These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Endogenous Human Antibodies Associated with Alzheimer’s Disease |
2023, 2024 $460,000 |
|
Validation of Endogenous Human Antibodies That are Correlated With Avoiding Alzheimer’s Disease and Their Corresponding Antigens, for Immunotherapeutic Development |
2017 $150,000 |
|
Identification of a Protective Human Immune Response for Alzheimer’s Disease |
2016 $125,000 |
|
Long Abetas, Intraneuronal Amyloid and an Alternative Amyloid Hypothesis of Alzheimer’s Disease |
2015 $100,000 |
|
Characterization of the pathological significance of a novel type of vascular amyloid |
2013 $100,000 |
|
Potential for Host Cytotoxicity from Microbially-derived Abeta Oligomers |
2009 $250,000 |
|
Cellular and Animal Models of Amyloid Pathology in Early Alzheimer’s Disease |
2011 $100,000 |
|
Oligomer Collaborative Projects |
2006 $1,550,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Haure-Mirande, J. V., Audrain, M., Fanutza, T., Kim, S. H., Klein, W. L., Glabe, C., Readhead, B., Dudley, J. T., Blitzer, R. D., Wang, M., Zhang, B., Schadt, E. E., Gandy, S., & Ehrlich, M. E. Deficiency of TYROBP, an adaptor protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology, Acta Neuropathologica, June 13, 2017, Read More
Kim, S. H., Steele, J. W., Lee, S. W., Clemenson, G. D., Carter, T. A., Treuner, K., Gadient, R., Wedel, P., Glabe, C., Barlow, C., Ehrlich, M. E., Gage, F. H., & Gandy, S. Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer A beta oligomer mouse, Molecular Psychiatry, August 12, 2014, Read More
Knight, E. M., Kim, S. H., Kottwitz, J. C., Hatami, A., Albay, R., Suzuki, A., Lublin, A., Alberini, C. M., Klein, W. L., Szabo, P., Relkin, N. R., Ehrlich, M., Glabe, C. G., Gandy, S., & Steele, J. W. Effective anti-Alzheimer A beta therapy involves depletion of specific A beta oligomer subtypes, Neurology Neuroimmunology & Neuroinflammation, May 10, 2016, Read More
Nussbaum, J. M., Schilling, S., Cynis, H., Silva, A., Swanson, E., Wangsanut, T., Tayler, K., Wiltgen, B., Hatami, A., Rönicke, R., Reymann, K., Hutter-Paier, B., Alexandru, A., Jagla, W., Graubner, S., Glabe, C. G., Demuth, H. U., & Bloom, G. S. Prion-like behavior and tau-dependent cytotoxicity of pyroglutamylated amyloid-beta, Nature, May 2, 2012, Read More
Rasool, S., Martinez-Coria, H., Wu, J. W., LaFerla, F., & Glabe, C. G. Systematic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing A deposition and tau pathology in 3xTg AD mice, Journal of Neurochemistry, August 1, 2013, Read More
Tomic, J. L., Pensalfini, A., Head, E., & Glabe, C. G. Soluble fibrillar oligomer levels are elevated in Alzheimer’s disease brain and correlate with cognitive dysfunction, Neurobiology of Disease, September 1, 2009, Read More
Pensalfini, A., Albay, R., 3rd, Rasool, S., Wu, J. W., Hatami, A., Arai, H., Margol, L., Milton, S., Poon, W. W., Corrada, M. M., Kawas, C. H., & Glabe, C. G. Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques, Neurobiology of Disease, November 1, 2014, Read More
Sosna, J., Philipp, S., Albay, R., 3rd, Reyes-Ruiz, J. M., Baglietto-Vargas, D., LaFerla, F. M., & Glabe, C. G. Early long-term administration of CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in FXFAD mouse models of Alzheimer’s disease., Molecular Neurodegeneration, March 1, 2018, Read More
Kayed, R., Canto, I., Breydo, L., Rasool, S., Lukacsovich, T., Wu, J., Albay, R., 3rd, Pensalfini, A., Yeung, S., Head, E., Marsh, J. L., & Glabe, C. Conformational dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar A beta oligomers, Molecular Neurodegeneration, December 13, 2010, Read More
Kayed, R., Head, E., Sarsoza, F., Saing, T., Cotman, C. W., Necula, M., Margol, L., Wu, J., Breydo, L., Thompson, J. L., Rasool, S., Gurlo, T., Butler, P., & Glabe, C. G. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers, Molecular Neurodegeneration, September 26, 2007, Read More
McLean, D., Cooke, M. J., Albay, R., 3rd, Glabe, C., & Shoichet, M. S. Positron Emission Tomography Imaging of Fibrillar Parenchymal and Vascular Amyloid-beta in TgCRND8 Mice, ACS Chemical Neuroscience, March 19, 2013, Read More
Wu, J. W., Breydo, L., Isas, J. M., Lee, J., Kuznetsov, Y. G., Langen, R., & Glabe, C. Fibrillar Oligomers Nucleate the Oligomerization of Monomeric Amyloid beta but Do Not Seed Fibril Formation, Journal of Biological Chemistry, December 15, 2009, Read More
Kayed, R., Pensalfini, A., Margol, L., Sokolov, Y., Sarsoza, F., Head, E., Hall, J., & Glabe, C. Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer, Journal of Biological Chemistry, February 13, 2009, Read More
Glabe C. G. Structural Classification of Toxic Amyloid Oligomers, Journal of Biological Chemistry, October 31, 2008, Read More
Reyes-Ruiz, J. M., Nakajima, R., Baghallab, I., Goldschmidt, L., Sosna, J., Mai Ho, P. N., Kumosani, T., Felgner, P. L., & Glabe, C. An “epitomic” analysis of the specificity of conformation-dependent, anti-Aß amyloid monoclonal antibodies, Journal of Biological Chemistry, December 14, 2020, Read More
Hatami, A., Monjazeb, S., Milton, S., & Glabe, C. G. Familial Alzheimer’s Disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid-beta peptide, Journal of Biological Chemistry, January 3, 2017, Read More
Hatami, A., Albay, R., 3rd, Monjazeb, S., Milton, S., & Glabe, C. Monoclonal antibodies against A beta 42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer’s disease brain, Journal of Biological Chemistry, October 3, 2014, Read More
Baghallab, I., Reyes-Ruiz, J. M., Abulnaja, K., Huwait, E., & Glabe, C. Epitomic Characterization of the specificity of the Anti-Amyloid A beta Monoclonal Antibodies 6E10 and 4G8, Journal of Alzheimer's Disease, November 5, 2018, Read More
Hatami, A., Monjazeb, S., & Glabe, C. The anti-amyloid beta monoclonal antibody 4G8 recognizes a generic sequence-independent epitope associated with alpha-synuclein and islet amyloid polypeptide amyloid fibrils, Journal of Alzheimer's Disease, December 1, 2016, Read More
Arai, H., Glabe, C., & Luecke, H. Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers, Biochimica et Biophysica Acta - General Subjects, August 24, 2012, Read More