The relationship between organismal aging and debilitating chronic diseases, including Alzheimer’s disease, is clearly linked. One potential culprit driving age-associated pathologies are senescent cells (SnCs), which are characterized by a permanent cell cycle arrest. These cells accumulate with advancing age and at sites of dysfunction in a number of age-related ...
December 27, 2018
Alzheimer’s disease is caused by the accumulation of toxic protein aggregates in the form of extracellular amyloid plaques and intracellular tangles composed of the tau protein. In the current genomic era, several genes have been discovered that are associated with Alzheimer’s disease risk. However, for most of these risk genes, ...
December 26, 2019
Selfless, loving, caring, and courageous. To the best of their ability, these four words encompass the kind of miraculous mother, grandmother and friend Nana is to everyone who crosses her path. Nana is a loving mother of three. The youngest being Mom. Her older two children suffered from cystic fibrosis and ...
September 29, 2017
2021 Alzheimer’s disease (AD) affects 5.5 million Americans and leads to progressive memory loss. Currently, there are few treatments to help prevent or slow this disease. Recently, the gut microbiota has emerged as a potential therapeutic target for AD, but little is known about which bacteria may be involved or how ...
January 9, 2020
The beta-amyloid hypothesis has dominated Alzheimer’s disease research for nearly 35 years. It proposes that plaques, comprised of the protein beta-amyloid, destroy synapses and stimulate the development of neurofibrillary tangles of the tau protein, which kills neurons in patients with the disease. Resultantly, neuroinflammation is triggered, which destroys more neurons ...
February 5, 2020
Sharon Sevransky joined Cure Alzheimer’s Fund in 2017. She brings years of experience in software analysis and testing in the financial industry and in web analytics for a consulting firm. Most recently, Sharon worked for Cradles to Crayons, an organization that provides everyday essentials for low-income and homeless children. Her ...
February 21, 2017
Advanced age is the greatest risk factor for developing Alzheimer’s disease and related dementias. Evidence suggests that these diseases begin decades prior to noticeable symptoms. A better understanding of how the brain changes with age may provide clues into how/why these diseases begin and progress. We discovered that the abnormal ...
November 4, 2020
Genome-wide association studies (GWAS) in Alzheimer’s disease (AD) suggest that studying the immune system of the brain may provide insights into disease resilience, onset and progression. Many think the brain immune system is likely the next target for drugs to treat this intractable disease. Currently though, there are huge knowledge ...
December 15, 2020
In 2014 after Nana’s high-risk bowel obstruction surgery, it was evident that it was in Nana’s best interest to transition to a nursing home, due to the rapid progression of her condition. The nursing home would provide her with the professional 24-hour care she needed. Since then, Nana has been ...
February 26, 2018
2019 SPARC, secreted protein acidic and rich in cysteine, is a 32kDa calcium-binding matricellular protein. The matricellular proteins (thrombospondin-1, tenascin-C and SPARC) are extracellular matrix proteins that antagonize cell adhesions when presented to cells as soluble molecules. This proposal is based on our findings from CALERIE-II (Comprehensive Assessment of Long-term Effects ...
December 24, 2018
