., Ranasinghe, J. C., Xue, Y., Sharma, S., Biase, I., Terrones, M., Choi, S. H., Ran, C., Tanzi, R. E., Huang, S. X., Zhang, C., & Huang, S. Rapid Biomarker Screening of Alzheimer’s Disease by Interpretable Machine Learning and Graphene-Assisted Raman Spectroscopy, ASC Nano, March 25, 2022, Read More

Ning, S., Jorfi, M., Patel, S. R., Kim, D. Y., & Tanzi, R. E. Neurotechnological Approaches to the Diagnosis and Treatment of Alzheimer’s Disease, Frontiers in Neuroscience, March 24, 2022, Read More

Prokopenko, D., Lee, S., Hecker, J., Mullin, K., Morgan, S., Katsumata, Y., Alzheimer’s Disease Neuroimaging Initiative (ADNI), Weiner, M. W., Fardo, D. W., Laird, N., Bertram, L., Hide, W., Lange, C., & Tanzi, R. E. Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer’s disease-associated genes: DTNB and DLG2, Molecular Psychiatry, March 4, 2022, Read More

Zhang, S., Bai, P., Lei, D., Liang, Y., Zhen, S., Bakiasi, G., Pang, H., Choi, S. H., Wang, C., Tanzi, R. E., & Zhang, C. Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer’s disease-related neuropathology in cell models, Journal of Biological Chemistry, March 3, 2022, Read More

Bhattacharyya, R., Teves, C. A. F., Long, A., Hofert, M., & Tanzi, R. E. The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner, Scientific Reports, March 3, 2022, Read More

Caldwell, A. B., Liu, Q., Zhang, C., Schroth, G. P., Galasko, D. R., Rynearson, K. D., Tanzi, R. E., Yuan, S. H., Wagner, S. L., & Subramaniam, S. Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer’s disease, Alzheimer's & Dementia, January 27, 2022, Read More

Lotlikar, M. S., Tarantino, M. B., Jorfi, M., Kovacs, D. M., Tanzi, R. E., & Bhattacharyya, R. Microfluidic separation of axonal and somal compartments of neural progenitor cells differentiated in a 3D matrix, STAR Protocols, January 7, 2022, Read More

Hahn, G., Prokopenko, D., Lutz, S. M., Mullin, K., Tanzi, R. E., Cho, M. H., Silverman, E. K., Lange, C., & On The Behalf Of The Nhlbi Trans-Omics For Precision Medicine TOPMed Consortium A Smoothed Version of the Lassosum Penalty for Fitting Integrated Risk Models Using Summary Statistics or Individual-Level Data, Genes, January 6, 2022, Read More

Dodiya, H. B., Lutz, H. L., Weigle, I. Q., Patel, P., Michalkiewicz, J., Roman-Santiago, C. J., Zhang, C. M., Liang, Y., Srinath, A., Zhang, X., Xia, J., Olszewski, M., Zhang, X., Schipma, M. J., Chang, E. B., Tanzi, R. E., Gilbert, J. A., & Sisodia, S. S. Gut microbiota-driven brain Aβ amyloidosis in mice requires microglia, Journal of Experimental Medicine, January 3, 2022, Read More

Lan, Y., Bai, P., Liu, Y., Afshar, S., Striar, R., Rattray, A. K., Meyer, T. N., Langan, A. G., Posner, A. M., Shen, S., Tanzi, R. E., Zhang, C., & Wang, C. Visualization of Receptor-Interacting Protein Kinase 1 (RIPK1) by Brain Imaging with Positron Emission Tomography, Journal of Medicinal Chemistry, October 15, 2021, Read More

Kim, J. J., Jorfi, M., Tanzi, R. E., Kim, D. Y., Doyle, P. S., & Irimia, D. Patterning of interconnected human brain spheroids, Lab on a Chip, September 14, 2021, Read More

Islam, M. R., Valaris, S., Young, M. F., Haley, E. B., Luo, R., Bond, S. F., Mazuera, S., Kitchen, R. R., Caldarone, B. J., Bettio, L. E. B., Christie, B. R., Schmider, A. B., Soberman, R. J., Besnard, A., Jedrychowski, M. P., Kim, H., Tu, H., Kim, E., Choi, S. H., Tanzi, R. E., … Wrann, C. D. Exercise hormone irisin is a critical regulator of cognitive function, Nature Metabolism, August 20, 2021, Read More

McAlpine, C. S., Park, J., Griciuc, A., Kim, E., Choi, S. H., Iwamoto, Y., Kiss, M. G., Christie, K. A., Vinegoni, C., Poller, W. C., Mindur, J. E., Chan, C. T., He, S., Janssen, H., Wong, L. P., Downey, J., Singh, S., Anzai, A., Kahles, F., Jorfi, M., Feruglio, P.F., Sadreyev, R. I., Weissleder, R., Kleinstiver, B. P., Nahrendorf, M., Tanzi, R. E., & Swirski, F. K. Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease, Nature, July 14, 2021, Read More

Yang, H. S., Zhang, C., Carlyle, B. C., Zhen, S. Y., Trombetta, B. A., Schultz, A. P., Pruzin, J. J., Fitzpatrick, C. D., Yau, W. W., Kirn, D. R., Rentz, D. M., Arnold, S. E., Johnson, K. A., Sperling, R. A., Chhatwal, J. P., & Tanzi, R. E. Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults, Alzheimer's & Dementia, June 23, 2021, Read More

