Rudolph Tanzi, Ph.D.

Vice Chair of Neurology; Director, Genetics and Aging Research Unit; Co-Director, Henry and Allison McCance Center for Brain Health; Co-Director, MassGeneral Institute for Neurodegenerative Disease (MIND); Joseph P. and Rose F. Kennedy Professor of Neurology, Harvard Medical School

Early in his career, Dr. Tanzi worked with Dr. James Gusella to discover the first human genetic markers and use them to find a disease gene (Huntington’s disease). He went on to first discover the amyloid precursor protein (APP) gene, the first Alzheimer’s disease (AD) gene, and he co-discovered the two other early-onset familial AD genes, known as the presenilins (PSEN1 and PSEN2). As leader of the Cure Alzheimer’s Fund Alzheimer’s Genome ProjectÔ, Dr. Tanzi identified several other AD genes, including ADAM10, ATXN1 and CD33, the first AD gene directly modulating neuroinflammation. He also discovered the Wilson’s disease gene and contributed to the discovery of several other neurological disease genes.

Dr. Tanzi and his team were the first to use human stem cells to create a human brain organoid model of AD, dubbed “Alzheimer’s in a Dish,” a three-dimensional human stem cell-derived neural culture system, which was the first to recapitulate the key AD pathological hallmarks. This system also was used to definitively show for the first time that amyloid plaques cause neurofibrillary tangles. This model has made drug screening for AD much faster and more effective. Using this system, Dr. Tanzi has developed several novel therapies for AD, including gamma secretase modulators aimed at plaque pathology, and other drugs, including repurposing of cromolyn for targeting neuroinflammation. Dr. Tanzi and his team also discovered that amyloid beta, the main component of senile plaques, plays a key role in the innate immune system of the brain operating as an antimicrobial peptide, suggesting a possible role for infection in driving AD pathology.

Dr. Tanzi serves as Chair of the Cure Alzheimer’s Fund Research Leadership Group and numerous advisory and editorial boards. He has published well more than 550 research papers and has received the highest awards in his field, including the Metropolitan Life Foundation Award, Potamkin Prize, Ronald Reagan Award, Silver Innovator Award and the Smithsonian American Ingenuity Award, the top national award for invention and innovation. He serves on dozens of editorial boards and scientific advisory boards and was named to TIME magazine’s list of TIME 100 Most Influential People in the World for 2015. He co-authored the books Decoding Darkness, and three international bestsellers, Super Brain, Super Genes and The Healing Self.


Related Research:

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Microbiome Consortium: Microbial Profiling of Human Brain and Gut Microbiomes in Alzheimer’s Disease 2023


Role of CD8+ T-Cell-Glial Interactions in Mediating Alzheimer’s Disease Pathogenesis 2023


Development of a Multicellular Brain Model to Study Brain-Vascular-Peripheral Immune Cells Crosstalk in Alzheimer’s Disease 2021, 2022


Effects of Depalmitoylation and ACAT Inhibition on Axonal Amyloid Beta Generation Via MAM-Associated palAPP 2021, 2022


Characterizing Gut Microbiome Synergy With Emphasis on Mycobiome and Its Impact on Alzheimer’s Disease (AD) Pathology in AD Mouse Models 2020, 2021


Microbes and Alzheimer’s Disease: Metagenomics on Saliva, Cerebrospinal Fluid, Blood and Brain 2020


Tau and Amyloid Beta are Innate Immune Antimicrobial Peptides in the Brain 2019


Alzheimer’s Genome Project™ 2005-2023


Two Genes Appear to Act as On/Off Switches for Neuroinflammation and Alzheimer’s Disease 2019
Single-Cell Analysis of 3D Human Triculture Model of Alzheimer’s Disease: The Impact of AD-Associated Genetic Variants 2018-2019


Compounds Modulating Microglial Uptake of Amyloid Beta and CD33-Targeted Immunotherapy for Alzheimer’s Disease 2017


The Role of Neurexins in Alzheimer’s Disease (Year 2) 2018


Search for Female-Specific Genetic Factors Contributing to Risk for Alzheimer’s Disease 2016


