Alzheimer’s Risk is Higher in Women: Identification of Female-specific Brain Bioenergetic Targets

2018

Of every three patients with Alzheimer’s disease, two are women. There is evidence that the ebb in estrogen heralding the onset of menopause causes the loss of a key neuroprotective element in the female brain, with an aggressively higher vulnerability to brain aging and Alzheimer’s disease. This project seeks to unravel the biological mechanism that increases AD vulnerability in women by using a novel brain imaging technique that allows quantification of energy production in the brain.


Funding to Date

$170,861

Focus

Foundational Genetics, Other Areas of Investigation