This research investigates how sleep promotes brain health and prevents neurodegeneration by maintaining optimal patterns of neural activity, potentially leading to new therapeutic strategies for neurodegenerative diseases that affect millions worldwide. By understanding how sleep’s restorative effects operate at both network and cellular levels, we aim to develop targeted interventions that could slow or prevent cognitive decline in conditions like Alzheimer’s disease and other tauopathies. This work could transform our approach to treating neurodegenerative disorders by establishing new therapeutic targets based on reinforcing the setpoints that allow for resilient cognition and behavior.