Zhang, X., Zhang, C. M., Prokopenko, D., Liang, Y., Zhen, S. Y., Weigle, I. Q., Han, W., Aryal, M., Tanzi, R. E., & Sisodia, S. S. An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo, Journal of Experimental Medicine, June 7, 2021, Read More

Bhattacharyya, R., Black, S. E., Lotlikar, M. S., Fenn, R. H., Jorfi, M., Kovacs, D. M., & Tanzi, R. E. Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes, Cell Reports, May 18, 2021, Read More

Xu, Y., Chen, Z., Wey, H. Y., Liang, Y., Tanzi, R. E., Zhang, C., & Wang, C. Molecular imaging of NAD(+) -dependent deacetylase SIRT1 in the brain, Alzheimer's & Dementia, April 15, 2021, Read More

Prokopenko, D., Morgan, S. L., Mullin, K., Hofmann, O., Chapman, B., Kirchner, R., Alzheimer's Disease Neuroimaging Initiative (ADNI), Amberkar, S., Wohlers, I., Lange, C., Hide, W., Bertram, L., & Tanzi, R. E. Whole-genome sequencing reveals new Alzheimer’s disease-associated rare variants in loci related to synaptic function and neuronal development, Alzheimer's & Dementia, April 2, 2021, Read More

Griciuc, A., & Tanzi, R. E. The role of innate immune genes in Alzheimer’s disease, Current Opinion in Neurology, April 1, 2021, Read More

Rynearson, K. D., Ponnusamy, M., Prikhodko, O., … Mobley, W. C., Thinakaran, G., Tanzi, R. E., Wagner, S. L. Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention, Journal of Experimental Medicine, March 2, 2021, Read More

Xu, Y., Wang, C., Wey, H. Y., Liang, Y., Chen, Z., Choi, S. H., Ran, C., Rynearson, K. D., Bernales, D. R., Koegel, R. E., Fiedler, S. A., Striar, R., Wagner, S. L., Tanzi, R. E., & Zhang, C. Molecular imaging of Alzheimer’s disease–related gamma-secretase in mice and nonhuman primates, Journal of Experimental Medicine, December 7, 2020, Read More

Lomoio, S., Willen, R., Kim, W., Ho, K. Z., Robinson, E. K., Prokopenko, D., Kennedy, M. E., Tanzi, R. E., & Tesco, G. Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings, Science Translational Medicine, November 18, 2020, Read More

Cuddy, L. K., Prokopenko, D., Cunningham, E. P., Brimberry, R., Song, P., Kirchner, R., Chapman, B. A., Hofmann, O., Hide, W., Procissi, D., Hanania, T., Leiser, S. C., Tanzi, R. E., & Vassar, R. Abeta-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice, Science Translational Medicine, September 30, 2020, Read More

Liu T, Zhu B, Liu Y, Zhang X, Yin J, Li X, Jiang L, Hodges AP, Rosenthal SB, Zhou L, Yancey J, McQuade A, Blurton-Jones M, Tanzi RE, Huang TY, Xu H. Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE, Journal of Experimental Medicine, September 17, 2020, Read More

Bertram, L., & Tanzi, R. E. Genomic Mechanisms in Alzheimer’s Disease, Brain Pathology, September 8, 2020, Read More

Rynearson, K. D., Buckle, R. N., Herr, R. J., Mayhew, N. J., Chen, X., Paquette, W. D., Sakwa, S. A., Yang, J., Barnes, K. D., Nguyen, P., Mobley, W. C., Johnson, G., Lin, J. H., Tanzi, R. E., & Wagner, S. L. Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators, Bioorganic and Medicinal Chemistry, September 1, 2020, Read More

Griciuc, A., Federico, A. N., Natasan, J., Forte, A. M., McGinty, D., Nguyen, H., Volak, A., LeRoy, S., Gandhi, S., Lerner, E. P., Hudry, E., Tanzi, R. E., & Maguire, C. A. Gene therapy for Alzheimer’s Disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation., Human Molecular Genetics, August 17, 2020, Read More

Liang, Y., Raven, F., Ward, J. F., Zhen, S., Zhang, S., Sun, H., Miller, S. J., Choi, S. H., Tanzi, R. E., & Zhang, C. Upregulation of Alzheimer’s Disease Amyloid-beta Protein Precursor in Astrocytes Both in vitro and in vivo, Journal of Alzheimer's Disease, August 4, 2020, Read More

Men, J., Li, A., Jerwick, J., Li, Z., Tanzi, R. E., & Zhou, C. Non-invasive red-light optogenetic control of Drosophila cardiac function, Communications Biology, June 29, 2020, Read More

Dujardin, S., Commins, C., Lathuiliere, A., Beerepoot, P., Fernandes, A. R., Kamath, T. V., De Los Santos, M. B., Klickstein, N., Corjuc, D. L., Corjuc, B. T., Dooley, P. M., Viode, A., Oakley, D. H., Moore, B. D., Mullin, K., Jean-Gilles, D., Clark, R., Atchison, K., Moore, R., Chibnik, L. B., Tanzi, R. E., … Hyman, B. T. Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease, Nature Medicine, June 22, 2020, Read More

