Role of common and rare APP DNA sequence variants in Alzheimer’s Disease

April 17, 2012

Christoph Lange, Lars Bertram, Rudy Tanzi

Combined treatment with phenolics (-)-epigallocatecin-3 gallate and ferulic acid improves cognition and reduces Alzhiemer-like pathology in mice

January 30, 2024

Terrence Town

Open peer commentary on “Prescribing anti‐amyloid immunotherapies to treat Alzheimer’s disease: Fully informing patient decisions”

January 30, 2024

Sam Gandy

Plasminogen mediates communication between the peripheral and central immune system during systemic immune challenge with lipopolysaccharide

January 30, 2024

Erin H. Norris, Sidney Strickland

THE EFFECT OF THE MENOPAUSAL TRANSITION PERIOD ON THE BRAIN

Throughout a single lifetime, the brain undergoes many changes. In early development, brain circuits are connected and pruned; in adolescence circuits mature and, in midlife, the menopause transition (MT) impacts a host of brain functions—from energy metabolism to synaptogenesis. Despite the clear link between MT and brain function, very little ...

June 9, 2021

Diabetes-associated SorCS1 regulates Alzheimer’s amyloid-beta metabolism: evidence for involvement of SorL1 and the Retromer Complex

September 29, 2010

Rudy Tanzi, Sam Gandy

Microbial Immuno-Communication in Neurodegenerative Diseases

January 30, 2024

Sangram S. Sisodia

Dysregulation of Signaling on Post Synaptic Density Scaffolds in Alzheimer’s Disease

In Alzheimer’s disease (AD), amyloid plaques and tau tangles are classic hallmark pathologies, but another important change that contributes to cognitive decline is the loss of synapses. Synapses are points of connection between neurons that support the transfer and receipt of information between them. They are essential for memory, learning, ...

July 29, 2024

Alexandra C. Newton

Traumatic brain injury increases cortical glutamate network activity by compromising GABAergic Control

January 30, 2024

Giuseppina Tesco

HOW THE APOE4 GENE COMPROMISES BRAIN DEFENSE IN WOMEN

Researchers have pinpointed a new mechanism that may explain why women with the APOE4 gene are at even greater risk for Alzheimer’s disease than are male carriers. The discovery centers on neutrophils, a type of white blood cell that normally helps the body fight off infections. In female APOE4 carriers, ...

July 3, 2024