In 2018, the original Alzheimer’s in a Dish—first used to culture neural stem cells—was updated to include the inflammatory factors known to contribute to neuroinflammation in Alzheimer’s disease. Alzheimer’s in a Dish now includes amyloid plaques, tau neuronal tangles, inflammation, and microglia. This provides for a more complete replication of the pathology of Alzheimer’s disease in the laboratory.

Rudy Tanzi, Ph.D., Massachusetts General Hospital and Hansang Cho, Ph.D., University of North Carolina