Cable, J., Holtzman, D. M., Hyman, B. T., Tansey, M. G., Colonna, M., Kellis, M., Brinton, R. D., Albert, M., Wellington, C. L., Sisodia, S. S., & Tanzi, R. E. Alternatives to Amyloid for Alzheimer’s Disease Therapies-A Symposium Report, Annals of the New York Academy of Sciences, May 29, 2020, Read More

Zhang, X., Zhang, C., Prokopenko, D., Liang, Y., Han, W., Tanzi, R. E., & Sisodia, S. S. Negative evidence for a role of APH1B T27I variant in Alzheimer’s disease, Human Molecular Genetics, April 15, 2020, Read More

Prokopenko, D., Hecker, J., Kirchner, R., Chapman, B. A., Hoffman, O., Mullin, K., Hide, W., Bertram, L., Laird, N., DeMeo, D. L., Lange, C., & Tanzi, R. E. Identification of Novel Alzheimer’s Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data, Scientific Reports, March 19, 2020, Read More

Kwak, S. S., Washicosky, K. J., Brand, E., von Maydell, D., Aronson, J., Kim, S., Capen, D. E., Cetinbas, M., Sadreyev, R., Ning, S., Bylykbashi, E., Xia, W., Wagner, S. L., Choi, S. H., Tanzi, R. E., & Kim, D. Y. Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease, Nature Communications, March 13, 2020, Read More

Prikhodko, O., Rynearson, K. D., Sekhon, T., Mante, M. M., Nguyen, P. D., Rissman, R. A., Tanzi, R. E., & Wagner, S. L. The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer’s Disease, Journal of Alzheimer's Disease, February 18, 2020, Read More

Wan, Y., Liang, Y., Liang, F., Shen, N., Shinozuka, K., Yu, J. T., Ran, C., Quan, Q., Tanzi, R. E., & Zhang, C. A Curcumin Analog Reduces Levels of the Alzheimer’s Disease-Associated Amyloid-beta Protein by Modulating A beta PP Processing and Autophagy, Journal of Alzheimer's Disease, November 26, 2019, Read More

Ma, C., Su, J., Sun, Y., Feng, Y., Shen, N., Li, B., Liang, Y., Yang, X., Wu, H., Zhang, H., Herrmann, A., Tanzi, R. E., Liu, K., & Zhang, C. Significant Upregulation of Alzheimer’s beta-Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides, Angewandte Chemie (International ed. in English), November 4, 2019, Read More

Huynh, T. V., Wang, C., Tran, A. C., Tabor, G. T., Mahan, T. E., Francis, C. M., Finn, M. B., Spellman, R., Manis, M., Tanzi, R. E., Ulrich, J. D., & Holtzman, D. M. Lack of hepatic apoE does not influence early A beta deposition: observations from a new APOE knock-in model, Molecular Neurodegeneration, October 17, 2019, Read More

Suh, J., Romano, D. M., Nitschke, L., Herrick, S. P., DiMarzio, B. A., Dzhala, V., Bae, J. S., Oram, M. K., Zheng, Y., Hooli, B., Mullin, K., Gennarino, V. A., Wasco, W., Schmahmann, J. D., Albers, M. W., Zoghbi, H. Y., & Tanzi, R. E. Loss of Ataxin-1 Potentiates Alzheimer’s Pathogenesis by Elevating Cerebral BACE1 Transcription, Cell, August 22, 2019, Read More

Shin, Y., Choi, S. H., Kim, E., Bylykbashi, E., Kim, J. A., Chung, S., Kim, D. Y., Kamm, R. D., & Tanzi, R. E. Blood Brain Barrier Dysfunction in a 3D in vitro model of Alzheimer’s Disease, Advanced Science, August 12, 2019, Read More

Griciuc, A., Patel, S., Federico, A. N., Choi, S. H., Innes, B. J., Oram, M. K., Cereghetti, G., McGinty, D., Anselmo, A., Sadreyev, R. I., Hickman, S. E., El Khoury, J., Colonna, M., & Tanzi, R. E. TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease, Neuron, July 10, 2019, Read More

Moir, R. D., & Tanzi, R. E. Low Evolutionary Selection Pressure in Senescence does not explain the persistence of amyloid-beta in the vertebrate genome, Frontiers in Aging Neuroscience, March 28, 2019, Read More

Bertram, L., & Tanzi, R. E. Alzheimer’s disease risk genes: 29 and counting, Nature Reviews Neurology, March 4, 2019, Read More

Wang, S., Tanzi, R. E., & Li, A. Quantitative Analysis of Neuronal Dendritic Arborization Complexity in Drosophila, Journal of Visualized Experiments, January 7, 2019, Read More

Li, A., Peng, Y., Taiclet, L. M., & Tanzi, R. E. (2019). Analysis of hidradenitis suppurativa-linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophages., Human Molecular Genetics, December 13, 2018, Read More

Norambuena, A., Wallrabe, H., Cao, R., Wang, D. B., Silva, A., Svindrych, Z., Periasamy, A., Hu, S., Tanzi, R. E., Kim, D. Y., & Bloom, G. S. A novel lysosome-to-micochondria signaling pathway disrupted by amyloid-beta oligomes, The EMBO Journal, October 22, 2018, Read More

Moir, R. D., Lathe, R., & Tanzi, R. E. The Antimicrobial protection hypothesis of Alzheimer’s disease, Alzheimer's & Dementia, October 9, 2018, Read More