Role of Neurexins in Alzheimer’s Disease Pathophysiology 2016


Microglial Core/CD33 and Alzheimer’s Disease: From Biology to Therapy 2015


Lead Optimization and Lead Evolution of Potent SGSMs for the Treatment of Alzheimer’s Disease 2015


Potential for Host Cytotoxicity from Microbially-derived Abeta Oligomers 2009


Whole Genome Sequencing 2012-2014


Oligomer Collaborative Projects 2006


Novel Soluable Gamma-Secretase Modulators 2010


Curcumin Collaborative Project 2010


Identification of Agents that Inhibit the Generation and Neurotoxicity of Cross-linked B-amyloid Protein Species 2006, 2007


Investigation of Certain Properties of Mitochondria Membranes Related to AD 2008


The Amylin Protein of Diabetes Mellitus is an Antimicrobial Peptide 2010, 2012, 2013


Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Rudy Tanzi, Se Hoon Choi Exercise and Improved Cognition, Science , September 6, 2018, Read More

Joseph Park, Isaac Wetzel, Ian Marriott, Didier Dréau, Carla D’Avanzo, Doo Yeon Kim, Rudolph E. Tanzi & Hansang Cho A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease, Nature Neuroscience , June 27, 2018, Read More

William A. Eimer,1,2 Deepak Kumar Vijaya Kumar,1,2 Nanda Kumar Navalpur Shanmugam,Alex S. Rodriguez, Teryn Mitchell, Kevin J. Washicosky, Bence Gyorgy, Xandra O. Breakefield, Rudolph E. Tanzi, and Robert D. Moir Alzheimer’s Disease-Associated b-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection, Neuron (Cell), July 11, 2018, Read More

Maitane Ortiz-Virumbrales, Cesar L. Moreno, Ilya Kruglikov, Paula Marazuela, Andrew Sproul, Samson Jacob, Matthew Zimmer, Daniel Paull, Bin Zhang, Eric E. Schadt, Michelle E. Ehrlich, Rudolph E. Tanzi, Ottavio Arancio, Scott Noggle, Sam Gandy CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2(N141I) neurons, Acta Neuropathologica Communications, 5, 27 Oct 2017, 77, Read More

Myles R. Minter, Reinhard Hinterleitner, Marlies Meisel, Can Zhang, Vanessa Leone, Xiaoqiong Zhang, Paul Oyler-Castrillo, Xulun Zhang, Mark W. Musch, Xunuo Shen, Bana Jabri, Eugene B. Change, Rudolph E. Tanzi, Sangram Sisodia Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APP(SWE)/PS1(Delta E9) murine model of Alzheimer’s disease, Scientific Reports, 7, 5 Sep 2017, Read More

Kanchana Padmanabhan, Kelly Nudelman, Steve Harenberg, Gonzalo Bello, Dongwha Sohn, Katie Shpanskaya, Priyanka Tiwari Dikshit, Pallavi S. Yerramsetty, Rudolph E. Tanzi, Andrew J. Saykin, Jeffrey R. Petrella, P. Murali Doraiswamy, Nagiza F. Samatova, Alzheimer’s Disease Neuroimaging Initiative Characterizing Gene and Protein Crosstalks in Subjects at Risk of Developing Alzheimer’s Disease: A New Computational Approach, Processes, 5(3), Sep 2017, 47, Read More

Dragan Gamberger, Nada Lavrač, Shantanu Srivatsa, Rudolph E. Tanzi, P. Murali Doraiswamy Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease, Scientific Reports, 7, 28 Jul 2017, Read More

Feng Liang, Yu Wan, Diane Schaak, Joseph Ward, Xunuo Shen, Rudolph E. Tanzi, Can Zhang, Qimin Quan Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer’s diseaserelated oligomers by curcumin, Scientific Reports, 7, 18 Jul 2017, Read More

Steven L. Wagner, Kevin D. Rynearson, Steven K. Duddy, Can Zhang, Phuong D. Nguyen, Ann Becker, Uyen Vo, Deborah Masliah, Louise Monte, Justin B. Klee, Corinne M. Echmalian, Weiming Xia, Luisa Quinti, Graham Johnson, Jiunn H. Lin, Doo Y. Kim, William C. Mobley, Robert A. Rissman, Rudolph E. Tanzi Pharmacological and Toxicological Properties of the Potent Oral gamma-Secretase Modulator BPN-15606, Journal Of Pharmacology And Experimental Therapeutics, 362(1), Jul 2017, 31-44, Read More

