Cure Alzheimer's Fund Cure Alzheimer's Fund

Charles Glabe, Ph.D.

Professor, Molecular Biology and Biochemistry, University of California, Irvine

Dr. Glabe’s research program is focused on amyloid structure and aggregation, in particular beta-amyloid, which is the key pathogenic hallmark of Alzheimer’s disease. Dr. Glabe made the seminal discovery that protein components of amyloid share a common structure that is recognized by a conformation-specific antibody. This discovery indicates that amyloids likely share a common primary mechanism of pathogenesis in disease.

Related Research:

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Endogenous Human Antibodies Associated with Alzheimer’s Disease 2023

$230,000
Validation of Endogenous Human Antibodies That are Correlated With Avoiding Alzheimer’s Disease and Their Corresponding Antigens, for Immunotherapeutic Development 2017

$150,000
Identification of a Protective Human Immune Response for Alzheimer’s Disease 2016

$125,000
Long Abetas, Intraneuronal Amyloid and an Alternative Amyloid Hypothesis of Alzheimer’s Disease 2015

$100,000
Characterization of the pathological significance of a novel type of vascular amyloid 2013

$100,000
Potential for Host Cytotoxicity from Microbially-derived Abeta Oligomers 2009

$250,000
Cellular and Animal Models of Amyloid Pathology in Early Alzheimer’s Disease 2011

$100,000
Oligomer Collaborative Projects 2006

$1,550,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Jean-Vianney Haure-Mirande, Mickael Audrain, Tomas Fanutza, Soong Ho Kim, William L. Klein, Charles Glabe, Ben Readhead, Joel T. Dudley, Robert D. Blitzer, Minghui Wang, Bin Zhang, Eric E. Schadt, Sam Gandy, Michelle E. Ehrlich Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology, Acta Neuropathologica, 134(5), Nov 2017, 769-788, Read More

Elysse M. Knight, PhD, Soong Ho Kim, PhD, Jessica C. Kottwitz, BS, Asa Hatami, PhD, Ricardo Albay, BS, Akinobu Suzuki, PhD, Alex Lublin, PhD, Cristina M. Alberini, PhD, William L. Klein, PhD, Paul Szabo, PhD, Norman R. Relkin, MD, PhD, Michelle Ehrlich, MD, Charles G. Glabe, PhD, Sam Gandy, MD, PhD and John W. Steele, PhD Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes, Neurol Neuroimmunol Neuroinflamm, 3(3), May 2016, Read More

J W Steele, M L Lachenmayer, S Ju, A Stock, J Liken, S H Kim, L M Delgado, I E Alfaro, S Bernales, G Verdile, P Bharadwaj, V Gupta, R Barr, A Friss, G Dolios, R Wang, D Ringe, P Fraser, D Westaway, P H St George-Hyslop, P Szabo, N R Relkin, J D Buxbaum, C G Glabe, A A Protter, R N Martins, M E Ehrlich, G A Petsko, Z Yue and S Gandy Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer’s mouse model, Mol Psychiatry, 18(8), Aug 2013, 889-897, Read More

Rasool S, Martinez-Coria H, Wu JW, LaFerla F, Glabe CG Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice, J Neurochem, 126(4), August 2013, 473-482, Read More

Arai H, Glabe C, Luecke H Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers, Biochim Biophys Acta, 1820(12), Dec 2012, 1908-14, Read More

Nussbaum, JM; Schilling, S; Cynis, H; Silva, A; Swanson, E; Wangsanut, T; Tayler, K; Wiltgen, B; Hatami, A; Ronicke, R; Reymann, K; Hutter-Paier, B; Alexandru, A; Jagla, W; Graubner, S; Glabe, CG; Demuth, HU; Bloom, GS Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β, Nature, 485, May 2, 2012, 651-655, Read More

Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers, Annals of Neurology, Volume 68, Issue 2, August 2010, Read More

Kayed, R., Pensalfini, A., Margol, L., Sokolov, Y., Sarsoza, F., Head, E., Hall, J., and Glabe, C Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer, J Biol Chem, 284, February 13, 2009, 4230-4237, Read More

Glabe, CG Structural classification of toxic amyloid oligomers, J Biol Chem, 283, October 31, 2008, 29639-29643, Read More

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