Choi, S. H., Bylykbashi, E., Chatila, Z. K., Lee, S. W., Pulli, B., Clemenson, G. D., Kim, E., Rompala, A., Oram, M. K., Asselin, C., Aronson, J., Zhang, C., Miller, S. J., Lesinski, A., Chen, J. W., Kim, D. Y., van Praag, H., Spiegelman, B. M., Gage, F. H., & Tanzi, R. E. Combined Adult Neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model, Science, September 7, 2018, Read More

Eimer, W. A., Vijaya Kumar, D. K., Navalpur Shanmugam, N. K., Rodriguez, A. S., Mitchell, T., Washicosky, K. J., György, B., Breakefield, X. O., Tanzi, R. E., & Moir, R. D. Alzheimer’s disease beta-amyloid is rapidly seeded by herpesviridae to protet against brain infection, Neuron, July 11, 2018, Read More

Park, J., Wetzel, I., Marriott, I., Dréau, D., D'Avanzo, C., Kim, D. Y., Tanzi, R. E., & Cho, H. A 3D Human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease, Nature Neuroscience, June 27, 2018, Read More

Moreno, C. L., Della Guardia, L., Shnyder, V., Ortiz-Virumbrales, M., Kruglikov, I., Zhang, B., Schadt, E. E., Tanzi, R. E., Noggle, S., Buettner, C., & Gandy, S. iPSC-derived familial Alzheimer’s PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling, Molecular Neurodegeneration, June 26, 2018, Read More

Sohn, D., Shpanskaya, K., Lucas, J. E., Petrella, J. R., Saykin, A. J., Tanzi, R. E., Samatova, N. F., & Doraiswamy, P. M. Sex Differences in cognitive decline in subjects with high likelihood of mild cognitive impairments due to Alzheimer’s disease, Scientific Reports, May 10, 2018, Read More

Jorfi, M., D'Avanzo, C., Tanzi, R. E., Kim, D. Y., & Irimia, D. Human Neurospheroid Arrays for in vitro studies of Alzheimer’s disease, Scientific Reports, February 5, 2018, Read More

Zhang, C., Griciuc, A., Hudry, E., Wan, Y., Quinti, L., Ward, J., Forte, A. M., Shen, X., Ran, C., Elmaleh, D. R., & Tanzi, R. E. Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid Beta Protein by Promoting microglial Phagocytosis, Scientific Reports, January 18, 2018, Read More

Ortiz-Virumbrales, M., Moreno, C. L., Kruglikov, I., Marazuela, P., Sproul, A., Jacob, S., Zimmer, M., Paull, D., Zhang, B., Schadt, E. E., Ehrlich, M. E., Tanzi, R. E., Arancio, O., Noggle, S., & Gandy, S. CRISPR/Cas9- Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN (N141l) neurons, Acta Neuropathologica Communications, October 27, 2017, Read More

Minter, M. R., Hinterleitner, R., Meisel, M., Zhang, C., Leone, V., Zhang, X., Oyler-Castrillo, P., Zhang, X., Musch, M. W., Shen, X., Jabri, B., Chang, E. B., Tanzi, R. E., & Sisodia, S. S. Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease, Scientific Reports, September 5, 2017, Read More

Raven, F., Ward, J. F., Zoltowska, K. M., Wan, Y., Bylykbashi, E., Miller, S. J., Shen, X., Choi, S. H., Rynearson, K. D., Berezovska, O., Wagner, S. L., Tanzi, R. E., & Zhang, C. Soluble Gamma-secretase Modulators Attenuate Alzheimer’s beta amyloid pathology and induce conformational changes in presenili 1, eBioMedicine, September 4, 2017, Read More

Padmanabhan, K., Nudelman, K., Harenberg, S., Bello, G., Sohn, D., Shpanskaya, K., Tiwari Dikshit, P., Yerramsetty, P.S., Tanzi, R.E., Saykin, A.J., Petrella, J.R., Doraiswamy, P. M., Samatova, N. & Alzheimer's Disease Neuroimaging Initiative. Characterizing Gene and Protein Crosstalks in Subjects at risk of developing Alzheimer’s disease: a new computational approach, Processes, September 1, 2017, Read More

Gamberger, D., Lavrač, N., Srivatsa, S., Tanzi, R. E., & Doraiswamy, P. M. Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease, Scientific Reports, July 28, 2017, Read More

Liang, F., Wan, Y., Schaak, D., Ward, J., Shen, X., Tanzi, R. E., Zhang, C., & Quan, Q. Nanoplasmic fiber tip probe detects significant reduction of intracellular Alzheimer’s disease related oligomers by curcumin, Scientific Reports, July 18, 2017, Read More

Wagner, S. L., Rynearson, K. D., Duddy, S. K., Zhang, C., Nguyen, P. D., Becker, A., Vo, U., Masliah, D., Monte, L., Klee, J. B., Echmalian, C. M., Xia, W., Quinti, L., Johnson, G., Lin, J. H., Kim, D. Y., Mobley, W. C., Rissman, R. A., & Tanzi, R. E. Pharmacological and Toxicological Properties of the Potent Oral gamma-secretase modulator BPN-15606, Journal of Pharmacology and Experimental Therapeutics, July 1, 2017, Read More