Heide Loehlein Fier, Dmitry Prokopenko, Julian Hecker, Michael H. Cho, Edwin K. Silverman, Scott T. Weiss, Rudolph E. Tanzi, Christoph Lange On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows, Genetic Epidemiology, 41(4), 20 Mar 2017, 332–340, Read More

Deepak Kumar Vijaya Kumar , William A Eimer , Rudolph E Tanzi and Robert D Moir Alzheimer’s disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide, Neurodegenerative Disease Management, 6(5), 7 Sep 2016, 345–348, Read More

Wilbur Song, Basavaraj Hooli, Kristina Mullin, Sheng Chih Jin, Marina Cella, Tyler K. Ulland, Yaming Wang, Rudolph E. Tanzi, Marco Colonna Alzheimer’s disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation, Alzheimer's & Dementia, 13(4), Apr 2017, 381–387, Read More

C Herold, B V Hooli, K Mullin, T Liu, J T Roehr, M Mattheisen, A R Parrado, L Bertram, C Lange and R E Tanzi Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer’s disease with OSBPL6, PTPRG, and PDCL3, Molecular Psychiatry, February 2016, Read More

Carla D'Avanzo, Jenna Aronson, Young Hye Kim, Se Hoon Choi, Rudolph E. Tanzi and Doo Yeon Kim Alzheimer’s in 3D culture: Challenges and perspectives, BioEssays, 37(10), October 2015, 1139–1148, Read More

Young Hye Kim, Se Hoon Choi, Carla D'Avanzo, Matthias Hebisch, Christopher Sliwinski, Enjana Bylykbashi, Kevin J Washicosky, Justin B Klee, Oliver Brüstle, Rudolph E Tanzi & Doo Yeon Kim A 3D human neural cell culture system for modeling Alzheimer’s disease, Nature Protocols, 10(7), June 2015, 985–1006, Read More

Carla D’Avanzo, Christopher Sliwinski, Steven L. Wagner, Rudolph E. Tanzi, Doo Yeon Kim, and Dora M. Kovacs γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation, The FASEB Journal, 29(8), 22 April 2015, 3335-3341, Read More

Karthikeyan Veeraraghavalu, Can Zhang, Xiaoqiong Zhang, Rudolph E. Tanzi, and Sangram S. Sisodia Age-Dependent, Non-Cell-Autonomous Deposition of Amyloid from Synthesis of β-Amyloid by Cells Other Than Excitatory Neurons, J Neurosci, 34(10), 5 March 2014, 3668-3673, Read More

Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice, Sci Rep, 4, January 20, 2014, 3766, Read More

Jaehong Suh, Se Hoon Choi, Donna M. Romano, Moira A. Gannon, Andrea N. Lesinski, Doo Yeon Kim, Rudolph E. Tanzi ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function, Neuron, 80(2), Oct 16, 2013, 385–401, Read More

Li A, Ahsen OO, Liu JJ, Du C, McKee ML, Yang Y, Wasco W, Newton-Cheh CH, O'Donnell CJ, Fujimoto JG, Zhou C, Tanzi RE Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography, Hum Mol Genet, 22(18), September 15, 2013, 3798-3806, Read More

Rudolph E Tanzi Decoding Alzheimer’s in the age of genome-wide analyses, Mol Neurodegener, 8(suppl 1), September 13. 2013, 01, Read More

Zhongcong Xie, MD, PhD, Sayre McAuliffe, Celeste A. Swain, Sarah A. P. Ward, Catherine A. Crosby, Hui Zheng, Janet Sherman, Yuanlin Dong, Yiying Zhang, Neelakantan Sunder, Dennis Burke, Kevin Washicosky, Rudolph E. Tanzi, and Edward R. Marcantonio Cerebrospinal Fluid Aβ to Tau Ratio and Postoperative Cognitive Change, Annals of Surgery, Ann Surg 2013;00, 5/10/2013, 1-6, Read More, Download Paper

