Cure Alzheimer's Fund Cure Alzheimer's Fund

Alison M. Goate, D.Phil.

Jean C. and James W. Crystal Professor and Chair; Director, Ronald M. Loeb Center for Alzheimer’s Disease; Professor of Neuroscience, Professor of Neurology, Icahn School of Medicine at Mount Sinai

Dr. Alison Goate is the Jean C. and James W. Crystal Professor and Chair of the Dept. of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai (ISMMS). She has worked on the genetics of neurodegenerative diseases including Alzheimer’s disease (AD) and Frontotemporal Dementia (FTD) since 1987 and is the founding director of the Ronald M. Loeb Center for Alzheimer’s disease at ISMMS. Over the last three decades, she has been part of many gene-finding teams that have successfully identified disease-causing variants for both AD and FTD. Whilst working at Imperial College she reported the first mutation to cause familial Alzheimer’s disease and early studies at Washington University identified the mutation in the Colombian families that are now part of the API clinical trial. Her lab was also part of the team that first reported MAPT mutations in FTD.

Dr. Goate is also a leader in the study of late-onset AD genetics using integrative genomic approaches to identify novel genetic risk factors. Her work led to the identification of Trem2 as a risk factor for AD and has highlighted the enrichment of AD risk variants in microglial enhancers, regulatory elements in DNA that control gene expression in immune cells of the brain. She is now building upon these insights using genome-editing in induced pluripotent stem cells to understand the molecular mechanisms of disease and to develop novel therapeutics. Dr. Goate has received the Potamkin Award, the Khalid Iqbal Lifetime Achievement Award from the Alzheimer’s Association, and the MetLife Award for her research on AD. She was elected a fellow of AAAS in 2012 and a fellow of the National Academy of Medicine in 2016.

To learn more, visit the Goate Laboratory website and the Department of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai and follow them on social media @SinaiGenetics and @IcahnInstitute.

 

 

 

 

Related Research:

Investigating the Pathogenetic Role of Microglial MEF2C in Alzheimer’s Disease Across the Lifespan: Developmental Priming vs. Adult Response to Injury Alison Goate Edoardo Marcora 2025-12-18 Combinatorial Roles of EED and PICALM in Microglial Clearance Pathways in Alzheimer’s Disease Alison Goate Hyo Lee 2025-11-04 Investigating MEF2C Transcription Factor as a Therapeutic Target to Reprogram Pathological Microglial States in Alzheimer’s Disease Alison Goate Edoardo Marcora 2024-01-11 Systems Integration and Therapeutics Translation in Alzheimer’s Disease Alison Goate Edoardo Marcora 2022-02-14

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Investigating the Pathogenetic Role of Microglial MEF2C in Alzheimer’s Disease Across the Lifespan: Developmental Priming vs. Adult Response to Injury 2025

$230,000

Combinatorial Roles of EED and PICALM in Microglial Clearance Pathways in Alzheimer’s Disease 2025

$80,500
Investigating MEF2C Transcription Factor as a Therapeutic Target to Reprogram Pathological Microglial States in Alzheimer’s Disease 2023, 2025

$402,500
Systems Integration and Therapeutics Translation in Alzheimer’s Disease 2021, 2022

$345,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Ayata, P., Crowley, J. M., Challman, M. F., ... Ulrich, J. D., Marcora, E., ... Schafer, D. P., Holtzman, D. M., Goate, A. M.,Tarakhovsky, A., & Schaefer, A. Lymphoid gene expression supports neuroprotective microglia function, Nature, November 5, 2025, Read More

Richardson, T. E., Orr, M. E., Orr, T. C., Rohde, S. K., Ehrenberg, A. J., ... Goate, A. M., ... Kautz, T. F., … Walker, J. M. Spatial proteomic differences in chronic traumatic encephalopathy, Alzheimer’s disease, and primary age-related tauopathy hippocampi, Alzheimer's & Dementia, December 31, 2024, Read More

Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., … Gate, D., … , Iadecola, C., Johnson, L. A., Kanekiyo, T., … Lamb, B.T., … Marcora, E., … Morganti, J. M., … Ramachandran, K. V., … Tsai, L. H., … Ulrich, J. D., van der Kant, R., … Wellington, C. L., … Zhao, N., Bu, G., Goate, A. M., Holtzman, D. M. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference, Alzheimer's & Dementia, July 19, 2024, Read More

Tcw, J., Qian, L., Pipalia, N. H., Chao, M. J., Liang, S. A., Shi, Y., Jain, B. R., Bertelsen, S. E., Kapoor, M., Marcora, E., Sikora, E., Andrews, E. J., Martini, A. C., Karch, C. M., Head, E., Holtzman, D. M., Zhang, B., Wang, M., Maxfield, F. R., Poon, W. W., & Goate, A. M. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia, Cell, June 23, 2022, Read More

Whitson, H. E., Colton, C., El Khoury, J., Gate, D., Goate, A., Heneka, M. T., Kaddurah-Daouk, R., Klein, R. S., Shinohara, M. L., Sisodia, S., Spudich, S. S., Stevens, B., Tanzi, R., Ting, J. P., Garden, G., & Symposium Planning Committee members. Infection and inflammation: New perspectives on Alzheimer’s disease, Brain, Behavior, & Immunity - Health, April 22, 2022, Read More

Martens, Y. A., Zhao, N., Liu, C. C., Kanekiyo, T., Yang, A. J., Goate, A. M., Holtzman, D. M., & Bu, G. ApoE Cascade Hypothesis in the pathogenesis of Alzheimer’s disease and related dementias, Neuron, March 16, 2022, Read More

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