Loehlein Fier, H., Prokopenko, D., Hecker, J., Cho, M. H., Silverman, E. K., Weiss, S. T., Tanzi, R. E., & Lange, C. On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows, Genetic Epidemiology, April 20, 2017, Read More

Li, A., Hooli, B., Mullin, K., Tate, R. E., Bubnys, A., Kirchner, R., Chapman, B., Hofmann, O., Hide, W., & Tanzi, R. E. Silencing of the Drosophila ortholog of SOX5 leads to abnormal neuronal development and behavioral impairment, Human Molecular Genetics, February 10, 2017, Read More

Ward, J., Wang, H., Saunders, A. J., Tanzi, R. E., & Zhang, C. Mechanisms that synergistically regulate η-secretase processing of APP and Aη-α protein levels: relevance to pathogenesis and treatment of Alzheimer’s disease., Discovery Medicine, February 1, 2017, Read More

Men, J., Jerwick, J., Wu, P., Chen, M., Alex, A., Ma, Y., Tanzi, R. E., Li, A., & Zhou, C. Drosophila preparation and longitudinal imaging of heart function in vivo using optical coherence microsopy (OCM), Journal of Visualized Experiments, December 12, 2016, Read More

Choi, S. H., Kim, Y. H., Quinti, L., Tanzi, R. E., & Kim, D. Y. 3D Culture Models of Alzheimer’s disease: a road map to a “cure-in-a-dish”, Molecular Neurodegeneration, December 9, 2016, Read More

Bhattacharyya, R., Fenn, R. H., Barren, C., Tanzi, R. E., & Kovacs, D. M. Palmitoylated APP forms Dimers, Cleaved BACE1, PLoS One, November 22, 2016, Read More

Song, W., Hooli, B., Mullin, K., Jin, S. C., Cella, M., Ulland, T. K., Wang, Y., Tanzi, R. E., & Colonna, M. Alzheimer’s Disease-associated TREM2 variants exhibit either a decreased or increased lignad-dependent activation, Alzheimer's & Dementia, August 9, 2016, Read More

Minter, M. R., Zhang, C., Leone, V., Ringus, D. L., Zhang, X., Oyler-Castrillo, P., Musch, M. W., Liao, F., Ward, J. F., Holtzman, D. M., Chang, E. B., Tanzi, R. E., & Sisodia, S. S. Antibiotic-induced perturbation in gut microbial diversity influences neuro-inflammation and amylodiosis in a murine model of Alzheimer’s disease, Scientific Reports, July 16, 2016, Read More

Kumar, D. K., Choi, S. H., Washicosky, K. J., Eimer, W. A., Tucker, S., Ghofrani, J., Lefkowitz, A., McColl, G., Goldstein, L. E., Tanzi, R. E., & Moir, R. D. Amyloid-beta peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease, Science Translational Medicine, May 25, 2016, Read More

Alfonso, S. I., Callender, J. A., Hooli, B., Antal, C. E., Mullin, K., Sherman, M. A., Lesné, S. E., Leitges, M., Newton, A. C., Tanzi, R. E., & Malinow, R. Gain of Function mutations in protein kinase c alpha (PKC alpha) may promote synaptic defects in Alzheimer’s disease, Science Signaling, May 10, 2016, Read More

Bettayeb, K., Hooli, B. V., Parrado, A. R., Randolph, L., Varotsis, D., Aryal, S., Gresack, J., Tanzi, R. E., Greengard, P., & Flajolet, M. Relevance of the COPI complex for Alzheimer’s disease progression in vivo, Proceedings of the National Academy of Sciences of the United States of America, April 25, 2016, Read More

Alex, A., Li, A., Tanzi, R. E., & Zhou, C. Optogenetic pacing in Drosophila melanogaster, Science Advances, October 9, 2015, Read More

D'Avanzo, C., Aronson, J., Kim, Y. H., Choi, S. H., Tanzi, R. E., & Kim, D. Y. Alzheimer’s in 3D culture: Challenges and Perspectives, BioEssays, October 1, 2015, Read More

Hyman, B. T., Growdon, J. H., Albers, M. W., Buckner, R. L., Chhatwal, J., Gomez-Isla, M. T., Haass, C., Hudry, E., Jack, C. R., Jr, Johnson, K. A., Khachaturian, Z. S., Kim, D. Y., Martin, J. B., Nitsch, R. M., Rosen, B. R., Selkoe, D. J., Sperling, R. A., St George-Hyslop, P., Tanzi, R. E., Yap, L., Young, A. B., Phelps, C. H., & McCaffrey, P.M. Massachusetts Alzheimer’s Disease Research Center: Progress and Challenges, Alzheimer's & Dementia, October 1, 2015, Read More

Alex, A., Li, A., Zeng, X., Tate, R. E., McKee, M. L., Capen, D. E., Zhang, Z., Tanzi, R. E., & Zhou, C. A circadian clock gene, cry, affects heart morphogenesis and function in Drosophila as revealed by optical coherence microscopy, PLoS One, September 8, 2015, Read More

Park, S., Lee, S., Lee, Y., Herold, C., Hooli, B., Mullin, K., Park, T., Park, C., Bertram, L., Lange, C., Tanzi, R., & Won, S. Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families, BMC Medical Genetics, August 19, 2015, Read More