BV Hooli1, ZM Kovacs-Vajna2, K Mullin1, MA Blumenthal1, M Mattheisen3, C Zhang1, C Lange4, G Mohapatra5, L Bertram6 and RE Tanzi1 Rare autosomal copy number variations in early-onset familial Alzheimer’s disease, Molecular Psychology, 6/11/2013, Read More, Download Paper

Wagner SL, Tanzi RE, Mobley WC, Galasko D Potential Use of γ-Secretase Modulators in the Treatment of Alzheimer Disease, Arch Neurol., July 16, 2012, Read More

Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, Xu Z, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β, Neurobiology of Aging, 33(7), July 2012, 1364-78, Read More

B.V. Hooli, PhD, G. Mohapatra, PhD, M. Mattheisen, MD, A.R. Parrado, PhD, J.T. Roehr, MS, Y. Shen, PhD, J.F. Gusella, PhD, R. Moir, PhD, A.J. Saunders, PhD, C. Lange, PhD, R.E. Tanzi, PhD and L. Bertram, MD Role of common and rare APP DNA sequence variants in Alzheimer disease, Neurology 78, 78/16, April 17, 2012, 1250-1257, Read More

Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing, Transl Neurodegener., 1:8, Mar 22, 2012, Read More

Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T, Hamza T, Hardy JA, Heutink P, Hill-Burns EM, Klein C, Latourelle JC, Maraganore DM, Martin ER, Martinez M, Myers RH, Nalls MA, Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Singleton AB, Stefansson K, Toda T, Tung JY, Vance J, Wood NW, Zabetian CP; 23andMe Genetic Epidemiology of Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium; Parkinson's Disease GWAS Consortium; Wellcome Trust Case Control Consortium 2), Young P, Tanzi RE, Khoury MJ, Zipp F, Lehrach H, Ioannidis JP, Bertram L Comprehensive research synopsis and systematic meta-analyses in Parkinson’s disease genetics: The PDGene database, PLoS Genet., 8(3), March 2012, e1002548, Read More

Yiying Zhang MD, MS1, Zhipeng Xu MD, PhD1, Hui Wang MD1,2, Yuanlin Dong MD, MS1, Hai Ning Shi PhD, DVM3, Deborah J. Culley MD4, Gregory Crosby MD4, Edward R. Marcantonio MD5, Rudolph E. Tanzi PhD.6, Zhongcong Xie MD, PhD1,* Anesthetics Isoflurane and Desflurane Differently Affect Mitochondrial Function, Learning, and Memory, Annals of Neurology, Volume 71, Issue 5, February 24, 2012, 687–698, Read More

Sungho Wona, Qing Luc, Lars Bertram, Rudolph E. Tanzi, Christoph Lange On the Meta-Analysis of Genome-Wide Association Studies: A Robust and Efficient Approach to Combine Population and Family-Based Studies, Human Heredity, 73, January 18, 2012, 35-46, Read More

Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M Cysteine 27 Variant of the δ-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking, Mol Cell Biol., 31(11), June 2011, 2326–2340, Read More

A. Li, C. Zhou, J. Moore, P. Zhang, T.-H. Tsai, H.-C. Lee, D.M. Romano, M.L. McKee, D.A. Schoenfeld, M.J. Serra,3 K. Raygor, H.F. Cantiello, J.G. Fujimoto, and R.E. Tanzi Changes in the Expression of the Alzheimer’s Disease- Associated Presenilin Gene in Drosophila Heart Leads to Cardiac Dysfunction, NIHPA Author Manuscripts, 8/3, May 1, 2011, 313-322, Read More

Viswanathan J, Haapasalo A, Bottcher C, Miettinen R, Kurkinen KMA, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Nertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M Alzheimer’s Disease-Associated Ubiquilin-1 Regulates Presenilin-1 Accumulation and Aggresome Formation, Traffic, 12(3), Mar 12, 2011, 330-48, Read More

