Charles Glabe, Ph.D.

Professor, Molecular Biology and Biochemistry, University of California, Irvine

Dr. Glabe’s research program is focused on amyloid structure and aggregation, in particular beta-amyloid, which is the key pathogenic hallmark of Alzheimer’s disease. Dr. Glabe made the seminal discovery that protein components of amyloid share a common structure that is recognized by a conformation-specific antibody. This discovery indicates that amyloids likely share a common primary mechanism of pathogenesis in disease.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Haure-Mirande, J. V., Audrain, M., Fanutza, T., Kim, S. H., Klein, W. L., Glabe, C., Readhead, B., Dudley, J. T., Blitzer, R. D., Wang, M., Zhang, B., Schadt, E. E., Gandy, S., & Ehrlich, M. E. Deficiency of TYROBP, an adaptor protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology, Acta Neuropathologica, June 13, 2017, Read More

Kim, S. H., Steele, J. W., Lee, S. W., Clemenson, G. D., Carter, T. A., Treuner, K., Gadient, R., Wedel, P., Glabe, C., Barlow, C., Ehrlich, M. E., Gage, F. H., & Gandy, S. Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer A beta oligomer mouse, Molecular Psychiatry, August 12, 2014, Read More

Knight, E. M., Kim, S. H., Kottwitz, J. C., Hatami, A., Albay, R., Suzuki, A., Lublin, A., Alberini, C. M., Klein, W. L., Szabo, P., Relkin, N. R., Ehrlich, M., Glabe, C. G., Gandy, S., & Steele, J. W. Effective anti-Alzheimer A beta therapy involves depletion of specific A beta oligomer subtypes, Neurology Neuroimmunology & Neuroinflammation, May 10, 2016, Read More

Nussbaum, J. M., Schilling, S., Cynis, H., Silva, A., Swanson, E., Wangsanut, T., Tayler, K., Wiltgen, B., Hatami, A., Rönicke, R., Reymann, K., Hutter-Paier, B., Alexandru, A., Jagla, W., Graubner, S., Glabe, C. G., Demuth, H. U., & Bloom, G. S. Prion-like behavior and tau-dependent cytotoxicity of pyroglutamylated amyloid-beta, Nature, May 2, 2012, Read More

Rasool, S., Martinez-Coria, H., Wu, J. W., LaFerla, F., & Glabe, C. G. Systematic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing A deposition and tau pathology in 3xTg AD mice, Journal of Neurochemistry, August 1, 2013, Read More

Tomic, J. L., Pensalfini, A., Head, E., & Glabe, C. G. Soluble fibrillar oligomer levels are elevated in Alzheimer’s disease brain and correlate with cognitive dysfunction, Neurobiology of Disease, September 1, 2009, Read More

Pensalfini, A., Albay, R., 3rd, Rasool, S., Wu, J. W., Hatami, A., Arai, H., Margol, L., Milton, S., Poon, W. W., Corrada, M. M., Kawas, C. H., & Glabe, C. G. Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques, Neurobiology of Disease, November 1, 2014, Read More

Sosna, J., Philipp, S., Albay, R., 3rd, Reyes-Ruiz, J. M., Baglietto-Vargas, D., LaFerla, F. M., & Glabe, C. G. Early long-term administration of CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in FXFAD mouse models of Alzheimer’s disease., Molecular Neurodegeneration, March 1, 2018, Read More

Kayed, R., Canto, I., Breydo, L., Rasool, S., Lukacsovich, T., Wu, J., Albay, R., 3rd, Pensalfini, A., Yeung, S., Head, E., Marsh, J. L., & Glabe, C. Conformational dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar A beta oligomers, Molecular Neurodegeneration, December 13, 2010, Read More

Kayed, R., Head, E., Sarsoza, F., Saing, T., Cotman, C. W., Necula, M., Margol, L., Wu, J., Breydo, L., Thompson, J. L., Rasool, S., Gurlo, T., Butler, P., & Glabe, C. G. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers, Molecular Neurodegeneration, September 26, 2007, Read More

McLean, D., Cooke, M. J., Albay, R., 3rd, Glabe, C., & Shoichet, M. S. Positron Emission Tomography Imaging of Fibrillar Parenchymal and Vascular Amyloid-beta in TgCRND8 Mice, ACS Chemical Neuroscience, March 19, 2013, Read More

Wu, J. W., Breydo, L., Isas, J. M., Lee, J., Kuznetsov, Y. G., Langen, R., & Glabe, C. Fibrillar Oligomers Nucleate the Oligomerization of Monomeric Amyloid beta but Do Not Seed Fibril Formation, Journal of Biological Chemistry, December 15, 2009, Read More

Kayed, R., Pensalfini, A., Margol, L., Sokolov, Y., Sarsoza, F., Head, E., Hall, J., & Glabe, C. Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer, Journal of Biological Chemistry, February 13, 2009, Read More

Glabe C. G. Structural Classification of Toxic Amyloid Oligomers, Journal of Biological Chemistry, October 31, 2008, Read More

Reyes-Ruiz, J. M., Nakajima, R., Baghallab, I., Goldschmidt, L., Sosna, J., Mai Ho, P. N., Kumosani, T., Felgner, P. L., & Glabe, C. An “epitomic” analysis of the specificity of conformation-dependent, anti-Aß amyloid monoclonal antibodies, Journal of Biological Chemistry, December 14, 2020, Read More

Hatami, A., Monjazeb, S., Milton, S., & Glabe, C. G. Familial Alzheimer’s Disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid-beta peptide, Journal of Biological Chemistry, January 3, 2017, Read More

Hatami, A., Albay, R., 3rd, Monjazeb, S., Milton, S., & Glabe, C. Monoclonal antibodies against A beta 42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer’s disease brain, Journal of Biological Chemistry, October 3, 2014, Read More

Baghallab, I., Reyes-Ruiz, J. M., Abulnaja, K., Huwait, E., & Glabe, C. Epitomic Characterization of the specificity of the Anti-Amyloid A beta Monoclonal Antibodies 6E10 and 4G8, Journal of Alzheimer's Disease, November 5, 2018, Read More

Hatami, A., Monjazeb, S., & Glabe, C. The anti-amyloid beta monoclonal antibody 4G8 recognizes a generic sequence-independent epitope associated with alpha-synuclein and islet amyloid polypeptide amyloid fibrils, Journal of Alzheimer's Disease, December 1, 2016, Read More

Arai, H., Glabe, C., & Luecke, H. Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers, Biochimica et Biophysica Acta - General Subjects, August 24, 2012, Read More