Kim, Y. H., Choi, S. H., D'Avanzo, C., Hebisch, M., Sliwinski, C., Bylykbashi, E., Washicosky, K. J., Klee, J. B., Brüstle, O., Tanzi, R. E., & Kim, D. Y. A 3D human neural cell culture system for modeling Alzheimer’s disease, Nature Protocols, July 1, 2015, Read More

D'Avanzo, C., Sliwinski, C., Wagner, S. L., Tanzi, R. E., Kim, D. Y., & Kovacs, D. M. Gamma-Secretase modulators reduce endogenous amyloid beta (42) levels in human neural progenitor cells without altering neuronal differentiation, The FASEB Journal, April 22, 2015, Read More

Weissmiller, A. M., Natera-Naranjo, O., Reyna, S. M., Pearn, M. L., Zhao, X., Nguyen, P., Cheng, S., Goldstein, L. S., Tanzi, R. E., Wagner, S. L., Mobley, W. C., & Wu, C. A gamma secretase inhibitor, but not a gamma-secretase modulator, induced defects in BDNF Axonal trafficking and signaling: evidence for a role for APP, PLoS One, February 24, 2015, Read More

Choi, S. H., Kim, Y. H., Hebisch, M., Sliwinski, C., Lee, S., D'Avanzo, C., Chen, H., Hooli, B., Asselin, C., Muffat, J., Klee, J. B., Zhang, C., Wainger, B. J., Peitz, M., Kovacs, D. M., Woolf, C. J., Wagner, S. L., Tanzi, R. E., & Kim, D. Y. A three-dimensional human neural cell culture model of Alzheimer’s disease, Nature, October 12, 2014, Read More

Hooli, B. V., Parrado, A. R., Mullin, K., Yip, W. K., Liu, T., Roehr, J. T., Qiao, D., Jessen, F., Peters, O., Becker, T., Ramirez, A., Lange, C., Bertram, L., & Tanzi, R. E. The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk, Neurology, October 7, 2014, Read More

Veeraraghavalu, K., Zhang, C., Zhang, X., Tanzi, R. E., & Sisodia, S. S. Age-dependent, non-cell autonomous deposition of amyloid from synthesis of beta-amyloid by cells other than excitatory neurons, Journal of Neuroscience, March 5, 2014, Read More

Wagner, S. L., Zhang, C., Cheng, S., Nguyen, P., Zhang, X., Rynearson, K. D., Wang, R., Li, Y., Sisodia, S. S., Mobley, W. C., & Tanzi, R. E. Soluble gamma-secretase modulators slectively inhibit the production of the 42 amino-acid amyloid beta peptide variant and augment the production of multiple carboxy-truncated amyloid beta species, Biochemistry, January 22, 2014, Read More

Xu, Z., Dong, Y., Wang, H., Culley, D. J., Marcantonio, E. R., Crosby, G., Tanzi, R. E., Zhang, Y., & Xie, Z. Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice, Scientific Reports, January 20, 2014, Read More

Suh, J., Choi, S. H., Romano, D. M., Gannon, M. A., Lesinski, A. N., Kim, D. Y., & Tanzi, R. E. ADAM10 Missense Mutations Potentiate beta-amyloid accumulation by impairing pro-domain chaperone function, Neuron, September 19, 2013, Read More

Xie, Z., McAuliffe, S., Swain, C. A., Ward, S. A., Crosby, C. A., Zheng, H., Sherman, J., Dong, Y., Zhang, Y., Sunder, N., Burke, D., Washicosky, K. J., Tanzi, R. E., & Marcantonio, E. R. Cerebrospinal fluid Abeta to Tau ratio and postoperative cognitive change, Annals of Surgery, August 1, 2013, Read More

Hooli, B. V., Kovacs-Vajna, Z. M., Mullin, K., Blumenthal, M. A., Mattheisen, M., Zhang, C., Lange, C., Mohapatra, G., Bertram, L., & Tanzi, R. E. Rare autosomal copy number variations in early-onset familial Alzheimer’s disease, Molecular Psychiatry, June 11, 2013, Read More

Griciuc, A., Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. H., Hyman, B. T., & Tanzi, R. E. Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta, Neuron, May 22, 2013, Read More

Li, A., Ahsen, O. O., Liu, J. J., Du, C., McKee, M. L., Yang, Y., Wasco, W., Newton-Cheh, C. H., O'Donnell, C. J., Fujimoto, J. G., Zhou, C., & Tanzi, R. E. Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography, Human Molecular Genetics, May 21, 2013, Read More

Viswanathan, J., Haapasalo, A., Kurkinen, K. M., Natunen, T., Mäkinen, P., Bertram, L., Soininen, H., Tanzi, R. E., & Hiltunen, M. Ubiquilin-1 modulates gamma-secretase-mediated epsilon-site cleavage in neuronal cells, Biochemsitry, May 10, 2013, Read More

Goldstein, L. E., Fisher, A. M., Tagge, C. A., Zhang, X. L., Velisek, L., Sullivan, J. A., Upreti, C., Kracht, J. M., Ericsson, M., Wojnarowicz, M. W., Goletiani, C. J., Maglakelidze, G. M., Casey, N., Moncaster, J. A., Minaeva, O., Moir, R. D., … Tanzi, R. E., ... McKee, A. C. Chronic Traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model, Science Translational Medicine, May 16, 2012, Read More