Brit-Maren M. Schjeide, BS; Cathrin Schnack, PhD; Jean-Charles Lambert, PhD; Christina M. Lill, MD; Julia Kirchheiner, MD, PhD; Hayrettin Tumani, MD; Markus Otto, MD; Rudolph E. Tanzi, PhD; Hans Lehrach, PhD; Philippe Amouyel, PhD; Christine A. F. von Arnim, MD; Lars Bertram, MD The Role of Clusterin, Complement Receptor 1, and Phosphatidylinositol Binding Clathrin Assembly Protein in Alzheimer Disease Risk and Cerebrospinal Fluid Biomarker Levels, Arch Gen Psychiatry, 68(2), February 7, 2011, 207-213, Read More

Mannix RC, Zhang J, Park J, Zhang X, Bilal K, Walker K, Tanzi RE, Tesco G, Whalen MJ Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice, Journal of Cerebral Blood Flow & Metabolism, 31, January 2011, 351–61, Read More

Bertram L, Lill CM, Tanzi RE The Genetics of Alzheimer Disease: Back to the Future, Neuron, 68(2), Oct 21, 2010, 270-81, Read More

Zhang C, Browne A, Child D, Tanzi RE Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein, The Journal of Biological Chemistry, 285(37), Sep 10, 2010, 28472-80, Read More

Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, Ericsson M, Soscia SJ, Mocofanescu A, Folkerth RD, Robb RM, Kuszak JR, Clark JI, Tanzi RE, Hunter DG, Goldstein LE Alzheimer’s Disease Amyloid-β Links Lens and Brain Pathology in Down Syndrome, PLoS ONE, 5(5), May 20, 2010, Read More

Zhang C, Browne A, Child D, DiVito JR, Stevenson JA, Tanzi RE Loss-of-Function of ATXN1 Increases Amyloid-Beta Levels by Potentiating Beta-Secretase Processing of APP, Journal of Biological Chemistry, 285(12), Mar 19, 2010, 8515-26, Read More

Gianni D, Li A, Tesco G, McKay KM, Moore J, Raygor K, Rota M, Gwathmey JK, Dec GW, Aretz T, Leri A, Semigran MJ, Anversa P, Macgillivray TE, Tanzi RE, delMonte F. Protein Aggregates and Novel Presenilin Gene Variants in Idiopathic Dilated Cardiomyopathy, Circulation: Journal of the American Heart Association, 121(10), Mar 16, 2010, 1216-26, Read More

Zhang C, Browne A, Kim DY, Tanzi RE Familial Alzheimer’s Disease Mutations in Presenilin 1 Do Not Alter Levels of the Secretase Amyloid-Beta Protein Precursor Generated by Beta-Secretase Cleavage, Current Alzheimer Research, 7(1), February 2010, 21-6, Read More

Giedraitis V, Glaser A, Sarajarvi T, Brundin R, Gunnarsson MD, Schjeide B-M, Tanzi RE, Helisalmi S, Pirttila T, Kilander L, Lannfelt L, Soininen H, Bertram L, Ingelsson M, Hiltunen M CALHM1 P86L polymorphism does not alter amyloid-β or tau in cerebrospinal fluid, Neuroscience Letters, Volume 469, Issue 2, Jan 22 2010, 265-267, Read More

Won S, Bertram L, Becker D, Tanzi RE, Lange C. Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family – Based Association Tests, Statistics in Biosciences, 1(2), Nov 2009, 125-143, Read More

Bertram, L, Tanzi RE Genome-wide association studies in Alzheimer’s disease, Human Molecular Genetics, Vol 18, Review Issue 2, Oct 15, 2009, Read More

Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliot K, Wagner SL, Moir RD, Becker KD, Tanzi RE. Potential late-onset Alzheimer’s disease-associated mutations in the ADAM10 gene attenuate alpha-secretase activity., Human Molecular Genetics, Vol 18, Oct 15, 2009, Read More

Hooli BV, Tanzi RE A current view of Alzheimer’s disease, F1000 Biology Rep., 1, July 8, 2009, 54, Read More

Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z The Common Inhalational Anesthetic Sevoflurane Induces Apoptosis and Increases β-Amyloid Protein Levels, Archives of Neurology, Vol. 66 No. 5, May 2009, Read More

