Nanobodies to Cross the Blood-Brain Barrier


The blood-brain barrier (BBB) is a vital barrier between the bloodstream and the brain. This barrier tightly controls which molecules can enter the brain. As a consequence of this barrier, the majority of currently available drugs can’t enter the brain. Importantly, to treat Alzheimer’s disease, drugs need to reach the brain. The aim of this project is to generate a universal tool that can transport drug molecules to the brain.

Funding to Date



Drug Delivery and Design, Drug Discovery


Bart De Strooper, M.D., Ph.D.

Maarten Dewilde, Ph.D.