Hooli, B. V., Mohapatra, G., Mattheisen, M., Parrado, A. R., Roehr, J. T., Shen, Y., Gusella, J. F., Moir, R., Saunders, A. J., Lange, C., Tanzi, R. E., & Bertram, L. Role of common and rare APP DNA sequence variants in Alzheimer’s Disease, Neurology, April 17, 2012, Read More

Craddock, T. J., Tuszynski, J. A., Chopra, D., Casey, N., Goldstein, L. E., Hameroff, S. R., & Tanzi, R. E. The Zinc Dyshomeostasis Hypothesis of Alzheimer’s Disease, PLoS One, March 23, 2012, Read More

Lill, C. M., Roehr, J. T., McQueen, M. B., Kavvoura, F. K., Bagade, S., Schjeide, B. M., Schjeide, L. M., Meissner, E., … Tanzi, R. E., ... Bertram, L. Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson’s Disease Genetics: the PDGene database, PLoS Genetics, March 15, 2012, Read More

Zhang, Y., Xu, Z., Wang, H., Dong, Y., Shi, H. N., Culley, D. J., Crosby, G., Marcantonio, E. R., Tanzi, R. E., & Xie, Z. Anesthetics isoflurane and desflurane directly affect mitochondrial function, learning, and memory, Annals of Neurology, February 24, 2012, Read More

Won, S., Lu, Q., Bertram, L., Tanzi, R. E., & Lange, C. On the Meta-Analysis of Genome-Wide Association studies: a robust and efficient approach to combine population and family-based studies, Human Heredity, January 18, 2012, Read More

Treusch, S., Hamamichi, S., Goodman, J. L., Matlack, K. E., Chung, C. Y., Baru, V., Shulman, J. M., Parrado, A., Bevis, B. J., Valastyan, J. S., Han, H., Lindhagen-Persson, M., Reiman, E. M., Evans, D. A., Bennett, D. A., Olofsson, A., DeJager, P. L., Tanzi, R. E., Caldwell, K. A., Caldwell, G. A., … Lindquist, S. Functional Links between A beta toxicity, Endocytic trafficking, and Alzheimer’s disease risk factors in yeast, Science, December 2, 2011, Read More

Li, A., Zhou, C., Moore, J., Zhang, P., Tsai, T. H., Lee, H. C., Romano, D. M., McKee, M. L., Schoenfeld, D. A., Serra, M. J., Raygor, K., Cantiello, H. F., Fujimoto, J. G., & Tanzi, R. E. Changes in the expression of the Alzheimer’s disease-associated presenilin gene in Drosophila heart leads to cardiac dysfunction, Current Alzheimer Research, May 1, 2011, Read More

Sarajärvi, T., Tuusa, J. T., Haapasalo, A., Lackman, J. J., Sormunen, R., Helisalmi, S., Roehr, J. T., Parrado, A. R., Mäkinen, P., Bertram, L., Soininen, H., Tanzi, R. E., Petäjä-Repo, U. E., & Hiltunen, M. Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking, Molecular and Cellular Biology, April 4, 2011, Read More

Schjeide, B. M., Schnack, C., Lambert, J. C., Lill, C. M., Kirchheiner, J., Tumani, H., Otto, M., Tanzi, R. E., Lehrach, H., Amouyel, P., von Arnim, C. A., & Bertram, L. The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzhiemer Disease risk and cerebrospinal fluid biomarker levels, Archives of General Psychiatry, February 1, 2011, Read More

Viswanathan, J., Haapasalo, A., Böttcher, C., Miettinen, R., Kurkinen, K. M., Lu, A., Thomas, A., Maynard, C. J., Romano, D., Hyman, B. T., Berezovska, O., Bertram, L., Soininen, H., Dantuma, N. P., Tanzi, R. E., & Hiltunen, M. Alzheimer’s disease-associated Ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation, Traffic, January 7, 2011, Read More

Wu, X., Lu, Y., Dong, Y., Zhang, G., Zhang, Y., Xu, Z., Culley, D. J., Crosby, G., Marcantonio, E. R., Tanzi, R. E., & Xie, Z. The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-alpha, IL-6, and IL-1 beta, Neurobiology of Aging, December 28, 2010, Read More

Bertram, L., Lill, C. M., & Tanzi, R. E. The Genetics of Alzheimer’s disease: back to the future, Neuron, October 21, 2010, Read More

Zhang, C., Browne, A., Divito, J. R., Stevenson, J. A., Romano, D., Dong, Y., Xie, Z., & Tanzi, R. E. Amyloid-beta Production Via Cleavage of Amyloid-beta Protein Precursor is Modulated by Cell Density, Journal of Alzheimer's Disease, October 1, 2010, Read More

Lane, R. F., Raines, S. M., Steele, J. W., Ehrlich, M. E., Lah, J. A., Small, S. A., Tanzi, R. E., Attie, A. D., & Gandy, S. Diabetes-associated SorCS1 regulates Alzheimer’s amyloid-beta metabolism: evidence for involvement of SorL1 and the Retromer Complex, Journal of Neuroscience, September 29, 2010, Read More

Zhang, C., Browne, A., Child, D., & Tanzi, R. E. Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein, Journal of Biological Chemistry, September 10, 2010, Read More

Moncaster, J. A., Pineda, R., Moir, R. D., Lu, S., Burton, M. A., Ghosh, J. G., Ericsson, M., Soscia, S. J., Mocofanescu, A., Folkerth, R. D., Robb, R. M., Kuszak, J. R., Clark, J. I., Tanzi, R. E., Hunter, D. G., & Goldstein, L. E. Alzheimer’s disease Amyloid-beta links lens and brain pathology in Down syndrome, PLoS One, May 20, 2010, Read More