Schjeide BM, McQueen MB, Mullin K, DiVito J, Hogan MF, Parkinson M, Hooli B, Lange C, Blacker D, Tanzi RE, and Bertram L. Assessment of Alzheimer’s disease case-control associations using family-based methods, Neurogenetics, DOI 10.1007/s10048-008-1051-3,, Feb 10, 2009, 568-580, Read More

Schjeide BM, Hooli B, Parkinson M, Hogan MF, DiVito J, Mullin K, Blacker D, Tanzi RE, Bertram L GAB2 as an Alzheimer Disease Susceptibility Gene, Follow up of Genomewide Association Results, Arch Neurol, 66, Feb 2009, 250 – 254, Read More

Bertram L, Schjeide BM, Hooli B, Mullin K, Hiltunen M, Soininen H, Ingelsson M, Lannfelt L, Blacker D, Tanzi RE. No association between CALHM1 and Alzheimer’s disease risk., Cell, 135(6), Dec 12 2008, 993-4, Read More

Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE.  The common inhalation anesthetic isoflurane induces caspase activation and increases Aβ level in vivo., Annals of Neurology, Volume 64, Dec 2008, Read More

Cotton RG, Auerbach AD, Axton M, Barash CI, Berkovic SF, Brookes AJ, Burn J, Cutting G, den Dunnen JT, Flicek P, Freimer N, Greenblatt MS, Howard HJ, Katz M, Macrae FA, Maglott D, Möslein G, Povey S, Ramesar RS, Richards CS, Seminara D, Smith TD, Sobrido MJ, Solbakk JH, Tanzi RE, Tavtigian SV, Taylor GR, Utsunomiya J, Watson M The Human Variome Project, Science., 322(5903), Nov 7 2008, 861-2, Read More

Bertram L, Lange CL, Mullin K, Parkinson M, Hsiao M, Hogan MF,  Schjeide BMM, Hooli B, DeVito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL, Blacker D, Becker KD, Tanzi RE. Genome-wide Association Analysis Reveals Putative Alzheimer’s Disease Susceptibility Loci in Addition to APOE, Am. J. Hum. Genet., 83, November 2008, 623-632, Read More

Schaffer B, Bertram L, Miller L, Mullin K, Weintraub S, Johnson N, Bigio E, Mesulam M, Wiedau-Pazos M, Jackson G, Cummings J, Cantor R, Levey A, Tanzi RE, and Geschwind D Association of GSK3B with Alzheimer’s Disease and Frontotemporal Dementia, Arch. Neurol., 65(10), October 2008, 1368-1374, Read More

Bertram L, Tanzi RE Thirty years of Alzheimer’s disease genetics: the implications of systematic meta-analyses, Nature Reviews Neurosci., October 2008, Read More

Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z The inhalation anesthetic desflurane induces caspase activation and increases amyloid-beta protein levels under hypoxic conditions., J Biol Chem., 2;283(18), May 2, 2008, 11866-75, Read More

Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z. Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine., J Neurosci, 28, April 23, 2008, 4551-60, Read More

Tesco G, Koh YH, Kang E, Cameron A, Das S, Sena-Esteves M, Hiltunen, Yang S-H, Zhong Z, Shen Y, Simpkins J, Tanzi RE. Depletion of GGA3 stabilizes BACE and enhances β-secretase activity, Neuron, 54(5), 06/07/2007, 721-37, Read More

Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE Decreased catalytic activity of the insulin degrading enzyme in chromosome 10-linked Alzheimer’s disease families., Journal of Biological Chemistry, 282(11), 03/16/2017, 7825-32, Read More

Xie Z, Dong Y, Maeda U, Moir R, Xia W, Culley DJ, Crosby G, Tanzi RE. The Inhalation Anaesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Aβ Accumulation., J. Neurosci., 27, 2/7/2007, 1247-1254, Read More

McQueen MB, Bertram L, Lange C, Becker KD, Albert MS, Tanzi RE, Blacker D. Exploring Candidate Gene Associations with Neuropsychological Performance., Am J Med Genet B Neuropsychiatr Genet, 144(8), 02/1/2007, 987-91, Read More