Soscia, S. J., Kirby, J. E., Washicosky, K. J., Tucker, S. M., Ingelsson, M., Hyman, B., Burton, M. A., Goldstein, L. E., Duong, S., Tanzi, R. E., & Moir, R. D. The Alzheimer’s Disease-Associated Amyloid beta-Protein Is an Antimicrobial Peptide, PLoS One, March 3, 2010, Read More

Gianni, D., Li, A., Tesco, G., McKay, K. M., Moore, J., Raygor, K., Rota, M., Gwathmey, J. K., Dec, G. W., Aretz, T., Leri, A., Semigran, M. J., Anversa, P., Macgillivray, T. E., Tanzi, R. E., & del Monte, F. Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy, Circulation, March 1, 2010, Read More

Zhang, C., Browne, A., Kim, D. Y., & Tanzi, R. E. Familial Alzhiemer’s Disease mutations in presenilin 1 do not alter levels of the secreted amyloid-protein precursor generated by beta-secretase cleavage, Current Alzheimer Research, February 1, 2010, Read More

Zhang, C., Browne, A., Child, D., Divito, J. R., Stevenson, J. A., & Tanzi, R. E. Loss of Function of ATXN1 Increases Amyloid beta-Protein Levels by Potentiating beta-Secretase Processing of beta-Amyloid Precursor Protein, Journal of Biological Chemistry, January 22, 2010, Read More

Giedraitis, V., Glaser, A., Sarajärvi, T., Brundin, R., Gunnarsson, M. D., Schjeide, B. M., Tanzi, R. E., Helisalmi, S., Pirttilä, T., Kilander, L., Lannfelt, L., Soininen, H., Bertram, L., Ingelsson, M., & Hiltunen, M. CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid, Neuroscience Letters, January 22, 2010, Read More

Kim, M., Suh, J., Romano, D., Truong, M. H., Mullin, K., Hooli, B., Norton, D., Tesco, G., Elliott, K., Wagner, S. L., Moir, R. D., Becker, K. D., & Tanzi, R. E. Potential late-onset Alzheimer’s disease-associated mutations in the ADAM10 gene attenuate alpha-secretase activity, Human Molecular Genetics, October 15, 2009, Read More

Bertram, L., & Tanzi, R. E. Genome-wide association studies in Alzheimer’s Disease, Human Molecular Genetics, October 15, 2009, Read More

Schjeide, B. M., Hooli, B., Parkinson, M., Hogan, M. F., DiVito, J., Mullin, K., Blacker, D., Tanzi, R. E., & Bertram, L. GAB2 as an Alzheimer Disease Susceptibility Gene, Archives of Neurology, February 1, 2009, Read More

Schjeide, B. M., McQueen, M. B., Mullin, K., DiVito, J., Hogan, M. F., Parkinson, M., Hooli, B., Lange, C., Blacker, D., Tanzi, R. E., & Bertram, L. Assessment of Alzheimer’s disease case-control associations using family-based methods, Neurogenetics, February 1, 2009, Read More

Xie, Z., Culley, D. J., Dong, Y., Zhang, G., Zhang, B., Moir, R. D., Frosch, M. P., Crosby, G., & Tanzi, R. E. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta protein level in vivo, Annals of Neurology, November 11, 2008, Read More

Bertram, L., Lange, C., Mullin, K., Parkinson, M., Hsiao, M., Hogan, M. F., Schjeide, B. M., Hooli, B., Divito, J., Ionita, I., Jiang, H., Laird, N., Moscarillo, T., Ohlsen, K. L., Elliott, K., Wang, X., Hu-Lince, D., Ryder, M., Murphy, A., Wagner, S. L., Blacker, D., … Tanzi, R. E. Genome-wide Association Analysis Reveals Putative Alzheimer’s Disease Susceptibility Loci in Addition to APOE, American Journal of Human Genetics, October 30, 2008, Read More

Lee, I. H., Culley, D. J., Baxter, M. G., Xie, Z., Tanzi, R. E., & Crosby, G. Spatial memory is intact in aged rats after propofol anesthesia, ​​Anesthesia & Analgesia, October 1, 2008, Read More

Schaffer, B. A., Bertram, L., Miller, B. L., Mullin, K., Weintraub, S., Johnson, N., Bigio, E. H., Mesulam, M., Wiedau-Pazos, M., Jackson, G. R., Cummings, J. L., Cantor, R. M., Levey, A. I., Tanzi, R. E., & Geschwind, D. H. Association of GSK3b with Alzheimer disease and frontotemporal dementia, Archives of Neurology, October 1, 2008, Read More

Bertram, L., & Tanzi, R. E. Thirty years of Alzheimer’s disease genetics: the implications of systematic meta-analyses, Nature Reviews Neuroscience, October 1, 2008, Read More

Kavvoura, F. K., McQueen, M. B., Khoury, M. J., Tanzi, R. E., Bertram, L., & Ioannidis, J. P. Evaluation of the Potential Excess of Statistically Significant Findings in Published Genetic Association Studies: Application to Alzheimer’s Disease, American Journal of Epidemiology, September 9, 2008, Read More